Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin

Toxicology Letters

Volumn 160, Issue 1, 2005, Pages 22-33

  Shiizaki, Kazuhiro ^a,b   Ohsako, Seiichiroh ^a,c   Koyama, Toshie ^b   Nagata, Ryoichi ^d   Yonemoto, Junzo ^a   Tohyama, Chiharu ^a,c  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Aryl hydrocarbon receptor; CYP1A1; CYP1B1; Endogenous ligand; SK HEP 1 cells

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DIOXIN; LIGAND; RECEPTOR BLOCKING AGENT;

ARTICLE; CANCER CELL CULTURE; CELL LINE; DOSE RESPONSE; ENZYME METABOLISM; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION;

ARYL HYDROCARBON HYDROXYLASES; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BENZOFLAVONES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DIOXINS; ELLIPTICINES; ENZYME INHIBITORS; GENE EXPRESSION; HUMANS; LIVER; PLASMIDS; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 27144465972     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.06.003     Document Type: Article

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