Characterization of in vivo acquired resistance of Mycoplasma hyopneumoniae to macrolides and lincosamides

Microbial Drug Resistance

Volumn 11, Issue 3, 2005, Pages 290-294

  Stakenborg, Tim ^a   Vicca, Jo ^b   Butaye, Patrick ^a   Maes, Dominiek ^a   Minion, F Chris ^c   Peeters, Johan ^a   De Kruif, Aart ^b   Haesebrouck, Freddy ^b  

^a VETERINARY AND AGROCHEMICAL RESEARCH CENTRE   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; CLARITHROMYCIN; CLINDAMYCIN; ERYTHROMYCIN; LINCOMYCIN; LINCOSAMIDE; MACROLIDE; RIBOSOME DNA; RNA 23S; RNA BINDING PROTEIN; TYLOSIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; DNA SEQUENCE; ESCHERICHIA COLI; GENE MUTATION; GENOTYPE; MINIMUM INHIBITORY CONCENTRATION; MYCOPLASMA HYOPNEUMONIAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STRAIN DIFFERENCE;

DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENES, RRNA; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MYCOPLASMA HYOPNEUMONIAE; RNA, RIBOSOMAL, 23S;

MYCOPLASMA; MYCOPLASMA HYOPNEUMONIAE; MYCOPLASMATALES; SUIDAE; SUS SCROFA;

EID: 26444537517     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.2005.11.290     Document Type: Article

References (37)

1. Aarestrup, F.M., and B. Carstensen. 1998. Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant enterococci and staphylococci in pigs. Microb. Drug Resist. 4:307-312.
2. Aarestrup, P.M., and N.F. Friis. 1998. Antimicrobial susceptibility testing of Mycoplasma hyosynoviae isolated from pigs during 1968 to 1971 and during 1995 and 1996. Vet. Microbiol. 61:33-39.
3. Artiushin, S., and F.C. Minion. 1996. Arbitrarily primed PCR analysis of Mycoplasma hyopneumoniae field isolates demonstrates genetic heterogeneity. Int. J. Syst. Bacteriol. 46:324-328.
4. Berisio, R., J. Harms, F. Schluenzen, R. Zarivach, H.A. Hansen, P. Fucini, and A. Yonath. 2003. Structural insight into the antibiotic action of telithromycin against resistant mutants. J. Bacteriol. 185:4276-4279.
5. Butaye, P., L.A. Devriese, and F. Haesebrouck. 2001. Differences in antibiotic resistance patterns of Enterococcus faecalis and Enterococcus faecium strains isolated from farm and pet animals. Antimicrob. Agents Chemother. 45:1374-1378.
6. Canu, A., B. Malbruny, M. Coquemont, T.A. Davies, P.C. Appelbaum, and R. Leclercq. 2002. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumonias. Antimicrob. Agents Chemother. 46:125-131.
7. Edelstein, P.H. 2004. Pneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes. Clin. Infect. Dis. (Suppl). 38:S322-S327.
8. Farrell, D.J., I. Morrissey, S. Bakker, S. Buckridge, and D. Felmingham. 2004. In vitro activities of telithromycin, linezolid, and quinupristin- dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations. Antimicrob. Agents Chemother. 48:3169-3171.
9. Franceschi, F., Z. Kanyo, E.C. Sherer, and J. Sutcliffe. 2004. Macrolide resistance from the ribosome perspective. Curr. Drug Targets Infect. Disord. 4:177-91.
10. Friis, N.F. 1975. Some recommendations concerning primary isolation of Mycoplasma suipneumoniae and Mycoplasma flocculare a survey. Nord. Vet. Med. 27: 337-339.
11. Furneri, P.M., G. Rappazzo, M.P. Musumarra, P. Di Pietro, L.S. Catania, and L.S. Roccasalva. 2001. Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis. Antimicrob. Agents Chemother. 45:2958-2960.
12. Furneri, P.M., G. Rappazzo, M.P. Musumarra, G. Tempera, and L.S. Roccasalva. 2000. Genetic basis of natural resistance to erythromycin in Mycoplasma hominis. J. Antimicrob. Chemother. 45:547-548.
13. Gabashvili, I. S., S.T. Gregory, M. Valle, R. Grassucci, M. Worbs, M.C. Wahl, A.E. Dahlberg, and J. Frank. 2001. The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22. Mol. Cell. 8:181-188.
14. Garza-Ramos, G., L. Xiong, P. Zhong, and A. Mankin. 2001. Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA. J. Bacteriol. 183:6898-6907.
15. Hannan, P.C., U.M. Windsor, and P.M. Ripley. 1997. In vitro susceptibilities of recent field isolates of Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae to valnemulin (Econor), tiamulin and enrofloxacin and the in vitro development of resistance to certain antimicrobial agents in Mycoplasma hyopneumoniae. Res. Vet. Sci. 63:157-160.
16. Hansen, J.L., J.A. Ippolito, N. Ban, P. Nissen, P.B. Moore, and T.A. Steitz. 2002. The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol. Cell. 10:117-128.
17. Hansen, L.H., P. Mauvais, and S. Douthwaite. 1999. The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA. Mol. Microbiol. 31:623-631.
18. Inamoto, T., H. Takahashi, K. Yamamoto, Y. Nakai, and K. Ogimoto. 1994. Antibiotic susceptibility of Mycoplasma hyopneumoniae isolated from swine. J. Vet. Med. Sci. 56:393-394.
19. Jones, RN., D.J. Farrell, and I. Morrissey. 2003. Quinupristindalfopristin resistance in Streptococcus pneumoniae: novel L22 ribosomal protein mutation in two clinical isolates from the SENTRY antimicrobial surveillance program. Antimicrob. Agents Chemother. 47:2696-2698.
20. Ludwig, W., G. Kirchhof, N. Klgubauer, M. Weizenegger, D. Betzl, M. Ehrmann, C. Hertel, S. Jilg, R. Tatzel, H. Zitzelsberger, S. Liebl, M. Hochberger, J. Shah, D. Lane, P.R. Wallnöfer, and K.H. Scheifer. 1992. Complete 23S ribosomal RNA sequences of Gram-positve bacteria with a low DNA G+C content. System. Appl. Microbiol. 15:487-501.
21. Minion, F.C., E.J. Lefkowitz, M.L. Madsen, B.J. Cleary, S.M. Swartzell, and G.G. Mahairas. 2004. The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis. J. Bacteriol. 186:7123-7133.
22. NCCLS. 1999. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria from animals. Approved standard M31-A. National Committee for Clinical Laboratory Standards, Pennsylvania, Wayne, PA, pp. 1-64.
23. O'Connor, M., S.T. Gregory, and A.E. Dahlberg. 2004. Multiple defects in translation associated with altered ribosomal protein L4. Nucleic Acids Res. 32:5750-5756.
24. Okazaki, N., M. Narita, S. Yamada, K. Izumikawa, M. Umetsu, T. Kenri, Y. Sasaki, Y. Arakawa, and T. Sasaki. 2001. Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol. Immunol. 45:617-620.
25. Pereyre, S., P. Gonzalez, B. De Barbeyrac, A. Darnige, H. Renaudin, A. Charron, S. Raherison, C. Bebear, and C.M. Bebear. 2002. Mutations in 23S rRNA account for intrinsic resistance to macrolides in Mycoplasma hominis and Mycoplasma fermentons and for acquired resistance to macrolides in M. hominis. Antimicrob. Agents Chemother. 46:3142-3150.
26. Pereyre, S., C. Guyot, H. Renaudin, A. Charron, C. Bebear, and C.M. Bebear. 2004. In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae. Antimicrob. Agents Chemother. 48:460-465.
27. Pihlajamaki, M., J. Kataja, H. Seppala, J. Elliot, M. Leinonen, P. Huovinen, and J. Jalava. 2002. Ribosomal mutations in Streptococcus pneumoniae clinical isolates. Antimicrob. Agents Chemother. 46:654-658.
28. Retsema, J., and W. Fu. 2001. Macrolides: structures and microbial targets. Int. J. Antimicrob. Agents(Suppl).18:S3-S10.
29. Schlünzen, F., J.M. Harms, F. Franceschi, H.A. Hansen, H. Bartels, R. Zarivach, and A. Yonath. 2003. Structural basis for the antibiotic activity of ketolides and azalides. Structure (Camb). 11:329-338.
30. Stemke, G.W., Y. Huang, F. Laigret, and J.M. Bove. 1994. Cloning the ribosomal RNA operons of Mycoplasma flocculare and comparison with those of Mycoplasma hyopneumoniae. Microbiology. 140:857-860.
31. Tait-Kamradt, A., T. Davies, M. Cronan, M.R. Jacobs, P.C. Appelbaum, and J. Sutcliffe. 2000. Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage. Antimicrob. Agents Chemother. 44:2118-2125.
32. Tanner, A.C., B.Z. Erickson, and R.F. Ross. 1993. Adaptation of the Sensititre broth microdilution technique to antimicrobial susceptibility testing of Mycoplasma hyopneumoniae. Vet. Microbiol. 36:301-306.
33. Tenson, T., M. Lovmar, and M. Ehrenberg. 2003. The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J. Mol. Biol. 330:1005-1014.
34. Ter Laak, E.A., A. Pijpers, J.H. Noordergraaf, E.G. Schoevers, and J.H. Verheijden. 1991. Comparison of methods for in vitro testing of susceptibility of porcine Mycoplasma species to antimicrobial agents. Antimicrob. Agents Chemother. 35:228-233.
35. Thomas, A., C. Nicolas, I. Dizier, J. Mainil, and A. Linden. 2003. Antibiotic susceptibilities of recent isolates of Mycoplasma bovis in Belgium. Vet. Rec. 153:428-431.
36. Vester, B., and S. Douthwaite. 2001. Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob. Agents Chemother. 45:1-12.
37. Vicca, J., T. Stakenborg, D. Maes, P. Butaye, J. Peeters, A. de Kruif, and F. Haesebrouck. 2004. In vitro susceptibilities of Mycoplasma hyopneumoniae field isolates. Antimicrob. Agents Chemother. 48:4470-4472.