H-ras and Nm23-H1 gene expression and proteolytic ctivity in squamous cell carcinoma of the uterine cervix

Archives of Medical Research

Volumn 31, Issue 2, 2000, Pages 172-181

  Utrera Barillas, Dolores ^a   Salcedo Vargas, Mauricio ^a   Gariglio Vidal, Patricio ^b   Hernández Hernández, Dulce María ^a   Gutiérrez Delgado, Francisco ^a   Benítez Bribiesca, Luis ^a  

^a HOSPITAL DE ONCOLOGÍA   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Carcinoma of the cervix; H ras; Invasion; Nm23; Proteases

Indexed keywords

CATHEPSIN B; COLLAGENASE; NUCLEOSIDE DIPHOSPHATE KINASE A; PLASMINOGEN ACTIVATOR; PROTEIN; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; CANCER STAGING; CONTROLLED STUDY; CYTOSOL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METASTASIS; ONCOGENE H RAS; PROGNOSIS; PROTEIN DEGRADATION; UTERINE CERVIX CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CATHEPSIN B; COLLAGENASES; CYTOSOL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION; MONOMERIC GTP-BINDING PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASM STAGING; NUCLEOSIDE-DIPHOSPHATE KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTO-ONCOGENE PROTEINS P21(RAS); TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 0034603605     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0188-4409(00)00070-9     Document Type: Article

References (81)

1. Brodt P. Cell adhesion and invasion in cancer metastasis. 1st ed:1996;1 Chapman Hall, Montreal, Quebec, Canada.
2. Poole A.R., Tiltman K.J., Recklies A.D., Stoker T.A. Differences in secretion of the proteinase cathepsin B at the edge of human breast carcinomas and fibroadenomas. Nature. 273:1978;545.
3. Mareel M., De Baetselier P., Van Roy F. Mechanisms of invasion and metastasis. 1st ed:1991;1 CRC Press, Boca Raton, FL, USA.
4. Ossowski L., Reich E. Experimental model for quantitative study of metastasis. Cancer Res. 40:1980;2300.
5. Liotta L., Tryggvason K., Garbisa S., Hart I., Foltz C., Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature. 284:1980;67.
6. Benítez L., Villanueva C., Freyre R., Amezcua J., De la Huerta R., Luévano E., Pastrana L. Serum proteinase levels and functional and morphological platelet alterations in patients with cervix uteri carcinoma. Correlation with the degree of progression of the malignancy. Arch Invest Med. 17:1986;211.
7. Pietras R., Szego C., Mangan C., Facog B., Burtnett M., Orevi M. Elevated serum cathepsin B1 and vaginal pathology after prenatal DES exposure. Obstet Gynecol. 52:1978;321.
8. Mort J., Buttle D. Molecules in focus. Cathepsin B. Int J Biochem Cell Biol. 29:1997;715.
9. Liotta L., Thorgeirsson U., Gaarbisa S. Role of collagenases in tumor cell invasion. Cancer Metastasis Rev. 1:1982;277.
10. Andreasen P., Kjoller L., Christensen L., Duffy M. The urokinase-type plasminogen activator system in cancer metastasis. a review Int J Cancer. 72:1997;1.
11. Kim K., Cai J., Shuja S., Kuo T., Murane M. Presence of activated Ras correlates with increased cysteine proteinase activities in human colorectal carcinomas. Int J Cancer (Pred Oncol). 79:1998;324.
12. Pietras R., Szego C., Mangan C., Facog B., Seeler B., Burtnett M. Elevated serum cathepsin B1-like activity in women with neoplastic disease. Gynecol Oncol. 7:1979;1.
13. Benítez L., De la Huerta R., Villanueva C., Freyre R., Pastrana L., Guevara R. Proteinase and antiproteinase balance in patients with carcinoma of the uterine cervix before and after radiotherapy. Arch Invest Med. 20:1989;9.
14. Makarewicz R., Drewa G.A. Possible application of cathepsin B activity determination for estimating the spread of the cervix uteri carcinoma. Acta Biochim Pol. 43:1996;521.
15. Douglas L. Function and regulation of Ras. Annu Rev Biochem. 62:1993;85.
16. De la Rosa A., Williams R., Steeg P. Nm23/nucleoside diphosphate kinase. toward a structural and biochemical understanding of its biological functions Bioessays. 17:1995;53.
17. Naot D., Sionov R., Ish-Shalom D. Cd 44. structure, function, and association with the malignant process Adv Cancer Res. 71:1997;241.
18. Grigorian M., Tulchinsky E., Zain S., Ebralidze A., Kramerov D., Kriajevska M., Georgiev G., Lakanidin E. The mts 1 gene and control of tumor metastasis. Gene. 135:1993;229.
19. Jeffers M., Fiscella M., Webb C., Anver M., Koochekpour S., Vande Woude G. The mutationally activated Met receptor mediates motility and metastasis. Proc Natl Acad Sci USA. 95:1998;14417.
20. Bevilacqua G., Sobel M., Liotta L., Steeg P. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res. 49:1989;5185.
21. Takeda O., Handa M., Vehara T., Maseki N., Sakashita A., Sakuri M., Kanda N., Arai Y., Chaneko Y. An increased nm23-H1 copy number may be a poor prognostic factor independent of LOH on 1p in neuroblastomas. Br J Cancer. 74:1996;1620.
22. Aryee D., Ströbel T., Kos K., Salzer-Kuntschik M., Zoubek A., Veron M., Ambros I., Traincart F., Gadner H., Kovar H. High nm23 H-1/NDPK-A expression in Ewing tumors. paradoxical immunohistochemical reactivity and lack of prognostic significance Int J Cancer. 64:1995;104.
23. Nakopoulou L., Constandinides C., Tzonou A., Lazaris A., Zervas A., Dimopoulos C. Immunohistochemical evaluation of nm23-H1 gene product in transitional cell carcinoma of the bladder. Histopathology. 28:1996;429.
24. Yokoyama A., Okabe-Kado J., Sakashita A., Maseki N., Kaneko Y., Hino K., Tomoyasu S., Tsuruoka N., Honma Y. Differentiation inhibitory factor as a new prognostic factor in acute monocytic leukemia. Blood. 88:1996;3555.
25. Aryee D., Simonitsch I., Mosberger I., Kos K., Mann G., Schlogl E., Potschger U., Gadner H., Radaszkiewicz T., Kovar H. Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness. Br J Cancer. 74:1996;1693.
26. Lacombe M.L., Sastre G.X., Lascu I., Vonica A., Wallet V., Thiery J.P., Véron M. Overexpression of nucleoside diphosphate kinase (nm23) in solid tumours. Eur J Cancer. 27:1991;1302.
27. Mandai M., Konishi I., Koshiyama M., Komatsu T., Yamamoto S., Nanbu K., Mori T., Fukumoto M. Altered expression of nm23-H1 and c-erbB-2 proteins have prognostic significance in adenocarcinoma but not in squamous cell carcinoma of the uterine cervix. Cancer. 75:1995;2523.
28. Wang L., Patel U., Ghosh L., Chao Chen H., Banerjee S. Mutation in the nm23 gene is associated with metastasis in colorectal cancer. Cancer Res. 53:1993;717.
29. Leone A., McBride W., Weston A., Wang M., Anglard P., Cropp C., Goepel J., Lidereau R., Callahan R., Linehan M., Rees R., Harris C., Liotta L., Steeg P. Somatic allelic deletion of nm23 in human cancer. Cancer Res. 51:1991;2490.
30. Cohn K., Wang F., DeSoto F., Solomon W., Patterson L., Arnold M., Weimar J., Feldman J., Levy A., Leone A., Steeg P. Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma. Lancet. 338:1991;722.
31. Biggs J., Hersperger E., Steeg P., Liotta L., Sharon A. A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell. 63:1990;933.
32. Postel E., Berberich S., Flint S., Ferrone C. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science. 261:1993;478.
33. Lakso M., Steeg P., Westphal H. Embryonic expression of nm23 during mouse organogenesis. Cell Growth Differ. 3:1992;873.
34. Kado J, Kasukabe T, Honma Y, Hayashi M, Henzel W, Hozumi M. Identity of a differentiation inhibiting factor for mouse myeloid leukemia cells with nm23/nucleoside diphosphate kinase. Biochem Biophys Res Commun 1992;182:3:987.
35. Kantor J., McCormick B., Steeg P., Zetter B. Inhibition of cell motility after nm23 transfection of human and murine tumor cells. Cancer Res. 53:1993;1971.
36. Liotta L., Steeg P. Clues to the function of nm23 and awd proteins in development, signal transduction, and tumor metastasis provided by studies of Dictyostelium discoideum. J Natl Cancer Inst. 82:1990;1170.
37. Zhang J., Schultz R. Fibroblasts transformed by different ras oncogenes show dissimilar patterns of protease gene expression and regulation. Cancer Res. 52:1992;6682.
38. Muranane M., Sheahan K., Ozdemirli M., Shuja S. Stage specific increases in cathepsin B messenger RNA content in human colorectal carcinoma. Cancer Res. 51:1991;1137.
39. Oka T., Ishida T., Nishino T., Sugimachi K. Immunohistochemical evidence for urokinase plasminogen activator in primary and metastatic tumors of pulmonary carcinoma. Cancer Res. 51:1991;3522.
40. Hasui Y., Marutsuka K., Suzumiya J., Kitada S., Osda Y., Sumiyoshi A. The content of urokinase-type plasminogen activator as a prognostic factor in bladder cancer. Int J Cancer. 50:1992;871.
41. Kobayashi H., Fujishiro S., Terao T. Impact of urokinase-type plasminogen activator and its inhibitor type 1 on prognosis in cervical cancer of the uterus. Cancer Res. 54:1994;6539.
42. McDonnell S., Navre M., Coffey R., Matrisian L. Expression and localization of the matrix metalloproteinase pump-1(MMP-7) in human gastric and colon carcinomas. Mol Carcinog. 4:1991;527.
43. Stetler-Stevenson W. Type IV collagenases in tumor invasion and metastasis. Cancer Metastasis Rev. 9:1990;289.
44. Tryggvason K., Hoyhtya M., Pyke C. Type IV collagenases in invasive tumors. Breast Cancer Res Treat. 24:1993;209.
45. Benítez B.L., Freyre R., Gallegos G. Protease and antiprotease concentrations in serum and vaginal fluid of patients with carcinoma of the cervix. Arch Invest Med. 11:1980;523.
46. Riou G., Barrois V., Tordjman I., Dutronguay V., Orth G. Presence of papillomavirus genomes and amplification of c-myc and c-Ha-ras oncogenes in invasive cancers of the uterine cervix. C R Acad Sci III. 299:1984;575.
47. Tenti P., Romagnoli S., Silini E., Pellegata N., Zappatore R., Spinillo A., Zara C., Ranzani N., Carnevali L. Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix. Int J Cancer. 64:1995;9.
48. Kristensen G., Holm R., Abeler V., Trope C. Evaluation of the prognostic significance of nm23/NDP kinase protein expression in cervical carcinoma. an immunohistochemical study Gynecol Oncol. 61:1996;378.
49. Marone M., Scambia G., Ferrandina G., Giannitelli C., Benedetti P., Jacovella S., Leone A., Mancuso S. Nm23 expression in endometrial and cervical cancer. inverse correlation with lymph node involvement and myometrial invasion Br J Cancer. 74:1996;1063.
50. Sarac E., Ayhan A., Ertoy D., Tuncer Z., Yasui W., Tahara E., Ayhan A. Nm23 expression in carcinoma of the uterine cervix. Eur J Gynaecol Oncol. 19:1998;312.
51. Szego C., Seeler B.J., Smith R. Lysosomal cathepsin B1. partial characterization in rat preputial gland and recompartmentation in response to estradiol-17-β Eur J Biochem. 69:1976;463.
52. Zimmerman M., Quigley J.P., Ashe B., Dorn C., Goldfarb R., Troll W. Direct fluorescent assay of urokinase and plasminogen activators of normal and malignant cells. kinetics and inhibitor profiles Proc Natl Acad Sci USA. 75:1978;750.
53. Kojima K., Kinoshita H., Kato T., Nagatsu T., Takada K., Sakakibara S.A. New and highly sensitive fluorescence assay for collagenase-like peptidase activity. Anal Biochem. 100:1979;43.
54. Bradford M.A. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dyebinding. Anal Biochem. 72:1976;248.
55. Vasishta A., Baker P., Preece P., Wood R., Cuschieri A. Inhibition of proteinase-like peptidase activities in serum and tissue from breast cancer patients. Anticancer Res. 8:1988;785.
56. Loebl J. Image analysis. Principles and practice. 1989;170 Short Run Press, UK.
57. Herrington C., Mc Gee J. Diagnostic molecular pathology. a practical approach. Vol. II. The practical approach series:1992;50 IRL Press, New York.
58. Pietras R.J., Szego C.M., Mangan C.E., Seeler B., Burtnett M., Orevi M. Cathepsin B-like enzymes. Subcellular distribution and properties in neoplastic and control cells from human ectocervix. J Biol Chem. 256:1981;8536.
59. Bajou K, Noel A, Gerard V. Masson V, Brunner N, Holst-Hansen C, Skobe M, Fusenig N, Carmeliet P, Collen D, Foidart J. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat Med 1998;4:923.
60. Collard G.et al. Invasive and metastatic potential induced by ras transfection into mouse BW 5147-lymphoma cells. Cancer Res. 47:1987;754.
61. Thorgeirsson U., Turpeenniemi H., Williams J., Westin E., Heilman C., Talmadge E., Liotta L. NIH/3T3 transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Mol Cell Biol. 5:1985;259.
62. Vousden K., Eccles S., Purvies H., Marshall C. Enhanced spontaneous metastasis of mouse carcinoma cells transfected with an activated c-Ha-ras-1 gene. Int J Cancer. 37:1986;425.
63. Rodenhuis S., Slebos R. Clinical significance of ras oncogene activation in human lung cancer. Cancer Res. 52(Suppl):1992;2665s.
64. Sloana B., Moin K., Sameni M., Tait L., Rozhin J., Ziegler G. Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene. J Cell Sci. 107:1994;373.
65. Ballin M., Gomez D., Sinha C., Thorgeirsson U. Ras oncogene mediated induction of a 92 kDa metalloproteinase. Biochem Biophys Res Commun. 154:1988;832.
66. Chambers A., Tuck A. Ras-responsive genes and tumor metastasis. Crit Rev Oncog. 4:1993;95.
67. Enomoto T., Inoue M., Perantoni A., Terakawa N., Tanizawa O., Rice J. K-ras activation in neoplasms of the human female reproductive tract. Cancer Res. 50:1990;6139.
68. Bos J. The ras gene family and human carcinogenesis. Mutat Res. 195:1988;255.
69. Khosravi-Far R., Cox A., Kato K., Der C. Protein prenylation. key to ras function and cancer intervention? Cell Growth Differ. 3:1992;461.
70. Guo X., Zhang Y., Mitchell D., Chambers A. Identification of ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cell. Mol Cell Biol. 15:1995;476.
71. Reddy M., Langer S., Colman M., Ostrowski M. An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites. Mol Endocrinol. 6:1992;1051.
72. Steeg P., Bevilacqua G., Kopper L., Thorgeirsson U., Talmadge E., Liotta L., Sobel M. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 80:1988;200.
73. Munier A., Feral C., Pinon V.P., Gyapay G., Capeau J., Guellaen G., Lacombe M. A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells. FEBS Lett. 434:1998;289.
74. Jiang X., Liu K., Zhou X. Cloning and sequencing of nm23-H3b, a new gene identified to nm23. Chin Med J (Engl). 74:1994;670.
75. Lascu I., Bonne D., Glaser P., Veron M. Equilibrium dissociation and unfolding of nucleoside diphosphate kinase from Dictyostelium discoideum. J Biol Chem. 268:1993;20268.
76. Hemmerich S., Pecht I. Oligomeric structure and autophosphorylation of nucleoside diphosphate kinase from rat mucosal mast cells. Biochemistry. 31:1992;4580.
77. Hiwasa T., Yokoyama S., Myung J., Noguchi S., Sakiyama S. c-Ha-ras gene products are potent inhibitors of cathepsins B and L. FEBS Lett. 211:1987;23.
78. Hiwasa T. Possible involvement of protease inhibitor ras proteins in malignant transformation. Biol Chem. 369:1988;239.
79. Hiwasa T., Sakiyama S., Noguchi S., Myung Ha J., Miyazawa T., Yokoyama S. Degradation of a cAMP-binding protein is inhibited by human c-Ha-ras gene products. Biochem Biophys Res Commun. 146:1987;731.
80. Hiwasa T., Fujita Y., Shirouzu M., Koide H., Sawada T., Sakiyama S., Yokoyama S. c-H-ras mutants with point mutations in Gln-Val-Val region have reduced inhibitory activity toward cathepsin B. Cancer Lett. 69:1993;161.
81. Hiwasa T., Kominami E. Physical association of ras and cathepsins B and L in the conditioned medium of v-Ha-ras transformed NIH3T3 cells. Biochem Biophys Res Commun. 216:1995;828.