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Volumn 3, Issue 5, 2005, Pages 821-829

Ranolazine: New approach for the treatment of stable angina pectoris

Author keywords

Angina pectoris; Coronary artery disease; Heart; Ischemia

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMLODIPINE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; LACTIC ACID; NITRIC ACID DERIVATIVE; PERHEXILINE; PROTON; RANOLAZINE; TRIMETAZIDINE;

EID: 26844553290     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.3.5.821     Document Type: Review
Times cited : (11)

References (57)
  • 1
    • 4644290060 scopus 로고    scopus 로고
    • Current and future treatment strategies for refractory angina
    • Yang EH, Barsness GW, Gersh BJ et al. Current and future treatment strategies for refractory angina. Mayo Clin. Proc. 79, 1284-1292 (2004).
    • (2004) Mayo Clin. Proc. , vol.79 , pp. 1284-1292
    • Yang, E.H.1    Barsness, G.W.2    Gersh, B.J.3
  • 2
    • 0028128613 scopus 로고
    • Effects of treatment on outcome in mildly symptomatic patients with ischaemia during daily life
    • The Atenolol Silent Ischaemia Study (ASIST)
    • Pepine CJ, Cohn PF, Deedwania PC et al. Effects of treatment on outcome in mildly symptomatic patients with ischaemia during daily life. The Atenolol Silent Ischaemia Study (ASIST). Circulation 90, 762-768 (1994).
    • (1994) Circulation , vol.90 , pp. 762-768
    • Pepine, C.J.1    Cohn, P.F.2    Deedwania, P.C.3
  • 3
    • 0031971168 scopus 로고    scopus 로고
    • Ranolazine: A novel metabolic modulator for the treatment of angina
    • McCormack JG, Stanley WC, Wolff AA. Ranolazine: a novel metabolic modulator for the treatment of angina. Gen. Pharmacol. 30, 639-645 (1998).
    • (1998) Gen. Pharmacol. , vol.30 , pp. 639-645
    • McCormack, J.G.1    Stanley, W.C.2    Wolff, A.A.3
  • 4
    • 0024972124 scopus 로고
    • Drug therapy. Combined β-adrenergic and calcium-entry blockade in angina pectoris
    • Packer M. Drug therapy. Combined β-adrenergic and calcium-entry blockade in angina pectoris. N. Engl. J. Med. 320, 709-718 (1989).
    • (1989) N. Engl. J. Med. , vol.320 , pp. 709-718
    • Packer, M.1
  • 5
    • 0025986895 scopus 로고
    • Efficacy of nifedipine and isosorbide mononitrate in combination with atenolol in stable angina
    • Akhras F, Jackson G. Efficacy of nifedipine and isosorbide mononitrate in combination with atenolol in stable angina. Lancet 338, 1036-1039 (1991).
    • (1991) Lancet , vol.338 , pp. 1036-1039
    • Akhras, F.1    Jackson, G.2
  • 6
    • 9244259094 scopus 로고    scopus 로고
    • Effects of atenolol, nifedipine SR and their combination on the exercise test and the total ischaemic burden in 608 patients with stable angina
    • The Total Ischaemic Burden European Trial (TIBET). The TIBET Study Group
    • Fox KM, Mulcahy D, Findlay I et al. The Total Ischaemic Burden European Trial (TIBET). Effects of atenolol, nifedipine SR and their combination on the exercise test and the total ischaemic burden in 608 patients with stable angina. The TIBET Study Group. Eur. Heart J. 17, 96-103 (1996).
    • (1996) Eur. Heart J. , vol.17 , pp. 96-103
    • Fox, K.M.1    Mulcahy, D.2    Findlay, I.3
  • 7
    • 0030046460 scopus 로고    scopus 로고
    • Combination therapy with metoprolol and nifedipine versus monotherapy in patients with stable angina pectoris
    • Results of the International Multicenter Angina Exercise (IMAGE) Study
    • Savonitto S, Ardissiono D, Egstrup K et al. Combination therapy with metoprolol and nifedipine versus monotherapy in patients with stable angina pectoris. Results of the International Multicenter Angina Exercise (IMAGE) Study. J. Am. Coll. Cardiol. 27, 311-316 (1996).
    • (1996) J. Am. Coll. Cardiol. , vol.27 , pp. 311-316
    • Savonitto, S.1    Ardissiono, D.2    Egstrup, K.3
  • 8
    • 0031036553 scopus 로고    scopus 로고
    • Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions
    • Stanley WC, Lopaschuk GD, Hall JL et al. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc. Res. 33, 243-257 (1997).
    • (1997) Cardiovasc. Res. , vol.33 , pp. 243-257
    • Stanley, W.C.1    Lopaschuk, G.D.2    Hall, J.L.3
  • 9
    • 4944244013 scopus 로고    scopus 로고
    • Myocardial energy metabolism during ischaemia and the mechanisms of metabolic therapies
    • Stanley WC. Myocardial energy metabolism during ischaemia and the mechanisms of metabolic therapies. J. Cardiovasc. Pharmacol. Ther. 9(Suppl. 1), S31-S45 (2004).
    • (2004) J. Cardiovasc. Pharmacol. Ther. , vol.9 , Issue.SUPPL. 1
    • Stanley, W.C.1
  • 10
    • 1342263839 scopus 로고    scopus 로고
    • Report from the 100th Cardiovascular and Renal Drugs Advisory Committee meeting: Us Food and Drug Administration: December 8-9, 2003 Gaithersburg, MD, USA
    • Fleming T, Nissen SE, Borer JS et al. Report from the 100th Cardiovascular and Renal Drugs Advisory Committee meeting: Us Food and Drug Administration: December 8-9, 2003 Gaithersburg, MD, USA. Circulation 109, e9004-e9005 (2004).
    • (2004) Circulation , vol.109
    • Fleming, T.1    Nissen, S.E.2    Borer, J.S.3
  • 11
    • 0037396373 scopus 로고    scopus 로고
    • Metabolic therapy in the treatment of ischaemic heart disease: The pharmacology of trimetazidine
    • Stanley WC, Marzilli M. Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. Fundam. Clin. Pharmacol. 17, 133-145 (2003).
    • (2003) Fundam. Clin. Pharmacol. , vol.17 , pp. 133-145
    • Stanley, W.C.1    Marzilli, M.2
  • 12
    • 18244401979 scopus 로고    scopus 로고
    • Combination treatment in stable effort angina using trimetazidine and metoprolol: Results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand
    • Szwed H, Sadowski Z, Elikowski W et al. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. Eur. Heart J. 22, 2267-2274 (2001).
    • (2001) Eur. Heart J. , vol.22 , pp. 2267-2274
    • Szwed, H.1    Sadowski, Z.2    Elikowski, W.3
  • 13
    • 0034678082 scopus 로고    scopus 로고
    • The anti-anginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • Kantor PF, Lucien A, Kozak R et al. The anti-anginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ. Res. 86, 580-588 (2000).
    • (2000) Circ. Res. , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3
  • 14
    • 0036278660 scopus 로고    scopus 로고
    • Metabolic approaches to the treatment of ischemic heart disease: The clinicians' perspective
    • Wolff AA, Rotmensch HH, Stanley WC et al. Metabolic approaches to the treatment of ischemic heart disease: the clinicians' perspective. Heart Fail Rev. 7, 187-203 (2002).
    • (2002) Heart Fail. Rev. , vol.7 , pp. 187-203
    • Wolff, A.A.1    Rotmensch, H.H.2    Stanley, W.C.3
  • 15
    • 0007619884 scopus 로고    scopus 로고
    • Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease
    • Killalea SM, Krum H. Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease. Am. J. Cardiovasc. Drugs. 1, 193-204 (2001).
    • (2001) Am. J. Cardiovasc. Drugs , vol.1 , pp. 193-204
    • Killalea, S.M.1    Krum, H.2
  • 16
    • 0030602865 scopus 로고    scopus 로고
    • Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone
    • Kennedy JA, Unger SA, Horowitz JD. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem. Pharmacol. 52, 273-280 (1996).
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 273-280
    • Kennedy, J.A.1    Unger, S.A.2    Horowitz, J.D.3
  • 17
    • 0025217267 scopus 로고
    • Ranolazine (RS-43285): A preliminary study of a new anti-anginal agent with selective effect on ischaemic myocardium
    • Jain D, Dasgupta P, Hughes LO et al. Ranolazine (RS-43285): a preliminary study of a new anti-anginal agent with selective effect on ischaemic myocardium. Eur. J. Clin. Pharmacol. 38, 111-114 (1990).
    • (1990) Eur. J. Clin. Pharmacol. , vol.38 , pp. 111-114
    • Jain, D.1    Dasgupta, P.2    Hughes, L.O.3
  • 18
    • 0026680239 scopus 로고
    • Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with β-blocker or diltiazem
    • Cocco G, Rousseau MF, Bouvy T et al. Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with β-blocker or diltiazem. J. Cardiavasc. Pharmacol. 20, 131-138 (1992).
    • (1992) J. Cardiavasc. Pharmacol. , vol.20 , pp. 131-138
    • Cocco, G.1    Rousseau, M.F.2    Bouvy, T.3
  • 19
    • 0028016058 scopus 로고
    • Double-blind efficacy and safety study of a novel anti-ischemic agent, ranolazine, versus placebo in patients with chronic stable angina pectoris
    • Ranolazine Study Group
    • Thadani U, Ezekowitz M, Fenney L et al. Double-blind efficacy and safety study of a novel anti-ischemic agent, ranolazine, versus placebo in patients with chronic stable angina pectoris. Ranolazine Study Group. Circulation 90, 726-734 (1994).
    • (1994) Circulation , vol.90 , pp. 726-734
    • Thadani, U.1    Ezekowitz, M.2    Fenney, L.3
  • 20
    • 12844280008 scopus 로고    scopus 로고
    • Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris
    • Rousseau MF, Pouleur H, Cocco G et al. Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris. Am. J. Cardiol. 95, 311-316 (2005).
    • (2005) Am. J. Cardiol. , vol.95 , pp. 311-316
    • Rousseau, M.F.1    Pouleur, H.2    Cocco, G.3
  • 21
    • 0032983310 scopus 로고    scopus 로고
    • A controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional anti-anginal agents
    • Ranolazine Study Group
    • Pepine CJ, Wolff AA. A controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional anti-anginal agents. Ranolazine Study Group. Am. J. Cardiol. 84, 46-50 (1999).
    • (1999) Am. J. Cardiol. , vol.84 , pp. 46-50
    • Pepine, C.J.1    Wolff, A.A.2
  • 22
    • 0348129532 scopus 로고    scopus 로고
    • Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial
    • Chaitman BR, Pepine CJ, Parker JO et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA 291, 309-316 (2004).
    • (2004) JAMA , vol.291 , pp. 309-316
    • Chaitman, B.R.1    Pepine, C.J.2    Parker, J.O.3
  • 23
    • 11144356285 scopus 로고    scopus 로고
    • Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina
    • Chaitman BR, Skettino SL, Parker JO et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol. 43, 1375-1382 (2004).
    • (2004) J. Am. Coll. Cardiol. , vol.43 , pp. 1375-1382
    • Chaitman, B.R.1    Skettino, S.L.2    Parker, J.O.3
  • 24
    • 0023865164 scopus 로고
    • The effects of the novel anti-anginal compound RS 43285 on myocardial conduction in the anaesthetized dog
    • Allely MC, Alps BJ. The effects of the novel anti-anginal compound RS 43285 on myocardial conduction in the anaesthetized dog. Br. J. Pharmacol. 93, 375-382 (1988).
    • (1988) Br. J. Pharmacol. , vol.93 , pp. 375-382
    • Allely, M.C.1    Alps, B.J.2
  • 25
    • 0024550477 scopus 로고
    • A comparison of the effects of a series of anti-anginal agents in a novel canine model of transient myocardial ischaemia
    • Allely MC, Alps BJ. A comparison of the effects of a series of anti-anginal agents in a novel canine model of transient myocardial ischaemia. Br. J. Pharmacol. 96, 977-985 (1989).
    • (1989) Br. J. Pharmacol. , vol.96 , pp. 977-985
    • Allely, M.C.1    Alps, B.J.2
  • 26
    • 0032997355 scopus 로고    scopus 로고
    • Anti-anginal effects of ranolazine in various experimental models of angina
    • Wang JX, Maruyama K, Murakami M et al. Anti-anginal effects of ranolazine in various experimental models of angina. Arzneimittelforschung 49, 193-199 (1999).
    • (1999) Arzneimittelforschung , vol.49 , pp. 193-199
    • Wang, J.X.1    Maruyama, K.2    Murakami, M.3
  • 27
    • 0027241659 scopus 로고
    • Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase
    • Clarke B, Spedding M, Patmore L et al. Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase. Br. J. Pharmacol. 109, 748-750 (1993).
    • (1993) Br. J. Pharmacol. , vol.109 , pp. 748-750
    • Clarke, B.1    Spedding, M.2    Patmore, L.3
  • 28
    • 0028030471 scopus 로고
    • Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart
    • Gralinski MR, Black SC, Kilgore KS et al. Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart. Cardiovasc. Res. 28, 1231-1237 (1994).
    • (1994) Cardiovasc. Res. , vol.28 , pp. 1231-1237
    • Gralinski, M.R.1    Black, S.C.2    Kilgore, K.S.3
  • 29
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • McCormack JG, Barr RL, Wolff AA et al. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 93, 135-142 (1996).
    • (1996) Circulation , vol.93 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3
  • 30
    • 0141723313 scopus 로고    scopus 로고
    • The anti-anginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • MacInnes A, Fairman DA, Binding P et al. The anti-anginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Cirr. Res. 93, e26-e32 (2003).
    • (2003) Cirr. Res. , vol.93
    • MacInnes, A.1    Fairman, D.A.2    Binding, P.3
  • 31
    • 0025134189 scopus 로고
    • Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion
    • Allely MC, Alps BJ. Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion. Br. J. Pharmacol. 99, 5-6 (1990).
    • (1990) Br. J. Pharmacol. , vol.99 , pp. 5-6
    • Allely, M.C.1    Alps, B.J.2
  • 32
    • 0035917675 scopus 로고    scopus 로고
    • Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat
    • Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur. J. Pharmacol. 418, 105-110 (2001).
    • (2001) Eur. J. Pharmacol. , vol.418 , pp. 105-110
    • Zacharowski, K.1    Blackburn, B.2    Thiemermann, C.3
  • 33
    • 0028657558 scopus 로고
    • Effect of ranolazine on infarct size in a canine model of regional myocardial ischaemia/reperfusion
    • Black SC, Gralinski MR, McCormack JG et al. Effect of ranolazine on infarct size in a canine model of regional myocardial ischaemia/reperfusion. J. Cardiovasc. Pharmacol. 24, 921-928 (1994).
    • (1994) J. Cardiovasc. Pharmacol. , vol.24 , pp. 921-928
    • Black, S.C.1    Gralinski, M.R.2    McCormack, J.G.3
  • 34
    • 0030879580 scopus 로고    scopus 로고
    • Effects of ranolazine on ischemic threshold, coronary sinus blood flow, and myocardial metabolism in coronary artery disease
    • Bagger JP, Botker HE, Thomassen A et al. Effects of ranolazine on ischemic threshold, coronary sinus blood flow, and myocardial metabolism in coronary artery disease. Cardiovasc. Drugs Ther. 11, 479-484 (1997).
    • (1997) Cardiovasc. Drugs Ther. , vol.11 , pp. 479-484
    • Bagger, J.P.1    Botker, H.E.2    Thomassen, A.3
  • 35
    • 0027232953 scopus 로고
    • Modulation of α-1-adrenoceptors in rat left ventricle by ischaemia and acyl carnitines: Protection by ranolazine
    • Allely MC, Brown CM, Kenny BA et al. Modulation of α-1-adrenoceptors in rat left ventricle by ischaemia and acyl carnitines: protection by ranolazine. J. Cardiovasc. Pharmacol. 21, 869-873 (1993).
    • (1993) J. Cardiovasc. Pharmacol. , vol.21 , pp. 869-873
    • Allely, M.C.1    Brown, C.M.2    Kenny, B.A.3
  • 36
    • 0029877510 scopus 로고    scopus 로고
    • Effects of ranolazine on L-type calcium channel currents in guinea-pig single ventricular myocytes
    • Allen TJ, Chapman RA. Effects of ranolazine on L-type calcium channel currents in guinea-pig single ventricular myocytes. Br. J. Pharmacol. 118, 249-254 (1996).
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 249-254
    • Allen, T.J.1    Chapman, R.A.2
  • 37
    • 0029746050 scopus 로고    scopus 로고
    • Effects of ranolazine on oxidative substrate preference in epitrochlearis muscle
    • McCormack JG, Baracos VE, Barr R et al. Effects of ranolazine on oxidative substrate preference in epitrochlearis muscle. J. Appl. Physiol, 81, 905-910 (1996).
    • (1996) J. Appl. Physiol. , vol.81 , pp. 905-910
    • McCormack, J.G.1    Baracos, V.E.2    Barr, R.3
  • 38
    • 0029996458 scopus 로고    scopus 로고
    • Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: Evidence for an indirect mechanism
    • Clarke B, Wyatt KM, McCormack JG. Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism. J. Mol. Cell Cardiol. 28, 341-350 (1996).
    • (1996) J. Mol. Cell Cardiol. , vol.28 , pp. 341-350
    • Clarke, B.1    Wyatt, K.M.2    McCormack, J.G.3
  • 39
    • 26844570106 scopus 로고    scopus 로고
    • Ranolzaine increases ATP synthesis in failing cardiomyocytes through timulation of mitochondrial respiratory activity
    • Todor A, Sharov V, Sabbah HN. Ranolzaine increases ATP synthesis in failing cardiomyocytes through timulation of mitochondrial respiratory activity. Eur. Heart J. 25, 197 (2004).
    • (2004) Eur. Heart J. , vol.25 , pp. 197
    • Todor, A.1    Sharov, V.2    Sabbah, H.N.3
  • 40
    • 0028841015 scopus 로고
    • The anti-anginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria
    • Wyatt KM, Skene C, Veitch K et al. The anti-anginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria. Biochem. Pharmacol. 50, 1599-1606 (1995).
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 1599-1606
    • Wyatt, K.M.1    Skene, C.2    Veitch, K.3
  • 41
    • 4944222848 scopus 로고    scopus 로고
    • Efficacy and safety of a metabolic modulator drug in chronic stable angina: Review of evidence from clinical trials
    • Chaitman BR. Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials. J. Cardiovasc. Pharmacol. Ther. 9(Suppl. 1), S47-S64 (2004).
    • (2004) J. Cardiovasc. Pharmacol. Ther. , vol.9 , Issue.SUPPL. 1
    • Chaitman, B.R.1
  • 42
    • 4344577023 scopus 로고    scopus 로고
    • Electrophysiological effects of ranolazine, a novel anti-anginal agent with anti-arrhythmic properties
    • Antzelevitch C, Belardinelli L, Zygmunt AC et al. Electrophysiological effects of ranolazine, a novel anti-anginal agent with anti-arrhythmic properties. Circulation 110, 904-910 (2004).
    • (2004) Circulation , vol.110 , pp. 904-910
    • Antzelevitch, C.1    Belardinelli, L.2    Zygmunt, A.C.3
  • 43
    • 4944257316 scopus 로고    scopus 로고
    • Electrophysiologic properties and anti-arrhythmic actions of a novel anti-anginal agent
    • Antzelevitch C, Belardinelli L, Wu L et al. Electrophysiologic properties and anti-arrhythmic actions of a novel anti-anginal agent. J. Cardiovasc. Pharmacol. Ther. 9(Suppl. 1), S65-S83 (2004).
    • (2004) J. Cardiovasc. Pharmacol. Ther. , vol.9 , Issue.SUPPL. 1
    • Antzelevitch, C.1    Belardinelli, L.2    Wu, L.3
  • 44
    • 4444302203 scopus 로고    scopus 로고
    • Ranolazine: Ion-channel-blocking actions and in vivo electrophysiological effects
    • Schram G, Zhang L, Derakhchan K et al. Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects. Br. J. Pharmacol. 142, 1300-1308 (2004).
    • (2004) Br. J. Pharmacol. , vol.142 , pp. 1300-1308
    • Schram, G.1    Zhang, L.2    Derakhchan, K.3
  • 45
    • 0035999736 scopus 로고    scopus 로고
    • Partial fatty acid oxidation inhibitors for stable angina
    • Stanley WC. Partial fatty acid oxidation inhibitors for stable angina. Expert Opin. Investig. Drugs 11, 615-629 (2002).
    • (2002) Expert Opin. Investig. Drugs , vol.11 , pp. 615-629
    • Stanley, W.C.1
  • 46
    • 0025726641 scopus 로고
    • Amiloride delays the ischaemia-induced rise in cytosolic free calcium
    • Murphy E, Perlman M, London RE et al. Amiloride delays the ischaemia-induced rise in cytosolic free calcium. Circ. Res. 68, 1250-1258 (1991).
    • (1991) Circ. Res. , vol.68 , pp. 1250-1258
    • Murphy, E.1    Perlman, M.2    London, R.E.3
  • 47
    • 0037138548 scopus 로고    scopus 로고
    • High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation
    • Liu Q, Docherty JC, Rendell JC et al. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J. Am. Coll. Cardiol. 39, 718-725 (2002).
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 718-725
    • Liu, Q.1    Docherty, J.C.2    Rendell, J.C.3
  • 48
    • 0029998606 scopus 로고    scopus 로고
    • Cardiac efficiency is improved after ischaemia by altering both the source and fate of protons
    • Liu B, Clanachan AS, Schulz R et al. Cardiac efficiency is improved after ischaemia by altering both the source and fate of protons. Circ. Res. 79, 940-948 (1996).
    • (1996) Circ. Res. , vol.79 , pp. 940-948
    • Liu, B.1    Clanachan, A.S.2    Schulz, R.3
  • 49
    • 0002761812 scopus 로고
    • Ranolazine: Anti-anginal therapy with a novel mechanism: Controlled comparison versus atenolol
    • Rousseau MF, Visser FG, Bax JJ et al. Ranolazine: anti-anginal therapy with a novel mechanism: controlled comparison versus atenolol. Eur. Heart J. 15, 95 (1994).
    • (1994) Eur. Heart J. , vol.15 , pp. 95
    • Rousseau, M.F.1    Visser, F.G.2    Bax, J.J.3
  • 50
    • 4944230867 scopus 로고    scopus 로고
    • Ranolazine decreases hemoglobin A1c (HbA1c) in angina patients with diabetes: Carbohydrate and lipid parameters in MARISA and CARISA
    • Chaitman B, Skettino S, Jerling M et al. Ranolazine decreases hemoglobin A1c (HbA1c) in angina patients with diabetes: carbohydrate and lipid parameters in MARISA and CARISA. Eur. Heart J. 24, 21 (2003).
    • (2003) Eur. Heart J. , vol.24 , pp. 21
    • Chaitman, B.1    Skettino, S.2    Jerling, M.3
  • 51
    • 0028284488 scopus 로고
    • Dose-response evaluation of once-daily therapy with a new formulation of diltiazem for stable angina pectoris
    • Diltiazem CD Study Group
    • Thadani U, Glasser S, Bittar N et al. Dose-response evaluation of once-daily therapy with a new formulation of diltiazem for stable angina pectoris. Diltiazem CD Study Group. Am. J. Cardiol. 74, 9-17 (1994).
    • (1994) Am. J. Cardiol. , vol.74 , pp. 9-17
    • Thadani, U.1    Glasser, S.2    Bittar, N.3
  • 52
    • 0025601869 scopus 로고
    • Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischaemia in patients with stable angina. Differential effects on ambulatory ischaemia, exercise performance, and anginal symptoms
    • The ASIS Study Group
    • Stone PH, Gibson RS, Glasser SP et al. Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischaemia in patients with stable angina. Differential effects on ambulatory ischaemia, exercise performance, and anginal symptoms. The ASIS Study Group. Circulation 82, 1962-1972 (1990).
    • (1990) Circulation , vol.82 , pp. 1962-1972
    • Stone, P.H.1    Gibson, R.S.2    Glasser, S.P.3
  • 53
    • 3342882854 scopus 로고    scopus 로고
    • Anti-arrhythmic effects of ranolazine in a guinea-pig in vitro model of long-QT syndrome
    • Wu L, Shryock JC, Song Y et al. Anti-arrhythmic effects of ranolazine in a guinea-pig in vitro model of long-QT syndrome. J. Pharmacol. Exp. Ther. 310, 599-605 (2004).
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 599-605
    • Wu, L.1    Shryock, J.C.2    Song, Y.3
  • 55
    • 0037163064 scopus 로고    scopus 로고
    • Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure
    • Chandler MP, Stanley WC, Morita H et al. Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. Circ. Res. 91, 278-280 (2002).
    • (2002) Circ. Res. , vol.91 , pp. 278-280
    • Chandler, M.P.1    Stanley, W.C.2    Morita, H.3
  • 56
    • 0036936426 scopus 로고    scopus 로고
    • Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure
    • Sabbah HN, Chandler MP, Mishima T et al. Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure. J. Card. Fail. 8, 416-422 (2002).
    • (2002) J. Card. Fail. , vol.8 , pp. 416-422
    • Sabbah, H.N.1    Chandler, M.P.2    Mishima, T.3
  • 57
    • 15844383954 scopus 로고    scopus 로고
    • Long-term therapy with ranolazine prevents progressive left ventricular dysfunction and remodeling in dogs with chronic heart failure
    • Sabbah HN, Imai M, Morita H et al. Long-term therapy with ranolazine prevents progressive left ventricular dysfunction and remodeling in dogs with chronic heart failure. Circulation 110 (2004).
    • (2004) Circulation , vol.110
    • Sabbah, H.N.1    Imai, M.2    Morita, H.3


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