The plasma pharmacokinetics and cerebral spinal fluid penetration of intravenous topiramate in newborn pigs

Biopharmaceutics and Drug Disposition

Volumn 25, Issue 6, 2004, Pages 265-271

  Galinkin, Jeffrey L ^a,b   Kurth, C Dean ^a,c   Shi, Heng ^a,c   Priestley, Margaret A ^a   Loepke, Andreas W ^a,c   Adamson, Peter C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL   (United States)

Author keywords

Hypoxia; Neonatal; Neuroprotectant

Indexed keywords

ANTICONVULSIVE AGENT; TOPIRAMATE;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; DRUG TOLERABILITY; ELECTROENCEPHALOGRAM; HEART RATE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEUROPROTECTION; NEWBORN; NONHUMAN; SINGLE DRUG DOSE; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; BLOOD PRESSURE; CHROMATOGRAPHY, LIQUID; ELECTROCARDIOGRAPHY; FEMALE; FRUCTOSE; HALF-LIFE; HEART RATE; HYPOXIA-ISCHEMIA, BRAIN; INJECTIONS, INTRAVENOUS; MALE; MASS SPECTROMETRY; NEUROPROTECTIVE AGENTS; SWINE; TIME FACTORS;

EID: 4644362680     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.408     Document Type: Article

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