Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase

Biochimica et Biophysica Acta - General Subjects

Volumn 1726, Issue 1, 2005, Pages 34-41

  Yang, Xiaoning ^b   Li, Jingya ^a   Zhou, Yueyang ^a   Shen, Qiang ^a   Chen, Jiwu ^b   Li, Jia ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

Competitive; High throughput screening; Inhibitor; LAR; meD peptide; Protein tyrosine phosphatase

Indexed keywords

HYDROLASE; HYDROLASE INHIBITOR; LEUKOCYTE ANTIGEN; LEUKOCYTE ANTIGEN RELATED PHOSPHATASE; PLANT EXTRACT; PROTEIN TYROSINE PHOSPHATASE OMEGA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHINESE MEDICINE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENE INSERTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; ESCHERICHIA COLI; HUMANS; INSULIN; KINETICS; MICE; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, CELL SURFACE; SESQUITERPENES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 27144434542     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2005.07.001     Document Type: Article

References (38)

1. A. Ostman, and F.D. Bohmer Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases Trends Cell Biol. 11 2001 258 266
2. Z.Y. Zhang, B. Zhou, and L. Xie Modulation of protein kinase signaling by protein phosphatases and inhibitors Pharmacol. Ther. 93 2002 307 317
3. B.G. Neel, and N.K. Tonks Protein tyrosine phosphatases in signal transduction Curr. Opin. Cell Biol. 9 1997 193 204
4. H.J. den Protein-tyrosine phosphatases in development Mech. Dev. 85 1999 3 14
5. M.F. White The insulin signaling system and the IRS proteins Diabetologia 40 1997 S2 S17
6. M.F. White, and L. Yenush The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action Curr. Opin. Microbiol. Immunol. 228 1998 179 208
7. P.G. Drake, and B.I. Posner Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action Mol. Cell. Biochem. 182 1998 79 89
8. A. Cheng, N. Dube, F. Gu, and M.L. Tremblay Coordinated action of protein tyrosine phosphatases in insulin signal transduction Eur. J. Biochem. 269 2002 1050 1059
9. L.A. Bleyle, Y. Peng, C. Ellis, and R.A. Mooney Dissociation of PTPase levels from their modulation of insulin receptor signal transduction Cell Signalling 11 1999 719 725
10. K. Norris, F. Norris, D.H. Kono, H. Vestergaard, O. Pedersen, A.N. Theofilopoulos, and N.P. Moller Expression of protein-tyrosine phosphatases in the major insulin target tissues FEBS Lett. 415 1997 243 248
11. F. Ahmad, J.L. Azevedo, R. Cortright, G.L. Dohm, and B.J. Goldstein Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes J. Clin. Invest. 100 1997 449 458
12. F. Ahmad, and B.J. Goldstein Alterations in specific protein-tyrosine phosphatases accompany insulin resistance of streptozotocin diabetes Metabolism 44 1995 1175 1184
13. F. Ahmad, R.V. Considine, and B.J. Goldstein Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects J. Clin. Invest. 95 1995 2806 2812
14. F. Ahmad, R.V. Considine, T.L. Bauer, J.P. Ohannesian, C.C. Marco, and B.J. Goldstein Improved sensitivity to insulin to obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue Metabolism 46 1997 1140 1145
15. M.C. McGuire, R.M. Fields, B.L. Nyomba, I. Raz, C. Bogardus, N.K. Tonks, and J. Sommercorn Abnormal regulation of protein tyrosine phosphatase activitied in skeletal muscle of insulin-resistant humans Diabetes 40 1991 939 942
16. M. Streuli, N.X. Krueger, L.R. Hall, S.F. Schlossman, and H. Saito A new member of immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen J. Exp. Med. 168 1988 1523 1530
17. W.R. Zhang, P.M. Li, M.A. Oswald, and B.J. Goldstein Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR Mol. Endocrinol. 10 1996 575 584
18. N. Hashimoto, E.P. Feener, W.R. Zhang, and B.J. Goldstein Insulin receptor protein-tyrosine phosphatases: leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain J. Biol. Chem. 267 1992 13811 13814
19. F. Ahmad, and B.J. Goldstein Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells J. Biol. Chem. 272 1997 448 457
20. D.T. Kulas, W.R. Zhang, B.J. Glodstein, R.W. Furlanetto, and R.A. Mooney Insulin receptor signaling is augmented by antisense inhibition of the protein-tyrosine phosphatase LAR J. Biol. Chem. 270 1995 2435 2438
21. J.M. Zabolotny, Y.B. Kim, O.D. Peroni, J.K. Kim, M.A. Pani, O. Boss, L.D. Klaman, S. Kamatkar, G.I. Shulman, B.B. Kahn, and B.G. Neel Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance Proc. Natl. Acad. Sci. U. S. A. 98 2001 5187 5192
22. J.M. Ren, P.M. Li, W.R. Zhang, L.J. Sweet, G. Cline, G.I. Shulman, J.N. Livingston, and B.J. Goldstein Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis Diabetes 47 1998 493 497
23. P. Bonvini, W.G. An, A. Rosolen, P. Nguyen, J. Trepel, H.A. Garcia, M. Dunach, and L.M. Neckers Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription Cancer Res. 61 2001 1671 1677
24. C.M. Levea, C.T. Mcgary, J.R. Symons, and R.A. Mooney PTP LAR expression compared to prognostic indices in metastatic and non-metastatic breast cancer Breast Cancer Res. Treat. 64 2000 221 228
25. Y. Xie, T.T. Yeo, C. Zhang, T. Yang, M.A. Tisi, S.M. Massa, and F.M. Longo The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo J. Neurosci. 21 2001 5130 5138
26. R.A. Mooney, and C.M. Levea The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting Curr. Top. Med. Chem. 3 2003 809 819
27. M. Streuli, N.X. Krueger, L.R. Hall, S.F. Schlossman, and H. Saito A new member if the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen J. Exp. Med. 168 1988 1523 1530
28. R. Higuchi, B. Krummel, and R.K. Saiki A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions Nucleic Acids Res. 16 1988 7351 7367
29. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
30. G. Huyer, S. Liu, J. Kelly, J. Moffat, P. Payette, B. Kennedy, G. Tsaprailis, M.J. Gresser, and C. Ramachandran Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate J. Biol. Chem. 272 1997 843 851
31. S. Walchli, M.L. Curchod, R.P. Gobert, S. Arkinstall, and R. Hooft van Huijsduijnen Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants J. Biol. Chem. 275 2000 9792 9796
32. K. Tamura, E.C. Southwick, J. Kerns, K. Rosi, B.I. Carr, C. Wilcox, and J.S. Lazo Cdc25 inhibition and cell cycle arrest by a synthetic tioalkyl vitamin K analogue Cancer Res. 60 2000 1317 1325
33. R. Pulido, C. Serra-Pages, M. Tang, and M. Streuli The LAR/PTPδ/PTPσ subfamily of transmembrane protein-tyrosine- phosphatases: Multiple human LAR, PTPδ and PTPσ isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1 Proc. Natl. Acad. Sci. U. S. A. 92 1995 11686 11690
34. R.B. Woodward, and T.R. Hoye Total synthesis of illudinine, illudalic acids, and illudacetalic acid J. Am. Chem. Soc. 99 1977 8007 8014
35. G.H. Peters, S. Branner, K.B. Moller, J.N. Andersen, and N.P. Moller Enzyme kinetic characterization of protein tyrosine phosphatases Biochimie 85 2003 527 534
36. W.R. Abraham Bioactive sesquiterpenes produced by fungi: are they useful for humans as well? Curr. Med. Chem. 8 2001 583 606
37. C.G. Ostenson, A.C. Sandberg-Nordqvist, J. Chen, M. Hallbrink, D. Rotin, U. Langel, and S. Efendic Overexpression of protein-tyrosine phosphatase PTPσ is linked to impaired glucose-induced insulin secretion in hereditary diabetic Toto-Kakizaki rats Biochem. Biophy. Res. Commun. 291 2002 945 950
38. J. Mclean, J. Batt, L.C. Doering, D. Rotin, and J.R. Bain Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protevin tyrosine phosphatase σ knock-out mice J. Neurosci. 22 2002 5481 5491