Econazole induces increases in free intracellular Ca2+ concentrations in human osteosarcoma cells

Human and Experimental Toxicology

Volumn 24, Issue 9, 2005, Pages 453-458

  Chang, H T ^a   Liu, C S ^b   Chou, C T ^a   Hsieh, C H ^b   Chang, C H ^b   Chen, W C ^b   Liu, S I ^a   Hsu, S S ^a   Chen, J S ^a   Jiann, B P ^a   Huang, J K ^a   Jan, C R ^a  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b PINGTUNG CHRISTIAN HOSPITAL   (Taiwan)

Author keywords

Ca2+; Ca2+ stores; Econazole; Fura 2; Human MG63 osteosarcoma cells

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CALCIUM; ECONAZOLE; FURA 2; HISTAMINE; INOSITOL 1,4,5 TRISPHOSPHATE; NIMODIPINE; PHOSPHOLIPASE C; THAPSIGARGIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG TISSUE LEVEL; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; BONE NEOPLASMS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ECONAZOLE; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; HUMANS; NIMODIPINE; OSTEOSARCOMA; THAPSIGARGIN; TIME FACTORS;

EID: 26444620903     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327105ht558oa     Document Type: Article

References (29)

1. Soboloff J, Zhang Y, Minden M, Berger SA. Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purging. Exp Hematol 2002; 30: 1219-26.
2. Zhang Y, Berger SA. Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines. J Biol Chem 2004; 279: 6507-16.
3. Denys A, Aires V, Hichami A, Khan NA. Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activation: inhibitory action of docosahexaenoic acid. FEBS Lett 2004; 564: 177-82.
4. Gamberucci A, Fulceri R, Benedetti A, Bygrave FL. On the mechanism of action of econazole, the capacitative calcium inflow blocker. Biochem Biophys Res Commun 1998; 248: 75-77.
5. Putney JW Jr. A model for receptor-regulated calcium entry. Cell Calcium 1986; 7: 1-12.
6. Barksmann TL, Kristensen BI, Christophersen P, Bennekou P. Pharmacology of the human red cell voltage-dependent cation channel; Part I. Activation by clotrimazole and analogues. Blood Cells Mol Dis 2004; 32: 384-88.
7. Jan CR, Ho CM, Wu SN, Tseng CJ. Multiple effects of econazole on calcium signaling: depletion of thapsigargin-sensitive calcium store, activation of extracellular calcium influx, and inhibition of capacitative calcium entry. Biochim Biophys Acta 1999; 1448: 533-42.
8. Bennekou P, Barksmann TL, Jensen LR, Kristensen BI, Christophersen P. Voltage activation and hysteresis of the non-selective voltage-dependent channel in the intact human red cell. Bioelectrochemistry 2004; 62: 181-85.
9. Walsh LP, Kuratko CN, Stocco DM. Econazole and miconazole inhibit steroidogenesis and disrupt steroidogenic acute regulatory (StAR) protein expression post-transcriptionally. J Steroid Biochem Mol Biol 1998; 75: 229-36.
10. Helmeste DM, Tang SW, Vu R. Inhibition of platelet serotonin uptake by cytochrome P450 inhibitors miconazole and econazole. Life Sci 1998; 62: 2203-208.
11. 2+ responses and production of NO and PGI2 in vascular endothelial cells. Mol Cell Biochem 2003; 248: 129-34.
12. + current in mouse aortic endothelial cells. Eur J Physiol 2004; 447: 426-35.
13. 2+ entry in porcine aortic endothelial cells. Br J Pharmacol 1997; 121: 1579-88.
14. Berridge MJ. Inositol trisphosphate and calcium signaling. Nature 1993; 361: 315-25.
15. Berridge MJ. Elementary and global aspects of calcium signalling. J Physiol (Lond) 1993; 499: 291-306.
16. Bootman MD, Berridge MJ, Lipp P. Cooking with calcium: the recipes for composing global signals from elementary events. Cell 1993; 91: 367-73.
17. Annunziato L, Amoroso S, Pannaccione A, Cataldi M, Pignataro G, D'Alessio A, Sirabella R, Secondo A, Sibaud L, Di Renzo GF. Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. Toxicol Lett 2003; 139: 125-33.
18. Rezzonico R, Schmid-Alliana A, Romey G, Bourget-Ponzio I, Breuil V, Breittmayer V, Tartare-Deckert S, Rossi B, Schmid-Antomarchi H. Prostaglandin E2 induces interaction between hSlo potassium channel and Syk tyrosine kinase in osteosarcoma cells. J Bone Miner Res 2002; 17: 869-78.
19. Kuo SY, Jiann BP, Lu YC, Chang HT, Chen WC, Huang JK, Jan CR. Thiol oxidation by 2,2′-dithiodipyridine induced calcium mobilization in MG63 human osteosarcoma cells. Life Sci 2003; 72: 1733-43.
20. 2+ increase in human osteosarcoma cells. Pharmacology 2002; 66: 120-27.
21. 2+ movement in human osteosarcoma cells. Pharmacol Toxicol 2002; 91: 34-39.
22. 2+ entry in MG63 human osteosarcoma cells. Biochem Pharmacol 2001; 61: 1537-41.
23. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-50.
24. 2+-ATPase. Proc Natl Acad Sci USA 1990; 87: 2466-70.
25. Thompson AK, Mostafapour SP, Denlinger LC, Bleasdale JE, Fisher SK. The aminosteroid U73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. J Biol Chem 1991; 266: 23856-62.
26. 2+-activated non-selective cation channel mediating cell membrane depolarization. Cell 2002; 109: 397-407.
27. McFadzean I, Gibson A. The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. Br J Pharmacol 2002; 135: 1-13.
28. Bergh JJ, Xu Y, Farach-Carson MC. Osteoprotegerin expression and secretion are regulated by calcium influx through the L-type voltage-sensitive calcium channel. Endocrinology 2004; 145: 426-36.
29. Duncan RL, Akanbi KA, Farach-Carson MC. Calcium signals and calcium channels in osteoblastic cells. Semin Nephrol 1998; 18: 178-90.