Effect of various concentrations of acyclovir on cell survival and micronuclei induction on cultured HeLa cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 446, Issue 2, 1999, Pages 155-165

  Jagetia, Ganesh Chandra ^a   Aruna, R ^a  

^a KASTURBA MEDICAL COLLEGE   (India)

Author keywords

Acyclovir; Cell proliferation index; Cell survival; Growth kinetics; HeLa cells; Micronuclei

Indexed keywords

ACICLOVIR;

ARTICLE; CELL CULTURE; CELL DIVISION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MICRONUCLEUS TEST; MULTINUCLEAR CELL; PRIORITY JOURNAL;

ACYCLOVIR; ANTIVIRAL AGENTS; CELL DIVISION; CELL NUCLEUS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MICRONUCLEUS TESTS; TUMOR STEM CELL ASSAY;

EID: 0032776240     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00159-X     Document Type: Article

References (27)

1. Schaeffer H.J., Beauchamp L., Demiranda P., Elion G.B., Bauer D.J., Collins P. 9-(2-Hydroxyethoxymethyl) guanine activity against viruses of the herpes group. Nature. 272:1978;583-585.
2. Elion B., Furaman P.A., Fyfe J.A., De Miranda P., Beauchamp L., Schaeffer H.J. Selectivity of action of an antiherpitic agent 9-(2-hydroxyethoxymethyl)guanine. Proc. Natl. Acad. Sci. U.S.A. 74:1977;5716-5720.
3. E. Walter, D.V.M. Tucker, Jr., Preclinical toxicology profile of acyclovir: an overview, Am. J. Medicine (1982) 27-30.
4. Clive D., Turner N.T., Hozier J., Batson A.G., Tucker W.E. Jr. Preclinical toxicology studies with acyclovir genetic toxicity tests. Fundam. Appl. Toxicol. 3:1983;587-602.
5. Clive D., Corey L., Reichman R.C., Davis L.G., Hozier J.C. A double-blind, placebo-controlled cytogenetic study of oral acyclovir in patients with recurrent genital herpes. J. Infect. Dis. 164:1991;753-757.
6. De-Clercq E., Cassiman J.J. Mutagenic potential of antiherpes agents. Life Sci. 38(3):1986;281-289.
7. Pratt R.M., Willis W.D. In vitro screening assay for teratogens using growth inhibition of human embryonic cells. Proc. Natl. Acad. Sci. U.S.A. 82:1985;5791-5794.
8. Puck T.T., Marcus P.I. A rapid method for viable cell titration and clone production with HeLa cells in tissue culture. The use of X-irradiated cells to supply conditioning factors. Proc. Natl. Acad. Sci. U.S.A. 41:1955;432-437.
9. Fenech M., Morley A.A. Measurement of micronuclei in lymphocytes. Mutat. Res. 147:1985;29-36.
10. Countryman P., Heddle J.A. The production of micronuclei from the chromosomal aberrations in irradiated cultures of human lymphocytes. Mutat. Res. 41:1976;321-332.
11. Levin M.J., Leary P.L., Arbeit R.D. Effect of acyclovir on the proliferation of human fibroblasts and peripheral blood mononuclear cells. Antimicrob. Agents Chemother. 17:1980;947-953.
12. Gotoh A., Ko S.C., Shirakawa T., Cheon J., Kao C., Miyamoto T., Gardner T.A., Ho L.J., Cleutjens C.B., Trapman J., Graham F.L., Chung L.W. Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer. J. Urol. 160(1):1998;220-229.
13. Thust R., Schacke M., Wutzler P. Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells: I. Purine nucleoside analogues. Antiviral Res. 31:1996;105-113.
14. McGuffin R.W., Shiota F.M., Meyers J.D. Lack of toxicity of acyclovir to granulocyte progenitor cells in vitro. Antimicrob. Agents Chemother. 18:1980;471-472.
15. Steele R.W., Marmer D.J., Keeney R.E. Comparative in vitro immunotoxicology of acyclovir and other antiviral agents. Infect. Immun. 28:1980;957-962.
16. Shobukhov V.M., Iurchenko V.V. Cytogenetic effects of 9-(2-hydroxyethoxymethyl) guanine. Bull. Eksp. Biol. Med. 105:1988;591-593.
17. Jagetia G.C., Vijayashree N. Micronuclei induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin. Cancer Lett. 110:1996;123-128.
18. Jagetia G.C., Nayak V., Vidyasagar M.S. Evaluation of the antineoplastic activity of Guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Lett. 127:1998;71-82.
19. Jagetia G.C., Adiga S.K. Influence of various concentration of taxol on cell survival, micronuclei induction and LDH activity in cultured V79 cells. Cancer Lett. 92:1995;195-200.
20. Jagetia G.C., Adiga S.K. Influence of vindesine exposure on the micronucleus formation and cell survival in V79 cells. Mutat. Res. 421:1998;55-63.
21. G.C. Jagetia, S.K. Adiga, Effect of various concentration of teniposide (VM-26) on the cell survival, micronuclei induction and LDH activity on V79 cells, Toxicology, in press (1999).
22. C. Streffer, D. van Beuningen, M. Molls, Possibilities of micronucleus test as an assay in radiotherapy, in: K.H. Kracher, H.D. Kogelink, G. Reinartz (Eds.), Progress in Radio Oncology, Vol. II, Reven Press, New York, pp. 243-251.
23. Geard C.R., Chen C.Y. Micronuclei and clonogenicity following low- and high-dose-rate gamma irradiation of normal human fibroblasts. Radiat. Res. 124:1990;S56-S61.
24. Mariya Y., Streffer C., Fuhrman C., Wojcik A. Correlation of radiation-induced micronucleus frequency with clonogenic survival in cells of one diploid and two tetraploid murine tumor cell lines of the same origin. Radiat. Res. 147:1997;29-34.
25. Bush C., McMillan T.J. Micronucleus formation in human tumor cells: lack of correlation with radiosensitivity. Br. J. Cancer. 67:1993;102-106.
26. McGuirt P.V., Furman P.A. Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus-infected cells. Am. J. Med. 73:1982;67-71. Suppl.
27. Furman P.A., St. Clair M.H., Spector T. Acyclovir triphosphate is a suicidal inactivator of the herpes simplex virus DNA polymerase. J. Biol. Chem. 259:1986;9575-9579.