Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides

Journal of Virology

Volumn 76, Issue 23, 2002, Pages 12349-12354

  Coull, Jason J ^a   He, Guocheng ^a   Melander, Christian ^a   Rucker, Victor C ^a   Dervan, Peter B ^a   Margolis, David M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE DEACETYLASE; IMIDAZOLE DERIVATIVE; POLYAMIDE; PYRROLE DERIVATIVE; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRICHOSTATIN A;

ARTICLE; CHROMATIN; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GEL MOBILITY SHIFT ASSAY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; LONG TERMINAL REPEAT; NONHUMAN; NUCLEOSOME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPRESSOR GENE; T LYMPHOCYTE;

BASE SEQUENCE; CELL LINE; DNA, VIRAL; DNA-BINDING PROTEINS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GENE EXPRESSION; GENES, VIRAL; HELA CELLS; HISTONE DEACETYLASES; HIV INFECTIONS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; IMIDAZOLES; MOLECULAR SEQUENCE DATA; NYLONS; PYRROLES; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 0036889182     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.23.12349-12354.2002     Document Type: Article

References (18)

1. Baird, E. E., and P. B. Dervan. 1996. Solid-phase synthesis of polyamides containing imidazole and pyrrole amino acids. J. Am. Chem. Soc. 118:6141-6146.
2. Bremer, R. E., E. E. Baird, and P. B. Dervan. 1998. Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch. Chem. Biol. 5:119-133.
3. Cho, J., M. E. Parks, and P. B. Dervan. 1995. Cyclic polyamides for recognition in the minor groove of DNA. Proc. Natl. Acad. Sci. USA 92:10389-10392.
4. Chun, T.-W., L. Carruth, D. Finzi, X. Shen, J. A. DiGiuseppe, H. Taylor, M. Hermankova, K. Chadwick, J. Margolick, T. C. Quinn, Y. H. Kuo, R. Brookmeyer, M. A. Zeiger, P. Barditch-Crovo, and R. F. Siliciano. 1997. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387:183-188.
5. Ciminale, V., B. K. Felber, M. Campbell, and G. N. Pavlakis. 1990. A bioassay for HIV-1 based on Env-CD4 interaction. AIDS Res. Hum. Retrovir. 6:1281-1287.
6. Coull, J., F. Romerio, J.-M. Sun, J. M. Volker, K. M. Galvin, J. R. Davie, Y. Shi, U. Hansen, and D. M. Margolis. 2000. The human factors YYI and LSF repress the human immunodeficiency virus type-1 long terminal repeat via recruitment of histone deacetylase 1. J. Virol 74:6790-6799.
7. Dickinson, L. A., J. W. Trauger, E. E. Baird, P. B. Dervan, B. J. Graves, and J. M. Gottesfeld. 1999. Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-κB, and DNA by a designed DNA-binding ligand. J. Biol. Chem. 274:12765-12773.
8. Dickinson, L. A., J. W. Trauger, E. E. Baird, P. Ghazal, P. B. Dervan, and J. M. Gottesfeld. 1999. Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. Biochemistry 38:10801-10807.
9. El Kharroubi, A., and E. Verdin. 1994. Protein-DNA interactions within DNase I-hypersensitive sites located downstream of the HIV-1 promoter. J. Biol. Chem. 269:19916-19924.
10. Finzi, D., M. Hermankova, T. Pierson, L. M. Carruth, C. Buck, R. E. Chaisson, T. C. Quinn, K. Chadwick, J. Margolick, R. Brookmeyer, J. Gallant, M. Markowitz, D. D. Ho, D. D. Richman, and R. F. Siliciano. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278:1295-1300.
11. He, G., and D. M. Margolis. 2002. Counter-regulation of chromatin acetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type I (HIV-1) by the HIV-1 activator Tat and the HIV-1 repressor YY1. Mol. Cell. Biol. 22:2965-2973.
12. Mapp, A. K., A. Z. Ansari, M. Ptashne, and P. B. Dervan. 2000. Activation of gene expression by small molecule transcription factors. Proc. Natl. Acad. Sci. USA 97:3930-3935.
13. Margolis, D. M., M. Somasundaran, M. R. Green. 1994. Human transcription factor YYI represses human immunodeficiency virus type-1 transcription and virion production, J. Virol. 68:905-910.
14. Romerio, F., M. Gabriel, and D. M. Margolis. 1997. Repression of human immunodeficiency virus type-1 through the novel cooperation of the human factors YY1 and LSF. J. Virol. 71:9375-9382.
15. Sheridan, P. L., T. P. Mayall, E. Verdin, and K. A. Jones. 1997. Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Genes Dev. 11:3327-3340.
16. Verdin, E., P. Paras, Jr., and C. Van Lint. 1993. Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation. EMBO J. 12:3249-3259.
17. Orlando, V., H. Strutt, and R. Paro. 1997. Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11:205-214.
18. Wong, J. K., M. Hezareh, H. F. Gunthard, D. V. Havlin, C. I. Ignacio, C. A. Spina, and D. D. Richman. 1997. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278:1291-1295.