Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation

Nature

Volumn 437, Issue 7061, 2005, Pages 1048-1052

  Rauh, Nadine R ^a   Schmidt, Andreas ^a   Bormann, Jenny ^a   Nigg, Erich A ^a   Mayer, Thomas U ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIODEGRADATION; CYTOLOGY; ENZYME INHIBITION; PHOSPHORS; PROTEINS; SIGNAL DETECTION;

ANAPHASE; CYTOSTATIC FACTOR (CSF); MEIOTIC EXIT; VERTEBRATE EGGS;

GENETIC ENGINEERING;

ANAPHASE PROMOTING COMPLEX; ANAPHASE PROMOTING COMPLEX INHIBITOR; CALCIUM; ENZYME INHIBITOR; POLO LIKE KINASE 1; UNCLASSIFIED DRUG; XERP1 PROTEIN;

BIOLOGY;

ARTICLE; CONTROLLED STUDY; FERTILIZATION; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

VERTEBRATA;

EID: 27144516795     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04093     Document Type: Article

References (22)

1. Tunquist, B. J. & Maller, J. L. Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs. Genes Dev. 17, 683-710 (2003).
2. Masui, Y. & Markert, C. L. Cytoplasmic control of nuclear behaviour during meiotic maturation of frog oocytes. J. Exp. Zool. 177, 129-145 (1971).
3. King, R. W. et al. A 20S complex containing CDC27 and CDC15 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288 (1995).
4. Sudakin, V. et al. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185-197 (1995).
5. Salah, S. M. & Nasmyth, K. Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast. Chromosoma 109, 27-34 (2000).
6. 2+ wave follows fertilization in eggs of the frog, Xenopus laevis. J. Cell Biol. 100, 1325-1329 (1985).
7. Lorca, T. et al. Degradation of the proto-oncogene product p39mos is not necessary for cyclin proteolysis and exit from meiotic metaphase: requirement for a Ca(2+)-calmodulin dependent event. EMBO J. 10, 2087-2093 (1991).
8. Lorca, T. et al. Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs. Nature 366, 270-273 (1993).
9. Schmidt, A. et al. Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. Genes Dev. 19, 502-513 (2005).
10. Fuchs, S. Y., Spiegelman, V. S. & Kumar, K. G. The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23, 2028-2036 (2004).
11. Descombes, P. & Nigg, E. A. The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J. 17, 1328-1335 (1998).
12. Elia, A. E., Cantley, L. C. & Yaffe, M. B. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 299, 1228-1231 (2003).
13. Elia, A. E. et al. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell 115, 83-95 (2003).
14. Holloway, S. L., Glotzer, M., King, R. W. & Murray, A. W. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73, 13393-13402 (1993).
15. Stemmann, O., Zou, H., Gerber, S. A., Gygi, S. P. & Kirschner, M. W. Dual inhibition of sister chromatid separation at metaphase. Cell 107, 715-726 (2001).
16. 2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 263, 18145-18151 (1988).
17. Zachariae, W. Emi1 and Erp1: who can stop these eggs? Dev. Cell 8, 301-303 (2005).
18. Ohsumi, K., Koyanagi, A., Yamamoto, T. M., Gotoh, T. & Kishimoto, T. Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest. Proc. Natl Acad. Sci. USA 101, 12531-12536 (2004).
19. Tung, J. J. et al. A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. Proc. Natl Acad. Sci. USA 102, 4318-4323 (2005).
20. Murray, A. W. Cell cycle extracts. Methods Cell Biol. 36, 581-605 (1991).
21. Desai, A., Murray, A., Mitchison, T. J. & Walczak, C. E. The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol. 61, 385-412 (1999).
22. Funabiki, H. & Murray, A. W. The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell 102, 411-424 (2000).