Design and evaluation of 5′-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 387-392

  Parker, William B ^a   Allan, Paula W ^a   Ealick, Steve E ^b   Sorscher, Eric J ^c   Hassan, Abdalla E A ^a   Silamkoti, A V ^a   Fowler, Anita T ^a   Waud, William R ^a   Secrist III, John A ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b Cornell University ^*  (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE PHOSPHORYLASE; 9 (6 DEOXY ALPHA DEXTRO TALOFURANOSYL) 2 ADENINE; 9 (6 DEOXY ALPHA DEXTRO TALOFURANOSYL) 6 METHYLPURINE; ADENINE DERIVATIVE; BACTERIAL ENZYME; NUCLEOSIDE PHOSPHORYLASE; PHOSPHORYLASE; PRODRUG; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; ENZYME BINDING; ENZYME MODIFICATION; ESCHERICHIA COLI; GENE MUTATION; MAMMAL; NONHUMAN; NUCLEOTIDE METABOLISM; SUICIDE GENE THERAPY; WILD TYPE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESCHERICHIA COLI; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; MUTATION; NUCLEOSIDES; PRODRUGS; PURINE-NUCLEOSIDE PHOSPHORYLASE; SUBSTRATE SPECIFICITY; THIONUCLEOSIDES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 26644451885     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200059807     Document Type: Conference Paper

References (12)

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