메뉴 건너뛰기




Volumn 9, Issue 1, 2004, Pages 23-37

The clinical application of monoclonal antibody therapies in renal transplantation

Author keywords

Immunosuppression; Monoclonal antibodies; Transplantation

Indexed keywords

ALEMTUZUMAB; ANTIMITOTIC AGENT; AZATHIOPRINE; BASILIXIMAB; BTI 322; CALCINEURIN INHIBITOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DACLIZUMAB; EFALIZUMAB; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5C8; MONOCLONAL ANTIBODY CAMPATH 1G; MONOCLONAL ANTIBODY CAMPATH 1M; MONOCLONAL ANTIBODY HU OKT3 GAMMA1; MONOCLONAL ANTIBODY HU1F1; MONOCLONAL ANTIBODY HU3D1; MONOCLONAL ANTIBODY IDEC 131; MONOCLONAL ANTIBODY LEA 29Y; ODULIMOMAB; OKT 3; OKT 4; ORTHOMUNE; PREDNISONE; RITUXIMAB; SIPLIZUMAB; STEROID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 2642542508     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.9.1.23     Document Type: Review
Times cited : (4)

References (120)
  • 1
    • 2642533182 scopus 로고    scopus 로고
    • National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
    • US RENAL DATA SYSTEM: USRDS 2003 Annual Data Report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA (2003).
    • (2003) 2003 Annual Data Report: Atlas of End-Stage Renal Disease in the United States
  • 2
    • 0005984244 scopus 로고
    • Activity acquired tolerance of foreign cells
    • BILLINGHAM RE, BRENT L, MEDAWAR PB: Activity acquired tolerance of foreign cells. Nature (1953) 172(4379):603-606. Landmark paper describing tolerance.
    • (1953) Nature , vol.172 , Issue.4379 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 3
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • KOHLER G, MILSTEIN C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975) 256(5517):495-497. Landmark paper on the discovery of monoclonal antibodies.
    • (1975) Nature , vol.256 , Issue.5517 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 4
    • 0345183785 scopus 로고
    • The reversal of rejection in human renal homografts with subsequent development of homografts tolerance
    • STARZL TE, MARCHIORO TL, WADDELL WR: The reversal of rejection in human renal homografts with subsequent development of homografts tolerance. Surg. Gynecol. Obstet. (1963) 117:385-395. Early paper using glucocorticoid immunosuppression in kidney transplantation.
    • (1963) Surg. Gynecol. Obstet. , vol.117 , pp. 385-395
    • Starzl, T.E.1    Marchioro, T.L.2    Waddell, W.R.3
  • 5
    • 0034075095 scopus 로고    scopus 로고
    • Infectious complications in renal transplant recipients
    • TANPHAICHITR NT, BRENNAN DC: Infectious complications in renal transplant recipients. Adv. Ren. Replace. Ther. (2000) 7(2):131-146.
    • (2000) Adv. Ren. Replace. Ther. , vol.7 , Issue.2 , pp. 131-146
    • Tanphaichitr, N.T.1    Brennan, D.C.2
  • 6
    • 0034113459 scopus 로고    scopus 로고
    • Cancers in renal transplant recipients
    • PENN I: Cancers in renal transplant recipients. Adv. Ren. Replace. Ther. (2000) 7(2):147-156.
    • (2000) Adv. Ren. Replace. Ther. , vol.7 , Issue.2 , pp. 147-156
    • Penn, I.1
  • 7
    • 0035756304 scopus 로고    scopus 로고
    • Hypertension after renal transplantation
    • SCHWENGER V, ZEIER M, RITZ E: Hypertension after renal transplantation. Ann. Transplant. (2001) 6(4):25-30.
    • (2001) Ann. Transplant. , vol.6 , Issue.4 , pp. 25-30
    • Schwenger, V.1    Zeier, M.2    Ritz, E.3
  • 8
    • 0037640050 scopus 로고    scopus 로고
    • Lipid profile before and after renal transplantation-a longitudinal study
    • PANNU HS, SINGH D, SANDHU JS: Lipid profile before and after renal transplantation-a longitudinal study. Ren. Fail. (2003) 25(3):411-417.
    • (2003) Ren. Fail. , vol.25 , Issue.3 , pp. 411-417
    • Pannu, H.S.1    Singh, D.2    Sandhu, J.S.3
  • 9
    • 0942301267 scopus 로고    scopus 로고
    • Bone disease after kidney transplantation
    • SPRAGUE SM, JOSEPHSON MA: Bone disease after kidney transplantation. Semin. Nephrol. (2004) 24(1):82-90.
    • (2004) Semin. Nephrol. , vol.24 , Issue.1 , pp. 82-90
    • Sprague, S.M.1    Josephson, M.A.2
  • 10
    • 0036303411 scopus 로고    scopus 로고
    • Calcineurin inhibitor nephrotoxicity: Reduction in dose results in marked improvement in renal function in patients with coexisting chronic allograft nephropathy
    • PILMORE HL, DITTMER ID: Calcineurin inhibitor nephrotoxicity: reduction in dose results in marked improvement in renal function in patients with coexisting chronic allograft nephropathy. Clin. Transplant. (2002) 16(3):191-195.
    • (2002) Clin. Transplant. , vol.16 , Issue.3 , pp. 191-195
    • Pilmore, H.L.1    Dittmer, I.D.2
  • 13
    • 0028201732 scopus 로고    scopus 로고
    • Tolerance, danger, and the extended family
    • MATZINGER P: Tolerance, danger, and the extended family. Ann. Rev. Immunol. 12:991-1045.
    • Ann. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 14
    • 0021999401 scopus 로고
    • Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy
    • SCHROFF RW, FOON KA, BEATTY SM, OLDHAM RK, MORGAN AC JR: Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Res. (1985) 45(2):879-885.
    • (1985) Cancer Res. , vol.45 , Issue.2 , pp. 879-885
    • Schroff, R.W.1    Foon, K.A.2    Beatty, S.M.3    Oldham, R.K.4    Morgan Jr., A.C.5
  • 15
    • 0022355587 scopus 로고
    • Human immune response to multiple injections of murine monoclonal IgG
    • SHAWLER DL, BARTHOLOMEW RM, SMITH LM, DILLMAN RO: Human immune response to multiple injections of murine monoclonal IgG. J. Immunol. (1985) 135(2):1530-1535.
    • (1985) J. Immunol. , vol.135 , Issue.2 , pp. 1530-1535
    • Shawler, D.L.1    Bartholomew, R.M.2    Smith, L.M.3    Dillman, R.O.4
  • 16
    • 0021713342 scopus 로고
    • Production of functional chimaeric mouse/human antibody
    • BOULIANNE GL, HOZUMI N, SHULMAN MJ: Production of functional chimaeric mouse/human antibody Nature (1984) 312(5995):643-646. Seminal paper on chimaeric antibody engineering.
    • (1984) Nature , vol.312 , Issue.5995 , pp. 643-646
    • Boulianne, G.L.1    Hozumi, N.2    Shulman, M.J.3
  • 17
    • 0021716682 scopus 로고
    • Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
    • MORRISON SL, JOHNSON MJ, HERZENBERG LA, OI VT: Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. USA (1984) 81(21):6851-6855. Seminal paper on chimaeric antibody engineering.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , Issue.21 , pp. 6851-6855
    • Morrison, S.L.1    Johnson, M.J.2    Herzenberg, L.A.3    Oi, V.T.4
  • 18
    • 0023911111 scopus 로고
    • Reshaping human antibodies for therapy
    • REICHMANN L, CLARK M, WALDMANN H, WINTER G: Reshaping human antibodies for therapy. Nature (1988) 332(6162):323-327. Seminal paper on humanised antibody engineering.
    • (1988) Nature , vol.332 , Issue.6162 , pp. 323-327
    • Reichmann, L.1    Clark, M.2    Waldmann, H.3    Winter, G.4
  • 19
    • 0022558297 scopus 로고
    • Replacing the complementarity-determining regions in a human antibody with those from a mouse
    • JONES PT, DEAR PH, FOOTE J, NEUBERGER MS, WINTER G: Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature (1986) 321(6069):522-525. Seminal paper on humanised antibody engineering.
    • (1986) Nature , vol.321 , Issue.6069 , pp. 522-525
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 20
    • 0031039315 scopus 로고    scopus 로고
    • Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
    • MENDEZ MJ, GREEN LL, CORVALAN JR et al.: Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat. Genet. (1997) 15(2):146-156.
    • (1997) Nat. Genet. , vol.15 , Issue.2 , pp. 146-156
    • Mendez, M.J.1    Green, L.L.2    Corvalan, J.R.3
  • 21
    • 0022593141 scopus 로고
    • Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: Distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation
    • LEDBETTER JA, JUNE CH, MARTIN PJ, SPOONER CE, HANSEN JA, MEIER KE: Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation. J. Immunol. (1986) 136(11):3945-3952.
    • (1986) J. Immunol. , vol.136 , Issue.11 , pp. 3945-3952
    • Ledbetter, J.A.1    June, C.H.2    Martin, P.J.3    Spooner, C.E.4    Hansen, J.A.5    Meier, K.E.6
  • 22
    • 0024342748 scopus 로고
    • Bivalent binding of an anti-CD3 antibody to Jurkat cells induces association of the T cell receptor complex with the cytoskeleton
    • MARANO N, HOLOWKA D, BAIRD B: Bivalent binding of an anti-CD3 antibody to Jurkat cells induces association of the T cell receptor complex with the cytoskeleton. J. Immunol. (1989) 143(3):931-938.
    • (1989) J. Immunol. , vol.143 , Issue.3 , pp. 931-938
    • Marano, N.1    Holowka, D.2    Baird, B.3
  • 23
    • 0024676035 scopus 로고
    • Muromonab CD3. A review of its pharmacology and therapeutic potential
    • TODD PA, BROGDEN RN: Muromonab CD3. A review of its pharmacology and therapeutic potential. Drugs (1989) 37(6):871-899.
    • (1989) Drugs , vol.37 , Issue.6 , pp. 871-899
    • Todd, P.A.1    Brogden, R.N.2
  • 24
    • 0027070429 scopus 로고
    • Fine needle aspiration biopsy in renal transplant patients on prophylactic OKT3 treatment
    • GONCALVES LF, RAUBER ML, MANFRO RC, PROMPT CA: Fine needle aspiration biopsy in renal transplant patients on prophylactic OKT3 treatment. Transplant. Proc. (1992) 24(6):3085-3086.
    • (1992) Transplant. Proc. , vol.24 , Issue.6 , pp. 3085-3086
    • Goncalves, L.F.1    Rauber, M.L.2    Manfro, R.C.3    Prompt, C.A.4
  • 25
    • 0025037316 scopus 로고
    • The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging
    • WONG JT, EYLATH AA, GHOBRIAL I, COLVIN RB: The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging. Transplantation (1990) 50(4):683-689.
    • (1990) Transplantation , vol.50 , Issue.4 , pp. 683-689
    • Wong, J.T.1    Eylath, A.A.2    Ghobrial, I.3    Colvin, R.B.4
  • 26
    • 0028812791 scopus 로고
    • Mechanisms of action and overview of OKT3
    • NORMAN DJ: Mechanisms of action and overview of OKT3. Ther. Drug Monit. (1995) 17(6):615-620.
    • (1995) Ther. Drug Monit. , vol.17 , Issue.6 , pp. 615-620
    • Norman, D.J.1
  • 27
    • 0021816056 scopus 로고
    • A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants
    • ORTHO MULTICENTER TRANSPLANT STUDY GROUP: A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants. N. Engl J. Med. (1985) 313(6):337-342. Landmark trial leading to first FDA approval of a monoclonal antibody.
    • (1985) N. Engl J. Med. , vol.313 , Issue.6 , pp. 337-342
  • 28
    • 0024554613 scopus 로고
    • Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients
    • ABRAMOWICZ D, SCHANDENE L, GOLDMAN M et al.: Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients. Transplantation (1989) 47(4):606-608.
    • (1989) Transplantation , vol.47 , Issue.4 , pp. 606-608
    • Abramowicz, D.1    Schandene, L.2    Goldman, M.3
  • 29
    • 0025228924 scopus 로고
    • In vivo cell activation following OKT3 administration. Systemic cytokine release and modulation by corticosteroids
    • CHATENOUD L, FERRAN C, LEGENDRE C et al.: In vivo cell activation following OKT3 administration. Systemic cytokine release and modulation by corticosteroids. Transplantation (1990) 49(4):697-702.
    • (1990) Transplantation , vol.49 , Issue.4 , pp. 697-702
    • Chatenoud, L.1    Ferran, C.2    Legendre, C.3
  • 30
    • 0027405088 scopus 로고
    • Cardiopulmonary effects of OKT3: Determinants of hypotension, pulmonary edema, and cardiac dysfunction
    • COSTANZO-NORDIN MR: Cardiopulmonary effects of OKT3: determinants of hypotension, pulmonary edema, and cardiac dysfunction. Transplant. Proc. (1993) 25(2 Suppl. 1):21-24.
    • (1993) Transplant. Proc. , vol.25 , Issue.2 SUPPL. 1 , pp. 21-24
    • Costanzo-Nordin, M.R.1
  • 31
    • 0023038734 scopus 로고
    • OKT3 monoclonal antibody plasma levels during therapy and the subsequent development of host antibodies to OKT3
    • GOLDSTEIN G, FUCCELLO AJ, NORMAN DJ, SHIELD CF 3rd, COLVIN RB, COSIMI AB: OKT3 monoclonal antibody plasma levels during therapy and the subsequent development of host antibodies to OKT3. Transplantation (1986) 42(5):507-511.
    • (1986) Transplantation , vol.42 , Issue.5 , pp. 507-511
    • Goldstein, G.1    Fuccello, A.J.2    Norman, D.J.3    Shield III, C.F.4    Colvin, R.B.5    Cosimi, A.B.6
  • 32
    • 0028178492 scopus 로고
    • A non-activating 'humanized' anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo
    • ALEGRE ML, PETERSON LJ, XU D et al.: A non-activating 'humanized' anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation (1994) 57(11):1537-1543.
    • (1994) Transplantation , vol.57 , Issue.11 , pp. 1537-1543
    • Alegre, M.L.1    Peterson, L.J.2    Xu, D.3
  • 33
    • 0033568236 scopus 로고    scopus 로고
    • Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gammal(Ala-Ala) in the treatment of acute renal allograft rejection
    • WOODLE ES, XU D, ZIVIN RA et al.: Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gammal(Ala-Ala) in the treatment of acute renal allograft rejection. Transplantation (1999) 68(5):608-616.
    • (1999) Transplantation , vol.68 , Issue.5 , pp. 608-616
    • Woodle, E.S.1    Xu, D.2    Zivin, R.A.3
  • 34
    • 0028360836 scopus 로고
    • In vivo effects of IgA and IgG2a anti-CD3 isotype switch variants
    • PARLEVLIET KJ, TEN BERGE IJ, YONG SL et al.: In vivo effects of IgA and IgG2a anti-CD3 isotype switch variants. J. Clin. Invest. (1994) 93(6):2519-2525.
    • (1994) J. Clin. Invest. , vol.93 , Issue.6 , pp. 2519-2525
    • Parlevliet, K.J.1    Ten Berge, I.J.2    Yong, S.L.3
  • 35
    • 0042326411 scopus 로고    scopus 로고
    • Treatment of acute kidney allograft rejection with a non-mitogenic CD3 antibody
    • MEIJER RT, SURACHNO S, YONG SL et al.: Treatment of acute kidney allograft rejection with a non-mitogenic CD3 antibody. Clin. Exp. Immunol. (2003) 133(3):485-492.
    • (2003) Clin. Exp. Immunol. , vol.133 , Issue.3 , pp. 485-492
    • Meijer, R.T.1    Surachno, S.2    Yong, S.L.3
  • 37
    • 0034660564 scopus 로고    scopus 로고
    • A randomized prospective trial of low-dose OKT3 induction therapy to prevent rejection and minimize side effects in recipients of kidney transplants
    • FLECHNER SM, GOLDFARB DA, FAIRCHILD R et al.: A randomized prospective trial of low-dose OKT3 induction therapy to prevent rejection and minimize side effects in recipients of kidney transplants. Transplantation (2000) 69(11):2374-2381.
    • (2000) Transplantation , vol.69 , Issue.11 , pp. 2374-2381
    • Flechner, S.M.1    Goldfarb, D.A.2    Fairchild, R.3
  • 38
    • 0031779374 scopus 로고    scopus 로고
    • Two low-dose OKT3 induction regimens following renal transplantation-clinical experience at a single center
    • OH HK, PROVENZANO R, TAYEB J, SATMARY N, JONES B: Two low-dose OKT3 induction regimens following renal transplantation-clinical experience at a single center. Clin. Transplant. (1998) 12(4):343-347.
    • (1998) Clin. Transplant. , vol.12 , Issue.4 , pp. 343-347
    • Oh, H.K.1    Provenzano, R.2    Tayeb, J.3    Satmary, N.4    Jones, B.5
  • 39
    • 0027991085 scopus 로고
    • CAMPATH-1 monoclonal antibodies in bone marrow transplantation
    • HALE G, WALDMANN H: CAMPATH-1 monoclonal antibodies in bone marrow transplantation. J. Hematoher. (1994) 3(1):15-31.
    • (1994) J. Hematoher. , vol.3 , Issue.1 , pp. 15-31
    • Hale, G.1    Waldmann, H.2
  • 40
    • 0036952617 scopus 로고    scopus 로고
    • Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning?
    • HALE G, SLAVIN S, GOLDMAN JM, MACKINNON S, GIRALT S, WALDMANN H: Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning? Bone Marrow Transplant. (2002) 30(12):797-804.
    • (2002) Bone Marrow Transplant. , vol.30 , Issue.12 , pp. 797-804
    • Hale, G.1    Slavin, S.2    Goldman, J.M.3    Mackinnon, S.4    Giralt, S.5    Waldmann, H.6
  • 41
    • 0020591822 scopus 로고
    • Removal of T cells from bone marrow for transplantation: A monoclonal antilymphocyte antibody that fixes human complement
    • HALE G, BRIGHT S, CHUMBLEY G et al.: Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood (1983) 62(4):873-882.
    • (1983) Blood , vol.62 , Issue.4 , pp. 873-882
    • Hale, G.1    Bright, S.2    Chumbley, G.3
  • 42
    • 0024315714 scopus 로고
    • Campath-1M-prophylactic use after kidney transplantation. A randomized controlled clinical trial
    • FRIEND PJ, HALE G, WALDMANN H et al.: Campath-1M-prophylactic use after kidney transplantation. A randomized controlled clinical trial. Transplantation (1989) 48(2):248-253.
    • (1989) Transplantation , vol.48 , Issue.2 , pp. 248-253
    • Friend, P.J.1    Hale, G.2    Waldmann, H.3
  • 43
    • 0025995822 scopus 로고
    • Reversal of allograft rejection using the monoclonal antibody, Campath-1G
    • FRIEND PJ, WALDMANN H, HALE G et al.: Reversal of allograft rejection using the monoclonal antibody, Campath-1G. Transplant. Proc. (1991) 23(4):2253-2254.
    • (1991) Transplant. Proc. , vol.23 , Issue.4 , pp. 2253-2254
    • Friend, P.J.1    Waldmann, H.2    Hale, G.3
  • 44
    • 17044453983 scopus 로고    scopus 로고
    • FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts
    • KNECHTLE SJ, VARGO D, FECHNER J et al.: FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts. Transplantation (1997) 63(1):1-6.
    • (1997) Transplantation , vol.63 , Issue.1 , pp. 1-6
    • Knechtle, S.J.1    Vargo, D.2    Fechner, J.3
  • 45
    • 0030871990 scopus 로고    scopus 로고
    • Preclinical studies of allograft tolerance in rhesus monkeys: A novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts
    • THOMAS JM, NEVILLE DM, CONTRERAS JL et al.: Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts. Transplantation (1997) 64(1):124-135.
    • (1997) Transplantation , vol.64 , Issue.1 , pp. 124-135
    • Thomas, J.M.1    Neville, D.M.2    Contreras, J.L.3
  • 46
    • 0032490341 scopus 로고    scopus 로고
    • Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients
    • CALNE R, FRIEND P, MOFFATTS et al.: Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet (1998) 351(9117):1701-1702. The first trial using alemtuzumab in transplantation and introducing the concept that depletional therapy can induce prope tolerance.
    • (1998) Lancet , vol.351 , Issue.9117 , pp. 1701-1702
    • Calne, R.1    Friend, P.2    Moffatts3
  • 47
    • 0033610681 scopus 로고    scopus 로고
    • Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients
    • CALNE R, MOFFATT SD, FRIEND PJ et al.: Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients. Transplantation (1999) 68(10):1613-1616.
    • (1999) Transplantation , vol.68 , Issue.10 , pp. 1613-1616
    • Calne, R.1    Moffatt, S.D.2    Friend, P.J.3
  • 48
    • 0038805159 scopus 로고    scopus 로고
    • Campath-1H induction plus rapamycin monotherapy for renal transplantation: Results of a pilot study
    • KNECHTLE SJ, PIRSCH JD, H FECHNER J, JR et al.: Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study. Am. J. Transplant. (2003) 3(6):722-730.
    • (2003) Am. J. Transplant. , vol.3 , Issue.6 , pp. 722-730
    • Knechtle, S.J.1    Pirsch, J.D.2    Fechner Jr., J.H.3
  • 49
    • 2642520035 scopus 로고    scopus 로고
    • Alemtuzumab (Campath 1-H) facilitates prednisone-free immunosuppression (IP) in kidney transplant recipients
    • LEVENTHAL JR, GALLON L, KAUFMAN DB et al.: Alemtuzumab (Campath 1-H) facilitates prednisone-free immunosuppression (IP) in kidney transplant recipients. Am J. Transplant. (2003) 3(Suppl. 5):310.
    • (2003) Am J. Transplant. , vol.3 , Issue.SUPPL. 5 , pp. 310
    • Leventhal, J.R.1    Gallon, L.2    Kaufman, D.B.3
  • 50
    • 0038638396 scopus 로고    scopus 로고
    • Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H)
    • KIRK AD, HALE DA, MANNON RB et al.: Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H). Transplantation (2003) 76(1):120-129. The only trial to investigate the isolated effects of depletion in man.
    • (2003) Transplantation , vol.76 , Issue.1 , pp. 120-129
    • Kirk, A.D.1    Hale, D.A.2    Mannon, R.B.3
  • 51
    • 11144355749 scopus 로고    scopus 로고
    • Homeostatic proliferation is a barrier to transplantation tolerance
    • WU Z, BENSINGER SJ, ZHANG J et al.: Homeostatic proliferation is a barrier to transplantation tolerance. Nat. Med. (2004) 10(1):87-92.
    • (2004) Nat. Med. , vol.10 , Issue.1 , pp. 87-92
    • Wu, Z.1    Bensinger, S.J.2    Zhang, J.3
  • 52
    • 0023173670 scopus 로고
    • Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion
    • DUSTIN ML, SANDERS ME, SHAW S, SPRINGER TA: Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. J. Exp. Med. (1987) 165(3):677-692.
    • (1987) J. Exp. Med. , vol.165 , Issue.3 , pp. 677-692
    • Dustin, M.L.1    Sanders, M.E.2    Shaw, S.3    Springer, T.A.4
  • 53
    • 0025085576 scopus 로고
    • Activation of tyrosine phosphorylation in human T cells via the CD2 pathway Regulation by the CD45 tyrosine phosphatase
    • SAMELSON LE, FLETCHER MC, LEDBETTER JA, JUNE CH: Activation of tyrosine phosphorylation in human T cells via the CD2 pathway Regulation by the CD45 tyrosine phosphatase. J. Immunol. (1990) 145(8):2448-2454.
    • (1990) J. Immunol. , vol.145 , Issue.8 , pp. 2448-2454
    • Samelson, L.E.1    Fletcher, M.C.2    Ledbetter, J.A.3    June, C.H.4
  • 54
    • 0034655399 scopus 로고    scopus 로고
    • The experimental (in vitro) and clinical (in vivo) immunosuppressive effects of a rat IgG2b anti-human CD2 mAb, LO-CD2a/BTI-322
    • NIZET Y, CHENTOUFI AA, DE LA PARRA B et al.: The experimental (in vitro) and clinical (in vivo) immunosuppressive effects of a rat IgG2b anti-human CD2 mAb, LO-CD2a/BTI-322. Transplantation (2000) 69(7):1420-1428.
    • (2000) Transplantation , vol.69 , Issue.7 , pp. 1420-1428
    • Nizet, Y.1    Chentoufi, A.A.2    De La Parra, B.3
  • 55
    • 0030808473 scopus 로고    scopus 로고
    • Prevention of rejection with BTI-322 after renal transplantation (results at 9 months)
    • BESSE T, MALAISE J, MOURAD M et al.: Prevention of rejection with BTI-322 after renal transplantation (results at 9 months). Transplant. Proc. (1997) 29(5):2425-2426.
    • (1997) Transplant. Proc. , vol.29 , Issue.5 , pp. 2425-2426
    • Besse, T.1    Malaise, J.2    Mourad, M.3
  • 56
    • 20244388936 scopus 로고    scopus 로고
    • Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies
    • SPITZER TR, MCAFEE SL, DEY BR et al.: Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation (2003) 75(10):1748-1751.
    • (2003) Transplantation , vol.75 , Issue.10 , pp. 1748-1751
    • Spitzer, T.R.1    Mcafee, S.L.2    Dey, B.R.3
  • 57
    • 0024327898 scopus 로고
    • The leukocyte common antigen family
    • THOMAS ML: The leukocyte common antigen family. Ann. Rev. Immunol. (1989) 7:339-369.
    • (1989) Ann. Rev. Immunol. , vol.7 , pp. 339-369
    • Thomas, M.L.1
  • 58
    • 0033986766 scopus 로고    scopus 로고
    • A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras
    • LYNCH KW, WEISS A: A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol. Cell. Biol. (2000) 20(1):70-80.
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.1 , pp. 70-80
    • Lynch, K.W.1    Weiss, A.2
  • 59
    • 0022271257 scopus 로고
    • Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis
    • BINDON CI, HALE G, CLARK M, WALDMANN H: Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis. Transplantation (1985) 40(5):538-544.
    • (1985) Transplantation , vol.40 , Issue.5 , pp. 538-544
    • Bindon, C.I.1    Hale, G.2    Clark, M.3    Waldmann, H.4
  • 60
    • 2642524079 scopus 로고    scopus 로고
    • Identification of gene expression profiles that correlate with tolerance induced by anti-CD45RB MAB treatment in a non-human-primate kidney allograft model
    • CAMERON MJ, XU L, LONGSI R et al.: Identification of gene expression profiles that correlate with tolerance induced by anti-CD45RB MAB treatment in a non-human-primate kidney allograft model. Am. J. Transplant. (2003) 3(Suppl. 5):263.
    • (2003) Am. J. Transplant. , vol.3 , Issue.SUPPL. 5 , pp. 263
    • Cameron, M.J.1    Xu, L.2    Longsi, R.3
  • 61
    • 0027394657 scopus 로고
    • The IL-2/IL-2 receptor system: A current overview
    • TANIGUCHI T, MINAMI Y: The IL-2/IL-2 receptor system: a current overview. Cell. (1993) 73(1):5-8.
    • (1993) Cell , vol.73 , Issue.1 , pp. 5-8
    • Taniguchi, T.1    Minami, Y.2
  • 62
    • 0034353413 scopus 로고    scopus 로고
    • Daclizumab (Zenapax) inhibits early interleukin-2 receptor signal transduction events
    • GOEBEL J, STEVENS E, FORREST K, ROSZMAN TL: Daclizumab (Zenapax) inhibits early interleukin-2 receptor signal transduction events. Transpl. Immunol. (2000) 8(3):153-159.
    • (2000) Transpl. Immunol. , vol.8 , Issue.3 , pp. 153-159
    • Goebel, J.1    Stevens, E.2    Forrest, K.3    Roszman, T.L.4
  • 63
    • 6844236357 scopus 로고    scopus 로고
    • Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation
    • Daclizumab Triple Therapy Study Group
    • VINCENTI F, KIRKMAN R, LIGHT S et al.: Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group. N. Engl. J. Med. (1998) 338(3):161-165. Pivotal trial with anti-IL-2R monoclonal antibodies and first important study using a humanised monoclonal antibodies.
    • (1998) N. Engl. J. Med. , vol.338 , Issue.3 , pp. 161-165
    • Vincenti, F.1    Kirkman, R.2    Light, S.3
  • 64
    • 0028353163 scopus 로고
    • The impact of an acute rejection episode on long-term renal allograft survival (t1/2)
    • MATAS AJ, GILLINGHAM KJ, PAYNE WD, NAJARIAN JS: The impact of an acute rejection episode on long-term renal allograft survival (t1/2). Transplantation (1994) 57(6):857-859.
    • (1994) Transplantation , vol.57 , Issue.6 , pp. 857-859
    • Matas, A.J.1    Gillingham, K.J.2    Payne, W.D.3    Najarian, J.S.4
  • 65
    • 0037433703 scopus 로고    scopus 로고
    • Interleukin-2 receptor monoclonal antibodies in renal transplantation: Meta-analysis of randomised trials
    • ADU D, COCKWELL P, IVES NJ, SHAW J, WHEATLEY K: Interleukin-2 receptor monoclonal antibodies in renal transplantation: meta-analysis of randomised trials. Br. Med. J. (2003) 326(7393):789.
    • (2003) Br. Med. J. , vol.326 , Issue.7393 , pp. 789
    • Adu, D.1    Cockwell, P.2    Ives, N.J.3    Shaw, J.4    Wheatley, K.5
  • 66
    • 0037243223 scopus 로고    scopus 로고
    • Economic implications of the use of basiliximab in addition to triple immunosuppressive therapy in renal allograft recipients: A UK perspective
    • WALTERS SJ, WHITFIELD M, AKEHURST RL, CHILCOTT JB: Economic implications of the use of basiliximab in addition to triple immunosuppressive therapy in renal allograft recipients: a UK perspective. Pharmacoeconomics (2003) 21(2):129-138.
    • (2003) Pharmacoeconomics , vol.21 , Issue.2 , pp. 129-138
    • Walters, S.J.1    Whitfield, M.2    Akehurst, R.L.3    Chilcott, J.B.4
  • 67
    • 0035875823 scopus 로고    scopus 로고
    • Economic analysis of basiliximab in renal transplantation
    • KEOWN PA, BALSHAW R, KRUEGER H, BALADI JF: Economic analysis of basiliximab in renal transplantation. Transplantation (2001) 71(11):1573-1579.
    • (2001) Transplantation , vol.71 , Issue.11 , pp. 1573-1579
    • Keown, P.A.1    Balshaw, R.2    Krueger, H.3    Baladi, J.F.4
  • 68
    • 0035872742 scopus 로고    scopus 로고
    • Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation
    • VINCENTI F, RAMOS E, BRATTSTROM C et al.: Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation. Transplantation (2001) 71(9):1282-1287.
    • (2001) Transplantation , vol.71 , Issue.9 , pp. 1282-1287
    • Vincenti, F.1    Ramos, E.2    Brattstrom, C.3
  • 69
    • 0033770939 scopus 로고    scopus 로고
    • Avoidance of cyclosporine in renal transplantation: Effects of daclizumab, mycophenolate mofetil, and steroids
    • TRAN HT, ACHARYA MK, MCKAY DB et al.: Avoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroids. J. Am. Soc. Nephrol. (2000) 11(10):1903-1909.
    • (2000) J. Am. Soc. Nephrol. , vol.11 , Issue.10 , pp. 1903-1909
    • Tran, H.T.1    Acharya, M.K.2    Mckay, D.B.3
  • 70
    • 0242491816 scopus 로고    scopus 로고
    • Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation
    • SARWAL MM, VIDHUN JR, ALEXANDER SR et al.: Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation (2003) 76(9):1331-1339. A good example of extended monoclonal antibody use suggesting applications other than induction therapy.
    • (2003) Transplantation , vol.76 , Issue.9 , pp. 1331-1339
    • Sarwal, M.M.1    Vidhun, J.R.2    Alexander, S.R.3
  • 71
    • 0026806050 scopus 로고
    • Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody
    • PEARSON TC, MADSEN JC, LARSEN CP, MORRIS PJ, WOOD KJ: Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation (1992) 54(3):475-483.
    • (1992) Transplantation , vol.54 , Issue.3 , pp. 475-483
    • Pearson, T.C.1    Madsen, J.C.2    Larsen, C.P.3    Morris, P.J.4    Wood, K.J.5
  • 72
    • 0025079741 scopus 로고
    • Prolonged survival of nonhuman primate renal allograft recipients treated only with anti-CD4 monoclonal antibody
    • COSIMI AB, DELMONICO FL, WRIGHT JK et al.: Prolonged survival of nonhuman primate renal allograft recipients treated only with anti-CD4 monoclonal antibody. Surgery (1990) 108(2):406-413.
    • (1990) Surgery , vol.108 , Issue.2 , pp. 406-413
    • Cosimi, A.B.1    Delmonico, F.L.2    Wright, J.K.3
  • 73
    • 0029851546 scopus 로고    scopus 로고
    • Anti-CD4 MoAb therapy in kidney transplantation - A pilot study in early prophylaxis of rejection
    • DANTAL J, NININ E, HOURMANT M et al.: Anti-CD4 MoAb therapy in kidney transplantation - a pilot study in early prophylaxis of rejection. Transplantation (1996) 62(10):1502-1506.
    • (1996) Transplantation , vol.62 , Issue.10 , pp. 1502-1506
    • Dantal, J.1    Ninin, E.2    Hourmant, M.3
  • 74
    • 17744416417 scopus 로고    scopus 로고
    • Murine OKT4A immunosuppression in cadaver donor renal allograft recipients
    • COOPERATIVE CLINICAL TRIALS IN TRANSPLANTATION RESEARCH GROUP: Murine OKT4A immunosuppression in cadaver donor renal allograft recipients. Transplantation (1997) 63(9):1243-1251.
    • (1997) Transplantation , vol.63 , Issue.9 , pp. 1243-1251
  • 75
    • 0023637951 scopus 로고
    • T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
    • JUNE CH, LEDBETTER JA, GILLESPIE MM, LINDSTEN T, THOMPSON CB: T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell Biol. (1987) 7(12):4472-4481.
    • (1987) Mol. Cell Biol. , vol.7 , Issue.12 , pp. 4472-4481
    • June, C.H.1    Ledbetter, J.A.2    Gillespie, M.M.3    Lindsten, T.4    Thompson, C.B.5
  • 76
    • 0024317711 scopus 로고
    • Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes
    • JUNE CH, LEDBETTER JA, LINDSTEN T, THOMPSON CB: Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes. J. Immunol. (1989) 143(1):153-161.
    • (1989) J. Immunol. , vol.143 , Issue.1 , pp. 153-161
    • June, C.H.1    Ledbetter, J.A.2    Lindsten, T.3    Thompson, C.B.4
  • 79
    • 0000324490 scopus 로고
    • CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines
    • THOMPSON CB, LINDSTEN T, LEDBETTER JA et al.: CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA (1989) 86(4):1333-1337.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , Issue.4 , pp. 1333-1337
    • Thompson, C.B.1    Lindsten, T.2    Ledbetter, J.A.3
  • 80
    • 0030947503 scopus 로고    scopus 로고
    • CD28 co-receptor signal transduction in T-cell activation
    • BLAIR PJ, RILEY JL, CARROLL RG et al.: CD28 co-receptor signal transduction in T-cell activation. Biochem. Soc. Trans. (1997) 25(2):651-657.
    • (1997) Biochem. Soc. Trans. , vol.25 , Issue.2 , pp. 651-657
    • Blair, P.J.1    Riley, J.L.2    Carroll, R.G.3
  • 81
    • 0031626414 scopus 로고    scopus 로고
    • CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bd-X(L) induction
    • BLAIR PJ, RILEY JL, LEVINE BL et al.: CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bd-X(L) induction. J. Immunol. (1998) 160(1):12-15.
    • (1998) J. Immunol. , vol.160 , Issue.1 , pp. 12-15
    • Blair, P.J.1    Riley, J.L.2    Levine, B.L.3
  • 82
    • 0028903939 scopus 로고
    • CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
    • SAYEGH MH, AKALIN E, HANCOCK WW et al.: CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. (1995) 181(5):1869-1874.
    • (1995) J. Exp. Med. , vol.181 , Issue.5 , pp. 1869-1874
    • Sayegh, M.H.1    Akalin, E.2    Hancock, W.W.3
  • 83
    • 0028886953 scopus 로고
    • T cell costimulatory pathways: Promising novel targets for immunosuppression and tolerance induction
    • SAYEGH MH, TURKA LA: T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction. J. Am. Soc. Nephrol. (1995) 6(4):1143-1150.
    • (1995) J. Am. Soc. Nephrol. , vol.6 , Issue.4 , pp. 1143-1150
    • Sayegh, M.H.1    Turka, L.A.2
  • 84
    • 0035882129 scopus 로고    scopus 로고
    • Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates
    • KIRK AD, TADAKI DK, CELNIKER A et al.: Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates. Transplantation (2001) 72(3):377-384.
    • (2001) Transplantation , vol.72 , Issue.3 , pp. 377-384
    • Kirk, A.D.1    Tadaki, D.K.2    Celniker, A.3
  • 86
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • SCHOENBERGER SP, TOES RE, VAN DER VOORT EI, OFFRINGA R, MELIEF CJ: T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. (1998) 393(6684):480-483.
    • (1998) Nature , vol.393 , Issue.6684 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    Van Der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 87
    • 0031570007 scopus 로고    scopus 로고
    • Bidirectional regulation of human B cell responses by CD40-CD40 ligand interactions
    • MIYASHITA T, MCILRAITH MJ, GRAMMER AC et al.: Bidirectional regulation of human B cell responses by CD40-CD40 ligand interactions. J. Immunol. (1997) 158(10):4620-4633.
    • (1997) J. Immunol. , vol.158 , Issue.10 , pp. 4620-4633
    • Miyashita, T.1    Mcilraith, M.J.2    Grammer, A.C.3
  • 89
    • 0032996618 scopus 로고    scopus 로고
    • Graft tolerance: A duel of two signals
    • MATZINGER P: Graft tolerance: a duel of two signals. Nat. Med. (1999) 5(6):616-617.
    • (1999) Nat. Med. , vol.5 , Issue.6 , pp. 616-617
    • Matzinger, P.1
  • 90
    • 0036061575 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates
    • ADAMS AB, SHIRASUGI N, DURHAM MM et al.: Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes (2002) 51(2):265-270.
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 265-270
    • Adams, A.B.1    Shirasugi, N.2    Durham, M.M.3
  • 91
    • 0033135564 scopus 로고    scopus 로고
    • CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris
    • ABRAMS JR, LEBWOHL MG, GUZZO CA et al.: CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J. Clin. Invest. (1999) 103(9):1243-1252.
    • (1999) J. Clin. Invest. , vol.103 , Issue.9 , pp. 1243-1252
    • Abrams, J.R.1    Lebwohl, M.G.2    Guzzo, C.A.3
  • 92
    • 0036061575 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates
    • ADAMS AB, SHIRASUGI N, DURHAM MM et al.: Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes (2002) 51(2):265-270.
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 265-270
    • Adams, A.B.1    Shirasugi, N.2    Durham, M.M.3
  • 93
    • 1842565107 scopus 로고    scopus 로고
    • Study design and baseline characteristics of a multiple dose, randomized, controlled open-label study comparing a costimulation blocker based regimen of BMS-224818 (LEA29Y) versus cyclosporine in renal transplant
    • VINCENTI F, DURBACH A, LARSEN C et al.: Study design and baseline characteristics of a multiple dose, randomized, controlled open-label study comparing a costimulation blocker based regimen of BMS-224818 (LEA29Y) versus cyclosporine in renal transplant. Am. J. Transplant. (2003) 3(suppl 5):473. First concerted effort to develop a costimulatory blockade monoclonal antibody for transplantation. Subsequent results of this trial will be closely watched.
    • (2003) Am. J. Transplant. , vol.3 , Issue.SUPPL. 5 , pp. 473
    • Vincenti, F.1    Durbach, A.2    Larsen, C.3
  • 94
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • KIRK AD, HARLAN DM, ARMSTRONG NN et al.: CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc. Natl. Acad. Sci. USA (1997) 94(16):8789-8794.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , Issue.16 , pp. 8789-8794
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 95
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • KIRK AD, BURKLY LC, BATTY DS et al.: Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat. Med. (1999) 5(6):686-693. The most definitive result from a preclinical anti-rejection trial using only monoclonal antibody therapy.
    • (1999) Nat. Med. , vol.5 , Issue.6 , pp. 686-693
    • Kirk, A.D.1    Burkly, L.C.2    Batty, D.S.3
  • 96
    • 0000203537 scopus 로고    scopus 로고
    • Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation
    • KIRK AD, KNECHTLE SJ, SOLLINGER HW et al.: Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation. Am. J. Transplant. (2001) 1(Suppl 1):191.
    • (2001) Am. J. Transplant. , vol.1 , Issue.SUPPL. 1 , pp. 191
    • Kirk, A.D.1    Knechtle, S.J.2    Sollinger, H.W.3
  • 97
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
    • KAWAI T, ANDREWS D, COLVIN RB, SACHS DH, COSIMI AB: Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat. Med. (2000) 6(2):114.
    • (2000) Nat. Med. , vol.6 , Issue.2 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3    Sachs, D.H.4    Cosimi, A.B.5
  • 98
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • HENN V, SLUPSKY JR, GRAFE M et al.: CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. (1998) 391(6667):591-594.
    • (1998) Nature , vol.391 , Issue.6667 , pp. 591-594
    • Henn, V.1    Slupsky, J.R.2    Grafe, M.3
  • 99
    • 0036899589 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: A randomized, double-blind, placebo-controlled trial
    • KALUNIAN KC, DAVIS JC JR, MERRILL JT et al.: Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. (2002) 46(12):3251-3258.
    • (2002) Arthritis Rheum. , vol.46 , Issue.12 , pp. 3251-3258
    • Kalunian, K.C.1    Davis Jr., J.C.2    Merrill, J.T.3
  • 100
    • 0032571299 scopus 로고    scopus 로고
    • Cell adhesion molecules in clinical renal transplantation
    • FUGGLE SV, KOO DD: Cell adhesion molecules in clinical renal transplantation. Transplantation. (1998) 65(6):763-769.
    • (1998) Transplantation , vol.65 , Issue.6 , pp. 763-769
    • Fuggle, S.V.1    Koo, D.D.2
  • 101
    • 0024443411 scopus 로고
    • T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
    • DUSTIN ML, SPRINGER TA: T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature. (1989) 341(6243):619-624.
    • (1989) Nature , vol.341 , Issue.6243 , pp. 619-624
    • Dustin, M.L.1    Springer, T.A.2
  • 102
    • 0024310225 scopus 로고
    • Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands
    • LO SK, VAN SEVENTER GA, LEVIN SM, WRIGHT SD: Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands. J. Immunol. (1989) 143(10):3325-3329.
    • (1989) J. Immunol. , vol.143 , Issue.10 , pp. 3325-3329
    • Lo, S.K.1    Van Seventer, G.A.2    Levin, S.M.3    Wright, S.D.4
  • 103
    • 0022257273 scopus 로고
    • LFA1 membrane molecule in the regulation of homotypic adhesion of human B lymphocytes
    • MENTZER SJ, GROMKOWSKI SH, KRENSKY AM, BURAKOFF SJ, MARTZ E: LFA1 membrane molecule in the regulation of homotypic adhesion of human B lymphocytes. J. Immunol. (1985) 135(1):9-11.
    • (1985) J. Immunol. , vol.135 , Issue.1 , pp. 9-11
    • Mentzer, S.J.1    Gromkowski, S.H.2    Krensky, A.M.3    Burakoff, S.J.4    Martz, E.5
  • 104
    • 0019448315 scopus 로고
    • Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA1): Mechanism of blockade of T-lymphocyte mediated killing and effects on other T and B lymphocyte functions
    • DAVIGNON D, MARTZ E, REYNOLDS T, KURZINGER K, SPRINGER TA: Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA1): mechanism of blockade of T-lymphocyte mediated killing and effects on other T and B lymphocyte functions. J. Immunol. (1981) 127(2):590-595.
    • (1981) J. Immunol. , vol.127 , Issue.2 , pp. 590-595
    • Davignon, D.1    Martz, E.2    Reynolds, T.3    Kurzinger, K.4    Springer, T.A.5
  • 105
    • 0030466367 scopus 로고    scopus 로고
    • A randomized multicenter trial comparing leukocyte function-associated antigen-1 monoclonal antibody with rabbit antithymocyte globulin as induction treatment in first kidney transplantations
    • HOURMANT M, BEDROSSIAN J, DURAND D et al.: A randomized multicenter trial comparing leukocyte function-associated antigen-1 monoclonal antibody with rabbit antithymocyte globulin as induction treatment in first kidney transplantations. Transplantation (1996) 62(11):1565-1570.
    • (1996) Transplantation , vol.62 , Issue.11 , pp. 1565-1570
    • Hourmant, M.1    Bedrossian, J.2    Durand, D.3
  • 107
    • 0035746070 scopus 로고    scopus 로고
    • Anti-adhesion antibodies efalizumab, a humanized anti-CD11a monoclonal antibody
    • DEDRICK RL, WALICKE P, GAROVOY M: Anti-adhesion antibodies efalizumab, a humanized anti-CD11a monoclonal antibody. Transpl. Immunol. (2002) 9(2-4):181-186.
    • (2002) Transpl. Immunol. , vol.9 , Issue.2-4 , pp. 181-186
    • Dedrick, R.L.1    Walicke, P.2    Garovoy, M.3
  • 108
    • 0022574146 scopus 로고
    • Induction by IL 1 and interferon-gamma: Tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)
    • DUSTIN ML, ROTHLEIN R, BHAN AK, DINARELLO CA, SPRINGER TA: Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. (1986) 137(1):245-254.
    • (1986) J. Immunol , vol.137 , Issue.1 , pp. 245-254
    • Dustin, M.L.1    Rothlein, R.2    Bhan, A.K.3    Dinarello, C.A.4    Springer, T.A.5
  • 109
    • 0025341115 scopus 로고
    • In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts
    • COSIMI AB, CONTI D, DELMONICO FL et al.: In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts. J. Immunol. (1990) 144(12):4604-4612.
    • (1990) J. Immunol. , vol.144 , Issue.12 , pp. 4604-4612
    • Cosimi, A.B.1    Conti, D.2    Delmonico, F.L.3
  • 110
    • 0027413809 scopus 로고
    • A: Phase I trial of immunosuppression with anti-ICAM-1 (CD54) mAb in renal allograft recipients
    • HAUG CE, COLVIN RB, DELMONICO FL et al.: A: Phase I trial of immunosuppression with anti-ICAM-1 (CD54) mAb in renal allograft recipients. Transplantation (1993) 55(4):766-772.
    • (1993) Transplantation , vol.55 , Issue.4 , pp. 766-772
    • Haug, C.E.1    Colvin, R.B.2    Delmonico, F.L.3
  • 111
    • 0033559042 scopus 로고    scopus 로고
    • A randomized multicenter trial of the anti-ICAM-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation: A report of the European Anti-ICAM-1 Renal Transplant Study Group
    • SALMELA K, WRAMNER L, EKBERG H et al.: A randomized multicenter trial of the anti-ICAM-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation: a report of the European Anti-ICAM-1 Renal Transplant Study Group. Transplantation (1999) 67(5):729-736.
    • (1999) Transplantation , vol.67 , Issue.5 , pp. 729-736
    • Salmela, K.1    Wramner, L.2    Ekberg, H.3
  • 112
    • 0141886902 scopus 로고    scopus 로고
    • Humanized anti-CD20 monoclonal antibody (Rituximab) treatment for post-transplant lymphoproliferative disorder
    • GANNE V, SIDDIQI N, KAMAPLATH B et al.: Humanized anti-CD20 monoclonal antibody (Rituximab) treatment for post-transplant lymphoproliferative disorder. Clin. Transplant. (2003) 17(5):417-422.
    • (2003) Clin. Transplant. , vol.17 , Issue.5 , pp. 417-422
    • Ganne, V.1    Siddiqi, N.2    Kamaplath, B.3
  • 113
    • 17844402696 scopus 로고    scopus 로고
    • Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: Depletion of CD20-and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody
    • ALWAYN IP, XU Y, BASKER M et al.: Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: depletion of CD20-and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody Xenotransplantation (2001) 8(3):157-171.
    • (2001) Xenotransplantation , vol.8 , Issue.3 , pp. 157-171
    • Alwayn, I.P.1    Xu, Y.2    Basker, M.3
  • 114
    • 0037112922 scopus 로고    scopus 로고
    • Successful A1-to-O ABO-incompatible kidney transplantation after a preconditioning regimen consisting of anti-CD20 monoclonal antibody infusions, splenectomy, and double-filtration plasmapheresis
    • SAWADA T, FUCHINOUE S, TERAOKA S: Successful A1-to-O ABO-incompatible kidney transplantation after a preconditioning regimen consisting of anti-CD20 monoclonal antibody infusions, splenectomy, and double-filtration plasmapheresis. Transpantation (2002) 74(9):1207-1210.
    • (2002) Transpantation , vol.74 , Issue.9 , pp. 1207-1210
    • Sawada, T.1    Fuchinoue, S.2    Teraoka, S.3
  • 115
    • 0041835959 scopus 로고    scopus 로고
    • Successful ABO-incompatible kidney transplantations without splenectomy using antigen-specific immunoadsorption and rituximab
    • TYDEN G, KUMLIEN G, FEHRMAN I: Successful ABO-incompatible kidney transplantations without splenectomy using antigen-specific immunoadsorption and rituximab. Transplantation (2003) 76(4):730-731.
    • (2003) Transplantation , vol.76 , Issue.4 , pp. 730-731
    • Tyden, G.1    Kumlien, G.2    Fehrman, I.3
  • 116
    • 0942275304 scopus 로고    scopus 로고
    • Rituximab: A highly successful therapy for treatment of vascular rejection
    • BECKER YT, PIRSCH JD, SOLLINGER HW: Rituximab: a highly successful therapy for treatment of vascular rejection. Am. J. Transplant. (2003) 3(suppl 5):476.
    • (2003) Am. J. Transplant. , vol.3 , Issue.SUPPL. 5 , pp. 476
    • Becker, Y.T.1    Pirsch, J.D.2    Sollinger, H.W.3
  • 117
    • 0038679758 scopus 로고    scopus 로고
    • Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling
    • SARWAL M, CHUA MS, KAMBHAM N et al.: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N. Engl. J. Med. (2003) 349(2):125-138.
    • (2003) N. Engl. J. Med , vol.349 , Issue.2 , pp. 125-138
    • Sarwal, M.1    Chua, M.S.2    Kambham, N.3
  • 119
    • 0034235747 scopus 로고    scopus 로고
    • An essential contribution by IFN-gamma to CD8+ T cell-mediated rejection of pancreatic islet allografts
    • DIAMOND AS, GILL RG: An essential contribution by IFN-gamma to CD8+ T cell-mediated rejection of pancreatic islet allografts. J. Immunol. (2000) 165(1):247-255.
    • (2000) J. Immunol. , vol.165 , Issue.1 , pp. 247-255
    • Diamond, A.S.1    Gill, R.G.2
  • 120
    • 0001696208 scopus 로고    scopus 로고
    • Results from a human tolerance trial using Campath-1H with and without infliximab
    • KIRK AD, HALE DA, HOFFMANN SC et al.: Results from a human tolerance trial using Campath-1H with and without infliximab. Am. J. Transplant. (2002) 2(Suppl. 2):379.
    • (2002) Am. J. Transplant. , vol.2 , Issue.SUPPL. 2 , pp. 379
    • Kirk, A.D.1    Hale, D.A.2    Hoffmann, S.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.