A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated ras

Molecular and Cellular Biology

Volumn 25, Issue 21, 2005, Pages 9427-9434

  Eastburn, Dennis J ^a   Han, Min ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR ETS;

ALLELE; ARTICLE; CAENORHABDITIS ELEGANS; ENZYME ACTIVATION; ENZYME ASSAY; GENE MAPPING; GENE MUTATION; GENETIC TRANSCRIPTION; LARVA; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; ENZYME ACTIVATION; HISTONE ACETYLTRANSFERASES; LARVA; MOLECULAR SEQUENCE DATA; P300-CBP TRANSCRIPTION FACTORS; POINT MUTATION; RAS PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 27144435840     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.21.9427-9434.2005     Document Type: Article

References (48)

1. Ait-Si-Ali, S., D. Carlisi, S. Ramirez, L. C. Upegui-Gonzalez, A. Duquet, P. Robin, B. Rudkin, A. Harel-Bellan, and D. Trouche. 1999. Phosphorylation by p44 MAP kinase/ERK1 stimulates CBP histone acetyl transferase activity in vitro. Biochem. Biophys. Res. Commun. 262:157-162.
2. Ait-Si-Ali, S., S. Ramirez, F. X. Barre, F. Dkhissi, L. Magnaghi-Jaulin, J. A. Girault, P. Robin, M. Knibiehler, L. L. Pritchard, B. Ducommun, D. Trouche, and A. Harel-Bellan. 1998. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature 396:184-186.
3. Aurandt, J., H. G. Vikis, J. S. Gutkind, N. Ahn, and K. L. Guan. 2002. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc. Natl. Acad. Sci. USA 99:12085-12090.
4. Bannister, A. J., and T. Kouzarides. 1996. The CBP co-activator is a histone acetyltransferase. Nature 384:641-643.
5. Beitel, G. J., S. Tuck, I. Greenwald, and H. R. Horvitz. 1995. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes Dev. 9:3149-3162.
6. Bettinger, J. C., K. Lee, and A. E. Rougvie. 1996. Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development. Development 122:2517-2527.
7. Brenner, S. 1974. The genetics of Caenorhabditis elegans. Genetics 77:71-94.
8. Dhalluin, C., J. E. Carlson, L. Zeng, C. He, A. K. Aggarwal, and M. M. Zhou. 1999. Structure and ligand of a histone acetyltransferase bromodomain. Nature 399:491-496.
9. Eisenmann, D. M., and S. K. Kim. 2000. Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development. Genetics 156:1097-1116.
10. Eisenmann, D. M., J. N. Maloof, J. S. Simske, C. Kenyon, and S. K. Kim. 1998. The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development 125:3667-3680.
11. Fay, D. S., and M. Han. 2000. The synthetic multivulval genes of C. elegans: functional redundancy, Ras-antagonism, and cell fate determination. Genesis 26:279-284.
12. Ferguson, E. L., and H. R. Horvitz. 1985. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics 110:17-72.
13. Gay, F., D. Calvo, M. C. Lo, J. Ceron, M. Maduro, R. Lin, and Y. Shi. 2003. Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Genes Dev. 17:717-722.
14. Gleason, J. E., H. C. Korswagen, and D. M. Eisenmann. 2002. Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Genes Dev. 16:1281-1290.
15. Goodman, R. H., and S. Smolik. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14:1553-1577.
16. Han, M., A. Golden, Y. Han, and P. W. Sternberg. 1993. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature 363:133-140.
17. Hanna-Rose, W., and M. Han. 1999. COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans. Development 126:169-179.
18. Hoier, E. F., W. A. Mohler, S. K. Kim, and A. Hajnal. 2000. The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Genes Dev. 14:874-886.
19. Hong, Y., R. Roy, and V. Ambros. 1998. Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. Development 125:3585-3597.
20. Howard, R. M., and M. V. Sundaram. 2002. C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 mediator component. Genes Dev. 16:1815-1827.
21. Hsu, V., C. L. Zobel, E. J. Lambie, T. Schedl, and K. Kornfeld. 2002. Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates. Genetics 160:481-492.
22. Jacobs, D., G. J. Beitel, S. G. Clark, H. R. Horvitz, and K. Kornfeld. 1998. Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase. Genetics 149:1809-1822.
23. Jakubowski, J., and K. Kornfeld. 1999. A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1. Genetics 153:743-752.
24. Janknecht, R., and T. Hunter. 1996. Versatile molecular glue. Transcriptional control. Curr. Biol. 6:951-954.
25. Koch, R., H. G. van Luenen, M. van der Horst, K. L. Thijssen, and R. H. Plasterk. 2000. Single nucleotide polymorphisms in wild isolates of Caenorhabditis elegans. Genome Res. 10:1690-1696.
26. Kornfeld, K. 1997. Vulval development in Caenorhabditis elegans. Trends Genet. 13:55-61.
27. Korswagen, H. C., D. Y. Coudreuse, M. C. Betist, S. van de Water, D. Zivkovic, and H. C. Clevers. 2002. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 16:1291-1302.
28. Kung, A. L., V. I. Rebel, R. T. Bronson, L. E. Ch'ng, C. A. Sieff, D. M. Livingston, and T. P. Yao. 2000. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 14:272-277.
29. Ludlam, W. H., M. H. Taylor, K. G. Tanner, J. M. Denu, R. H. Goodman, and S. M. Smolik. 2002. The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster. Mol. Cell. Biol. 22:3832-3841.
30. Miller, L. M., M. E. Gallegos, B. A. Morisseau, and S. K. Kim. 1993. lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development. Genes Dev. 7:933-947.
31. Miller, R. W., and J. H. Rubinstein. 1995. Tumors in Rubinstein-Taybi syndrome. Am. J. Med. Genet. 56:112-115.
32. Mohler, W. A., J. S. Simske, E. M. Williams-Masson, J. D. Hardin, and J. G. White. 1998. Dynamics and ultrastructure of developmental cell fusions in the Caenorhabditis elegans hypodermis. Curr. Biol. 8:1087-1090.
33. Ogryzko, V. V., R. L. Schiltz, V. Russanova, B. H. Howard, and Y. Nakatani. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959.
34. Owen, D. J., P. Ornaghi, J. C. Yang, N. Lowe, P. R. Evans, P. Ballario, D. Neuhaus, P. Filetici, and A. A. Travers. 2000. The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p. EMBO J. 19:6141-6149.
35. Riddle, D. L., T. Blumental, B. J. Meyer, and J. R. Priess. 1997. C. elegans II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
36. Shi, Y., and C. Mello. 1998. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev. 12:943-955.
37. Sieburth, D. S., Q. Sun, and M. Han. 1998. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell 94:119-130.
38. Sieburth, D. S., M. Sundaram, R. M. Howard, and M. Han. 1999. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction. Genes Dev. 13:2562-2569.
39. Sternberg, P. W., and M. Han. 1998. Genetics of RAS signaling in C. elegans. Trends Genet. 14:466-472.
40. Sternberg, P. W., and H. R. Horvitz. 1986. Pattern formation during vulval development in C. elegans. Cell 44:761-772.
41. Sulston, J. E., and H. R. Horvitz. 1977. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56:110-156.
42. Sundaram, M., and M. Han. 1995. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83:889-901.
43. Tan, P. B., M. R. Lackner, and S. K. Kim. 1998. MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell 93:569-580.
44. Victor, M., Y. Bei, F. Gay, D. Calvo, C. Mello, and Y. Shi. 2002. HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans. EMBO Rep. 3:50-55.
45. Waltzer, L., and M. Bienz. 1998. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 395:521-525.
46. Wassarman, D. A., M. Therrien, and G. M. Rubin. 1995. The Ras signaling pathway in Drosophila. Curr. Opin. Genet. Dev. 5:44-50.
47. Wu, Y., and M. Han. 1994. Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes Dev. 8:147-159.
48. Yang, C., L. H. Shapiro, M. Rivera, A. Kumar, and P. K. Brindle. 1998. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol. Cell. Biol. 18:2218-2229.