Does DHEA exert direct effects on androgen and estrogen receptors, and does it promote or prevent prostate cancer?

Endocrinology

Volumn 146, Issue 11, 2005, Pages 4565-4567

  Arnold, Julia T ^a   Blackman, Marc R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR; PRASTERONE;

CANCER GROWTH; DIET SUPPLEMENTATION; DRUG ABUSE; DRUG ACTIVITY; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; HUMAN; IMMUNE SYSTEM; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SHORT SURVEY; TRANSCRIPTION INITIATION;

DEHYDROEPIANDROSTERONE; HUMANS; MALE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN;

EID: 26844575977     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-0901     Document Type: Short Survey

References (36)

1. Orentreich N, Brind JL, Vogelman JH, Andres R, Baldwin H 1992 Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. J Clin Endocrinol Metab 75:1002-1004
2. Alesci S, Manoli I, Blackman MR 2005 Dehydroepiandrosterone (DHEA). In: Coates P, Blackman MR, Cragg G, Levine M, Moss J, White J, eds. Encyclopedia of dietary supplements. 1st ed. New York: Marcel Dekker, Inc.; 167-176
3. Martel C, Melner MH, Gagne D, Simard J, Labrie F 1994 Widespread tissue distribution of steroid sulfatase, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD), 17 beta-HSD 5 alpha-reductase and aromatase activities in the rhesus monkey. Mol Cell Endocrinol 104:103-111
4. Labrie F, Belanger A, Labrie C, Simard J, Cusan L, Gomez JL, Candas B 1998 DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging. Steroids 63:322-328
5. Tan J, Sharief Y, Hamil KG, Gregory CW, Zang DY, Sar M, Gumerlock PH, deVere White RW, Pretlow TG, Harris SE, Wilson EM, Mohler JL, French FS 1997 Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells. Mol Endocrinol 11:450-459
6. Martin C, Ross M, Chapman KE, Andrew R, Bollina P, Seckl JR, Habib FK 2004 CYP7B generates a selective estrogen receptor β agonist in human prostate. J Clin Endocrinol Metab 89:2928-2935
7. Williams MR, Dawood T, Ling S Dai A, Lew R, Myles K, Funder JW, Sudhir K, Komesaroff PA 2004 Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J Clin Endocrinol Metab 89:4708-4715
8. Acacio BD, Stanczyk FZ, Mullin P, Saadat P, Jafarian N, Sokol RZ 2004 Pharmacokinetics of dehydroepiandrosterone and its metabolites after longterm daily oral administration to healthy young men. Fertil Steril 81:595-604
9. Chen F, Knecht K, Birzin E, Fisher J, Wilkinson H, Mojena M, Moreno CT, Schmidt A, Harada S-i, Freedman LP, Reszka AA 2005 Direct agonist/antagonist functions of dehydroepiandrosterone. Endocrinology 146:4568-4576
10. Begin D, Luthy IA, Labrie F 1988 Adrenal precursor C19 steroids are potent stimulators of growth of androgen-sensitive mouse mammary carcinoma Shionogi cells in vitro. Mol Cell Endocrinol 58:213-219
11. Green JE, Shibata MA, Shibata E, Moon RC, Anver MR, Kelloff G, Lubet R 2001 2-Difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. Cancer Res 61:7449-7455
12. Lubet RA, McCormick DM, Gordon GM, Grubbs C, Lei XD, Prough RA, Steele VE, Kelloff GJ, Thomas CF, Moon RD 1998 Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations. Cancer Res 58:921-926
13. Perkins SN, Hursting SD, Haines DC, James SJ, Miller BJ, Phang JM 1997 Chemoprevention of spontaneous tumorigenesis in nullizygous p53-deficient mice by dehydroepiandrosterone and its analog 16α-fluoro-5-androsten-17-one. Carcinogenesis 18:989-994
14. Schwartz AG, Pashko LL 1995 Cancer prevention with dehydroepiandrosterone and non-androgenic structural analogs. J Cell Biochem Suppl 22:210-217
15. Ciolino H, MacDonald C, Memon O, Dankwah M, Yeh GC 2003 Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo. Int J Cancer 105:321-325
16. Martin-Du Pan RC 1999 [Are the hormones of youth carcinogenic?]. Ann Endocrinol (Paris) 60:392-397
17. Comstock GW, Gordon GB, Hsing AW 1993 The relationship of serum dehydroepiandrosterone and its sulfate to subsequent cancer of the prostate. Cancer Epidemiol Biomarkers Prev 2:219-221
18. Oesterling JE, Epstein JI, Walsh PC 1986 The inability of adrenal androgens to stimulate the adult human prostate: an autopsy evaluation of men with hypogonadotropic hypogonadism and panhypopituitarism. J Urol 136:1030-1034
19. Klein H, Molwitz T, Bartsch W 1989 Steroid sulfate sulfatase in human benign prostatic hyperplasia: characterization and quantification of the enzyme in epithelium and stroma. J Steroid Biochem 33:195-200
20. Labrie F 1991 Intracrinology. Mol Cell Endocrinol 78:C113-C118
21. Geller J 1985 Rationale for blockade of adrenal as well as testicular androgens in the treatment of advanced prostate cancer. Semin Oncol 12:28-35
22. Culig Z, Hobisch A, Cronauer MV, Cato AC, Hittmair A, Radmayr C, Eberle J, Bartsch G, Klocker H 1993 Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Mol Endocrinol 7:1541-1550
23. Arnold JT, Le H, McFann KK, Blackman MR 2005 Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells. Am J Physiol Endocrinol Metab 288:E573-E584
24. Weihua Z, Warner M, Gustafsson JA 2002 Estrogen receptor β in the prostate. Mol Cell Endocrinol 193:1-5
25. Leav I, Lau KM, Adams JY, McNeal JE, Taplin ME, Wang J, Singh H, Ho SM 2001 Comparative studies of the estrogen receptors β and α and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. Am J Pathol 159:79-92
26. Zhu X, Leav I, Leung YK, Wu M, Liu Q, Gao Y, McNeal JE, Ho SM 2004 Dynamic regulation of estrogen receptor-β expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol 164:2003-2012
27. Lai JS, Brown LG, True LD, Hawley SJ, Etzioni RB, Higano CS, Ho SM, Vessella RL, Corey E 2004 Metastases of prostate cancer express estrogen receptor-β. Urology 64:814-820
28. Koehler KF, Helguero LA, Haldosén LA, Warner M, Gustafsson J-Å 2005 Reflections on the discovery and significance of estrogen receptor β. Endocr Rev 26:465-478
29. Signoretti S, Loda M 2001 Estrogen receptor β in prostate cancer: brake pedal or accelerator? Am J Pathol 159:13-16
30. Weihua Z, Makela S, Andersson LC, Salmi S, Saji S, Webster JI, Jensen EV, Nilsson S, Warner M, Gustafsson JA 2001 A role for estrogen receptor β in the regulation of growth of the ventral prostate. Proc Natl Acad Sci USA 98:6330-6335
31. Risbridger GP, Wang H, Frydenberg M, Cunha G 2001 The metaplastic effects of estrogen on mouse prostate epithelium: proliferation of cells with basal cell phenotype. Endocrinology 142:2443-2450
32. Zhu YS, Cai LQ, Huang Y, Fish J, Wang L, Zhang ZK, Imperato-McGinley JL 2005 Receptor isoform and ligand-specific modulation of dihydrotestosterone- induced prostate specific antigen gene expression and prostate tumor cell growth by estrogens. J Androl 26:500-508; discussion 509-510
33. Hennebold JD, Daynes RA 1994 Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines. Endocrinology 135:67-75
34. Simard J, Gingras S 2001 Crucial role of cytokines in sex steroid formation in normal and tumoral tissues. Mol Cell Endocrinol 171:25-40
35. De Marzo AM, Marchi VL, Epstein JI, Nelson WG 1999 Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol 155:1985-1992
36. Cunha GR, Cooke PS, Kurita T 2004 Role of stromal-epithelial interactions in hormonal responses. Arch Histol Cytol 67:417-434