Animal models of amino acid metabolism: A focus on the intestine

Journal of Nutrition

Volumn 134, Issue 6 SUPPL., 2004, Pages

  Baracos, Vickie E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Amino acid metabolism; Animal models; Intestine; Piglet; Protein metabolism

Indexed keywords

AMINO ACID;

AMINO ACID METABOLISM; ANIMAL MODEL; BASOLATERAL MEMBRANE; CATABOLISM; CONFERENCE PAPER; GASTROINTESTINAL TRACT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SWINE;

ANIMALIA; SUS SCROFA;

EID: 2642543346     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.6.1656s     Document Type: Conference Paper

References (35)

1. Yu, Y. M., Wagner, D. A., Tredget, E. E., Walaszewski, J. A., Burke, J. F. & Young, V. R. (1990) Quantitative role of splanchnic region in leucine metabolism: L-[1-13C,15N]leucine and substrate balance studies. Am. J. Physiol. 259: E36-E51.
2. 15N]leucine within the whole body and the splanchnic region. J. Parenter. Enteral Nutr. 19: 209-215.
3. 13C]leucine infused simultaneously by gut and vein. Am. J. Physiol. 260: E111-E117.
4. Hoerr, R. A., Matthews, D. E., Bier, D. M. & Young, V. R. (1993) Effects of protein restriction and acute refeeding on leucine and lysine kinetics in young men. Am. J. Physiol. 264: E567-E575.
5. Biolo, G., Tessari, P., Inchiostro, S., Bruttomesso, D., Fongher, C., Sabadin, L., Fratton, M. G., Valerio, A. & Tiengo, A. (1992) Leucine and phenylalanine kinetics during mixed meal ingestion: a multiple tracer approach. Am. J. Physiol. 262: E455-E463.
6. Matthews, D. E., Marano, M. A. & Campbell, R. G. (1993) Splanchnic bed utilization of leucine and phenylalanine in humans. Am. J. Physiol. 264: E109-E118.
7. Stoll, B., Burrin, D. G., Henry, J., Jahoor, F. & Reeds, P. J. (1997) Phenylalanine utilization by the gut and liver measured with intravenous and intragastric tracers in pigs. Am. J. Physiol. 273: G1208-G1217.
8. van Goudoever, J. B., Stoll, B., Henry, J. F., Burrin, D. G. & Reeds, P. J. (2000) Adaptive regulation of intestinal lysine metabolism. Proc. Natl. Acad. Sci. U. S. A. 97: 11620-11625.
9. Stoll, B., Henry, J., Reeds, P. J., Yu, H., Jahoor, F. & Burrin, D. G. (1998) Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J. Nutr. 128: 606-614.
10. Bertolo, R. F. P., Pencharz, P. B. & Ball, R. O. (2000) Organ and plasma amino acid concentrations are profoundly different in piglets fed identical diets via gastfic, central venous or portal venous routes. J. Nutr. 130: 1261-1266.
11. Lobley, G. E., Milne, V., Lovie, J. M., Reeds, P. J. & Pennie, K. (1980) Whole body and tissue protein synthesis in cattle. Br. J. Nutr. 43: 491-502.
12. McNurlan, M. A. & Garlick, P. J. (1980) Contribution of rat liver and gastrointestinal tract to whole-body protein synthesis in the rat. Biochem. J. 186: 381-383.
13. Burrin, D. G., Ferrell, C. L., Bdtton, R. A. & Bauer, M. (1990) Level of nutrition and visceral organ size and metabolic activity in sheep. Br. J. Nutr. 64: 439-448.
14. Adegoke, O. A., McBurney, M. I. & Baracos, V. E. (1999) Jejunal mucosal protein synthesis: validation of luminal flooding dose method and effect of luminal osmolarity. Am. J. Physiol. 276: G14-G20.
15. Adegoke, O. A., McBurney, M. I., Samuels, S. E. & Baracos, V. E. (1999) Luminal amino acids acutely decrease intestinal mucosal protein synthesis and protease tuRNA in piglets. J. Nutr. 129: 1871-1878.
16. Adegoke, O. A., McBurney, M. I., Samuels, S. E. & Baracos, V. E. (2003) Modulation of intestinal protein synthesis and protease mRNA by luminal and systemic nutrients. Am. J. Physiol. 284: G1017-G1026.
17. Dudley, M. A., Wykes, L. J., Dudley, A. W., Jr., Burrin, D. G., Nichols, B. L., Rosenberger, J., Jahoor, F., Heird, W. C. & Reeds, P. J. (1998) Parenteral nutrition selectively decreases protein synthesis in the small intestine. Am. J. Physiol. 274: G131-G137.
18. Baracos, V. E., Brun-Bellut, J. & Marie, M. (1991) Tissue protein synthesis in lactating and dry goats. Br. J. Nutr. 66: 451-465.
19. Wu, G. (1998) Amino acid metabolism in the small intestine. Trends in Comp. Biochem. & Physiol. 4: 39-74.
20. Yu, Y. M., Burke, J. F., Vogt, J. A., Chambers, L. & Young, V. R. (1992) Splanchnic and whole body L-[1-13C,15N]leucine kinetics in relation to enteral and parenteral amino acid supply. Am. J. Physiol. 262: E687-E694.
21. 13C]leucine metabolism by the portal-drained viscera of sheep fed on dried grass with acute intravenous and intraduodenal infusions of glucose. Br. J. Nutr. 78: 931-946.
22. Deutz, N. E., Bruins, M. J. & Soeters, P. B. (1998) Infusion of soy and casein protein meals affects interorgan amino acid metabolism and urea kinetics differently in pigs. J. Nutr. 128: 2435-2445.
23. 15N]-soy protein isolate assessed from ileal digestibility and postprandial protein utilization in humans. J. Nutr. 129: 1992-1997.
24. 15N]-labeled milk protein nitrogen is influenced by diet composition in humans. J. Nutr. 129: 890-895.
25. van der Meulen, J., Bakker, J. G., Smits, B. & de Visser, H. (1997) Effects of source of starch on net portal flux of glucose, lactate, volatile fatty acids and amino acids in the pig. Br. J. Nutr. 78: 533-544.
26. Stoll, B., Burrin, D. G., Henry, J. F., Jahoor, F. & Reeds, P. J. (1999) Dietary and systemic phenylalanine utilization for mucosal and hepatic constitutive protein synthesis in pigs. Am. J. Physiol. 276: G49-G57.
27. Yu, F., Bruce, L. A., Calder, A. G., Mime, E., Coop, R. L., Jackson, F., Horgan, G. W. & MacRae, J. C. (2000) Subclinical infection with the nematode Trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues. J. Anim. Sci. 78: 380-390.
28. Bruins, M. J., Soeters, P. B. & Deutz, N. E. (2000) Endotoxemia affects organ protein metabolism differently during prolonged feeding in pigs. J. Nutr. 130: 3003-3013.
29. Bertolo, R. F. P., Chen, C. Z. L., Law, G., Pencharz, P. B. & Ball, R. O. (1998) Threonine requirement of neonatal piglets receiving total parenteral nutrition is considerably lower than that of piglets receiving an identical diet intragastrically. J. Nutr. 128: 1752-1759.
30. Lamont, J. (1992) Mucus: the front line of intestinal mucosal defense. Ann. N. Y. Acad. Sci. 664: 190-201.
31. Shoveller, A. K., Brunton, J. A., Pencharz, P. B. & Ball, R. O. (2003) The methionine requirement is lower in neonatal piglets fed parenterally than in those fed enterally. J. Nutr. 133: 1390-1397.
32. Elango, R., Pencharz, P. B. & Ball, R. O. (2002) Branched chain amino acid (BCAA) requirement of parenterally fed neonatal piglets is less than the enteral requirement. J. Nutr. 132: 3123-3129.
33. Cvitkovic, S., Bertolo, R. F., Brunton, J. A., Pencharz, P. B. & Ball, R. O. (2004) Enteral tryptophan requirement determined by oxidation of gastrically or intravenously infused phenylalanine is not different from the parenteral requirement in neonatal piglets. Pediatr. Res. 55: 630-636.
34. House, J. D., Pencharz, P. B. & Ball, R. O. (1997) Tyrosine kinetics and requirements during total parenteral nutrition in the neonatal piglet: the effect of glycyl-L-tyrosine supplementation. Pediatr. Res. 41: 575-583.
35. House, J. D., Pencharz, P. B. & Ball, R. O. (1997) Phenylalanine requirements determined by using L-[1-14C]phenylalanine in neonatal piglets receiving total parenteral nutrition supplemented with tyrosine. Am. J. Clin. Nutr. 65:984-993.