Cytochrome P450/NADPH-dependent biosynthesis of 5,6-trans- epoxyeicosatrienoic acid from 5,6-trans-arachidonic acid

Biochemical Journal

Volumn 390, Issue 3, 2005, Pages 719-727

  Roy, Uzzal ^a   Joshua, Robert ^a   Stark, Russell L ^a   Balazy, Michael ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Arachidonic acid; Biosynthesis; Cytochrome P450; Free radical; Microsomal epoxidation and hydroxylation; Trans fatty acid

Indexed keywords

FATTY ACIDS; HYDROLYSIS; KETONES; LIPIDS; ORGANIC ACIDS;

ARACHIDONIC ACIDS; CYTOCHROME P450; FREE RADICAL; MICROSOMAL EXPOIDATION AND HYDROLYLATION; TRANS FATTY ACIDS;

BIOSYNTHESIS;

5,6 ARACHIDONIC ACID; 5,6 EPOXY 8,11,14 ICOSATRIENOIC ACID; ARACHIDONIC ACID DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2E1; EPOXIDE; ETHYLENE OXIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ICOSATRIENOIC ACID; OXYGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BIOSYNTHESIS; CHEMICAL BOND; CIS TRANS ISOMERISM; CONJUGATION; CONTROLLED STUDY; ENZYME MECHANISM; EPOXIDATION; HYDROLYSIS; HYDROXYLATION; LACTONIZATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

8,11,14-EICOSATRIENOIC ACID; ANIMALS; ARACHIDONIC ACID; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROLYSIS; HYDROXYEICOSATETRAENOIC ACIDS; HYDROXYLATION; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NADP; OXIDATION-REDUCTION; RATS;

EID: 25844477213     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050681     Document Type: Article

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