The Drosophila MSL complex activates the transcription of target genes

Genes and Development

Volumn 19, Issue 19, 2005, Pages 2284-2288

  Straub, Tobias ^a   Gilfillan, Gregor D ^a   Maier, Verena K ^a   Becker, Peter B ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Dosage compensation; MSL complex; Transcription

Indexed keywords

ANIMAL CELL; ARTICLE; AUTOSOME; CONTROLLED STUDY; DROSOPHILA; EMBRYO; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; X CHROMOSOME;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; MALE; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; X CHROMOSOME; Y CHROMOSOME;

EID: 25844440873     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1343105     Document Type: Article

References (40)

1. Akhtar, A. and Becker, P.B. 2000. Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila. Mol. Cell 5: 367-375.
2. Arbeitman, M.N., Furlong, E.E., Imam, F., Johnson, E., Null, B.H., Baker, B.S., Krasnow, M.A., Scott, M.P., Davis, R.W., and White, K.P. 2002. Gene expression during the life cycle of Drosophila melanogaster. Science 297: 2270-2275.
3. Bashaw, G.J. and Baker, B.S. 1995. The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal. Development 121: 3245-3258.
4. Belote, J.M. and Lucchesi, J.C. 1980. Control of X chromosome transcription by the maleless gene in Drosophila. Nature 285: 573-575.
5. Benos, P.V., Gatt, M.K., Ashburner, M., Murphy, L., Harris, D., Barrell, B., Ferraz, C., Vidal, S., Brun, C., Demailles, J., et al. 2000. From sequence to chromosome: The tip of the X chromosome of D. melanogaster. Science 287: 2220-2222.
6. Bhadra, U., Pal-Bhadra, M., and Birchler, J.A. 1999. Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila. Genetics 152: 249-268.
7. _. 2000. Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila. Genetics 155: 753-763.
8. Birchler, J.A., Bhadra, U., Bhadra, M.P., and Auger, D.L. 2001. Dosage-dependent gene regulation in multicellular eukaryotes: Implications for dosage compensation, aneuploid syndromes, and quantitative traits. Dev. Biol. 234: 275-288.
9. Birchler, J.A., Pal-Bhadra, M., and Bhadra, U. 2003. Dosage dependent gene regulation and the compensation of the X chromosome in Drosophila males. Genetica 117: 179-190.
10. Birchler, J.A., Riddle, N.C., Auger, D.L., and Veitia, R.A. 2005. Dosage balance in gene regulation: Biological implications. Trends Genet. 21: 219-226.
11. Bone, J.R. and Kuroda, M.I. 1996. Dosage compensation regulatory proteins and the evolution of sex chromosomes in Drosophila. Genetics 144: 705-713.
12. Buscaino, A., Kocher, T., Kind, J.H., Holz, H., Taipale, M., Wagner, K., Wilm, M., and Akhtar, A. 2003. MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex. Mol. Cell 11: 1265-1277.
13. Chiang, P.W. and Kurnit, D.M. 2003. Study of dosage compensation in Drosophila. Genetics 165: 1167-1181.
14. Church, G.M. and Gilbert, W. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. 81: 1991-1995.
15. Demakova, O.V., Kotlikova, I.V., Gordadze, P.R., Alekseyenko, A.A., Kuroda, M.I., and Zhimulev, I.F. 2003. The MSL complex levels are critical for its correct targeting to the chromosomes in Drosophila melanogaster. Chromosoma 112: 103-115.
16. Franke, A. and Baker, B.S. 1999. The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila. Mol. Cell 4: 117-122.
17. Gorman, M. and Baker, B.S. 1994. How flies make one equal two: Dosage compensation in Drosophila. Trends Genet. 10: 376-380.
18. Gorman, M., Franke, A., and Baker, B.S. 1995. Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila. Development 121: 463-475.
19. Gu, W., Szauter, P., and Lucchesi, J.C. 1998. Targeting of MOF, a putative histone acetyl transferase, to the X chromosome of Drosophila melanogaster. Dev. Genet. 22: 56-64.
20. Hamada, F.N., Park, P.J., Gordadze, P.R., and Kuroda, M.I. Global regulation of X-chromosomal genes by the MSL complex in Drosophila melanogaster. Genes & Dev. (this issue).
21. Hiebert, J.C. and Birchler, J.A. 1994. Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster. Genetics 136: 913-926.
22. Hilfiker, A., Hilfiker-Kleiner, D., Pannuti, A., and Lucchesi, J.C. 1997. mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J. 16: 2054-2060.
23. Kageyama, Y., Mengus, G., Gilfillan, G., Kennedy, H.G., Stuckenholz, C., Kelley, R.L., Becker, P.B., and Kuroda, M.I. 2001. Association and spreading of the Drosophila dosage compensation complex from a discrete roX1 chromatin entry site. EMBO J. 20: 2236-2245.
24. Kelley, R.L. and Kuroda, M.I. 1995. Equality for X chromosomes. Science 270: 1607-1610.
25. Kelley, R.L., Solovyeva, I., Lyman, L.M., Richman, R., Solovyev, V., and Kuroda, M.I. 1995. Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila. Cell 81: 867-877.
26. Kuroda, M.I., Kernan, M.J., Kreber, R., Ganetzky, B., and Baker, B.S. 1991. The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell 66: 935-947.
27. -δδC(T) method. Methods 25: 402-408.
28. Lucchesi, J.C. 1998. Dosage compensation in flies and worms: The ups and downs of X-chromosome regulation. Curr. Opin. Genet. Dev. 8: 179-184.
29. Maiato, H., Sunkel, C.E., and Earnshaw, W.C. 2003. Dissecting mitosis by RNAi in Drosophila tissue culture cells. Biol. Proced. Online 5: 153-161.
30. Marin, I., Siegal, M.L., and Baker, B.S. 2000. The evolution of dosage-compensation mechanisms. Bioessays 22: 1106-1114.
31. Merante, F., Raha, S., Reed, J.K., and Proteau, G. 1996. The simultaneous isolation of RNA and DNA from tissues and cultured cells. Methods Mol. Biol. 58: 3-9.
32. Moon, H., Filippova, G., Loukinov, D., Pugacheva, E., Chen, Q., Smith, S.T., Munhall, A., Grewe, B., Bartkuhn, M., Arnold, R., et al. 2005. CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep. 6: 165-170.
33. Pal Bhadra, M., Bhadra, U., Kundu, J., and Birchler, J.A. 2005. Gene expression analysis of the function of the MSL complex in Drosophila. Genetics 169: 2061-2074.
34. Palmer, M.J., Mergner, V.A., Richman, R., Manning, J.E., Kuroda, M.I., and Lucchesi, J.C. 1993. The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males. Genetics 134: 545-557.
35. Sass, G.L., Pannuti, A., and Lucchesi, J.C. 2003. Male-specific lethal complex of Drosophila targets activated regions of the X chromosome for chromatin remodeling. Proc. Natl. Acad. Sci. USA 100: 8287-8291.
36. Schwartz, Y.B., Kahn, T.G., and Pirrotta, V. 2005. Characteristic low density and shear sensitivity of cross-linked chromatin containing polycomb complexes. Mol. Cell. Biol. 25: 432-439.
37. Siden-Kiamos, I., Saunders, R.D., Spanos, L., Majerus, T., Treanear, J., Savakis, C., Louis, C., Glover, D.M., Ashburner, M., and Kafatos, F.C. 1990. Towards a physical map of the Drosophila melanogaster genome: Mapping of cosmid clones within defined genomic divisions. Nucleic Acids Res. 18: 6261-6270.
38. Straub, T., Dahlsveen, I.K., and Becker, P.B. 2005a. Dosage compensation in flies: Mechanism, models, mystery. FEBS Lett. 579: 3258-3263.
39. Straub, T., Neumann, M.F., Prestel, M., Kremmer, E., Kaether, C., Haas, C., and Becker, P.B. 2005b. Stable chromosomal association of MSL2 defines a dosage compensated nuclear compartment. Chromosoma (in press).
40. Zhou, S., Yang, Y., Scott, M.J., Pannuti, A., Fehr, K.C., Eisen, A., Koonin, E.V., Fouts, D.L., Wrightsman, R., Manning, J.E., et al. 1995. Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster. EMBO J. 14: 2884-2895.