TGF-β signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions

International Immunology

Volumn 17, Issue 5, 2005, Pages 531-538

  Mehal, Wajahat Z ^a   Sheikh, Shehzad Z ^a   Gorelik, Leonid ^b   Flavell, Richard A ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BIOGEN   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Antigen peptides epitopes; Cellular activation; Rodent; T lymphocytes

Indexed keywords

CD69 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ADOPTIVE TRANSFER; AGE DISTRIBUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; IMMUNOREGULATION; IN VIVO STUDY; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TISSUE INJURY; TRANSGENIC MOUSE;

EID: 26444531712     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh233     Document Type: Article

References (35)

1. Letterio, J. J. and Roberts, A. B. 1998. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16:137.
2. Shull, M. M., Ormsby, I., Kier, A. B. et al. 1992. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359:693.
3. Kulkarni, A. B., Huh, C. G., Becker, D. et al. 1993. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl Acad. Sci. USA 90:770.
4. Gorelik, L. and Flavell, R. A. 2000. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12:171.
5. Lucas, P. J., Kim, S. J., Melby, S. J. and Gress, R. E. 2000. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J. Exp. Med. 191:1187.
6. Kobayashi, S., Yoshida, K., Ward, J. M. et al. 1999. Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J. Immunol. 163:4013.
7. Wu, H. Y. and Weiner, H. L. 2003. Oral tolerance. Immunol. Res. 28:265.
8. Sun, J., Dirden-Kramer, B., Ito, K., Ernst, P. B. and Van Houten, N. 1999. Antigen-specific T cell activation and proliferation during oral tolerance induction. J. Immunol. 162:5868.
9. Crispe, I. N., Dao, T., Klugewitz, K., Mehal, W. Z. and Metz, D. P. 2000. The liver as a site of T cell apoptosis: Graveyard, or killing field? Immunol. Rev. 174:47.
10. Grasl-Kraupp, B., Rossmanith, W., Ruttkay-Nedecky, B. et al. 1998. Levels of transforming growth factor beta and transforming growth factor beta receptors in rat liver during growth, regression by apoptosis and neoplasia. Hepatology 28:717.
11. Sloan-Lancaster, J. and Allen, P. M. 1996. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
12. Basu, D., Williams, C. B. and Allen, P. M. 1998. In vivo antagonism of a T cell response by an endogenously expressed ligand. Proc. Natl Acad. Sci. USA 95:14332.
13. Rosette, C., Werlen, G., Daniels, M. A. et al. 2001. The impact of duration versus extent of TCR occupancy on T cell activation: A revision of the kinetic proofreading model. Immunity 15:59.
14. Mehal, W. Z., Azzaroli, F. and Crispe, I. N. 2001. Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J. Immunol. 167:667.
15. Bommireddy, R., Saxena, V., Ormsby, I. et al. 2003. TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. J. Immunol. 170:4612.
16. Rogers, P. R., Grey, H. M. and Croft, M. 1998. Modulation of naive CD4 T cell activation with altered peptide ligands: The nature of the peptide and presentation in the context of costimulation are critical for a sustained response. J. Immunol. 160:3698.
17. Varedi, M., Jeschke, M. G., Englander, E. W., Herndon, D. N. and Barrow, R. E. 2001. Serum TGF-beta in thermally injured rats. Shock 16:380.
18. Blanas, E., Davey, G. M., Carbone, F. R. and Heath, W. R. 2000. A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells. J. Immunol. 164:2890.
19. Dubois, B., Chapat, L., Goubier, A., Papiernik, M., Nicolas, J. F. and Kaiserlian, D. 2003. Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood 102:3295.
20. Limmer, A., Ohl, J., Kurts, C. et al. 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat. Med. 6:1348.
21. Kojima, S., Hayashi, S., Shimokado, K. et al. 2000. Transcriptional activation of urokinase by the Kruppel-like factor Zf9/ COPEB activates latent TGF-beta1 in vascular endothelial cells. Blood 95:1309.
22. Roth, S., Gong, W. and Gressner, A. M. 1998. Expression of different isoforms of TGF-beta and the latent TGF-beta binding protein (LTBP) by rat Kupffer cells. J. Hepatol. 29: 915.
23. Nishikawa, Y., Wang, M. and Carr, B. I. 1998. Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: Increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. J. Cell. Physiol. 176:612.
24. Takeda, S., Rodewald, H. R., Arakawa, H., Bluethmann, H. and Shimizu, T. 1996. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity 5:217.
25. Tanchot, C., Lemonnier, F. A., Perarnau, B., Freitas, A. A. and Rocha, B. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276: 2057.
26. Billiau, A. and Matthys, P. 2001. Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J. Leukoc. Biol. 70:849.
27. Kleinau, S., Dencker, L. and Klareskog, L. 1995. Oil-induced arthritis in DA rats: Tissue distribution of arthritogenic 14C-labelled hexadecane. Int. J. Immunopharmacol. 17:393.
28. Tsuji, S., Matsumoto, M., Takeuchi, O. et al. 2000. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: Involvement of Toll-like receptors. Infect. Immun. 68:6883.
29. Nicol, T, Quantock, D. C. and Vernon-Roberts, B. 1966. Stimulation of phagocytosis in relation to the mechanism of action of adjuvants. Nature 209:1142.
30. Okuda, Y., Sakoda, S. and Yanagihara, T. 1998. The pattern of cytokine gene expression in lymphoid organs and peripheral blood mononuclear cells of mice with experimental allergic encephalomyelitis. J. Neuroimmunol. 87:147.
31. Wilson, M. E., Young, B. M., Davidson, B. L., Mente, K. A. and McGowan, S. E. 1998. The importance of TGF-beta in murine visceral leishmaniasis. J. Immunol. 161:6148.
32. Allen, S. S. and McMurray, D. N. 2003. Coordinate cytokine gene expression in vivo following induction of tuberculous pleurisy in guinea pigs. Infect. Immun. 71:4271.
33. McAdam, A. J., Schweitzer, A. N. and Sharpe, A. H. 1988. The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells. Immunol. Rev. 165:231.
34. Watts, T. H. and DeBenedette, M. A. 1999. T cell co-stimulatory molecules other than CD28. Curr. Opin. Immunol. 11:286.
35. Trimble, L. A., Xu, Z. and Lieberman, J. 1999. Clonal expansion of antigen-specific CD8+ cytotoxic T lymphocytes is regulated by late exposure to serum to prevent apoptosis. J. Immunol. Methods 225:39.