Caspofungin is less nephrotoxic than amphotericin B in vitro and predominantly damages distal renal tubular cells

Nephrology Dialysis Transplantation

Volumn 20, Issue 10, 2005, Pages 2071-2079

  Wegner, Binytha ^a   Baer, Patrick ^a   Gauer, Stefan ^a   Oremek, Gerhard ^a   Hauser, Ingeborg A ^a   Geiger, Helmut ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Amphotericin B; Caspofungin; In vitro; Nephrotoxicity

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMPHOTERICIN B; CASPOFUNGIN; DNA; LACTATE DEHYDROGENASE; LIPOCORTIN 5;

ARTICLE; CELL CULTURE; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DRUG EXPOSURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY TUBULE CELL; NEPHROTOXICITY; PRIORITY JOURNAL; STAINING; SUPERNATANT;

AMPHOTERICIN B; ANNEXIN A5; ANTIFUNGAL AGENTS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DNA FRAGMENTATION; FLUORESCENT DYES; HUMANS; INDOLES; KIDNEY; KIDNEY TUBULES, DISTAL; KIDNEY TUBULES, PROXIMAL; L-LACTATE DEHYDROGENASE; NECROSIS; PEPTIDES, CYCLIC;

EID: 27144518277     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfh948     Document Type: Article

References (20)

1. Stone JA, Holland SD, Wickersham PJ et al. Single- and multiple-dose pharmacokinetics of Caspofungin in healthy men. Antimicrob Agents Chemother 2002; 46: 739-745
2. Wingard JR, Kubilis P, Lee L et al. Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosis. Clin lnfect Dis 1999; 29: 1402-1407
3. Villanueva A, Arathoon EG, Gotuzzo E, Berman RS. DiNubile MJ, Sable CA. A randomized double-blind study of Caspofungin versus amphotericin for the treatment of candidal esophagitis. Clin Infect Dis 2001; 33: 1529-1535
4. Villanueva A, Gotuzzo E, Arathoon EG et al. A randomized double-blind study of Caspofungin versus fluconazole for treatment of esophageal candidiasis. Am J Med 2002; 113: 294-299
5. Arathoon EG, Gotuzzo E, Noriega LM, Berman RS, DiNubile MJ, Sable CA. Randomized, double-blind, multi-center study of Caspofungin versus amphotericin B for treatment of oropharyngeal and esophageal candidiases. Antimicrob Agents Chemother 2002: 46: 451-457
6. Walsh TJ, Teppler H, Donowitz GR et al. Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia. N Engl J Med 2004; 351: 1391-1402
7. Mora-Duarte J, Betts R, Rotstein C et al. Comparison of Caspofungin and amphotericin B for invasive candidiasis. N Engl J Med 2002; 347: 2020-2029
8. Gouge TH, Andriole VT. An experimental model of amphotericin B nephrotoxicity with renal tubular acidosis. J Lab Clin Med 1971; 78: 713-724
9. Baer PC, Nockher WA, Haase W, Scherberich JE. Isolation of proximal and distal tubule cells from human kidney by immunomagnetic separation. Kidney Int 1997; 52: 1321-1331
10. Baer PC, Scherberich JE, Bereiter-Hahn J, Geiger H. Induction of RANTES, HLA-DR, and intercellular adhesion molecule-1 on highly purified distal tubular cells from human kidney. Transplantation 2000; 69: 2456-2459
11. Blaheta RA, Franz M, Auth MK, Wenisch HJ, Markus BH. A rapid non-radioactive fluorescence assay for the measurement of both cell number and proliferation. J Immunol Methods 1991; 142: 199-206
12. Cancidas R (package insert). MSD, Haar, BPI Service GmbH, Auladorf, Germany, 2003
13. Hajdu R, Thompson R. Sundelof JG et al. Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743872). Antimicrob Agents Chemother 1997; 41: 2339-2344
14. Bekersky I, Fielding RM, Dressler DE, Lee JW, Buell DN, Walsh TJ. Pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate in humans. Antimicrob Agents Chemother 2002; 46: 828-833
15. Joly V, Saint-Julien L, Carbon C. Yeni P. Interactions of free and liposomal amphotericin B with renal proximal tubular cells in primary culture. J Pharmacol Exp Ther 1990; 255: 17-22
16. Varlam, DE, Siddiq MM, Parton LA, Rüssmann H. Apoptosis contributes to amphotericin B-induced nephrotoxicity. Antimicrob Agents Chemother 2001; 45: 679-685
17. Walev I. Bhakdi S. Possible reason for preferential damage to renal tubular epithelial cells evoked by amphotericin B. Antimicrob Agents Chemother 1996; 40: 1116-1120
18. Lash LH, Putt DA, Hueni SE, Krause RJ, Elfarra AA. Roles of necrosis, apoptosis, and mitochondrial dysfunction in S-(1,2-Dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells. J Pharmacol Exp Ther 2003; 305: 1163-1172
19. Sable CA, Nguyen B-YT, Chodakewitz JA, DiNubile MJ. Safety and tolerability of Caspofungin acetate in the treatment of fungal infections. Transpl Infect Dis 2002; 4: 25-30
20. Lash LH, Tokarz JJ, Pegouske DM. Susceptibility of primary cultures of proximal tubular and distal tubular cells from rat kidney to chemically induced toxicity. Toxicology 1995; 103: 85-103