Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 413, Issue 1, 1998, Pages 1-6

  Robbiano, Luigi ^a   Mereto, Eugenio ^a   Migliazzi Morando, Andrea ^a   Pastore, Patrizia ^a   Brambilla, Giovanni ^a  

^a Div Clin Pharmacol Toxicol   (Italy)

Author keywords

Chloroform; Enflurane; Halothane; Isoflurane; Micronucleus assay, in vivo; Rat kidney cell; Sevoflurane; Trichloroethylene

Indexed keywords

CHLOROFORM; ENFLURANE; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; SEVOFLURANE; TRICHLOROETHYLENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENOTOXICITY; GROWTH INHIBITION; MICRONUCLEUS; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANESTHETICS, INHALATION; ANIMALS; CHLOROFORM; HALOTHANE; ISOFLURANE; KIDNEY; MALE; METHYL ETHERS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENS; RATS; RATS, SPRAGUE-DAWLEY; TRICHLOROETHYLENE;

EID: 0032559676     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00187-3     Document Type: Article

References (14)

1. IARC, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Suppl. 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Vol. 1 to 42, IARC, Lyon, 1987, pp. 93-95.
2. IARC, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Suppl. 6, Genetics and Related Effects: An Updating of Selected IARC Monographs Vol. 1 to 42, IARC, Lyon, 1987, pp. 284-285, 325-327, 345-346.
3. Kenna J.G., Jones R.M. The organ toxicity of inhaled anesthetics. Anesth. Analg. 81:1995;S51-66.
4. Eyre R.J., Stevens D.K., Parker J.C., Bull R.J. Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidney of F344 rats and B6C3F1 mice. J. Toxicol. Environ. Health. 46:1995;465-481.
5. Bergman K. Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo. Arch. Toxicol. 54:1983;181-193.
6. Walles S.A.S. Induction of single-strand breaks in DNA of mice by trichloroethylene and tetrachloroethylene. Toxicol. Lett. 31:1986;31-35.
7. Robbiano L., Mereto E., Migliazzi-Morando A., Pastore P., Brambilla G. An in vivo micronucleus assay for detecting the clastogenic effect in rat kidney cells. Mutation Res. 390:1997;51-57.
8. NIOSH, Registry of Toxic Effects of Chemical Substances. U.S. Government Printing Office, Washington, DC, 1987.
9. IARC, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 63, Dry Cleaning, Some Chlorinated Solvents and other Industrial Chemicals, IARC, Lyon, 1995, pp. 75-158.
10. Fahrig R., Madle S., Baumann H. Genetic toxicology of trichloroethylene (TCE). Mutation Res. 340:1995;1-36.
11. Reitz M., Dasgupta K., Brandt L. Detection of DNA damage in stimulated human lymphocytes after enflurane exposure in vitro. Environ. Res. 59:1992;476-484.
12. Lamberti L., Bigatti P., Ardito G., Armellino F. Chromosome analysis in operating room personnel. Mutagenesis. 4:1989;95-97.
13. Sardas S., Cuhruk H., Karakaya A.E., Atakurt Y. Sister-chromatid exchanges in operating room personnel. Mutation Res. 279:1992;117-120.
14. Reitz M., Antonini-Rumpf E., Lanz E. DNA single strand breaks in peripheral human lymphocytes after anesthesia with isoflurane-nitrous oxide-oxygen. Arzneim. Forsch. Drug Res. 43:1993;1258-1261.