Do wine polyphenols modulate p53 gene expression in human cancer cell lines?

Clinical Biochemistry

Volumn 34, Issue 5, 2001, Pages 415-420

  Soleas, George J ^a,b   Goldberg, David M ^a   Grass, Linda ^c   Levesque, Michael ^a,c   Diamandis, Eleftherios P ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b Liquor Control Board of Ontario   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

(+) Catechin; Apoptosis; Caffeic acid; Cancer; P53; Polyphenols; Quercetin; Time resolved fluorescence immunoassay; Trans Resveratrol; Wine

Indexed keywords

ANTINEOPLASTIC AGENT; CAFFEIC ACID; CATECHIN; POLYPHENOL DERIVATIVE; PROTEIN P53; QUERCETIN; RESVERATROL;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CELL LYSATE; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STIMULATION; TOXICITY; WINE;

ANTIOXIDANTS; BREAST NEOPLASMS; CAFFEIC ACIDS; CATECHIN; COLONIC NEOPLASMS; FLAVONOIDS; FLUOROIMMUNOASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; MODELS, STRUCTURAL; PHENOLS; POLYMERS; QUERCETIN; STILBENES; TIME FACTORS; TUMOR CELLS, CULTURED; WINE;

EID: 0034889449     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9120(01)00246-6     Document Type: Article

References (35)

1. Wine as a biological fluid: History, production and its role in disease prevention
2. The world of resveratrol
3. The p53 tumour suppressor gene
4. The p53 tumor suppressor gene
5. p53 mutation in human cancers
6. TP53 tumor suppressor gene: A model for investigating human mutagenesis
7. Analysis of antioxidant wine polyphenols by high performance liquid chromatography
8. Analysis of antioxidant wine polyphenols by gas chromatography-mass spectrometry
9. Steroid hormone regulation of prostate specific antigen gene expression in breast cancer
10. Time-resolved immunofluorometric assay of p53 protein
11. Diet and health; what should we eat?
12. Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries Study
13. The effect of quercetin on cell cycle progression and growth of human gastric cancer cells
14. Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells
15. Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds
16. Delayed tumor onset in transgenic mice fed an amino acid-based diet supplemented with red wine solids
17. Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics, and evidence for in vivo tyrosine kinase inhibition
18. Effect of red wine ingestion on the antioxidant capacity of serum
19. Principal phenolic phytochemicals in selected California wines and their antioxidant activity in inhibiting oxidation of human low-density lipoproteins
20. Inhibitory effect of phenolic compounds on aflatoxin BI metabolism and induced mutagenesis
21. Antimutagenic effect of resveratrol against Trp-P-1
22. Selectivity of neutrophil 5-lipoxygenase and cyclooxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids
23. Differential inhibitory effects on the activities of reverse transcriptase and cellular DNA and RNA polymerases
24. Identification and assay of trihydroxystilbenes in wine and their biological properties
25. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells
26. Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell-line MDA-MB468
27. Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals
28. Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-) -epigallocatechin-3-gallate
29. Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
30. Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation
31. Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy
32. Flavonoids activate wild-type p53
33. Prognostic value of prostate-specific antigen for women with breast cancer: A large U.S. cohort study