Pharmacology of the human red cell voltage-dependent cation channel: Part I. Activation by clotrimazole and analogues

Blood Cells, Molecules, and Diseases

Volumn 32, Issue 3, 2004, Pages 384-388

  Barksmann, Trine L ^a   Kristensen, Berit I ^a   Christophersen, Palle ^b   Bennekou, Poul ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

G rdos channel blockers; Human red cells; Nonselective voltage dependent cation channel; NSVDC channel; NSVDC channel activators

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CATION CHANNEL; CETIEDIL; CLOTRIMAZOLE; ECONAZOLE; MICONAZOLE; NITRENDIPINE; RINGER SOLUTION;

ARTICLE; CELL ACTIVATION; CELL STIMULATION; CELL SUSPENSION; CHANNEL GATING; CONCENTRATION RESPONSE; CONDUCTANCE; DRUG MECHANISM; DRUG POTENCY; ERYTHROCYTE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MODULATION; NONSELECTIVE VOLTAGE DEPENDENT CATION CHANNEL; NORMAL HUMAN; PRIORITY JOURNAL;

AZEPINES; CLOTRIMAZOLE; ELECTROPHYSIOLOGY; ERYTHROCYTES; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KINETICS; NITRENDIPINE; POTASSIUM CHANNELS, CALCIUM-ACTIVATED;

MUS;

EID: 2342588821     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2004.01.011     Document Type: Article

References (19)

1. Dawson H. Studies on the permeability of erythrocytes. VI. The effect of reducing the salt concentration in the medium surrounding the cell. Biochem. J. 33:1939;389-401
2. Wilbrandt W., Schatzmann H.J. Wolstenholme G.E.W., O'Connor C.M. Changes in the passive cation permeability of erythrocytes in low electrolyte media. Ciba Foundation Study Group. vol. 5:1960;34-53 J. & A. Churchill, London
3. LaCelle P.L., Rothstein A. The passive permeability of the red blood cell to cations. J. Gen. Physiol. 50:1966;171-189
4. Halperin J.A., Brugnara C., Tosteson M.T., Van Ha T., Tosteson D.C. Voltage-activated cation transport in human erythrocytes. Am. J. Physiol. 257:1989;C986-C996
5. Christophersen P., Bennekou P. Evidence for a voltage-gated, non-selective cation channel in the human red cell membrane. Biochim. Biophys. Acta. 1065:1991;103-106
6. Kaestner L., Christophersen P., Bernhardt I., Bennekou P. The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterization. Bioelectrochemistry. 52:2001;117-125
7. Ishii T.M., Silvia C., Hirschberg B., Bond C.T., Adelman J.P., Maylie J. A human intermediate conductance calcium-activated potassium channel. Proc. Natl. Acad. Sci. 94:1998;11651-11655
8. + channel. Am. J. Physiol. 275:1998;C848-C856
9. +-channel (Gárdos channel) in human red blood cells. Proc. Natl. Acad. Sci. 100:2003;7366-7371
10. 2+-pump. J. Membr. Biol. 195:2003;1-8
11. Berkowitz L.R., Orringer P. Effect of cetiedil, an in vitro anti-sickling agent, on erythrocyte membrane cation permeability. J. Clin. Invest. 68:1981;1215-1220
12. Ellory J.C., Culliford S.J., Smith P.A., Wolowyk M.W., Knaus E.E. Specific inhibition of Ca-activated K channels in red cells by selected dihydropyridine derivatives. Br. J. Pharmacol. 111:1994;903-905
13. + channels by cytochrome P-450 inhibitors. J. Biol. Chem. 267:1992;11789-11793
14. P. Christophersen, O. Pedersen, Eur. 1977. W097/45400.
15. Macey R.I., Adorante J.S., Orme F.W. Erythrocyte membrane potentials determined by hydrogen ion distribution. Biochim. Biophys. Acta. 512:1978;284-295
16. Bennekou P., Christophersen P. A human red cell cation channel showing hysteresis like voltage activation/inactivation. Acta Physiol. Scand. 146:1992;608
17. Bennekou P., Barksmann T.L., Jensen L.R., Kristensen B.I., Christophersen P. Voltage activation and hysteresis of the non-selective voltage-dependent channel in the intact human red cell. Bioelectrochemistry. 2003;. (in Press)
18. Bennekou P., Christophersen P. Multiple conductances of a cation selective channel from human red cells. Acta Physiol. Scand. 143:1991;P22
19. 2+-activated cation channel TRPM4. J. Biol. Chem. 278:2003;30813-30820