-
1
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
Huntington Disease Collaborative Research Group: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971-983.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
2
-
-
0035940412
-
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
-
Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, and DiFiglia M: Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci USA 2001;98:12784-12789.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12784-12789
-
-
Kim, Y.J.1
Yi, Y.2
Sapp, E.3
Wang, Y.4
Cuiffo, B.5
Kegel, K.B.6
Qin, Z.H.7
Aronin, N.8
Difiglia, M.9
-
3
-
-
0035869544
-
Tissue-specific proteolysis of Huntingtin (htt) in human brain: Evidence of enhanced levels of N- And C-terminal htt fragments in Huntington's disease striatum
-
Mende-Mueller LM, Toneff T, Hwang SR, Chesselet MF, and Hook VY: Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum. J Neurosci 2001;21:1830-1837.
-
(2001)
J Neurosci
, vol.21
, pp. 1830-1837
-
-
Mende-Mueller, L.M.1
Toneff, T.2
Hwang, S.R.3
Chesselet, M.F.4
Hook, V.Y.5
-
4
-
-
0037107151
-
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
-
Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, and Hayden MR: Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci 2002; 22:7862-7872.
-
(2002)
J Neurosci
, vol.22
, pp. 7862-7872
-
-
Wellington, C.L.1
Ellerby, L.M.2
Gutekunst, C.A.3
Rogers, D.4
Warby, S.5
Graham, R.K.6
Loubser, O.7
Van Raamsdonk, J.8
Singaraja, R.9
Yang, Y.Z.10
Gafni, J.11
Bredesen, D.12
Hersch, S.M.13
Leavitt, B.R.14
Roy, S.15
Nicholson, D.W.16
Hayden, M.R.17
-
5
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA, Scherzinger E, Wanker EE, Mangiarini L, and Bates GP: Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 1997; 90:537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
Difiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
6
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neuntes in brain
-
DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP, and Aronin N: Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neuntes in brain. Science 1997;277: 1990-1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
7
-
-
0033025958
-
Distribution of inclusions in neuronal nuclei and dystrophic neuntes in Huntington disease brain
-
Maat-Schieman ML, Dorsman JC, Smoor MA, Siesling S, Van Duinen SG, Verschuuren JJ, den Dunnen JT, van Ommen GJ, and Roos RA: Distribution of inclusions in neuronal nuclei and dystrophic neuntes in Huntington disease brain. J Neuropathol Exp Neurol 1999;58:129-137.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 129-137
-
-
Maat-Schieman, M.L.1
Dorsman, J.C.2
Smoor, M.A.3
Siesling, S.4
Van Duinen, S.G.5
Verschuuren, J.J.6
Den Dunnen, J.T.7
Van Ommen, G.J.8
Roos, R.A.9
-
8
-
-
18544400323
-
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
-
Scherzinger E, Lurz R, Turmaine M, Mangiarini L, Hollenbach B, Hasenbank R, Bates GP, Davies SW, Lehrach H, and Wanker EE: Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell 1997;90:549-558.
-
(1997)
Cell
, vol.90
, pp. 549-558
-
-
Scherzinger, E.1
Lurz, R.2
Turmaine, M.3
Mangiarini, L.4
Hollenbach, B.5
Hasenbank, R.6
Bates, G.P.7
Davies, S.W.8
Lehrach, H.9
Wanker, E.E.10
-
9
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, and Bates GP: Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996;87:493-506.
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
Bates, G.P.11
-
10
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price DL, Ross CA, and Borchelt DR: Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet 1999;8:397-407.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.A.6
Slunt, H.H.7
Ratovitski, T.8
Cooper, J.K.9
Jenkins, N.A.10
Copeland, N.G.11
Price, D.L.12
Ross, C.A.13
Borchelt, D.R.14
-
11
-
-
7144253143
-
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture
-
Cooper JK, Schilling G, Peters MF, Herring WJ, Sharp AH, Kaminsky Z, Masone J, Khan FA, Delanoy M, Borchelt DR, Dawson VL, Dawson TM, and Ross CA: Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet 1998;7: 783-790.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 783-790
-
-
Cooper, J.K.1
Schilling, G.2
Peters, M.F.3
Herring, W.J.4
Sharp, A.H.5
Kaminsky, Z.6
Masone, J.7
Khan, F.A.8
Delanoy, M.9
Borchelt, D.R.10
Dawson, V.L.11
Dawson, T.M.12
Ross, C.A.13
-
12
-
-
0033168302
-
Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin
-
Li SH, Cheng AL, Li H, and Li XJ: Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin. J Neurosci 1999;19:5159-5172.
-
(1999)
J Neurosci
, vol.19
, pp. 5159-5172
-
-
Li, S.H.1
Cheng, A.L.2
Li, H.3
Li, X.J.4
-
13
-
-
0029055601
-
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form
-
Trottier Y, Devys D, Imbert G, Saudou F, An I, Lutz Y, Weber C, Agid Y, Hirsch EC, and Mandel JL: Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form. Nat Genet 1995;10:104-110.
-
(1995)
Nat Genet
, vol.10
, pp. 104-110
-
-
Trottier, Y.1
Devys, D.2
Imbert, G.3
Saudou, F.4
An, I.5
Lutz, Y.6
Weber, C.7
Agid, Y.8
Hirsch, E.C.9
Mandel, J.L.10
-
14
-
-
0141725601
-
Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain
-
Fusco FR, Zuccato C, Tartari M, Martorana A, De March Z, Giampa C, Cattaneo E, and Bernardi G: Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain. Eur J Neurosci 2003; 18:1093-1102.
-
(2003)
Eur J Neurosci
, vol.18
, pp. 1093-1102
-
-
Fusco, F.R.1
Zuccato, C.2
Tartari, M.3
Martorana, A.4
De March, Z.5
Giampa, C.6
Cattaneo, E.7
Bernardi, G.8
-
15
-
-
0035179456
-
Mutant protein in Huntington disease is resistant to proteolysis in affected brain
-
Dyer RB, and McMurray CT: Mutant protein in Huntington disease is resistant to proteolysis in affected brain. Nat Genet 2001; 29:270-278.
-
(2001)
Nat Genet
, vol.29
, pp. 270-278
-
-
Dyer, R.B.1
McMurray, C.T.2
-
16
-
-
0036671821
-
Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
-
Lunkes A, Lindenberg KS, Ben Haiem L, Weber C, Devys D, Landwehrmeyer GB, Mandel JL, and Trottier Y: Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol Cell 2002;10: 259-269.
-
(2002)
Mol Cell
, vol.10
, pp. 259-269
-
-
Lunkes, A.1
Lindenberg, K.S.2
Ben Haiem, L.3
Weber, C.4
Devys, D.5
Landwehrmeyer, G.B.6
Mandel, J.L.7
Trottier, Y.8
-
17
-
-
0004136246
-
-
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
Sambrook J, and Russell DW: Molecular Cloning: A Laboratory Manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2001.
-
(2001)
Molecular Cloning: A Laboratory Manual, 3rd Ed.
-
-
Sambrook, J.1
Russell, D.W.2
-
19
-
-
0023806075
-
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
-
Smith DB, and Johnson KS: Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 1988;67:31-40.
-
(1988)
Gene
, vol.67
, pp. 31-40
-
-
Smith, D.B.1
Johnson, K.S.2
-
20
-
-
0027634052
-
Retrospective: 12 Years of antigenic determinant predictions, and more
-
Hopp TP: Retrospective: 12 years of antigenic determinant predictions, and more. Pept Res 1993;6:183-190.
-
(1993)
Pept Res
, vol.6
, pp. 183-190
-
-
Hopp, T.P.1
-
21
-
-
0000448982
-
Prediction of protein antigenic determinants from amino acid sequences
-
Hopp TP, and Woods KR: Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci USA 1981; 78:3824-3828.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 3824-3828
-
-
Hopp, T.P.1
Woods, K.R.2
|