Vitamin K3 triggers human leukemia cell death through hydrogen peroxide generation and histone hyperacetylation

Pharmazie

Volumn 60, Issue 10, 2005, Pages 765-771

  Lin, Changjun ^a   Kang, Jiuhong ^a   Zheng, Rongliang ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BUTYRIC ACID; CATALASE; HISTONE; HISTONE DEACETYLASE INHIBITOR; HYDROGEN PEROXIDE; MENADIONE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; DRUG EFFECT; DRUG MECHANISM; LEUKEMIA CELL;

ACETYLATION; BUTYRATES; CELL DEATH; HISTONES; HL-60 CELLS; HUMANS; HYDROGEN PEROXIDE; LEUKEMIA, PROMYELOCYTIC, ACUTE; REACTIVE OXYGEN SPECIES; VITAMIN K 3;

EID: 27144479275     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Archer SY, Hodin RA (1999) Histones acetylation and cancer. Curr Opin Genet Dev 9: 171-174.
2. Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP, Kundu TK (2004a) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem 279: 33716-33726.
3. Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U, Kundu TK (2004b) Curcumin, a novel p300/CBP specific inhibitor of acetyltransferase, represses the acetylation of histones/non-histone proteins and HAT dependent chromatin transcription. J Biol Chem 279: 51163-51171.
4. Bernhard D, Ausserlechner MJ, Tonko M, Loffler M, Hartmann BL, Csordas A, Kofler R (1999) Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts. FASEB J 13: 1991-2001.
5. Boffa LC, Vidali G, Mann RS, Allfrey VG (1978) Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J Biol Chem 253: 3364-3366.
6. Brinkmann H, Dahler AL, Popa C, Serewko MM, Parsons PG, Gabrielli BG, Burgess AJ, Saunders NA (2001) Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J Biol Chem 276: 22491-22499.
7. Brown PC, Dulik DM, Jones TW (1991) The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells. Arch Biochem Biophys 285: 187-196.
8. Cheung WL, Briggs SD, Allis CD (2000) Acetylation and chromosomal functions. Curr Opin Cell Biol 12: 326-333.
9. Coull JJ, He G, Melander C, Rucker VC, Dervan PB, Margolis DM (2002) Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol 76: 12349-12354.
10. Cousens LS, Gallwitz D, Alberts BM (1979) Different accessibilities in chromatin to histone acetylase. J Biol Chem 254: 1716-1723.
11. Gilloteaux J, Jamison JM, Arnold D, Taper HS, Von Gruenigen VE, Summers JL (2003) Microscopic aspects of autoschizic cell death in human ovarian carcinoma (2774) cells following vitamin C, vitamin K3 or vitamin C: K3 treatment. Microsc Microanal 9: 311-329.
12. Gilmour PS, Rahman I, Donaldson K, Macnee W (2002) Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am J Physiol 284: L533-L540.
13. Grunstein M (1997) Histone acetylation in chromatin structure and transcription. Nature 389: 349-352.
14. Hileman EO, Liu J, Albitar M, Keating MJ, Huang P (2004) Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. Cancer Chemother Pharmacol 53: 209-219.
15. Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM (2001) Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 15: 1110-1112.
16. Jamison JM, Gilloteaux J, Nassiri MR, Venugopal M, Neal DR, Summers JL (2004) Cell cycle arrest and autoschizis in a human bladder carcinoma cell line following Vitamin C and Vitamin K3 treatment. Biochem Pharmacol 67: 337-351.
17. Juan CC, Wu FY (1993) Vitamin K3 inhibits growth of human hepatoma HepG2 cells by decreasing activities of both p34cdc2 kinase and phosphatase. Biochem Biophys Res Commun 190: 907-913.
18. Kachadourian R, Liochev SI, Cabelli DE, Patel MN, Fridovich I, Day BJ (2001) 2-methoxyestradiol does not inhibit superoxide dismutase. Arch Biochem Biophys 392: 349-353.
19. Kang J, Zhang Y, Chen J, Chen H, Lin C, Wang Q, Ou Y (2003) Nickel-induced histione hypoacetylation: the role of reactive oxygen species. Toxicol Sci 74: 279-286.
20. 2+-induced Bcl-2 down-regulation and human hepatoma cell apoptosis. J Biol Inorg Chem 9: 713-723.
21. Kang J, Lin C, Chen J, Liu Q (2004b) Copper induces histone acetylation through directly inhibiting histone acetyltransferase activity. Chem-Biol Interact 148: 115-123.
22. 2+. Redox Rep 9: 37-48.
23. Klochendler-Yeivin A, Moshe Y (2001) Chromatin modifiers and tumor suppression. Biochim Biophys Acta 1551: M1-M10.
24. Lamson DW, Plaza SM (2003) The anticancer effects of vitamin K. Altern Med Rev 8: 303-318.
25. LeBel CP, Ischiropoulos H, Bondy SC (1992) Evaluation of the probe 2′,7′-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5: 227-231.
26. Liao WC, Wu FY, Wu CW (2000) Binary/ternary combined effects of vitamin K3 with other antitumor agents in nasopharyngeal carcinoma CG1 cells. Int J Oncol 17: 323-328.
27. Marks PA, Richon VM, Rifkind RA (2000) Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 92: 1210-1216.
28. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL (1998) Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 82: 1298-1305.
29. 2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity. Am J Physiol 268(1 Pt 1): C227-C236.
30. Noto V, Taper HS, Jiang YH, Janssens J, Bonté J, De Loecker W (1989) Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action. Cancer 63: 901-906.
31. Nutter LM, Cheng AL, Hung HL, Hsieh RK, Ngo EO, Liu TW (1991) Menadione: spectrum of anticancer activity and effects on nucleotide metabolism in human neoplastic cell lines. Biochem Pharmacol 41: 1283-1292.
32. Riggs MG, Whittaker RG, Neumann JR, Ingram VM (1977) n-Butyrate causes histone modification in HeLa and Friend erythroleukemia cells. Nature 268: 462-464.
33. Saito M, Sakagami H, Fujisawa S (2003) Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). Anticancer Res 23(6C): 4693-4701.
34. Somers MJ, Mavromatis K, Gabs ZS, Harrison DG (2000) Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation 101: 1722-1728.
35. Sun JS, Tsuang YH, Huang WC, Chen LT, Hang YS, Lu FJ (1997) Mena-dione-induced cytotoxicity to rat osteoblasts. Cell Mol Life Sci 53: 967-976.
36. Taper HS, Keyeux A, Roberfroid M (1996) Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice bearing solid transplantable tumor. Anticancer Res 16: 499-503.
37. Taper HS, Jamison JM, Gilloteaux J, Summers JL, Calderon PB (2004) Inhibition of the development of metastases by dietary vitamin C: K3 combination. Life Sci 75: 955-967.
38. Tomita K, Barnes PJ, Adcock IM (2003) The effect of oxidative stress on histone acetylation on IL-8 release. Biochem Biophys Res Commun 301: 572-577.
39. Vanden Hoek TL, Li C, Shao Z, Schumacker PT, Becker LB (1997) Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol 29: 2571-2583.
40. Verrax J, Cadrobbi J, Marques C, Taper H, Habraken Y, Piette J, Calderon PB (2004) Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death. Apoptosis 9: 223-233.
41. von Gruenigen VE, Jamison JM, Gilloteaux J, Lorimer HE, Summers M, Pollard RR, Gwin CA, Summers JL (2003) The in vitro antitumor activity of vitamins C and K3 against ovarian carcinoma. Anticancer Res 23: 3279-3287.
42. Wang Z, Wang M, Finn F, Carr BI (1995) The growth inhibitory effects of vitamins K and their actions on gene expression. Hepatology 22: 876-882.
43. Warren MC, Bump EA, Medeiros D, Braunhut SJ (2000) Oxidative stress-induced apoptosis of endothelial cells. Free Radic Biol Med 29: 537-547.
44. Woods JA, Young AJ, Gilmore IT, Morris A, Bilton RF (1997) Measurement of menadione-mediated DNA damage in human lymphocytes using the comet assay. Free Radic Res 26: 113-124.
45. Zhang W, Negoro T, Satoh K, Jiang Y, Hashimoto K, Kikuchi H, Nishikawa H, Miyata T, Yamamoto Y, Nakano K, Yasumoto E, Nakayachi T, Mineno K, Satoh T, Sakagami H (2001) Synergistic cytotoxic action of vitamin C and vitamin K3. Anticancer Res 21: 3439-3444.