A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation

British Journal of Cancer

Volumn 93, Issue 6, 2005, Pages 639-646

  Bruce, W R ^a   Cirocco, M ^b   Giacca, A ^c   Kim, Y I ^a,b,c   Marcon, N ^b,c   Minkin, S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

C reactive protein; Calcium; Calprotectin; Folate; Free fatty acids; Homocysteine; Insulin; n 3 fatty acids; Triacylglycerol

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CALCIUM CARBONATE; CALPROTECTIN; CYANOCOBALAMIN; FATTY ACID; FISH OIL; FOLIC ACID; GLUCOSE; HOMOCYSTEINE; INSULIN; OMEGA 3 FATTY ACID; PLACEBO; THIAMINE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CANCER RISK; CLINICAL TRIAL; COLITIS; COLON CARCINOGENESIS; COLON POLYP; COLORECTAL CANCER; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE MARKER; FEASIBILITY STUDY; FECES ANALYSIS; FEMALE; FOLATE METABOLISM; FOLIC ACID BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; RISK REDUCTION; VITAMIN DEFICIENCY;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD GLUCOSE; C-REACTIVE PROTEIN; CALCIUM CARBONATE; COLITIS; COLORECTAL NEOPLASMS; DIETARY SUPPLEMENTS; FEMALE; FISH OILS; FOLIC ACID; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; PILOT PROJECTS; RISK FACTORS; THIAMINE; TREATMENT OUTCOME; VITAMIN B 12 DEFICIENCY; VITAMIN B DEFICIENCY;

EID: 27144462002     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602770     Document Type: Article

References (66)

1. Alberts DS, Martínez ME, Roe DJ, Guillén-Rodríguez JM, Marshall JR, van Leewen JB, Reid ME, Ritenbaugh C, Vargas PA, Bhattacharyya A, Earnest DL, Sampliner RE (2000) Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. N Engl J Med 342: 1156-1162
2. Bakker SJ, Heine RJ, Gans RO (1997) Thiamin may indirectly act as an antioxidant. Diabetologia 40: 741-742
3. Bakker SJ, Hoogeveen EK, Nijpels G, Kostense PJ, Dekker JM, Gans RO (1998) The association of dietary fibres with glucose tolerance is partly explained by concomitant intake of thiamine: the Hoorn Study. Diabetologia 41: 1168-1175
4. Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, Beck GJ, Bond JH, Greenberg ER (1999) Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 340: 101-107
5. Bartsch H, Nair J, Owen RW (1999) Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 20: 2209-2218
6. Biasco G, Brandi G, Paganelli GM, Rossini FP, Santucci R, Di Febo G, Miglioli M, Risio M, Morselli Labate AM, Barbara L (1995) Colorectal cancer in patients with ulcerative colitis. Cancer 75: 2045-2050
7. Bonithon-Kopp C, Kronborg O, Giacosa A, Rath U, Faivre J (2000) Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomized intervention trial. Lancet 356: 1300-1306
8. Bruce WR, Furrer R, Shangari N, O'Brien PJ, Medline A, Wang Y (2003) Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats. Cancer Lett 202: 125-129
9. Bruce WR, McKeown-Eyssen G, Ciampi A, Dion PW, Boyd N (1981) Strategies for dietary intervention studies in colon cancer. Cancer 47: 1121-1125
10. Bruce WR, Wolever TMS, Giacca A (2000) Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance. Nutr Cancer 37: 19-26
11. Connelly PW, Hanley AJ, Harris SB, Hegele RA, Zinman B (2003) Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree. Int J Obes Relat Metab Disord 27: 347-354
12. Corpet DE, Tache S (2002) Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency. Nutr Cancer 43: 1-21
13. Cravo M, Fidalgo P, Pereira AD, Gouveia-Oliveira A, Chaves P, Selhub J, Mason JB, Mira FC, Leitao CN (1994) DNA methylation as an intermediate biomarker in colorectal cancer. Modulation by folic acid supplementation. Eur J Cancer Prev 3: 473-479
14. DeFronzo RA, Ferrannini E (1991) Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173-194
15. Erlinger TP, Platz EA, Rifai N, Helzlsouer KJ (2004) C-reactive protein and the risk of incident colorectal cancer. JAMA 291: 585-590
16. 12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 18: 1329-1336
17. 6 is associated with elevation of the inflammatory marker C-reactive protein independently of plasma homocysteine levels. Circulation 103: 2788-2791
18. Gillen CD, Walmsley RS, Prior P, Andrews HA, Allan RN (1994) Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut 35: 1590-1592
19. Giovannucci E (1995) Insulin and colon cancer. Cancer Causes Control 6: 164-179
20. Giovannucci E (2002) Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 132: 2350S-2355S
21. Greenberg ER, Baron JA, Tosteson TD, Freeman DH, Beck GJ, Bond JH, Colacchio TA, Coller JA, Frankl HD, Haile RW, Mandel JS, Nierenberg DW, Rothstein R, Snover DC, Stevens MM, Summers RW, van Stolk RU (1994) A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 331: 141-147
22. James MJ, Gibson RA, Cleland LG (2000) Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71(Suppl): 343S-348S
23. Kaaks R, Toniolo P, Akhmedkhanov A, Lukanova A, Biessy C, Dechaud H, Rinaldi S, Zeleniuch-Jacqotte A, Shore RE, Riboli E (2000) Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins and risk of colorectal cancer in women. J Natl Cancer Inst 92: 1592-1600
24. Karlsson PC, Hughes R, Rafter JJ, Bruce WR (2005) Polyethylene glycol reduced inflammation and aberrant crypt foci in carcinogen-initiated rats. Cancer Lett 223: 203-209
25. Kim YI (1998) Diet, lifestyle, and colorectal cancer: is hyperinsulinemia the missing link? Nutr Rev 56: 275-279
26. Kim Y-I (1999) Folate and carcinogenesis: evidence, mechanisms and implications. J Nutr Biochem 10: 66-88
27. Kim YI, Baik HW, Fawaz K, Knox T, Lee YM, Norton R, Libby E, Mason JB (2001) Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial. Am J Gastroenterol 96: 184-195
28. Kim YI, Fawaz K, Knox T, Lee YM, Norton R, Arora S, Paiva L, Mason JB (1998) Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps. Am J Clin Nutr 68: 866-872
29. Kim Y-I, Salomon RN, Graeme-Cook F, Choi SW, Smith DE, Dallal GE, Mason JB (1996) Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats. Gut 39: 732-740
30. Knowler WC, Barret-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393-403
31. Konings EJ, Goldbohm RA, Brants HA, Saris WH, van den Brandt PA (2002) Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study. Cancer 95: 1421-1433
32. Koohestani N, Chia MC, Pham N-A, Tran TT, Minkin S, Wolever TMS, Bruce WR (1998) Aberrant crypt focus promotion and glucose intolerance: correlation in the rat across diets differing in fat, n-3 fatty acids and energy. Carcinogenesis 19: 1679-1684
33. Kristinsson J, Røseth A, Fagerhol MK, Aadland E, Schjønsby H, Børmer OP, Raknerud N, Nygaard K (1998) Fecal calprotectin concentration in patients with colorectal carcinoma. Dis Colon Rectum 41: 316-321
34. Kristinsson J, Røseth AG, Sundset A, Nygaard K, Løberg EM, Paulsen JE, Aadland E, Fagerhol MK (1999) Granulocyte marker protein is increased in stool from rats with azoxymethane-induced colon cancer. Scand J Gastroenterol 34: 1216-1223
35. Kronborg O, Ugstad M, Faglerud P, Johne B, Hardcastle J, Scholefield JH, Vellacott K, Moshakis V, Reynolds JR (2000) Faecal calprotectin levels in a high risk population for colorectal neoplasia. Gut 46: 795-800
36. Lovegrove JA, Lovegrove SS, Lesauvage SVM, Brady LM, Saini N, Minihane AM, Williams CM (2004) Moderate fish-oil supplementation reverses low-platelet, long-chain n-3 polyunsaturated fatty acid status and reduces plasma triacylglycerol concentrations in British Indo-Asians. Am J Clin Nutr 79: 974-982
37. MacLennan R, Macrae F, Bain C, Battistutta D, Chapuis P, Gratten H, Lambert J, Newland RC, Ngu M, Russell A, Ward M, Wahlquist ML (1995) Randomized trial of intake of fat, fiber and beta carotene to prevent colorectal adenomas. J Natl Cancer Inst 87: 1760-1766
38. Martinez ME, Henning SM, Alberts DS (2004) Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma formation. Am J Clin Nutr 79: 691-697
39. Matsubara K, Komatsu S, Oka T, Kato N (2003) Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis (review). J Nutr Biochem 14: 246-250
40. McKeown-Eyssen G (1994) Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev 3: 687-695
41. Moxon D, Raza M, Kenney R, Ewing R, Arozullah A, Mason JB, Carroll RE (2005) Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population. Clinical Gastroenterol Hepatol 3: 271-278
42. Newmark HL, Wargovich MJ, Bruce WR (1984) Colon cancer and dietary fat, phosphate and calcium: a hypothesis. J Natl Cancer Inst 72: 1323-1325
43. Newmark HL, Yang K, Lipkin M, Kopelovich L, Liu Y, Fan K, Shinozaki HA (2001) Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis 22: 1871-1875
44. Okayasu I, Yamada M, Mikami T, Yoshida T, Kanno J, Ohkusa T (2002) Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J Gastroenterol Hepatol 17: 1078-1083
45. Paulsen JE, Stamm T, Alexander J (1998) A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. Pharmacol Toxicol 82: 28-33
46. Poullis A, Foster R, Shetty A, Fagerhol MK, Mendall MA (2004) Bowel inflammation as measured by fecal calprotectin: a link between lifestyle factors and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 13: 279-284
47. Ray JG, Cole DEC, Boss SC (2000) An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise? Clin Biochem 33: 337-343
48. Ridker PM, Wilson PWF, Grundy SM (2004) Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation 109: 2818-2825
49. Røseth AG, Fagerol MK, Aadland E, Schjønsby H (1992) Assessment of neutrophil dominating protein calprotectin in feces. A methodological study. Scand J Gastroenterol 27: 793-798
50. Rudolf RE, Dominitz JA, Lampe JW, Levy L, Qu P, Li SS, Lampe PD, Bronner MP, Potter JD (2005) Risk factors for colorectal cancer in relation to number and size of aberrant crypt foci in humans. Cancer Epidemiol Biomarkers Prev 14: 605-608
51. Schatzkin A, Lanza E, Corle D, Lance P, Iber F, Caan B, Shike M, Weissfeld J, Burt R, Cooper MR, Kikendall JW, Cahill J (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal cancer. N Engl J Med 342: 1149-1155
52. Selhub J, Jacques PF, Rozenberg IH, Rogers G, Bowman BA, Gunter EW, Wright JD, Johnson CL (1999) Serum total homocysteine concentration in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 131: 331-339
53. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270: 2693-2698
54. Shangari N, Bruce W R, Poon R, O'Brien PJ (2003) Toxicity of glyoxals - role of oxidative stress. Metabolic detoxification and thiamine deficiency. Biochem Soc Trans 31: 1390-1393
55. Soler AP, Miller RD, Laughlin KV, Carp NZ, Klurfeld DM, Mullin JM (1999) Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis 20: 1425-1431
56. 12, Pantothenic Acid, Biotin, and Choline1 pp 196-305. Washington, DC: Food and Nutrition Board, Institute of Medicine, National Academy Press
57. Stark KD, Park EJ, Maines VA, Holub BJ (2000) Effect of fish-oil concentrate on serum lipids in postmenopausal women receiving and not receiving hormone replacement therapy in a placebo-controlled, double-blind trial. Am J Clin Nutr 72: 389-394
58. Stemmermann GN, Heilbrun LK, Nomura A, Yano K, Hayashi T (1986) Adenomatous polyps and atherosclerosis: an autopsy study of Japanese men in Hawaii. Int J Cancer 38: 789-794
59. Storlien LH, Higgins JA, Thomas TC, Brown MA, Wang HQ, Huang XF, Else PL (2000) Diet composition and insulin action in animal models. Br J Nutr 83(Suppl 1): S85-S90
60. Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW (1991) Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40: 280-289
61. Tran TT, Gupta N, Goh T, Naigamwalla D, Chia MC, Koohestani N, McKeown-Eyssen G, Giacca A, Bruce WR (2003) Direct measure of insulin sensitivity with hyperinsulinemic - euglycemic clamp and surrogate measures of insulin sensitivity with oral glucose tolerance test: correlations with aberrant crypt foci (ACF) promotion in rats. Cancer Epidemiol Biomarkers Prev 12: 47-56
62. Tran TT, Medline A, Bruce WR (1996) Insulin promotion of colon tumors in rats. Cancer Epidemiol Biomarkers Prev 5: 1013-1015
63. Wargovich MJ, Allnutt D, Palmer C, Anaya P, Stephens LC (1990) Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: effect of simulating two human nutrient density levels. Cancer Lett 53: 17-25
64. Wargovich MJ, Eng VWS, Newmark HL, Bruce WR (1983) Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Carcinogenesis 4: 1205-1207
65. Whincup PH, Refsum H, Perry IJ, Morris R, Walker M, Lennon L, Thomson A, Ueland PM, Ebrahim SBJ (1999) Serum total homocysteine and coronary heart disease: prospective study in middle aged men. Heart 82: 448-454
66. World Cancer Research Fund (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective pp 216-251. Washington, USA: American Institute for Cancer Research