Kinetics of Cryptosporidium parvum-specific cytokine responses in healing and nonhealing murine models of C. parvum infection

Parasitology Research

Volumn 97, Issue 4, 2005, Pages 309-317

  Singh, Inderpal ^a   Theodos, Cynthia ^b   Li, Wenjun ^c   Tzipori, Saul ^a  

^a TUFTS UNIVERSITY   (United States)

^b BIOGEN   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE MODEL; EX VIVO STUDY; HEALING; IMMUNE RESPONSE; IMMUNOSTIMULATION; KINETICS; LYMPHOCYTE PROLIFERATION; MALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPOROZOITE; SUPERNATANT; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, PROTOZOAN; BODY WEIGHT; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; KINETICS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPECIES SPECIFICITY; T-LYMPHOCYTE SUBSETS;

CRYPTOSPORIDIUM PARVUM; MURINAE;

EID: 26944455613     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-005-1436-1     Document Type: Article

References (35)

1. Abrahamsen MS, Templeton TJ, Enomoto S, Abrahante JE, Zhu G, Lancto CA, Deng M, Liu C, Widmer G, Tzipori S, Buck GA, Xu P, Bankier AT, Dear PH, Konfortov BA, Spriggs HF, Iyer L, Anantharaman V, Aravind L, Kapur V (2004) Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science 304:441-445
2. Aguirre SA, Mason PH, Perryman LE (1994) Susceptibility of major histocompatibility complex (MHC) class I- and MHC class II-deficient mice to Cryptosporidium parvum infection. Infect Immun 62:697-699
3. Aguirre SA, Perryman LE, Davis WC, McGuire TC (1998) IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium parvum infection: Analysis of CD4 + alpha beta + IFN-gamma + and CD4 + alpha beta + IL-4 + lymphocytes in gut-associated lymphoid tissue during resolution of infection. J Immunol 161:1891-1900
4. Chen W, Harp JA, Harmsen AG (1993a) Requirements for CD4 + cells and gamma interferon in resolution of established Cryptosporidium parvum infection in mice. Infect Immun 61:3928-3932
5. Chen W, Harp JA, Harmsen AG, Havell EA (1993b) Gamma interferon functions in resistance to Cryptosporidium parvum infection in severe combined immunodeficient mice. Infect Immun 61:3548-3551
6. Cosyns M, Tsirkin S, Jones M, Flavell R, Kikutani H, Hayward AR (1998) Requirement of CD40-CD40 ligand interaction for elimination of Cryptosporidium parvum from mice. Infect Immun 66:603-607
7. Current WL, Garcia LS (1991) Cryptosporidiosis. Clin Microbiol Rev 4:325-358
8. Enriquez FJ, Sterling CR (1991) Cryptosporidium infections in inbred strains of mice. J Protozool 38:100S-102S
9. Enriquez FJ, Sterling CR (1993) Role of CD4 + Th1-cell and Th2-cell-secreted cytokines in cryptosporidiosis. Folia Parasitol (Praha) 40:307-311
10. Fayer R, Ungar BL (1986) Cryptosporidium spp. and cryptosporidiosis. Microbiol Rev 50:458-483
11. Harp JA, Whitmire WM, Sacco R (1994) In vitro proliferation and production of gamma interferon by murine CD4 + cells in response to Cryptosporidium parvum antigen. J Parasitol 80:67-72
12. Hayward AR, Chmura K, Cosyns M (2000) Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 182:1001-1004
13. Heine J, Moon HW, Woodmansee DB (1984) Persistent cryptosporidium infection in congenitally athymic (nude) mice. Infect Immun 43:856-859
14. Kuhls TL, Mosier DA, Abrams VL, Crawford DL, Greenfield RA (1994) Inability of interferon-gamma and aminoguanidine to alter Cryptosporidium parvum infection in mice with severe combined immunodeficiency. J Parasitol 80:480-485
15. Lacroix S, Mancassola R, Naciri M, Laurent F (2001) Cryptosporidium parvum-specific mucosal immune response in C57BL/6 neonatal and gamma interferon-deficient mice: Role of tumor necrosis factor alpha in protection. Infect Immun 69:1635-1642
16. Lean IS, McDonald SA, Bajaj-Elliott M, Pollok RC, Farthing MJ, McDonald V (2003) Interleukin-4 and transforming growth factor beta have opposing regulatory effects on gamma interferon-mediated inhibition of Cryptosporidium parvum reproduction. Infect Immun 71:4580-4585
17. McDonald V, Bancroft GJ (1994) Mechanisms of innate and acquired resistance to Cryptosporidium parvum infection in scid mice. Parasite Immunol 16:315-320
18. McDonald V, Deer R, Uni S, Iseki M, Bancroft GJ (1992) Immune responses to cryptosporidium muris and Cryptosporidium parvum in adult immunocompetent or immunocompromised (nude and scid) mice. Infect Immun 60:3325-3331
19. Mead JR, You X (1998) Susceptibility differences to Cryptosporidium parvum infection in two strains of gamma interferon knockout mice. J Parasitol 84:1045-1048
20. Perryman LE, Mason PH, Chrisp CE (1994) Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in scid mice. Infect Immun 62:1474-1477
21. Sherwood D, Angus KW, Snodgrass DR, Tzipori S (1982) Experimental cryptosporidiosis in laboratory mice. Infect Immun 38:471-475
22. Smith LM, Bonafonte MT, Mead JR (2000) Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice. J Parasitol 86:300-307
23. Taghi-Kilani R, Sekla L, Hayglass KT (1990) The role of humoral immunity in cryptosporidium spp. Infection. Studies with B cell-depleted mice. J Immunol 145:1571-1576
24. Theodos CM (1998) Innate and cell-mediated immune responses to Cryptosporidium parvum. Adv Parasitol 40:87-119
25. Theodos CM, Sullivan KL, Griffiths JK, Tzipori S (1997) Profiles of healing and nonhealing Cryptosporidium parvum infection in C57BL/6 mice with functional B and T lymphocytes: the extent of gamma interferon modulation determines the outcome of infection. Infect Immun 65:4761-4769
26. Tzipori S (1988) Cryptosporidiosis in perspective. Adv Parasitol 27:63-129
27. Tzipori S, Rand W, Theodos C (1995) Evaluation of a two-phase SCID mouse model preconditioned with anti-interferon-gamma monoclonal antibody for drug testing against cryptosporidium parvum. J Infect Dis 172:1160-1164
28. Ungar BL, Burris JA, Quinn CA, Finkelman FD (1990) New mouse models for chronic cryptosporidium infection in immunodeficient hosts. Infect Immun 58:961-969
29. Ungar BL, Kao TC, Burris JA, Finkelman FD (1991) Cryptosporidium infection in an adult mouse model. Independent roles for IFN-gamma and CD4 + T lymphocytes in protective immunity. J Immunol 147:1014-1022
30. Urban JF Jr, Fayer R, Chen SJ, Gause WC, Gately MK, Finkelman FD (1996) IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum. J Immunol 156:263-268
31. Waters WR, Harp JA (1996) Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice. Infect Immun 64:1854-1857
32. Waters WR, Harp JA, Nonnecke BJ (1996) In vitro blastogenic responses and interferon-gamma production by intestinal intraepithelial lymphocytes of calves. Res Vet Sci 61:45-48
33. Whitmire WM., Harp JA (1990) In vitro murine lymphocyte blastogenic responses to Cryptosporidium parvum. J Parasitol 76:450-452
34. Widmer G, Tzipori S, Fichtenbaum CJ, Griffiths JK (1998) Genotypic and phenotypic characterization of Cryptosporidium parvum isolates from people with aids. J Infect Dis 178:834-840
35. You X, Mead JR (1998) Characterization of experimental Cryptosporidium parvum infection in IFN-gamma knockout mice. Parasitology 117(6):525-531