Lymphangiogenesis does not occur in breast cancer

American Journal of Surgical Pathology

Volumn 29, Issue 11, 2005, Pages 1449-1455

  Agarwal, Beamon ^a   Saxena, Romil ^a   Morimiya, Akira ^a   Mehrotra, Sanjana ^a   Badve, Sunil ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Breast cancer; D2 40; Lymphangiogenesis; Lymphatic vessel density; Podoplanin; Prox 1

Indexed keywords

CYCLINE; PODOPLANIN;

ADULT; AGED; ARTICLE; BREAST BIOPSY; BREAST CANCER; CARCINOMA IN SITU; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FIBROCYSTIC BREAST DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; MAJOR CLINICAL STUDY;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARCINOMA, LOBULAR; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROLIFERATING CELL NUCLEAR ANTIGEN; TUMOR MARKERS, BIOLOGICAL;

EID: 27244454539     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000174269.99459.9d     Document Type: Article

References (55)

1. Barsky S, Alpaugh M. The molecular basis of inflammatory breast carcinoma [Abstract 1831]. Proc Am Assoc Cancer Res. 2002;43:368.
2. Beasley NJ, Prevo R, Banerji S, et al. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res. 2002;62: 1315-1320.
3. Birner P, Schindl M, Obermair A, et al. Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer. Int J Cancer. 2001;95:29-33.
4. Boardman KC, Swartz MA. Interstitial flow as a guide for lymphangiogenesis. Circ Res. 2003;92:801-808.
5. Bono P, Wasenius VM, Heikkila P, et al. High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer. Clin Cancer Res. 2004;10:7144-7149.
6. Borron P, Hay JB. Characterization of ovine lymphatic endothelial cells and their interactions with lymphocytes. Lymphology. 1994;27:6-13.
7. Breiteneder-Geleff S, Matsui K, Soleiman A, et al. Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am J Pathol. 1997;151:1141-1152.
8. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium. Am J Pathol. 1999;154:385-394.
9. Byzova TV, Goldman CK, Jankau J, et al. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Blood. 2002;99:4434-4442.
10. Chandler DE. Exocytosis in vitro: ultrastructure of the isolated sea urchin egg cortex as seen in platinum replicas. J Ultrastruct Res. 1984;89:198-211.
11. Choi WW, Lewis MM, Lawson D, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression. Mod Pathol. 2005; 18:143-152.
12. Cursiefen C, Chen L, Dana MR, et al. Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology. Cornea. 2003;22:273-281.
13. Dadras SS, Paul T, Bertoncini J, et al. Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol. 2003;162:1951-1960.
14. Enholm B, Karpanen T, Jeltsch M, et al. Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin. Circ Res. 2001;88:623-629.
15. Franchi A, Gallo O, Massi D, et al. Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations. Cancer. 2004;101:973-978.
16. Gupta A, Deshpande CG, Badve S. Role of E-cadherins in development of lymphatic tumor emboli. Cancer. 2003;97:2341-2347.
17. Hartveit E. Attenuated cells in breast stroma: the missing lymphatic system of the breast. Histopathology. 1990;16:533-543.
18. Jackson DG. New molecular markers for the study of tumour lymphangiogenesis. Anticancer Res. 2001;21:4279-4283.
19. Jain RK, Fenton BT. Intratumoral lymphatic vessels: a case of mistaken identity or malfunction? J Natl Cancer Inst. 2002;94:417-421.
20. Jeltsch M, Kaipainen A, Joukov V, et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science. 1997;276:1423-1425.
21. Johnston MG, Walker MA. Lymphatic endothelial and smooth-muscle cells in tissue culture. In Vitro. 1984;20:566-572.
22. Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002; 15:434-440.
23. Kahn HJ, Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest. 2002;82:1255-1257.
24. Karpanen T, Egeblad M, Karkkainen MJ, et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res. 2001;61:1786-1790.
25. Kidwai N, Swartz M, Badve S. VEGFR-3 is down regulated in breast cancer. Lab Invest. 2004;84:36A.
26. Leak LV, Jones M. Lymphatic endothelium isolation, characterization and long-term culture. Anat Rec. 1993;236:641-652.
27. Leu AJ, Berk DA, Lymboussaki A, et al. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. Cancer Res. 2000;60:4324-4327.
28. Makinen T, Veikkola T, Mustjoki S, et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 2001;20:4762-4773.
29. Mandriota SJ, Jussila L, Jeltsch M, et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J. 2001;20:672-682.
30. Marks A, Sutherland DR, Bailey D, et al. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. Br J Cancer. 1999;80:569-578.
31. Maula SM, Luukkaa M, Grenman R, et al. Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res. 2003;63:1920-1926.
32. Mouta Carreira C, Nasser SM, di Tomaso E, et al. LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001; 61:8079-8084.
33. Nakamura Y, Yasuoka H, Tsujimoto M, et al. Flt-4-positive vessel density correlates with vascular endothelial growth factor-d expression, nodal status, and prognosis in breast cancer. Clin Cancer Res. 2003;9:5313-5317.
34. Nicosia RF. Angiogenesis and the formation of lymphatic like channels in cultures of thoracic duct. In Vitro Cell Dev Biol. 1987;23:167-174.
35. Oliver G, Detmar M. The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev. 2002;16:773-783.
36. Padera TP, Kadambi A, di Tomaso E, et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002;296:1883-1886.
37. Pepper MS, Wasi S, Ferrara N, et al. In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells. Exp Cell Res. 1994;210: 298-305.
38. Scavelli C, Weber E, Agliano M, et al. Lymphatics at the crossroads of angiogenesis and lymphangiogenesis: crosstalk between angiogenesis and lymphangiogenesis in tumor progression. J Anat. 2004;204:433-449.
39. Schoppmann SF, Bayer G, Aumayr K, et al. Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Ann Surg. 2004;240:306-312.
40. Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med. 2001;7:192-198.
41. Soule S, Shak S, Baker J, et al. Predicting response to neoadjuvant chemotherapy in invasive breast cancer: gene expression profiling of paraffin-embedded core biopsy tissue [Abstract 3466]. Proc Am Soc Clin Oncol. 2003;22:862.
42. Stacker SA, Achen MG, Jussila L, et al. Lymphangiogenesis and cancer metastasis. Nat Rev Cancer. 2002;2:573-583.
43. Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med. 2001;7:186-191.
44. Stanton AW, Kadoo P, Mortimer PS, et al. Quantification of the initial lymphatic network in normal human forearm skin using fluorescence microlymphography and stereological methods. Microvasc Res. 1997;54: 156-163.
45. Trojan L, Michel MS, Rensch F, et al. Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1). J Urol. 2004; 172:103-107.
46. Veikkola T, Jussila L, Makinen T, et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J. 2001;20:1223-1231.
47. Vleugel MM, Bos R, van der Groep P, et al. Lack of lymphangiogenesis during breast carcinogenesis. J Clin Pathol. 2004;57:746-751.
48. Weber E, Lorenzoni P, Lozzi G, et al. Culture of bovine thoracic duct endothelial cells. In Vitro Cell Dev Biol Anim. 1994;30A:287-288.
49. Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N Engl J Med. 1991; 324:1-8.
50. Weninger W, Partanen TA, Breiteneder-Geleff S, et al. Expression of vascular endothelial growth factor receptor-3 and Podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells. Lab Invest. 1999;79:243-251.
51. Wigle JT, Harvey N, Detmar M, et al. An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 2002;21: 1505-1513.
52. Wigle JT, Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell. 1999;98:769-778.
53. Williams CS, Leek RD, Robson AM, et al. Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer. J Pathol. 2003;200:195-206.
54. Yanai Y, Furuhata T, Kimura Y, et al. Vascular endothelial growth factor C promotes human gastric carcinoma lymph node metastasis in mice. J Exp Clin Cancer Res. 2001;20:419-428.
55. Yong LC, Jones BE. A comparative study of cultured vascular and lymphatic endothelium. Exp Pathol. 1991;42:11-25.