Glucose and [13C]leucine metabolism by the portal-drained viscera of sheep fed on dried grass with acute intravenous and intraduodenal infusions of glucose

British Journal of Nutrition

Volumn 78, Issue 6, 1997, Pages 931-946

  Piccioli Cappelli, F ^a,b   Seal, C J ^a   Parker, D S ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

Author keywords

Glucose metabolism; Gut tissue metabolism; Leucine absorption; Sheep

Indexed keywords

GLUCOSE; LEUCINE; AMINO ACID; CARBON;

ABSORPTION; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET; DUODENUM; GLUCOSE INFUSION; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; GRASS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PORTAL VEIN; SHEEP; TISSUE METABOLISM; VISCERA; ANIMAL; BLOOD; COMPARATIVE STUDY; ENTERIC FEEDING; INTESTINE ABSORPTION; JUGULAR VEIN; MALE; METABOLISM; PHYSIOLOGY; VASCULARIZATION;

ANIMALIA; OVIS ARIES;

AMINO ACIDS; ANIMALS; CARBON ISOTOPES; DUODENUM; ENTERAL NUTRITION; GLUCOSE; INFUSIONS, INTRAVENOUS; INTESTINAL ABSORPTION; JUGULAR VEINS; LEUCINE; MALE; PORTAL SYSTEM; SHEEP; VISCERA;

EID: 0031283196     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN19970210     Document Type: Article

References (39)

1. Agricultural and Food Research Council (1993). Energy and Protein Requirements of Ruminants. An Advisory Manual Prepared by the AFRC Technical Committee on Responses to Nutrients. Wallingford: CAB INTERNATIONAL.
2. Armstrong, D. G. & Smithard, R. R. (1979). The fate of carbohydrate in the small intestine of the ruminant. Proceedings of the Nutrition Society 38, 283-294.
3. Baird, G. D., Lomax, M. A., Symonds, H. W. & Shaw, S. R. (1980). Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cows in vivo in relation to lactation and nutrient supply. Biochemical Journal 186, 47-57.
4. Balcells, J., Seal, C. J. & Parker, D. S. (1995). Effect of intravenous glucose infusion on metabolism of portal-drained viscera in sheep fed a cereal/straw-based diet. Journal of Animal Science 73, 2146-2155.
5. Bassett, J. M. & Thornburn, G. D. (1971). The regulation of insulin secretion by the ovine foetus in utero. Journal of Endocrinology 50, 59-74.
6. Bauer, M. L., Harmon, D. L., McLeod, K. R. & Huntington, G. B. (1995). Adaptation to small intestinal starch assimilation and glucose transport in ruminants. Journal of Animal Science 73, 1828-1838.
7. Bergman, E. N., Katz, M. L. & Kaufman, C. F. (1970). Quantitative aspects of hepatic and portal glucose metabolism and turnover in sheep. American Journal of Physiology 219, 785-793.
8. Bergman, E. N. & Wolff, J. E. (1971). Metabolism of volatile fatty acids by liver and portal-drained viscera in sheep. American Journal of Physiology 221, 586-592.
9. Calder, A. G. & Smith, A. (1988). Stable isotope ratio analyses of leucine and ketoisocaproic acid in blood plasma by gas chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 2, 14-16.
10. Chaiyabutr, N., Faulkner, A. & Peaker, M. (1983). Effects of exogenous glucose on glucose metabolism in the lactating goat. British Journal of Nutrition 49, 159-165.
11. Fuller, M. F., Weekes, T. E. C., Cadenhead, A. & Bruce, J. B. (1977). The protein-sparing effect of carbohydrate 2. The role of insulin. British Journal of Nutrition 38, 489-496.
12. Janes, A. N., Weekes, T. E. C. & Armstrong, D. G. (1985). Absorption and metabolism of glucose by the mesenteric-drained viscera of sheep fed on dried-grass or ground, maize-based diets. British Journal of Nutrition 54, 449-458.
13. Katz, M. L. & Bergman, E. N. (1969). Simultaneous measurements of hepatic and portal venous blood flow in the sheep and dog. American Journal of Physiology 216, 946-952.
14. Krehbiel, C. R., Britton, R. A., Harmon, D. L., Peters, J. P., Stock, R. A. & Grotjan, H. E. (1996). Effects of varying levels of duodenal or midjejunal glucose and 2-deoxyglucose infusion on small intestinal disappearance and net portal glucose flux in steers. Journal of Animal Science 74, 693-700.
15. Kreikemeier, K. K. & Harmon, D. L. (1995). Abomasal glucose, maize starch and maize dextrin infusions in cattle: small-intestinal disappearance, net portal glucose flux and ileal oligosaccharide flow. British Journal of Nutrition 73, 763-772.
16. Kreikemeier, K. K., Harmon, D. L., Brandt, R. T. Jr, Avery, T. B. & Johnson, D. E. (1991). Small intestinal starch digestion in steers: effect of various levels of abomasal glucose, corn starch and corn dextrin infusion on small intestinal disappearance and net glucose absorption. Journal of Animal Science 69, 328-338.
17. Lobley, G. E., Milne, V., Lovie, J. M., Reeds, P. J. & Pennie, K. (1980). Whole-body and tissue protein synthesis in cattle. British Journal of Nutrition 43, 491-496.
18. Lomax, M. A., Baird, G. B., Mallison, C. B. & Symonds, H. W. (1979). Differences between lactating and non-lactating dairy cows in concentration and secretion rate of insulin. Biochemical Journal 180, 281-289.
19. MacRae, J. C., Lobley, G. E., Bruce, L. A., Luo, Q., Calder, A. G. & Farningham, D. A. H. (1993). Leucine kinetics across the portal drained viscera of sheep. Journal of Animal Science 71, Suppl. 1, 279 Abstr.
20. 3H]glucose tracer in non-steady state. The role of a tritiated tracer impurity. Diabetologia 33, 681-687.
21. Nocek, J. E. & Taminga, S. (1991). Site of digestion of starch in the gastrointestinal tract of dairy cows and its effect on milk yield and composition. Journal of Dairy Science 74, 3598-3629.
22. Parker, D. S. (1990). Manipulation of the functional activity of the gut by dietary and other means (antibiotics/probiotics) in ruminants. Journal of Nutrition 120, 639-648.
23. Pell, J. M., Caldarone, E. M. & Bergman, E. N. (1986). Leucine and α-ketoisocaproate metabolism and interconversions in fed and fasted sheep. Metabolism 35, 1005-1016.
24. Perry, K. W., Weekes, T. E. C., Rooke, J. A., Parker, D. S. & Armstrong, D. A. (1988). Effect on protein intake of gastrin secretion in the ruminant. Quarterly Journal of Experimental Physiology 73, 985-993.
25. Piccioli Cappelli, F., Seal, C. J. & Parker, D. S. (1993a). Portal glucose absorption and utilisation in sheep receiving exogenous glucose intravascularly or intraduodenally. Journal of Animal Science 71, Suppl. 1, 279 Abstr.
26. 13C]Leucine uptake into the portal vein of sheep receiving exogenous glucose intravascularly or intraduodenally. Proceedings of the Nutrition Society 52, 192A.
27. Reynolds, C. K. & Huntington, G. B. (1988). Partition of portal-drained visceral net flux in beef steers. 1. Blood flow and net flux of oxygen, glucose and nitrogenous compounds across stomach and post-stomach tissues. British Journal of Nutrition 60, 539-551.
28. Reynolds, G. W., Simpson, H. V., Carr, D. H. & McLeay, L. M. (1991). Gastrin: its molecular forms and secretion in sheep. In Proceedings of the 7th International Symposium on Ruminant Physiology, Sendai, Japan, pp. 63-87 [T. Tsuda, Y. Sasaki and R. Kawashima, editors]. London: Academic Press.
29. 13C enrichment of carbon dioxide in breath and blood samples. Biomedical and Environmental Mass Spectrometry 15, 365-367.
30. Seal, C. J. & Parker, D. S. (1994). Effect of intraruminal propionic acid infusion on metabolism of mesenteric-and portal-drained viscera in growing steers fed a forage diet: I. Volatile fatty acids, glucose and lactate. Journal of Animal Science 72, 1325-1334.
31. Seal, C. J. & Parker, D. S. (1996). Effect of intraruminal propionic acid infusion on metabolism of mesenteric-and portal-drained viscera in growing steers fed a forage diet: II. Ammonia, urea, amino acids and peptides. Journal of Animal Science 74, 245-256.
32. Seal, C. J., Parker, D. S. & Avery, P. J. (1992). The effect of forage and forage-concentrate diets on rumen fermentation and metabolism of nutrients by mesenteric-and portal-drained viscera in growing steers. British Journal of Nutrition 67, 355-370.
33. Seal, C. J., Parker, D. S. & Lobley, G. E. (1993). Effect of intraduodenal starch infusion on glucose metabolism of growing steers fed alfalfa. Journal of Animal Science 70, Suppl. 1, 279 Abstr.
34. Seal, C. J. & Reynolds, C. K. (1993). Nutritional implications of gastrointestinal and liver metabolism in ruminants. Nutrition Research Reviews 6, 185-208.
35. Stangassinger, M. & Gieseke, D. (1986). Splanchnic metabolism of glucose and related energy substrates. In Control of Digestion and Metabolism in Ruminants [L. P. Milligan, W. L. Grovum and A. Dobson, editors]. Englewood Cliffs, NJ: Prentice Hall.
36. 14C]glucose in humans. American Journal of Physiology 259, E397-E404.
37. White, R. G., Steel, J. E., Leng, R. A. & Luik, J. R. (1969). Evaluation of three isotope-dilution techniques for studying the kinetics of glucose metabolism in sheep. Biochemical Journal 114, 203-214.
38. Windmeuller, H. G. & Spaeth, A. E. (1978). Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine. Journal of Biological Chemistry 253, 69-76.
39. Wu, G., Borbolla, A. G. & Knabe, D. A. (1994). The uptake of glutamine and release of arginine, citrulline and proline by the small intestine of developing pigs. Journal of Nutrition 124, 2437-2444.