Contrasting roles of protein kinase C in induction versus suppression of group I mGluR-mediated epileptogenesis in vitro

Journal of Neurophysiology

Volumn 94, Issue 5, 2005, Pages 3643-3647

  Cuellar, John C ^a   Griffith, Elvin L ^a   Merlin, Lisa R ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; CHELERYTHRINE; CYSTEINE SULFINIC ACID; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR AGONIST; PHOSPHOLIPASE D; PICROTOXIN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; CORTICAL SYNCHRONIZATION; ENZYME ACTIVATION; EPILEPTIC DISCHARGE; EPILEPTOGENESIS; GUINEA PIG; HIPPOCAMPUS; IN VITRO STUDY; MONITORING; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

ACTION POTENTIALS; BIOLOGICAL CLOCKS; CELLS, CULTURED; CYSTEINE; EPILEPSY; HIPPOCAMPUS; NEURONAL PLASTICITY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 27144515532     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00548.2005     Document Type: Article

References (24)

1. Bhattacharya M, Babwah AV, Godin C, Anborgh PH, Dale LB, Poulter MO, and Ferguson SSG. Ra1 and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. J Neurosci 24: 8752-8761, 2004.
2. Biber K, Laurie DJ, Berthele A, Sommer B, Toile TR, Gebicke-Harter PJ, van Calker D, and Boddeke HW. Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. J Neurochem 72: 1671-1680, 1999.
3. Blümcke I, Behle K, Malitschek B, Kuhn R, Knöpfel T, Wolf HK, and Wiestler OD. Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluRlb, mGluR2/3, mGluR4a and mGluRS in human hippocampus. Brain Res 736: 217-226, 1996.
4. Boss V, Nutt KM, and Conn PJ. L-Cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. Mol Pharmacol 45: 1177-1182, 1994.
5. Catania MV, Aronica E, Sortino MA, Canonico PL, and Nicoletti F. Desensitization of metabotropic glutamate receptors in neuronal cultures. J Neurochem 56: 1329-1335, 1991.
6. Chuang S-C, Bianchi R, Kim D, Shin, H-S, and Wong RKS. Group I metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCβ1 signaling. J Neurosci 21: 6387-6394, 2001.
7. Chuang S-C, Zhao W, Young SR, Conquet F, Bianchi R, and Wong RKS. Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells. J Physiol 541: 113-121, 2002.
8. Delmas P, Crest M, and Brown DA. Functional organization of PLC signaling microdomains in neurons. Trends Neurosci 27: 41-47, 2004.
9. Fotuhi M, Standaert DG, Testa CM, Penney JB Jr, and Young AB. Differential expression of metabotropic glutamate receptors in the hippocampus and entorhinal cortex of the rat. Mol Brain Res 21: 283-292, 1994.
10. Galoyan SM and Merlin LR. Long-lasting potentiation of epileptiform bursts by group I mGluRS is NMDA receptor independent. J Neurophysiol 83: 2463-2467, 2000.
11. Griffith EL and Merlin LR. Phospholipase D inhibits group I mGluR-induced epileptogenesis via a protein kinase C-dependent pathway. Neurology 64 (1 Suppl.): A314, 2005 (abstract).
12. B receptor-mediated inhibition to the expression and termination of group I mGluR-induced ictaform bursts. Epilepsy Res 61: 161-165, 2004.
13. Löffelholz K. Receptor regulation of choline phospholipids hydrolysis. A novel source of diacylglycerol and phosphatidic acid. Biochem Pharmacol 38: 1543-1549, 1989.
14. Merlin LR and Wong RKS. Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro. J Neurophysiol 78: 539-544, 1997.
15. Merlin LR, Bergold PJ, and Wong RKS. Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges. J Neurophysiol 80: 989-993, 1998.
16. Merlin LR. Group I mGluR-mediated silent induction of long-lasting epileptiform discharges. J Neurophysiol 82: 1078-1081, 1999.
17. Merlin LR. Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts. J Neurophysiol 87: 621-625, 2002.
18. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9: 484-496, 1995.
19. Rico MJ and Merlin LR. Evidence that phospholipase D activation prevents group I mGluR-induced persistent prolongation of epileptiform bursts. J Neurophysiol 91: 2385-2388, 2004.
20. Park SK, Min DS, and Exton JH. Definition of the protein kinase C interaction site of phospholipase D. Biochem Biophys Res Commun 244: 364-367, 1998.
21. Pellicciari R, Marinozzi M, Costantino G, Natalini B, Moroni F, and Pellegrini-Giampietro D. (2R, 1′ S,2′ R,3′ S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties. J Med Chem 42: 2716-2720, 1999.
22. Servitja JM, Masgrau R, Sarri E, and Picatoste F. Group I metabotropic glutamate receptors mediate phospholipase D stimulation in rat cultured astrocytes. J Neurochem 72: 1441-1447, 1999.
23. Wong RKS, Blanchi R, Chuang S-C, and Merlin LR. Group I mGluR-induced epileptogenesis: distinct and overlapping roles of mGluRl and mGluRS and implications for antiepileptic drug design. Epilepsy Curr 5: 63-68, 2005.
24. Zhao W, Bianchi R, Wang M, and Wong RKS. Extracellular signal-regulated kinase 1/2 is required for the induction of group I metabotropic glutamate receptor-mediated epileptiform discharges. J Neurosci 24: 76-84, 2004.