Pesticides and the induction of aneuploidy in human sperm

Cytogenetic and Genome Research

Volumn 111, Issue 3-4, 2005, Pages 378-383

  Harkonen K ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANOPHOSPHATE PESTICIDE; PESTICIDE;

ANEUPLOIDY; COMPARATIVE STUDY; ENVIRONMENTAL EXPOSURE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC TOXICOLOGY; GENOTOXICITY; HUMAN; PESTICIDE SPRAYING; PRIORITY JOURNAL; REVIEW; SEMEN ANALYSIS; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY;

ANEUGENS; ANEUPLOIDY; ANIMALS; FEMALE; HUMANS; MALE; MUTAGENS; PESTICIDES; SPERMATOZOA;

EID: 26244444334     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086915     Document Type: Review

References (96)

1. Aardema MJ, Albertini S, Arni P, Henderson LM, Kirsch-Volders M, Mackay JM, Sarrif AM, Stringer DA, Taalman RD: Aneuploidy: a report of an ECETOC task force. Mutat Res 410:3-79 (1998).
2. Adler ID: Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study. Mutat Res 287:131-137 (1993).
3. Adler ID: Comparison of the duration of spermatogenesis between male rodents and humans. Mutat Res 352:169-172 (1996).
4. Albertini S, Friederich U, Holderegger C, Wurgler FE: The in vitro porcine brain tubulin assembly assay: effects of a genotoxic carcinogen (aflatoxin B1), eight tumor promoters and nine miscellaneous substances. Mutat Res 201:283-292 (1988).
5. Allen JW, Liang JC, Carrano AV, Preston RJ: Review of literature on chemical-induced aneuploidy in mammalian germ cells. Mutat Res 167:123-137 (1986).
6. Aprea C, Colosio C, Mammone T, Minoia C, Maroni M: Biological monitoring of pesticide exposure: a review of analytical methods. J Chromatogr B 769:191-219 (2002).
7. Barale R, Scapoli C, Meli C, Casini D, Minunni M, Marrazzini A, Loprieno N, Barrai I: Cytogenetic effects of benzimidazoles in mouse bone marrow. Mutat Res 300:15-28 (1993).
8. Barr DB, Needham LL: Analytical methods for biological monitoring of exposure to pesticides: a review. J Chromatogr B 778:5-29 (2002).
9. Baumgartner A, Van Hummelen P, Lowe XR, Adler ID, Wyrobek AJ: Numerical and structural chromosomal abnormalities detected in human sperm with a combination of multicolor FISH assays. Environ Mol Mutagen 33:49-58 (1999).
10. Baumgartner A, Schmid TE, Maerz HK, Adler ID, Tarnok A, Nuesse M: Automated evaluation of frequencies of aneuploid sperm by laser-scanning cytometry (LSC). Cytometry 44:156-160 (2001).
11. Bernardini L, Martini E, Geraedts JP, Hopman AH, Lanteri S, Conte N, Capitanio GL: Comparison of gonosomal aneuploidy in spermatozoa of normal fertile men and those with severe male factor detected by in-situ hybridization. Mol Hum Reprod 3:431-438 (1997).
12. Blanco J, Egozcue J, Vidal F: Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization. Hum Reprod 11:722-726 (1996).
13. Bond DJ: Mechanisms of aneuploid induction. Mutat Res 181:257-266 (1987).
14. Brook JD, Chandley AC: Testing for the chemical induction of aneuploidy in the male mouse. Mutat Res 164:117-125 (1986).
15. Burruel VR, Raabe OG, Overstreet JW, Wilson BW, Wiley LM: Paternal effects from methamidophos administration in mice. Toxicol Appl Pharmacol 165:148-157 (2000).
16. Caballo C, Herrera A, Barrueco C, Santa-Maria A, Sanz F, de la Pena E: Analysis of cytogenetic damage induced in CHO cells by the pyrethroid insecticide fenvalerate. Teratog Carcinog Mutagen 12:243-249 (1992).
17. Calogero AE, De Palma A, Grazioso C, Barone N, Romeo R, Rappazzo G, D'Agata R: Aneuploidy rate in spermatozoa of selected men with abnormal semen parameters. Hum Reprod 16:1172-1179 (2001).
18. Chen HH, Hsueh JL, Sirianni SR, Huang CC: Induction of sister-chromatid exchanges and cell cycle delay in cultured mammalian cells treated with eight organophosphorus pesticides. Mutat Res 88:307-316 (1981).
19. Courtney KD, Andrews JE, Springer J: Assessment of teratogenic potential of trichlorfon in mice and rats. J Environ Sci Health B 21:207-227 (1986).
20. Czeizel AE: Phenotypic and cytogenetic studies in self-poisoned patients. Mutat Res 313:175-181 (1994).
21. Czeizel AE, Elek C, Gundy S, Métneki J, Nemes E, Reis A, Sperling K, Tímár L, Tusnády G, Virágh Z: Environmental trichlorfon and cluster of congenital abnormalities. Lancet 341:539-542 (1993).
22. Davidse LC, Flach W: Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans. J Cell Biol 72:174-193 (1977).
23. de Mas P, Daudin M, Vincent MC, Bourrouillou G, Calvas P, Mieusset R, Bujan L: Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin. Hum Reprod 16:1204-1208 (2001).
24. de Stoppelaar JM, van de Kuil T, Bedaf M, Verharen HW, Slob W, Mohn GR, Hoebee B, van Benthem J: Increased frequencies of diploid sperm detected by multicolour FISH after treatment of rats with carbendazim without micronucleus induction in peripheral blood erythrocytes. Mutagenesis 14:621-632 (1999).
25. Dellarco VL, Voytek PE, Hollaender A: Aneuploidy: Etiology and Mechanism, pp 103, 150 (Plenum, New York 1985).
26. Doherty AT, Ellard S, Parry EM, Parry JM: A study of the aneugenic activity of trichlorfon detected by centromere-specific probes in human lymphoblastoid cell lines. Mutat Res 372:221-231 (1996).
27. Falck GC, Hirvonen A, Scarpato R, Saarikoski ST, Migliore L, Norppa H: Micronuclei in blood lymphocytes and genetic polymorphism for GSTM1, GSTT1 and NAT2 in pesticide-exposed greenhouse workers. Mutat Res 441:225-237 (1999).
28. Ferguson LR, Allen JW, Mason JM: Meiotic recombination and germ cell aneuploidy. Environ Mol Mutagen 28:192-210 (1996).
29. Fleming LE, Gomez-Marin O, Zheng D, Ma F, Lee D: National Health Interview Survey mortality among US farmers and pesticide applicators. Am J Ind Med 43:227-233 (2003).
30. Franekić J, Bratulic N, Pavlica M, Papes D: Genotoxicity of dithiocarbamates and their metabolites. Mutat Res 325:65-74 (1994).
31. Garry VF, Schreinemachers D, Harkins ME, Griffith J: Pesticide appliers, biocides, and birth defects in rural Minnesota. Environ Health Perspect 104:394-399 (1996).
32. Garry VF, Harkins ME, Erickson LL, Long-Simpson LK, Holland SE, Burroughs BL: Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA. Environ Health Perspect 110 (Suppl 3):441-449 (2002).
33. Griffin DK, Abruzzo MA, Millie EA, Sheean LA, Feingold E, Sherman SL, Hassold TJ: Non-disjunction in human sperm: evidence for an effect of increasing paternal age. Hum Mol Genet 4:2227-2232 (1995).
34. Härkönen K, Viitanen T, Larsen SB, Bonde JP, Lähdetie J: Aneuploidy in sperm and exposure to fungicides and lifestyle factors. ASCLEPIOS. A European Concerted Action on Occupational Hazards to Male Reproductive Capability. Environ Mol Mutagen 34:39-46 (1999).
35. Härkönen K, Suominen J, Lähdetie J: Aneuploidy in spermatozoa of infertile men with teratozoospermia. Int J Androl 24:197-205 (2001).
36. Hassold T, Abruzzo M, Adkins K, Griffin D, Merrill M, Millie E, Saker D, Shen J, Zaragoza M: Human aneuploidy: incidence, origin, and etiology. Environ Mol Mutagen 28:167-175 (1996).
37. Hemavathi E, Rahiman MA: Toxicological effects of ziram, thiram, and dithane M-45 assessed by sperm shape abnormalities in mice. J Toxicol Environ Health 38:393-398 (1993).
38. Jeffay SC, Libbus BL, Barbee RR, Perreault SD: Acute exposure of female hamsters to carbendazim (MBC) during meiosis results in aneuploid oocytes with subsequent arrest of embryonic cleavage and implantation. Reprod Toxicol 10:183-189 (1996).
39. Ji BT, Silverman DT, Stewart PA, Blair A, Swanson GM, Baris D, Greenberg RS, Hayes RB, Brown LM, Lillemoe KD, Schoenberg JB, Pottern LM, Schwartz AG, Hoover RN: Occupational exposure to pesticides and pancreatic cancer. Am J Ind Med 39:92-99 (2001).
40. Kackar R, Srivastava MK, Raizada RB: Induction of gonadal toxicity to male rats after chronic exposure to mancozeb. Ind Health 35:104-111 (1997).
41. Kinakin B, Rademaker A, Martin R: Paternal age effect of YY aneuploidy in human sperm, as assessed by fluorescence in situ hybridization. Cytogenet Cell Genet 78:116-119 (1997).
42. Kurinniy AI: Comparative investigation of the cytogenetic effect of certain organophosphorous insecticides. Genetika 11:64-69 (1975).
43. Kurinniy AI, Pilinskaya MA: Cytogenetic activity of the pesticides imidan, dipterex and gardona in cultured human lymphocytes. Genetika 13:337-339 (1977).
44. Lander F, Knudsen LE, Gamborg MO, Järventaus H, Norppa H: Chromosome aberrations in pesticide-exposed greenhouse workers. Scand J Work Environ Health 26:436-442 (2000).
45. Lewis-Jones I, Aziz N, Seshadri S, Douglas A, Howard P: Sperm chromosomal abnormalities are linked to sperm morphologic deformities. Fertil Steril 79:212-215 (2003).
46. Lähdetie J, Larsen SB, Härkönen K: Analysis of chromosome aneuploidy in sperm by fluorescence in situ hybridization - a new approach to the study of male fertility in environmental exposures. Asclepios. Scand J Work Environ Health 25 (Suppl 1):26-27 (1999).
47. Madrigal-Bujaidar E, Cadena SR, Trujillo-Valdes VM, Cassani M: Sister-chromatid exchange frequencies induced by metrifonate in mammalian in vivo and in vitro systems. Mutat Res 300:135-140 (1993).
48. Mailhes JB, Aardema MJ: Benomyl-induced aneuploidy in mouse oocytes. Mutagenesis 7:303-309 (1992).
49. Mathew G, Vijayalaxmi KK, Abdul Rahiman M: Methyl parathion-induced sperm shape abnormalities in mouse. Mutat Res 280:169-173 (1992).
50. Meinert R, Schuz J, Kaletsch U, Kaatsch P, Michaelis J: Leukemia and non-Hodgkin's lymphoma in childhood and exposure to pesticides: results of a register-based case-control study in Germany. Am J Epidemiol 151:639-646; discussion 647-650 (2000).
51. Nehéz M, Huszta E, Mazzag E, Scheufler H, Schneider P, Fischer GW: Cytogenetic, genetic, and embryotoxicity studies with dimethyl 2,2,2-trichloro-1-(2,2,2-trichloro-1-hydroxyethoxy)-ethylphosphonate, a hypothetical impurity in technical grade trichlorfon. Ecotoxicol Environ Saf 13:216-224 (1987).
52. Olshan AF, Teschke K, Baird PA: Paternal occupation and congenital anomalies in offspring. Am J Ind Med 20:447-475 (1991).
53. Padungtod C, Hassold TJ, Millie E, Ryan LM, Savitz DA, Christiani DC, Xu X: Sperm aneuploidy among Chinese pesticide factory workers: scoring, by the FISH method. Am J Ind Med 36:230-238 (1999).
54. Parry EM, Henderson L, Mackay JM: Procedures for the detection of chemically induced aneuploidy: recommendations of a UK Environmental Mutagen Society working group. Mutagenesis 10:1-14 (1995).
55. Parry JM: Detecting chemical aneugens: a commentary to "Aneuploidy: a report of an ECETOC task force". Mutat Res 410:117-120 (1998).
56. Parry JM, Sors A: The detection and assessment of the aneugenic potential of environmental chemicals: the European Community Aneuploidy Project. Mutat Res 287:3-16 (1993).
57. Parry JM, Parry EM, Bourner R, Doherty A, Ellard S, O'Donovan J, et al: The detection and evaluation of aneugenic chemicals. Mutat Res 353:11-46 (1996).
58. Preston RJ: Aneuploidy in germ cells: disruption of chromosome mover components. Environ Mol Mutagen 28:176-181 (1996).
59. Puig M, Carbonell E, Xamena N, Creus A, Marcos R: Analysis of cytogenetic damage induced in cultured human lymphocytes by the pyrethroid insecticides cypermethrin and fenvalerate. Mutagenesis 4:72-74 (1989).
60. Recio R, Robbins WA, Borja-Aburto V, Moran-Martinez J, Froines JR, Hernandez RM, Cebrian ME: Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy. Environ Health Perspect 109:1237-1240 (2001).
61. Restrepo M, Munoz N, Day NE, Parra JE, de Romero L, Nguyen-Dinh X: Prevalence of adverse reproductive outcomes in a population occupationally exposed to pesticides in Colombia. Scand J Work Environ Health 16:232-238 (1990).
62. Robbins WA, Segraves R, Pinkel D, Wyrobek AJ: Detection of aneuploid human sperm by fluorescence in situ hybridization: evidence for a donor difference in frequency of sperm disomic for chromosomes 1 and Y. Am J Hum Genet 52:799-807 (1993).
63. nd, Weier HU, Blakey D, Wyrobek AJ: Three-probe fluorescence in situ hybridization to assess chromosome X, Y, and 8 aneuploidy in sperm of 14 men from two healthy groups: evidence for a paternal age effect on sperm aneuploidy. Reprod Fertil Dev 7:799-809 (1995).
64. Robbins WA, Meistrich ML, Moore D, Hagemeister FB, Weier HU, Cassel MJ, Wilson G, Eskenazi B, Wyrobek AJ: Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm. Nat Genet 16:74-78 (1997a).
65. Robbins WA, Vine MF, Truong KY, Everson RB: Use of fluorescence in situ hybridization (FISH) to assess effects of smoking, caffeine, and alcohol on aneuploidy load in sperm of healthy men. Environ Mol Mutagen 30:175-183 (1997b).
66. Rousseaux S, Hazzouri M, Pelletier R, Monteil M, Usson Y, Sele B: Disomy rates for chromosomes 14 and 21 studied by fluorescent in-situ hybridization in spermatozoa from three men over 60 years of age. Mol Hum Reprod 4:695-699 (1998).
67. Rubes J, Lowe X, Moore D 2nd, Perreault S, Slott V, Evenson D, Selevan SG, Wyrobek AJ: Smoking cigarettes is associated with increased sperm disomy in teenage men. Fertil Steril 70:715-723 (1998).
68. Rupa DS, Reddy PP, Reddi OS: Reproductive performance in population exposed to pesticides in cotton fields in India. Environ Res 55:123-128 (1991).
69. Sarrif AM, Bentley KS, Fu LJ, O'Neil RM, Reynolds VL, Stahl RG: Evaluation of benomyl and carbendazim in the in vivo aneuploidy/micronucleus assay in BDF1 mouse bone marrow. Mutat Res 310:143-149 (1994).
70. Schrader SM, Turner TW, Ratcliffe JM: The effects of ethylene dibromide on semen quality: a comparison of short-term and chronic exposure. Reprod Toxicol 2:191-198 (1988).
71. Schreinemachers DM: Birth malformations and other adverse perinatal outcomes in four U.S. wheat-producing states. Environ Health Perspect 111:1259-1264 (2003).
72. Schreinemachers DM, Creason JP, Garry VF: Cancer mortality in agricultural regions of Minnesota. Environ Health Perspect 107:205-211 (1999).
73. Shi Q, Martin RH: Aneuploidy in human spermatozoa: FISH analysis in infertile men with constitutional chromosomal abnormalities, and in infertile men. Reproduction 121:655-666 (2001).
74. Skakkebaek NE, Rajpert-De Meyts E, Main KM: Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16:972-978 (2001).
75. Smith JL, Garry VF, Rademaker AW, Martin RH: Human sperm aneuploidy after exposure to pesticides. Mol Reprod Dev 67:353-359 (2004).
76. Staples RE, Goulding EH: Dipterex teratogenicity in the rat, hamster and mouse when given by gavage. Environ Health Perspect 30:105-113 (1979).
77. Sun FY, Schmid TE, Schmid E, Baumgartner A, Adler ID: Trichlorfon induces spindle disturbances in V79 cells and aneuploidy in male mouse germ cells. Mutagenesis 15:17-24 (2000).
78. Surrallés J, Carbonell E, Puig M, Xamena N, Creus A, Marcos R: Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes. Toxicol Lett 54:151-155 (1990).
79. Templado C, Hoang T, Greene C, Rademaker A, Chernos J, Martin R: Aneuploid spermatozoa in infertile men: teratozoospermia. Mol Reprod Dev 61:200-204 (2002).
80. Undeger U, Institoris L, Siroki O, Nehez M, Desi I: Simultaneous geno- and immunotoxicological investigations for early detection of organophosphate toxicity in rats. Ecotoxicol Environ Saf 45:43-48 (2000).
81. US EPA: Pesticide fact sheet: Mancozeb (Office of Pesticide Programs, Washington DC 1987).
82. Ushijima C, Kumasako Y, Kihaile PE, Hirotsuru K, Utsunomiya T: Analysis of chromosomal abnormalities in human spermatozoa using multi-colour fluorescence in-situ hybridization. Hum Reprod 15:1107-1111 (2000).
83. van Bao T, Szabo I, Ruzicska P, Czeizel A: Chromosome aberrations in patients suffering acute organic phosphate insecticide intoxication. Human-genetik 1974:24:33-57 (1974).
84. Vicari E, de Palma A, Burrello N, Longo G, Grazioso C, Barone N, Zahi M, D'Agata R, Calogero AE: Absolute polymorphic teratozoospermia in patients with oligo-asthenozoospermia is associated with an elevated sperm aneuploidy rate. J Androl 24:598-603 (2003).
85. Warburton D, Kinney A: Chromosomal differences in susceptibility to meiotic aneuploidy. Environ Mol Mutagen 28:237-247 (1996).
86. Waters MD, Sandhu SS, Simmon VF, Mortelmans KE, Mitchell AD, Jorgenson TA, Jones DC, Valencia R, Garrett NE: Study of pesticide genotoxicity. Basic Life Sci 21:275-326 (1982).
87. Weisenburger DD: Human health effects of agrichemical use. Hum Pathol 24:571-576 (1993).
88. WHO (World Health Organization): International Programme on Chemical Safety: Trichlorfon, Health Safety Guide no. 66. (WHO, Geneva 1991).
89. WHO (World Health Organization) working group: Benomyl. Environmental Health Criteria 148:17 (1993a).
90. WHO (World Health Organization) working group: Carbendazim. Environmental Health Criteria 149:17 (1993b).
91. Whorton D, Krauss RM, Marshall S, Milby TH: Infertility in male pesticide workers. Lancet 2:1259-1261 (1977).
92. Wyrobek AJ, Watchmaker G, Gordon L, Wong K, Moore D 2nd, Whorton D: Sperm shape abnormalities in carbaryl-exposed employees. Environ Health Perspect 40:255-265 (1981).
93. Xia Y, Bian Q, Xu L, Cheng S, Song L, Liu J, Wu W, Wang S, Wang X: Genotoxic effects on human spermatozoa among pesticide factory workers exposed to fenvalerate. Toxicology 203:49-60 (2004).
94. Yin H, Cukurcam S, Betzendahl I, Adler ID, Eichenlaub-Ritter U: Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes. Chromosoma 1107:514-522 (1998).
95. Zahm SH, Ward MH, Blair A: Pesticides and cancer. Occup Med 12:269-289 (1997).
96. Zuelke KA, Perreault SD: Carbendazim (MBC) disrupts oocyte spindle function and induces aneuploidy in hamsters exposed during fertilization (meiosis II). Mol Reprod Dev 42:200-209 (1995).