IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium parvum infection: Analysis of CD4+αβ+IFN-γ+ and CD4+ αβ+ IL-4+ lymphocytes in gut-associated lymphoid tissue during resolution of infection

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1891-1900

  Aguirre, Shirley A ^a   Perryman, Lance E ^b   Davis, William C ^c   McGuire, Travis C ^c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DISEASE SEVERITY; IMMUNE RESPONSE; INFECTION PREVENTION; INTESTINE LYMPHATIC TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; ANTIBODIES, MONOCLONAL; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-4; INTESTINAL MUCOSA; LYMPHOID TISSUE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; REMISSION INDUCTION; SPECIES SPECIFICITY; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

EID: 0032529212     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Payer, R. 1997. Cryptosporidium and Cryptosporidiosis. CRC, Boca Raton, FL.
2. Guerrant, R. L. 1997. Cryptosporidiosis: an emerging, highly infectious threat. Emerg. Infect. Dis. 3:51.
3. Meinhardt, P. L., D. P. Casemore, and K. B. Miller. 1996. Epidemiologic aspects of human cryptosporidiosis and the role of waterborne transmission. Epidemiol. Rev. 18:118.
4. + T lymphocytes in protective immunity. J. Immunol. 147:1014.
5. Perryman, L. E., P. H. Mason, and C. E. Chrisp. 1994. Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice. Infect. Immun. 62:1474.
6. Aguirre, S. A., P. H. Mason, and L. E. Perryman. 1994. Susceptibility of major histocompatibility complex (MHC) class I-and MHC class II-deficient mice to Cryptosporidium parvum infection. Infect. Immun. 62:697.
7. Waters, W. R., and J. A. Harp. 1996. Cryptosporidium parvum infection in T-cell receptor (TCR)-α-and TCR-δ-deficient mice. Infect. Immun. 64:1854.
8. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
9. + cells and γ interferon in resolution of established Cryptosporidium parvum infection in mice. Infect. Immun. 61:3928.
10. Theodos, C. M., K. L. Sullivan, J. K. Griffiths, and S. Tzipori. 1997 Profiles of healing and nonhealing Cryptosporidium parvum infection in C57BL/6 mice with functional B and T lymphocytes: the extent of γ interferon modulation determines the outcome of infection. Infect. Immun. 65:4761.
11. Ogra, P. L., M. E. Lamm, J. R. McGhee, J. Mestecky, W. Strober, and J. Bienenstock. 1994. Handbook of Mucosal Immunology. Academic Press, San Diego.
12. Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707.
13. Perryman, L. E., K. A. Kegerris, and P. H. Mason. 1993. Effect of orally administered mAb on persistent Cryptosporidium parvum infection in scid mice. Infect. Immun. 61:4906.
14. Riggs, M. W., and L. E. Perryman. 1987. Infectivity and neutralization of Cryptosporidium parvum sporozoites. Infect. Immun. 55:2081.
15. Savelkoul, H. F., A. C. Vossen, E. G. Breedland, and G. J. Tibbe. 1994. Semi-preparative purification and validation of monoclonal antibodies for immunotherapy in mice. J. Immunol. Methods 172:33.
16. Darby, C. R., K. Hamano, and K. J. Wood. 1993. Purification of monoclonal antibodies from tissue culture medium depleted of IgG. J. Immunol. Methods 159:125.
17. Jung, T., U. Schauer, C. Heusser, C. Neumann, and C. Rieger. 1993. Detection of intracellular cytokines by flow cytometry. J. Immunol. Methods 159:197.
18. Sander, B., J. Andersson, and U. Andersson. 1991. Assessment of cytokines by immunofluorescencc and the paraformaldehyde-saponin procedure. Immunol. Rev. 119:65.
19. + T cells that secrete IFN-γ and IL-5. J. Immunol. 145:68.
20. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749.
21. Dimier, I. H., and D. T. Bout. 1993. Rat intestinal epithelial cell line IEC-6 is activated by recombinant interferon-γ to inhibit replication of the coccidian Toxoplasma gondii. Eur. J. Immunol. 23:981.
22. Pfefferkorn, E. R., and P. M. Guyre. 1984. Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant γ interferon. Infect. Immun. 44:211.
23. Gupta, S. L., J. M. Carlin, P. Pyati, W. Dai, E. R. Pfefferkorn, and M. J. Murphy, Jr. 1994. Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts. Infect. Immun. 62:2277.
24. Pfefferkorn, E. R. 1984. Interferon γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc. Natl. Acad. Sci. USA 81:908.
25. Colgan, S. P., C. A. Parkos, J. B. Matthews, D. A. L., C. S. Awtrey, A. H. Lichtman, C. Delp-Archer, and J. L. Madara. 1994. Interferon-γ induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am. J. Physiol. 267:C402.
26. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739.
27. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249.
28. Graham, M. B., D. K. Dalton, D. Giltinan, V. L. Braciale, T. A. Stewart, and T. J. Braciale. 1993. Response to influenza infection in mice with a targeted disruption in the interferon γ gene. J. Exp. Med. 178:1725.
29. Urban, J. F., Jr., R. Fayer, S. J. Chen, W. C. Gause, M. K. Gately, and F. D. Finkelman. 1996. IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum. J. Immunol. 156: 263.
30. Rehg, J. E. 1996. Effect of interferon-γ in experimental Cryptosporidium parvum infection. J. Infect. Dis. 174:229.
31. Leitch, G. J., and Q. He. 1994. Arginine-derived nitric oxide reduces fecal oocyst shedding in nude mice infected with Cryptosporidium parvum. Infect. Immun. 62:5173.
32. Chen, W., J. A. Harp, A. G. Harmsen, and E. A. Havell. 1993. γ Interferon functions in resistance to Cryptosporidium parvum infection in severe combined immunodeficient mice. Infect. Immun. 61:3548.
33. Suzuki, Y., Q. Yang, S. Yang, N. Nguyen, S. Lim, O. Liesenfeld, T. Kojima, and J. S. Remington. 1996. IL-4 is protective against development of toxoplasmic encephalitis. J. Immunol. 157:2564.
34. Kropf, P., R. Etges, L. Schopf, C. Chung, J. Sypek, and I. Muller. 1997. Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4. J. Immunol. 159:3434.
35. Chensue, S. W., K. Warmington, J. H. Ruth, N. Lukacs, and S. L. Kunkel. 1997. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-γ and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks. J. Immunol. 159:3565.
36. Dugas, B., J. C. Renauld, J. Pene, J. Y. Bonnefoy, C. Peti-Frere, P. Braquet, J. Bousquet, J. Van Snick, and J. M. Mencia-Huerta. 1993. Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes. Eur. J. Immunol. 23:1687.
37. Petit-Frere, C., B. Dugas, P. Braquet, and J. M. Mencia-Huerta. 1993. Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes. Immunology 79:146.
38. Zurawski, G., and J. E. de Vries. 1994. Interleukin 13 elicits a subset of the activities of its close relative interleukin 4. Stem Cells 12:169.
39. Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
40. Le Gros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
41. Finkelman, F. D., T. Shea-Donohue, J. Goldhill, C. A. Sullivan, S. C. Morris, K. B. Madden, W. C. Gause, and J. F. Urban, Jr. 1997. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu. Rev. Immunol. 15:505.
42. Kopf, M., G. Le Gros, A. J. Coyle, M. Kosco-Vilbois, and F. Brombacher. 1995. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol. Rev. 148:45.
43. Huang, H., J. Hu-Li, H. Chen, S. Z. Ben-Sasson, and W. E. Paul. 1997. IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent. J. Immunol. 159:3731.
44. Beagley, K. W., J. H. Eldridge, F. Lee, H. Kiyono, M. P. Everson, W. J. Koopman, T. Hirano, T. Kishimoto, and J. R. McGhee. 1989. Interleukins and IgA synthesis: human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J. Exp. Med. 169:2133.
45. Beagley, K. W., J. H. Eldridge, H. Kiyono, M. P. Everson, W. J. Koopman, T. Honjo, and J. R. McGhee. 1988. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. J. Immunol. 141:2035.
46. Elliot, B. C., A. V. Wisnewski, J. Johnson, D. Fenwick-Smith, P. Wiest, D. Hamer, T. Kresina, and T. P. Flanigan. 1997. In vitro inhibition of Cryptosporidium parvum infection by human monoclonal antibodies. Infect. Immun. 65:3933.
47. Riggs, M. W., T. C. McGuire, P. H. Mason, and L. E. Perryman. 1989. Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites. J. Immunol. 143:1340.
48. Riggs, M. W., A. L. Stone, P. A. Yount, R. C. Langer, M. J. Arrowood, and D. L. Bentley. 1997. Protective mAb defines a circumsporozoite-like glycoprotein exoantigen of Cryptosporidium parvum sporozoites and merozoites. J. Immunol. 158:1787.
49. Bjorneby, J. M., D. R. Leach, and L. E. Perryman. 1991. Persistent cryptosporidiosis in horses with severe combined immunodeficiency. Infect. Immun. 59:3823.
50. Greenberg, P. D., and J. P. Cello. 1996. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 13:348.
51. Plettenberg, A., A. Stoehr, H. J. Stellbrink, H. Albrecht, and W. Meigel. 1993. A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea. Clin. Invest. 71:42.
52. Taghi-Kilani, R., L. Sekla, and K. T. Hayglass. 1990. The role of humoral immunity in Cryptosporidium spp. infection: studies with B cell-depleted mice. J. Immunol. 145:1571.
53. Stevenson, M. M., M. F. Tam, M. Belosevic, P. H. van der Meide, and J. E. Podoba. 1990. Role of endogenous γ interferon in host response to infection with blood-stage Plasmodium chabaudi AS. Infect. Immun. 58:3225.
54. von der Weid, T., M. Kopf, G. Kohler, and J. Langhorne. 1994. The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur. J. Immunol 24:2285.
55. Suzuki, Y., M. A. Orellana, R. D. Schreiber, and J. S. Remington. 1988. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 240:516.
56. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
57. Noben-Trauth, N., P. Kropf, and I. Muller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987.