Serum total homocysteine and coronary heart disease: Prospective study in middle aged men

Heart

Volumn 82, Issue 4, 1999, Pages 448-454

  Whincup, P H ^a   Refsum, H ^b   Perry, I J ^c   Morris, R ^a   Walker, M ^a   Lennon, L ^a   Thomson, A ^a   Ueland, P M ^b   Ebrahim, S B J ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Coronary heart disease; Epidemiology; Homocysteine

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMORBIDITY; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE CLASSIFICATION; FOLLOW UP; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR;

EID: 0032829806     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.82.4.448     Document Type: Article

References (39)

1. 1 Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic basis of inherited disease. New York: McGraw-Hill, 1995:1279-327.
2. 2 Ueland PM, Refsum H. Plasma homocysteine as a risk factor for vascular disease: plasma levels in health, disease and drug therapy. J Lab Clin Med 1989;114:473-501.
3. 3 Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62.
4. 4 Boushey CJ, Beresford SAA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 1995;274:1049-57.
5. 5 Den Heijer M, Koster T, Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. N Engl Med 1996;334:759-62.
6. 6 Selhub J, Jacques PF, Wilson PWF, et al. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993;270:2693-8.
7. 7 Stampfer MJ, Malinow MR. Can lowering homocysteine levels reduce cardiovascular risk? N Engl J Med 1995;332: 328-9.
8. 8 Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA 1992;268:877-81.
9. 9 Alfthan G, Pekkanen J, Jauhiainen M, et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 1994;106:9-19.
10. 10 Arnesen E, Refsum H, Bonaa KH, et al. Serum total homocysteine and coronary heart disease. Int J Epidemiol 1995;24:704-9.
11. 11 Evans RW, Shaten BJ, Hempel JD, et al. Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. Arterioscler Thromb Vasc Biol 1997;17:1947-53.
12. 12 Nygard O, Nordrehaug JE, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6.
13. 13 Wald NJ, Watt HC, Law MR, et al. Homocysteine and ischaemic heart disease. Results of a prospective study with implications regarding prevention. Arch Intern Med 1998; 158:862-7.
14. 14 Danesh J, Lewington S. Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies. J Cardiovasc Risk 1998;5:229-32.
15. 15 Perry IJ, Refsum H, Morris RW, et al. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995;346:1395-8.
16. 16 Perry IJ. Serum total homocysteine concentration and risk of stroke. Lancet 1996;348:1526.
17. 17 Shaper AG, Pocock SJ, Walker M, et al. The British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns. BMJ 1981;283:179-86.
18. 18 Phillips AN, Shaper AG, Pocock SJ, et al. The role of risk factors in heart attack occurring in men with pre-existing ischaemic heart disease. Br Heart J 1988;60:404-10.
19. 19 Walker M, Shaper AG. Follow-up of subjects in prospective studies in general practice. J R Coll Gen Pract 1984;34:197-209.
20. 20 Shaper AG, Pocock SJ, Walker M, et al. Risk factors for ischaemic heart disease: the prospective phase of the British Regional Heart Study. J Epidemiol Community Health 1985: 39:197-209.
21. 21 Whincup PH, Mendall MA, Perry IJ, et al. Prospective relations between Helicobacter pylori infection, coronary heart disease, and stroke in middle aged men. Heart 1996;75: 568-72.
22. 22 Cook DG, Shaper AG, Macfarlane PW. Using WHO (Rose) angina questionnaire in cardiovascular epidemiological studies. Administration, definition and predictive value. Int J Epidemiol 1989;18:607-13.
23. 23 Shaper AG, Wannamethee G. Physical activity and ischaemic heart disease in middle-aged British men. Br Heart J 1991;66:384-94.
24. 24 Fiskerstrand T, Refsum H, Kvalheim G, et al. Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Chem 1993;39:263-71.
25. 25 Refsum H, Ueland PM, Svardal AM. Fully automated fluorescence assay for determining total homocysteine in plasma. Clin Chem 1989;35:1921-7.
26. 26 Wannamethee G, Shaper A. Haematocrit: relationships with blood lipids, blood pressure and other cardiovascular risk factors. Thromb Haemost 1994;72:58-64.
27. 27 Egerton W, Silberberg J, Crooks R, et al. Serial measures of plasma homocyst(e)ine after acute myocardial infarction. Am J Cardiol 1996;77:759-61.
28. 28 Israelsson B, Brattstrom L, Refsum H. Homocysteine in frozen plasma samples: a short cut to establish hyperhomocysteinaemia as a risk factor for arteriosclerosis? Scand J Lab Invest 1993;53:465-9.
29. 29 Bates CJ, Mansoor MA, van der Pols J, et al. Plasma total homocysteine in a representative sample of 972 British men and women aged 65 and over. Eur J Clin Nutr 1997;51:691-7.
30. 30 Alfthan G, Ato A, Gey KF. Plasma homocysteine and cardiovascular disease mortality. Lancet 1997;349:397.
31. 31 Pancharuniti N, Lewis CA, Sauberlich HE, et al. Plasma homocyst(e)ine, folate and vitamin B12 concentrations and risk for early onset coronary artery disease. Am J Clin Nutr 1994;59:940-8.
32. 32 von Eckardstein A, Malinow MR, Upson B, et al. Effects of age, lipoproteins and hemostatic parameters on the role of homocyst(e)inaemia as a cardiovascular risk factor in men. Arterioscler Thromb 1994;14:460-4.
33. 6 and risk of myocardial infarction in US physicians. J Am Coll Nutr 1996;15:136-43.
34. 34 Brattstrom L, Lindgren A, Israelsson B, et al. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994;236:633-41.
35. 35 Bostom AG, Lathrop L. Hyperhomocysteinaemia in end stage renal disease: prevalence, aetiology and potential relationship to arteriosclerotic outcomes. Kidney Int 1997; 52:10-20.
36. 36 Nygard O, Vollset SE, Refsum H, et al. Total plasma homocysteine and cardiovascular risk profile: the Hordaland Homocysteine Study. JAMA 1995;274:1526-33.
37. 37 Ministry of Agriculture, Fisheries and Food. National food survey 1994. London: HMSO, 1996.
38. 38 Gudnason V, Stansbie D, Scott J, et al. C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis 1998;136:347-54.
39. 39 Verhoef P, Stampfer MJ, Rimm EB. Folate and coronary heart disease [review]. Curr Opin Lipidol 1998;9:17-22.