Resveratrol modulates gene expression associated with apoptosis, proliferation and cell cycle in cells with mutated human c-Ha-Ras, but does not alter c-Ha-Ras mRNA or protein expression

Journal of Nutritional Biochemistry

Volumn 16, Issue 11, 2005, Pages 663-674

  Young, Leeanne F ^a   Hantz, Holly L ^a   Martin, Keith R ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell cycle; Ha ras; p53; Proliferation

Indexed keywords

CYCLIN D; CYCLIN G1; EARLY GROWTH RESPONSE FACTOR 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MESSENGER RNA; PROTEIN; PROTEIN MAD21; PROTEIN MCL 1; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; RAS PROTEIN; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE MUTATION; MOUSE; NONHUMAN; ONCOGENE C H RAS; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL CYCLE; CELL LINE; CELL PROLIFERATION; GENE EXPRESSION; GENES, P53; GENES, RAS; HUMANS; MICE; MUTATION; RAS PROTEINS; RNA, MESSENGER; STILBENES;

EID: 26844559984     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2005.03.004     Document Type: Article

References (66)

1. J. DiGiovanni Multistage carcinogenesis in mouse skin Pharmacol Ther 54 1 1992 63 128
2. T. Buttke, and P. Sandstrom Oxidative stress as a mediator of apoptosis Immunol Today 15 1 1994 7 10
3. K. Bhat, and J.M. Pezzuto Cancer chemopreventive activity of resveratrol Ann N Y Acad Sci 957 2002 210 229
4. C. Cal, H. Garban, A. Jazirehi, C. Yeh, Y. Mizutani, and B. Bonavida Resveratrol and cancer: chemoprevention, apoptosis, and chemoimmunosensitizing activities Curr Med Chem Anti-Canc Agents 3 2 2003 77 93
5. Z. Dong Molecular mechanism of the chemopreventive effect of resveratrol Mutat Res 523-524 2003 145 150
6. J. Gusman, H. Malonne, and G. Atassi A reappraisal of the chemopreventive and chemotherapeutic properties of resveratrol Carcinogenesis 22 8 2001 1111 1117
7. J. Savouret, and M. Quesne Resveratrol and cancer Biomed Pharmacother 56 2 2002 84 87
8. M. Roberti, D. Pizzirani, and D. Simoni Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents J Med Chem 46 16 2003 3546 3554
9. M. Jang, L. Cai, and G. Udeani Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 275 1997 218 220
10. F. Bianchini, and H. Vainio Wine and resveratrol: mechanisms of cancer prevention? Eur J Cancer Prev 12 5 2003 417 425
11. C. Bral, and K. Ramos Identification of benzo[a]pyrene-inducible cis-acting elements within c-Ha-ras transcriptional regulatory sequences Mol Pharmacol 52 6 1997 974 982
12. V. Ayllon, and A. Rebollo Ras-induced cellular events Oncogene 17 1998 1395 1413
13. S. Campbell, R. Khosravi-Far, K. Rossman, G. Clark, and C. Der Increasing complexity of Ras signaling Oncogene 17 1998 1395 1413
14. I. Macar, K. Lounsbury, S. Richards, C. McKiernan, and D. Bar-Sagi The Ras superfamily of GTPases FASEB J 10 1996 625 630
15. I.A. Prior, C. Muncke, R.G. Parton, and J.F. Hancock Direct visualization of Ras proteins in spatially distinct cell surface domains J Cell Biol 160 2 2003 165 170
16. H. Lander, J. Ogiste, K. Teng, and A. Novogrodsky p21ras as a common signaling target of reactive free radicals and cellular redox stress J Biol Chem 270 36 1995 21195 21198
17. K.R. Martin, and J.C. Barrett Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity Hum Exp Toxicol 21 2002 71 75
18. A. Levine p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331
19. L. Donehower, M. Harvey, B. Slagle, M. Mcarthur, C. Montgomery, and A. Bradley Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors Nature 356 1992 215 221
20. S. Ries, C. Biederer, and D. Woods Opposing effects of ras on p53: transcriptional activation of mdm2 and induction of p19ARF Cell 1 1999 321 330
21. G. Soleas, D. Goldberg, L. Grass, M. Leveesque, and E. Diamandis Do wine polyphenols modulate p53 gene expression in human cancer cell lines? Clin Biochem 34 2001 415 420
22. L.L. Nielsen, M. Gurnani, G. Porter, S. Trexler, D. Emerson, and R.D. Tyler Development of a nude mouse model of ras-mediated neoplasia using WR-21 cells from a transgenic mouse salivary tumor In Vivo 8 3 1994 295 302
23. K.R. Martin, M.L. Failla, and J.C. Smith Jr Beta-carotene and lutein protect HepG2 human liver cells against oxidant-induced damage J Nutr 126 9 1996 2098 2106
24. J.H. Kang, Y.H. Park, S.W. Choi, E.K. Yang, and W.J. Lee Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells Exp Mol Med 35 6 2003 467 474
25. Y.A. Kim, B.T. Choi, and Y.T. Lee Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells Oncol Rep 11 2 2004 441 446
26. X.Z. Ding, and T.E. Adrian Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells Pancreas 25 4 2002 e71 e76
27. F. Wolter, B. Akoglu, A. Clausnitzer, and J. Stein Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines J Nutr 131 8 2001 2197 2203
28. H. Ferry-Dumazet, O. Garnier, and M. Mamani-Matsuda Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells Carcinogenesis 23 8 2002 1327 1333
29. A. Sgambato, R. Ardito, B. Faraglia, A. Boninsegna, F.I. Wolf, and A. Cittadini Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage Mutat Res 496 1-2 2001 171 180
30. A.K. Joe, H. Liu, M. Suzui, M.E. Vural, D. Xiao, and I.B. Weinstein Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines Clin Cancer Res 8 3 2002 893 903
31. Y.C. Liang, S.H. Tsai, L. Chen, S.Y. Lin-Shiau, and J.K. Lin Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells Biochem Pharmacol 65 7 2003 1053 1060
32. F.D. Ragione, V. Cucciolla, and A. Borriello Resveratrol arrests the cell division cycle at S/G2 phase transition Biochem Biophys Res Commun 250 1 1998 53 58
33. B. Pucci, M. Kasten, and A. Giordano Cell cycle and apoptosis Neoplasia 2 4 2000 291 299
34. M. McMahon, and D. Woods Regulation of the p53 pathway by Ras, the plot thickens Biochim Biophys Acta 1471 2001 M63 M71
35. P.L. Kuo, L.C. Chiang, and C.C. Lin Resveratrol-induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells Life Sci 72 1 2002 23 34
36. Q.B. She, C. Huang, Y. Zhang, and Z. Dong Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosis Mol Carcinog 33 4 2002 244 250
37. Q.B. She, A.M. Bode, W.Y. Ma, N.Y. Chen, and Z. Dong Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase Cancer Res 61 4 2001 1604 1610
38. C. Huang, W.Y. Ma, A. Goranson, and Z. Dong Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway Carcinogenesis 20 2 1999 237 242
39. M. Holmes-McNary, and A.S. Baldwin Jr Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase Cancer Res 60 13 2000 3477 3483
40. H.Y. Lin, A. Shih, and F.B. Davis Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line J Urol 168 2 2002 748 755
41. A. Shih, F.B. Davis, H.Y. Lin, and P.J. Davis Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism J Clin Endocrinol Metab 87 3 2002 1223 1232
42. S.K. Chiou, M.K. Jones, and A.S. Tarnawski Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond Med Sci Monit 9 4 2003 PI25 PI29
43. Z. Wang, S. Fukuda, and L.M. Pelus Survivin regulates the p53 tumor suppressor gene family Oncogne 23 49 2004 8146 8153
44. S.M. Lens, R.M. Wolthuis, and R. Klompmaker Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension EMBO J 22 12 2003 2934 2947
45. D.M. Rasper, J.P. Vaillancourt, and S. Hadano Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex Cell Death Differ 5 4 1998 271 288
46. E. Liu, A.A. Thant, and F. Kikkawa The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1 Cancer Res 60 9 2000 2361 2364
47. S.K. Binz, Y. Lao, D.F. Lowry, and M.S. Wold The phosphorylation domain of the 32-kDa subunit of replication protein A (RPA) modulates RPA-DNA interactions. Evidence for an intersubunit interaction J Biol Chem 278 37 2003 35584 35591
48. D. Utrera-Barillas, M. Salcedo-Vargas, P. Gariglio-Vidal, D.M. Hernandez-Hernandez, F. Gutierrez-Delgado, and L. Benitez-Bribiesca H-ras and Nm23-H1 gene expression and proteolytic activity in squamous cell carcinoma of the uterine cervix Arch Med Res 31 2 2000 172 181
49. B.S. Wung, J.J. Cheng, Y.J. Chao, H.J. Hsieh, and D.L. Wang Modulation of Ras/Raf/extracellular signal-regulated kinase pathway by reactive oxygen species is involved in cyclic strain-induced early growth response-1 gene expression in endothelial cells Circ Res 84 7 1999 804 812
50. J. Collette, A.S. Ulku, C.J. Der, A. Jones, and A.H. Erickson Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells Int J Cancer 112 2 2004 190 199
51. P.D. Donatien, S.L. Diment, R.E. Boissy, and S.J. Orlow Melanosomal and lysosomal alterations in murine melanocytes following transfection with the v-rasHa oncogene Int J Cancer 66 4 1996 557 563
52. Y. Schneider, P. Chabert, and J. Stutzmann Resveratrol analog (Z)-3,5,4'-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization Int J Cancer 107 2 2003 189 196
53. L.M. Shantz Transcriptional and translational control of ornithine decarboxylase during Ras transformation Biochem J 377 Pt 1 2004 257 264
54. C. Liu, V.M. Rangnekar, E. Adamson, and D. Mercola Suppression of growth and transformation and induction of apoptosis by EGR-1 Cancer Gene Ther 5 1 1998 3 28
55. F.D. Ragione, V. Cucciolla, V. Criniti, S. Indaco, A. Borriello, and V. Zappia p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect J Biol Chem 278 26 2003 23360 23368
56. G. Thiel, and G. Cibelli Regulation of life and death by the zinc finger transcription factor Egr-1 J Cell Physiol 193 3 2002 287 292
57. A. Quinones, K.U. Dobberstein, and N.G. Rainov The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells Life Sci 72 26 2003 2975 2992
58. M. Saegusa, B. Machida, and I. Okayasu Possible associations among expression of p14(ARF), p16(INK4a), p21(WAF1/CIP1), p27 (KIP1), and p53 accumulation and the balance of apoptosis and cell proliferation in ovarian carcinomas Cancer 92 5 2001 1177 1189
59. M. Larrosa, F.A. Tomas-Barberan, and J.C. Espin Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells J Agric Food Chem 51 16 2003 4576 4584
60. E.J. Lee, H.Y. Min, and H. Joo Park G2/M cell cycle arrest and induction of apoptosis by a stilbenoid, 3,4,5-trimethoxy-4′-bromo-cis-stilbene, in human lung cancer cells Life Sci 75 23 2004 2829 2839
61. A. Shimizu, J. Nishida, and Y. Ueoka Cyclin G contributes to G2/M arrest of cells in response to DNA damage Biochem Biophys Res Commun 242 3 1998 529 533
62. K. Okamoto, and C. Prives A role of cyclin G in the process of apoptosis Oncogene 18 32 1999 4606 4615
63. T. Ohtsuka, M. Jensen, H. Kim, H. Kim, and S. Lee The negative role of cyclin G in ATM-dependent p53 activation Oncogene 22 11 2004 1678 1687
64. X. Chen Cyclin G: a regulator of the p53-Mdm2 network Dev Cell 2 5 2002 518 519
65. W. Tao, and A.J. Levine P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2 Proc Natl Acad Sci U S A 96 12 1999 6937 6941
66. M. Fontecave, M. Lepoivre, E. Elleingand, C. Gerez, and O. Guittet Resveratrol, a remarkable inhibitor of ribonucleotide reductase FEBS Lett 421 3 1998 277 279