Advanced glycation end-product-induced mitogenesis and collagen production are dependent on angiotensin II and connective tissue growth factor in NRK-49F cells

Journal of Cellular Biochemistry

Volumn 95, Issue 2, 2005, Pages 281-292

  Lee, Chu I ^a   Guh, Jinn Yuh ^b   Chen, Hung Chun ^b   Hung, Wen Chun ^b   Yang, Yu Lin ^c   Chuang, Lea Yea ^b  

^a FOOYIN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

Author keywords

Advanced glycation end product; Angiotensin; Collagen; Connective tissue growth factor; Mitogenesis

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANGIOTENSIN; ANGIOTENSIN RECEPTOR ANTAGONIST; CAPTOPRIL; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; JANUS KINASE 2; JANUS KINASE INHIBITOR; LOSARTAN; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; OLIGODEOXYNUCLEOTIDE;

ANIMAL CELL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FIBROBLAST; GENE EXPRESSION; GLOMERULOPATHY; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; KIDNEY TUBULE; MITOGENESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANGIOTENSIN II; ANGIOTENSINOGEN; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; COLLAGEN; DNA PRIMERS; GLYCOSYLATION END PRODUCTS, ADVANCED; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOSIS; OLIGONUCLEOTIDES; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 26444547680     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20380     Document Type: Article

References (51)

1. Blom IE, Goldschmeding R, Leask A. 2002. Gene regulation of connective tissue growth factor: New targets for anti-fibrotic therapy? Matrix Biol 21:473-482.
2. Bluher M, Kratzsch J, Paschke R. 2001. Plasma levels of tumor necrosis factor-alpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance. Diabetes Care 24:328-334.
3. Brigstock DR. 1999. The connective tissue growth factor/ cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 20:189-206.
4. Brizzi MF, Dentelli P, Rosso A, Calvi C, Gambino R, Cassader M, Salvidio G, Deferrari G, Camussi G, Pegoraro L, Pagano G, Cavallo-Perin P. 2004. RAGE-and TGF-beta receptor-mediated signals converge on STAT5 and p21waf to control cell-cycle progression of mesangial cells: A possible role in the development and progression of diabetic nephropathy. Faseb J 18:1249-1251.
5. Carey RM, Siragy HM. 2003. The intrarenal renin-angiotensin system and diabetic nephropathy. Trends Endocrinol Metab 14:274-281.
6. Chuang LY, Guh JY. 2001. Extracellular signals and intracellular pathways in diabetic nephropathy. Nephrology 6:165-172.
7. Cooper ME. 2001. Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 44:1957-1972.
8. Correia ML, Haynes WG. 2004. Leptin, obesity and cardiovascular disease. Curr Opin Nephrol Hypertens 13:215-223.
9. Derynck R, Zhang YE. 2003. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577-584.
10. Finckenberg P, Inkinen K, Ahonen J, Merasto S, Louhelainen M, Vapaatalo H, Muller D, Ganten D, Luft F, Mervaala E. 2003. Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways. Am J Pathol 163:355-366.
11. Forbes JM, Cooper ME, Oldfield MD, Thomas MC. 2003a. Role of advanced glycation end products in diabetic nephropathy. J Am Soc Nephrol 14:8254-8258.
12. Forbes JM, Thallas V, Thomas MC, Founds HW, Burns WC, Jerums G, Cooper ME. 2003b. The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. FASEB J 17:1762-1764.
13. Frazier K, Williams S, Kothapalli D, Klapper H, Grotendorst GR. 1996. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 107:404-411.
14. Grotendorst GR, Rahmanie H, Duncan MR. 2004. Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation. FASEB J 18: 469-479.
15. Guh JY, Yang ML, Yang YL, Chang CC, Chuang LY. 1996. Captopril reverses high-glucose-induced growth effects on LLC-PK1 cells partly by decreasing transforming growth factor-beta receptor protein expressions. J Am Soc Nephrol 7:1207-1215.
16. Guh JY, Huang JS, Chen HC, Hung WC, Lai YH, Chuang LY. 2001. Advanced glycation end product-induced proliferation in NRK-49F cells is dependent on the JAK2/STAT5 pathway and cyclin D1. Am J Kidney Dis 38:1096-1104.
17. Guo Y, Mascareno E, Siddiqui MA. 2004. Distinct components of Janus kinase/signal transducer and activator of transcription signaling pathway mediate the regulation of systemic and tissue localized renin-angiotensin system. Mol Endocrinol 18:1033-1041.
18. Heald AF, Ita CE, Singhvi SM, Migdalof BH. 1985. Tissue distribution of 14C- and 35S-captopril in rats after intravenous and oral administration. Xenobiotica 15:51-56.
19. Huang JS, Guh JY, Hung WC, Yang ML, Lai YH, Chen HC, Chuang LY. 1999. Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells. Biochem J 342(Pt 1): 231-238.
20. Huang JS, Guh JY, Chen HC, Hung WC, Lai YH, Chuang LY. 2001. Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells. J Cell Biochem 81:102-113.
21. Iwanciw D, Rehm M, Porst M, Goppelt-Struebe M. 2003. Induction of connective tissue growth factor by angiotensin II: Integration of signaling pathways. Arterioscler Thromb Vasc Biol 23:1782-1787.
22. Jerums G, Panagiotopoulos S, Forbes J, Osicka T, Cooper M. 2003. Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease. Arch Biochem Biophys 419:55-62.
23. Kondo Y, Nakanishi T, Takigawa M, Ogawa N. 1999. Immunohistochemical localization of connective tissue growth factor in the rat central nervous system. Brain Res 834:146-151.
24. Leask A, Abraham DJ. 2004. TGF-beta signaling and the fibrotic response. FASEB J 18:816-827.
25. Leask A, Holmes A, Black CM, Abraham DJ. 2003. Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem 278:13008-13015.
26. Lee C-I, Guh J-Y, Chen H-C, Lin K-H, Yang Y-L, Hung W-C, Lai Y-H, Chuang L-Y. 2004. Leptin and connective tissue growth factor in advanced glycation end-product-induced effects in NRK-49F cells. J Cell Biochem 93:940-950.
27. Li JH, Huang XR, Zhu HJ, Oldfield M, Cooper M, Truong LD, Johnson RJ, Lan HY. 2004. Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: Implications for diabetic renal and vascular disease. FASEB J 18:176-178.
28. Lijnen PJ, Petrov W, Fagard RH. 2004. Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases. J Hypertens 22:209-216.
29. Luo C, Laaja P. 2004. Inhibitors of JAKs/STATs and the kinases: A possible new cluster of drugs. Drug Discov Today 9:268-275.
30. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE. 1995. Direct stimulation of Jak/STAT pathway by the angiotensin II ATI receptor. Nature 375:247-250.
31. Mezzano S, Droguett A, Burgos ME, Ardiles LG, Flores CA, Aros CA, Caorsi I, Vio CP, Ruiz-Ortega M, Egido J. 2003. Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney Int Suppl 64:64-70.
32. Min LJ, Cui TX, Yahata Y, Yamasaki K, Shiuchi T, Liu HW, Chen R, Li JM, Okumura M, Jinno T, Wu L, Iwai M, Nahmias C, Hashimoto K, Horiuchi M. 2004. Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes. Endocrinology 145: 253-260.
33. Moritani NH, Kubota S, Eguchi T, Fukunaga T, Yamashiro T, Takano-Yamamoto T, Tahara H, Ohyama K, Sugahara T, Takigawa M. 2003. Interaction of AP-1 and the ctgf gene: A possible driver of chondrocyte hypertrophy in growth cartilage. J Bone Miner Metab 21:205-210.
34. Okada H, Inoue T, Kanno Y, Kobayashi T, Watanabe Y, Kopp JB, Carey RM, Suzuki H. 2002. Interstitial fibroblast-like cells express renin-angiotensin system components in a fibrosing murine kidney. Am J Pathol 160:765-772.
35. Philippoussis F, Gagne D, Hugo P, Gosselin D. 2004. Concentrations of alpha-fetoprotein, insulin-like growth factor binding protein-3, c-erbB-2, and epidermal growth factor in serum of patients with endometriosis. J Soc Gynecol Investig 11:175-181.
36. Riser BL, Cortes P. 2001. Connective tissue growth factor and its regulation: A new element in diabetic glomerulosclerosis. Ren Fail 23:459-470.
37. Riser BL, Cortes P, DeNichilo M, Deshmukh PV, Chahal PS, Mohammed AK, Yee J, Kahkonen D. 2003. Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: Preliminary report. Kidney Int 64:451-458.
38. Ruiz-Ortega M, Egido J. 1997. Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts. Kidney Int 52: 1497-1510.
39. Schuttert JB, Liu MH, Gliem N, Fiedler GM, Zopf S, Mayer C, Muller GA, Grunewald RW. 2003. Human renal fibroblasts derived from normal and fibrotic kidneys show differences in increase of extracellular matrix synthesis and cell proliferation upon angiotensin II exposure. Pflugers Arch 446:387-393.
40. Sweeney G. 2002. Leptin signalling. Cell Signal 14:655-663.
41. Tikellis C, Cooper ME, Twigg SM, Burns WC, Tolcos M. 2004. Connective tissue growth factor is up-regulated in the diabetic retina: Amelioration by angiotensin-converting enzyme inhibition. Endocrinology 145:860-866.
42. Twigg SM, Chen MM, Joly AH, Chakrapani SD, Tsubaki J, Kim HS, OhY, Rosenfeld RG. 2001. Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: A potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinology 142:1760-1769.
43. Twigg SM, Cao Z, MCLennan SV, Burns WC, Brammar G, Forbes JM, Cooper ME. 2002. Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology 143:4907-4915.
44. Wada J, Makino H, Kanwar YS. 2002. Gene expression and identification of gene therapy targets in diabetic nephropathy. Kidney Int Suppl 61(Suppl 1):73-78.
45. Wahab NA, Yevdokimova N, Weston BS, Roberts T, Li XJ, Brinkman H, Mason RM. 2001. Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem J 359:77-87.
46. Wang S, DeNichilo M, Brubaker C, Hirschberg R. 2001. Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy. Kidney Int 60:96-105.
47. Wilkinson-Berka JL, Kelly DJ, Koerner SM, Jaworski K, Davis B, Thallas V, Cooper ME. 2002. ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. Diabetes 51:3283-3289.
48. Wolf G, Hamann A, Han DC, Helmchen U, Thaiss F, Ziyadeh FN, Stahl RA. 1999. Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells: Potential role in glomerulosclerosis (see comments). Kidney Int 56:860-872.
49. Yang ML, Guh JY, Yang YL, Chang CC, Chuang LY. 1997. Captopril reverses high glucose-induced effects on LLC-PK1 cells partly by enhancing facultative glucose transporter messenger RNA expressions. Biochem Mol Biol Int 41:511-519.
50. Yokoi H, Mukoyama M, Nagae T, Mori K, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Nishida T, Takigawa M, Sugawara A, Nakao K. 2004. Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis. J Am Soc Nephrol 15:1430-1440.
51. Ziyadeh FN. 2004. Mediators of diabetic renal disease: The case for tgf-Beta as the major mediator. J Am Soc Nephrol 15(Suppl 1):S55-S57.