Carbodiimide-mediated preparation of the tricyclic pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine ring system and its application to the synthesis of the potent antitumoral marine alkaloid variolin B and analog

Journal of Organic Chemistry

Volumn 68, Issue 2, 2003, Pages 489-499

  Molina, Pedro ^a   Fresneda, Pilar M ^a   Delgado, Santiago ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

THERMAL DECARBOXYLATION;

ANNEALING; ORGANIC ACIDS; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

ALKALOID; ANTINEOPLASTIC ALKALOID; CYANAMIDE; PYRIDO[3',2':4,5]PYRROLO[1,2 C]PYRIMIDINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VARIOLIN B;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; INFRARED SPECTROSCOPY; MARINE ENVIRONMENT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ALKALOIDS; ANTINEOPLASTIC AGENTS; AZA COMPOUNDS; CARBODIIMIDES; COMBINATORIAL CHEMISTRY TECHNIQUES; CYCLIZATION; INDICATORS AND REAGENTS; MESYLATES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037462339     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo026508x     Document Type: Article

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