Processing of lysozyme at distinct loops by pepsin: A novel action for generating multiple antimicrobial peptide motifs in the newborn stomach

Biochimica et Biophysica Acta - General Subjects

Volumn 1726, Issue 1, 2005, Pages 102-114

  Ibrahim, Hisham R ^a   Inazaki, Daisuke ^a   Abdou, Adham ^b   Aoki, Takayoshi ^a   Kim, Mujo ^b  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b Pharma Foods International Co Ltd   (Japan)

Author keywords

Antimicrobial activity; Gastrointestinal mucosa; Human breast milk; Lysozyme; Membrane damage; Muramidase; Pepsin; Peptide motif; Proteolysis

Indexed keywords

DOUBLE STRANDED DNA; HELIX LOOP HELIX PROTEIN; LEUCINE; LYSOZYME; PEPSIN A;

ALPHA HELIX; AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; BETA SHEET; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; GEL FILTRATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INNATE IMMUNITY; MASS SPECTROMETRY; MUCOSAL IMMUNITY; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE ANALYSIS; STOMACH PH;

ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL MEMBRANE; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; IMMUNITY, MUCOSAL; MASS SPECTROMETRY; MODELS, MOLECULAR; MURAMIDASE; PEPSIN A; PROTEIN CONFORMATION; SEQUENCE ANALYSIS, DNA;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 27144540982     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2005.07.008     Document Type: Article

References (47)

1. P. Jolles, and J. Jolles What's new in lysozyme research? Mol. Cell. Biochem. 63 1984 165 189
2. G.F. Brooks, J.S. Butel, and L.N. Ornston Medical Microbiology 19th ed. 1991 Prentice-Hall International Inc. London
3. J.G. Banks, R.G. Board, and N.H. Sparks Natural antimicrobial systems and their potential in food preservation of the future Biotechnol. Appl. Biochem. 8 1986 103 147
4. H.R. Ibrahim, T. Aoki, and A. Pellegrini Strategies for new antimicrobial proteins and peptides: lysozyme and aprotinin as model molecules Curr. Pharm. Des. 8 2002 671 693
5. S. Lee-Huang, P. Huang, Y. Sun, H.f. Kung, D.L. Blithe, and H.C. Chen Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin Proc. Natl. Acad. Sci. U S A 96 1999 2678 2681
6. F.X. Hasselberger Uses of Enzymes and Immobilized Enzymes 1978 Nelson-Hall Inc. Chicago
7. P.L. Kokoshis, D.L. Williams, J.A. Cook, and N.R. Di-Luzio Increased resistance to Staphylococcus aureus infection and enhancement in serum lysozyme activity by glucan Science 199 1978 1340 1342
8. G. Sava, V. Ceschia, and G. Zabucchi Evidence for host-mediated antitumour effects of lysozyme in mice bearing the MCa mammary carcinoma Eur. J. Cancer Clin. Oncol. 24 1988 1737 1743
9. J. Hankiewicz, and E. Swierczek Lysozyme activity in various human body fluids Clin. Chem. Acta 57 1974 205 209
10. E.F. Osserman, M. Klockars, J. Halper, and R.E. Fischel Effects of lysozyme on normal and transformed mammalian cells Nature 243 1973 331 335
11. P. Venge, T. Foucard, J. Henriksen, L. Hakansson, and A. Kreuger Serum-levels of lactoferrin, lysozyme and myeloperoxidase in normal, infection-prone and leukemic children Clin. Chim. Acta 136 1984 121 130
12. H.R. Ibrahim, S. Higashiguchi, L.R. Juneja, M. Kim, and T. Yamamoto A structural phase of heat-denatured lysozyme with novel antimicrobial action J. Agric. Food Chem. 44 1996 1416 1423
13. H.R. Ibrahim, S. Higashiguchi, M. Koketsu, L.R. Juneja, M. Kim, T. Yamamoto, Y. Sugimoto, and T. Aoki Partially unfolded lysozyme at neutral pH agglutinates and kills Gram-negative and Gram-positive bacteria through membrane damage mechanism J. Agric. Food Chem. 44 1996 3799 3806
14. H.R. Ibrahim On the novel catalytically-independent antimicrobial function of hen egg-white Lysozyme: a conformation-dependent activity Nahrung 42 1998 187 193
15. H.R. Ibrahim, T. Matsuzaki, and T. Aoki Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function FEBS Lett. 506 2001 27 32
16. H.R. Ibrahim, U. Thomas, and A. Pellegrini A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action J. Biol. Chem. 276 2001 43767 43774
17. C.M. Black, M. Paliescheskey, B.L. Beaman, R.M. Donovan, and E. Goldstein Modulation of lysosomal protease-esterase and lysozyme in Kupffer cells and peritoneal macrophages infected with Nocardia asteroides Infect. Immun. 54 1986 917 919
18. L. Bjermer, O. Back, G. Roos, and M. Thunell Mast cells and lysozyme positive macrophages in bronchoalveolar lavage from patients with sarcoidosis. Valuable prognostic and activity marking parameters of disease Acta Med. Scand. 220 1986 161 166
19. W. Pruzanski, N.S. Ranadive, and S. Saito Modulation of phagocytosis and intracellular bactericidal activity of polymorphonuclear and mononuclear cells by cationic proteins from human granulocytes: alternative pathway of phagocytic enhancement Inflammation 8 1984 445 457
20. E. Flescher, Y. Keisari, J. Lengy, and D. Gold On the possible schistosomulicidal effect of macrophage-derived lysozyme Parasitology 103 1991 161 164
21. K.J.I. Throne, R.C. Oliver, and A.J. Barrett Lysis and killing of bacteria by lysosomal proteinases Infect. Immun. 14 1976 555 563
22. P. Benes, G. Koelsch, B. Dvorak, M. Fusek, and V. Vetvicka Detection of procathepsin D in rat milk Comp. Biochem. Physiol. 133 2002 113 118
23. J.D. Coonrod The role of extracellular bactericidal factors in pulmonary host defense Semin. Respir. Infect. 1 1986 118 129
24. S. Sathe, M. Sakata, A.R. Beaton, and R.A. Sack Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid Curr. Eye Res. 17 1998 348 362
25. K.A. McClellan Mucosal defense of the outer eye Surv. Ophthalmol. 42 1997 233 246
26. L.A. Hanson, M. Hahn-Zoric, M. Berndes, R. Ashraf, V. Herias, F. Jalil, T.I. Bhutta, A. Laeeq, and I. Mattsby-Baltzer Breast feeding: overview and breast milk immunology Acta Pediatr. Jpn. 36 1994 557 561
27. H. Kohler, S. Donarski, B. Stocks, A. Parret, C. Edwards, and H. Schroten Antibacterial characteristics in the feces of breast-fed and formula-fed infants during the first year of life J. Pediatr. Gastroenterol. Nutr. 34 2002 188 193
28. A. NascimentodeAraujo, and L.G. Giugliano Human milk fractions inhibit the adherence of diffusely adherent Escherichia coli (DAEC) and enteroaggregative E. coli (EAEC) to HeLa cells FEMS Microbiol. Lett. 184 2000 91 94
29. R.T. Ellison III, and T.J. Giehl Killing of gram-negative bacteria by lactoferrin and lysozyme J. Clin. Invest. 88 1991 1080 1091
30. N.M. Hooper Proteases in Biology and Medicine 2002 Portland Press London
31. I.Y. Filippova, E.N. Lysogorskaya, V.V. Anisimova, L.I. Suvorov, E.S. Oksenoit, and V.M. Stepanov Aspartic proteases distribution Anal. Biochem. 234 1996 113 118
32. R.I. Lehrer, and T. Ganz Antimicrobial polypeptides of human neutrophils Blood 76 1990 2169 2181
33. E. Caputo, G. Manco, L. Mandrich, and J. Guardiola A novel aspartyl proteinase from apocrine epithelia and breast tumors J. Biol. Chem. 275 2000 7935 7941
34. T. Kageyama Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development Cell. Mol. Life Sci. 59 2002 288 306
35. K. Hayashi, S. Yasugi, and T. Mizuno Isolation and structural analysis of embryonic chicken pepsinogen gene: avian homologue of prochymosin gene Biochem. Biophys. Res. Commun. 152 1988 776 782
36. M. Ichinose, K. Miki, C. Furihata, M. Tatematsu, Y. Ichihara, and T. Ishihara DNA methylation and expression of the rat pepsinogen gene in embryonic, adult, and neoplastic tissues Cancer Res. 48 1988 1603 1609
37. M.C. Vissers, and C.C. Winterbourn Myeloperoxidase-dependent oxidative inactivation of neutrophil neutral proteinase and microbicidal enzymes Biochem. J. 245 1987 277 280
38. K. Yamauchi, M. Tomita, T.J. Giehl, and R.T. Ellison Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment Infect. Immun. 61 1993 719 728
39. I.M. Helander, and T.M. Sandholm Fluorometric assessment of Gram-negative bacterial permeabilization J. Appl. Microbiol. 88 2000 213 219
40. E. Prosperi Intracellular turnover of fluorescein diacetate. Influence of membrane ionic gradients on fluorescein efflux Histochem. J. 22 1990 227 233
41. P. Polverino de Laureto, E. Frare, R. Gottardo, H. Van Dael, and A. Fontana Partly folded states of members of the lysozyme/lactalbumin superfamily: a comparative study by circular dichroism spectroscopy and limited proteolysis Protein Sci. 11 2002 2932 2946
42. D. Hoefel, W.L. Grooby, P.T. Monis, S. Andrews, and C.P. Saint A comparative study of carboxyfluorescein diacetate and carboxyfluorescein diacetate succinimidyl ester as indicators of bacterial activity J. Microbiol. Methods 52 2003 379 388
43. H. Rottenberg The generation of proton electrochemical potential gradient by cytochrome c oxidase Biochim. Biophys. Acta 1364 1998 1 16
44. K. Bagrarnyan, and A. Trchounkm Decrease of redox potential in the anaerobic growing E. coli suspension and proton-potassium exchange Bioelectrochem. Bioenerg. 43 1997 129 134
45. B.C. Pressman Biological applications of ionophores Annu. Rev. Biochem. 45 1976 501 530
46. M.G. Scott, and R.E. Hancock Cationic antimicrobial peptides and their multifunctional role in the immune system Crit. Rev. Immunol. 20 2000 407 431
47. R.M. Epand, and H.J. Vogel Diversity of antimicrobial peptides and their mechanisms of action Biochem. Biophys. Acta 1462 1999 11 28