Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation

Blood

Volumn 89, Issue 10, 1997, Pages 3544-3553

  Goncalves, Frédérique ^a   Lacout, Catherine ^a   Villeval, Jean Luc ^a   Wendling, Françoise ^a   Vainchenker, William ^a   Duménil, Dominique ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOPOIETIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BURST FORMING UNIT E; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CLONOGENIC ASSAY; COLONY FORMING UNIT GEMM; COLONY FORMING UNIT GM; COLONY FORMING UNIT M; COLONY FORMING UNIT S; CONTROLLED STUDY; ERYTHROID CELL; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; MALE; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030997437     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.10.3544     Document Type: Article

References (48)

1. Vigon I, Mornon J-P, Cocault L, Mitjavila M-T, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1992
2. Skoda RC, Seldin DC, Chiang M-K, Peichel CL, Vogt TF, Leder P: Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J 12:2645, 1993
3. Vigon I, Florindo C, Fichelson S, Guenet J-L, Mattei M-G, Souyri M, Cosman D, Gisselbrecht S: Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: Molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene 8:2607, 1993
4. Methia N, Louache F, Vainchenker W, Wendung F: Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395, 1993
5. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
6. Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
7. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
8. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
9. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
10. Kato T, Ogami K, Shimada Y, Iwamatsu A, Sohma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kobayashi K, Ohashi H, Ozawa T, Inoue H, Kawamura K: Purification and characterization of thrombopoietin. J Biol Chem 118:229, 1995
11. Wendung F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
12. Debili N, Wendung F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
13. Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C: Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92:3234, 1995
14. Farese AM, Hunt P, Boone T, MacVittie TJ: Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 86:54, 1995
15. Hunt P, Li Y-S, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Hornkohl AC, Lu H, Clogston C, Merewether LA, Johnson MJ, Parker V, Knudten A, Farese A: Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood 86:540, 1995
16. Kuter DJ, Rosenberg RD: The reciprocal relationship of thrombopoietin (c-Mpl Ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720, 1995
17. Kaushansky K, Broudy VC, Groosman A, Humes J, Lin N, Ren HP, Bailey MC, Papayanopoulou T, Forstrom JW, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96:1683, 1995
18. Broudy VC, Lin NL, Kaushansky K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719, 1995
19. Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544, 1996
20. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT: Functional isolation and characterization of human hematopoietic stem cells. Science 267:104, 1995
21. Alexander WS, Roberts AW, Nicola NA, Metcalf B: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 87:2162, 1996
22. Markowitz D, Goff S, Bank A: Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400, 1988
23. Worton RG, McCulloch EA, Till JE: Physical separation of hematopoietic stem cell forming colonies in culture. J Cell Physiol 74:171, 1969
24. Johnson GR: Colony formation in agar by adult bone marrow multipotential hematopoietic cells. J Cell Physiol 103:371, 1980
25. Metcalf D: The Hemopoietic Colony Stimulating Factors. New York, NY, Elsevier Science, 1984
26. Karnovsky MJ, Roots L: A direct colouring thiocholine method for cholinesterase. J Histochem Cytochem 12:219, 1964
27. Till JE, MacCulloch EA: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213, 1961
28. Stewart CL, Schuetze S, Vanek M, Wagner EF: Expression of retroviral vectors in transgenic mice obtained by embryo infection. EMBO J 6:383, 1987
29. Ihle JN, Kerr IM: Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 11:69, 1995
30. Gurney AL, Wong SC, Henzel WJ, De Sauvage FJ: Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc Natl Acad Sci USA 92:5292, 1995
31. Sattler M, Durstin MA, Frank DA, Okuda K, Kaushansky K, Salgia R, Griffin JD: The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp Hematol 23:1040, 1995
32. Drachman JG, Griffin JD, Kaushansky K: The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270:4979, 1995
33. Tortolani PJ, Johnston JA, Bacon CM, McVicar DW, Shimosaka A, Linnekin D, Longo DL, O'Shea JJ: Thrombopoietin induces tyrosine phosphorylation and activation of the janus kinase, Jak2. Blood 85:3444, 1996
34. Miyakawa Y, Oda A, Druker BJ, Miyazaki H, Handa M, Ohashi H, Ikeda Y: Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. Blood 87:439, 1996
35. Pallard C, Gouilleux F, Bénit L, Cocault L, Souyri M, Levy D, Groner B, Gisselbrecht S, Dusanter-Fourt I: Thrombopoietin activates a STAT-5-like factor in hematopoietic cells. EMBO J 14:2847, 1995
36. Metcalf D: The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood 67:257, 1986
37. Jiang S, Levine JD, Fu Y, Deng B, London R, Groopman JE, Avraham H: Cytokine production by primary bone marrow megakaryocytes. Blood 84:4151, 1994
38. Shimada Y, Kato T, Ogami K, Horie K, Kokubo A, Kudo Y, Maeda E, Sohma Y, Akahori H, Kawamura K, Miyazaki H: Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. Exp Hematol 23:1388, 1995
39. Gurney AL, Kuang W-J, Xie M-H, Malloy BE, Eaton DL, De Sauvage FJ: Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin. Blood 85:981, 1995
40. Chang M, McNinch J, Basu R, Shutter J, Hsu R-Y, Perkins C, Mar V, Suggs S, Welcher A, Li L, Lu H, Bartley T, Hunt P, Martin F, Samal B: Cloning and characterization of the human megakaryocyte growth factor and development factor (MGDF) gene. J Biol Chem 2:511, 1995
41. Rafii S, Shapiro F, Pettengell R, Ferris B, Nachman RL, Moore MS, Asch AS: Human bone marrow microvascular endothelial cell support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors. Blood 86:3353, 1995
42. Nagahisa H, Nagata Y, Ohnuki T, Osada M, Nagasawa T, Abe T, Todokoro K: Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood 87:1305, 1996
43. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, de Sauvage J: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154, 1996
44. de Sauvage FJ, Carver-Moore K, Luoh SM, Ryan A, Dowd M, Eaton DL, Moore MW: Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 183:651, 1996
45. Cohen-Solal K, Villeval JL, Titeux M, Lok S, Vainchenker W, Wendung F: Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis. Blood 88:2578, 1996
46. McCarthy JM, Kaushansky K: Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 84:241, 1994
47. Dubart A, Feger F, Lacout C, Goncalves F, Vainchenker W, Duménil D: Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation. Mol Cell Biol 14:4834, 1994
48. McArthur GA, Longmore GD, Klingler K, Johnson GR: Lineage-restricted recruitment of immature hematopoietic progenitor cells in response to EPO after normal hematopoietic cell transfection with Epo-R. Exp Hematol 23:645, 1995