Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone

Digestive Diseases and Sciences

Volumn 50, Issue 11, 2005, Pages 2110-2120

  Su, Youn Nam ^a   Kim, Nayoung ^b   Chang, Soo Lee ^a   Kee, Don Choi ^a   Hye, Seung Lee ^b   Hyun, Chae Jung ^a   Song, In Sung ^a,c  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Geranylgeranylacetone; Heat shock protein 70; MUC5AC; MUC6; Nitric oxide synthase

Indexed keywords

ALCOHOL; AMINOGUANIDINE; HEAT SHOCK PROTEIN 70; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; TEPRENONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; MALE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STOMACH MUCOSA; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTI-ULCER AGENTS; CYCLOOXYGENASE 2; DITERPENES; ETHANOL; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; HEXOSAMINES; HSP70 HEAT-SHOCK PROTEINS; MALE; MUCINS; MUCUS; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; STOMACH DISEASES;

EID: 27144526118     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-3016-8     Document Type: Article

References (54)

1. Flemstrom G, Garner A: Gastroduodenal HCO3(-) transport: Characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol Gastrointest Liver Physiol 242:G183-G193, 1982
2. Allen A, Flemstrom G, Garner A, Kivilaakso E: Gastroduodenal mucosal protection. Physiol Rev 73:823-857, 1993
3. Feil W, Klimesch S, Karner P, et al.: Importance of an alkaline microenvironment for rapid restitution of the rabbit duodenal mucosa in vitro. Gastroenterology 97:112-122, 1989
4. Barnard J, Beauchamp R, Russell W, Dubois R, Coffey R: Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology 108:564-580, 1995
5. Corfield AP, Carroll D, Myerscough N, Probert CS: Mucins in the gastrointestinal tract in health and disease. Front Biosci 1:1321-1357, 2001
6. Arias EB, Verhage HG, Jaffe RC: Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. Biol Reprod 51:685-694, 1994
7. Williams SJ, McGuckin MA, Gotley DC, Eyre HJ, Sutherland GR, Antalis TM: Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res 59:4083-4089, 1999
8. Byrd JC, Bresalier RS: Mucins and mucin binding proteins in colorectal cancer. Cancer Metastasis Rev 23:77-99, 2004
9. Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M: Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 47:589-594, 2000
10. Ho SB, Shekels LL, Toribara NW, et al.: Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res 55:2681-2690, 1995
11. Ho SB, Niehans GA, Lyftogt C, et al.: Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 53:641-651, 1993
12. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH: MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas. Cancer 92:1427-1434, 2001
13. Reis CA, David L, Seixas M, Burchell J, Sobrinho-Simoes M: Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma. Int J Cancer 79:402-410, 1998
14. Reis CA, David L, Nielsen PA, et al.: Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody. Int J Cancer 74:112-121, 1997
15. Ho SB, Roberton AM, Shekels LL, Lyftgof CT, Niehans GA, Toribara NW: Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression. Gastroenterology 109:735-747, 1995
16. Carrato C, Balague C, Bolos C, et al.: Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology 107:160-172, 1994
17. Filipe MI, Linehan JM, Durrant LG, et al.: Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions of gastric carcinoma. Eur J Cancer Prev 5:287-295, 1996
18. Jass JR, Walsh MD: Altered mucin expression in the gastrointestinal tract: A review. J Cell Mol Med 5:327-351, 2001
19. Murakami M, Oketani K, Fujisaki H, Wakabayashi T, Ohgo T: Effects on the antiulcer drug geranylgeranylacetone on aspirin induced gastric ulcers in rats. Jpn J Pharmacol 32:299-306, 1982
20. Arakawa T, Yamada H, Nakamura A, et al.: Gastric cytoprotection by tetraprenylacetone in human subjects. Digestion 39:111-117, 1988
21. Terano A, Hiraishi H, Ota S, Sugimoto T: Geranylgeranylacetone, a novel antiulcer drug, stimulates mucus synthesis and secretion in rat gastric culture cells. Digestion 33:206-210, 1986
22. Hirakawa T, Rokutan K, Nikawa T, Kishi K: Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 111:345-357, 1996
23. Bilski J, Sarosik J, Murty VL, et al.: Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone. Biochem Pharmacol 36:4059-4065, 1987
24. Fujimoto M, Yamanaka T, Bessho M, Igarashi T: Effects of geranylgeranylacetone on gastrointestinal secretion in rats. Eur J Pharmacol 77:113-118, 1982
25. Terano A, Shiga J, Hiraish H, Ota S, Sugimoto T: Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa. Digestion 35:182-188, 1986
26. Pandit S, Sur TK, Jana U, Bhattacharyya D, Debnath PK: Anti-ulcer effect of shankha bhasma in rats: A preliminary study. Indian J Pharm 32:378-380, 2000
27. Lacy ER, Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with prostaglandin. Gastroenterology 83:538-548, 1982
28. Nishida K, Ohta Y, Ishiguro I: Teprenone, an anti-ulcer agent, increase gastric mucosal mucus level via nitric oxide in rats. Jpn J Pharmacol 78:519-522, 1998
29. Neuhaus OW, Letzring M: Determination of hexosamine in conjunction with electrophoresis on starch. Anal Chem 29:1230-1233, 1957
30. Kitagawa H, Takeda F, Kohei H: A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats. Arzneim Forcsh/Drug Res 36:1240-1244, 1986
31. Nakamura K, Takahashi T, Taniuchi M, Hsu CX, Owyang C: Nicotinic receptor mediates nitric oxide synthase expression in the rat gastric myenteric plexus. J Clin Invest 101:1479-1489, 1998
32. Matsumoto T, Mitchell JA, Schmidt HH, et al.: Nitric oxide synthase in ferret brain: localization and characterization. Br J Pharmacol 107:849-852, 1992
33. Murakami M, Oketani K, Fujisaki H, Wakabayashi T: Effect of geranylgeranylacetone (GGA) on gastric lesions induced by topical aspirin plus HCl. Jpn J Pharmacol 32:921-924, 1982
34. Kawakubo M, Ito Y, Okimura Y, et al.: Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science 305:1003-1006, 2004
35. Dekker J, Rossen JWA, Buller HA, Einerhand AWC: The MUC family: An obituary. Trends Biochem Sci 27:126-131, 2002
36. Wataru T, Naoko T, Chiho K, Kazuhito R, Tomofusa T, Tohru M: Expression of immediate early genes, HSP70, and COX-2 mRNAs in rat stomach following ethanol ingestion. Dig Dis Sci 45:2455-2462, 2000
37. Desseyn JL, Buisine MP, Porchet N, Aubert N, Degand P, Laine A: Evolutionary history of the 11p15 human mucin gene family. J Mol Evol 46:102-106, 1998
38. Byrd JC, P Sternberg YL, Yunker CK, Scheiman JM, Bresalier RS: Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients. Gastroenterology 113:455-464, 1997
39. Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761-767, 1979
40. Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433-443, 1979
41. Tsukimi Y Okabe S: Recent advances in gastrointestinal pathophysiology: Role of heat shock proteins in mucosal defense and ulcer healing. Biol Pharm Bull 24:1-9, 2001
42. Rokutan K, Teshima S, Kawai T, et al.: geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase. J Gastroenterol 35:673-681, 2000
43. Nishida K, Ohta Y, Ishiguro I: Preventive effect of teprenone on stress-induced gastric mucosal lesions and relation to gastric mucosal constitutive nitric oxide synthase activity. Pharmacol Res 39:325-332, 1999
44. Hiraishi H, Terano A, Ota S, et al.: Role for mucous cells against toxic oxygen metabolites. J Lab Clin Med 121:570-578, 1993
45. Wataru T, Naoko T, Chiho K, Kazuhito R, Tomofusa T, Tohru M: Geranylgeranylacetone protects cultured guinea pig gastric mucosal cells from indomethacin. Dig Dis Sci 45:1674-1679, 2000
46. Tatsunori T, Shinji T, Wataru T, Tatsuya H, Tomofusa T, Tohru M: Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced apoptosis. Dig Dis Sci 47:1546-1553, 2002
47. Hirakawa T, Rokutan K, Nikawa T, Kishi K: Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 111:345-357, 1996
48. Mizuno H, Sakamoto C, Matsuda K, et al.: Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112:387-397, 1997
49. Shigeta J, Takahashi S, Okabe S: Role of cyclooxygenase-2 in the healing of gastric ulcers in rats. J Pharmacol Exp Ther 286:1383-1390, 1998
50. Lopes-Belmonte JB, Whittle GSJ, Moncada S: The actions of nitric oxide donors in prevention or induction of injury to the rat gastric mucosa. Br J Pharmacol 108:73-78, 1994
51. Takeuchi K, Ohuchi T, Okabe S: Endogenous nitric oxide in gastric alkaline response in the rat stomach after damage. Gastroenterology 106:367-374, 1994
52. Masuda E, Kawano S, Nagano K, et al.: Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats. Gastroenterology 108:58-64, 1995
53. Ohta M, Tanoue K, Tarnawski AS, et al.: Overexpressed nitric oxide synthase in portal-hypertensive stomach of rat: key role to increased susceptibility to damage? Gastroenterology 112:1920-1930, 1997
54. Mercer DW, Castaneda AA, Denning JW, Chang L, Russel DH: Effects of endotoxin on gastric injury from luminal irritants in rats: potential roles of nitric oxide. Am J Physiol 275:G449-G459, 1998