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Kelley, R.L.1
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0030913367
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Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism
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of special interest. Together with [10], there are six consensus SXL-binding sites in the msl-2 transcript: two in the 5′ and four in the 3′ UTRs. In Drosophila females, the SXL protein binds to the msl-2 transcript and prevents its translation. Without MSL-2, the complex does not form and X-chromosome function remains at the level appropriate to the presence of two X chromosomes. In males, the absence of SXL allows MSL-2 synthesis and complex formation resulting in doubling of X-linked gene activity.
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Kelley RL, Wang J, Bell L, Kuroda MI. Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism. of special interest Nature. 387:1997;195-199 Together with [10], there are six consensus SXL-binding sites in the msl-2 transcript: two in the 5′ and four in the 3′ UTRs. In Drosophila females, the SXL protein binds to the msl-2 transcript and prevents its translation. Without MSL-2, the complex does not form and X-chromosome function remains at the level appropriate to the presence of two X chromosomes. In males, the absence of SXL allows MSL-2 synthesis and complex formation resulting in doubling of X-linked gene activity.
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Nature
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Kelley, R.L.1
Wang, J.2
Bell, L.3
Kuroda, M.I.4
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3
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0030678550
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The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control
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of special interest. See annotation [9].
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Bashaw GJ, Baker BS. The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control. of special interest Cell. 89:1997;789-798 See annotation [9].
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Bashaw, G.J.1
Baker, B.S.2
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4
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The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males
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Palmer MJ, Mergner VA, Richman R, Manning JE, Kuroda MI, Lucchesi JC. The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males. Genetics. 134:1993;545-557.
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Palmer, M.J.1
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Kuroda, M.I.5
Lucchesi, J.C.6
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0029063585
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Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila
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Kelley, R.L.1
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Solovyev, V.5
Kuroda, M.I.6
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Sex-specific regulation of the male-specific lethal-1 dosage compensation gene in Drosophila
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0028885520
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The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal
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Bashaw, G.J.1
Baker, B.S.2
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8
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0030782516
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Drosophila male-specific lethal-2 protein: Structure/function analysis and dependence on MSL-1 for chromosome association
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of special interest. Together with [16], indirect cytoimmunofluorescence is used to monitor the binding of MSL proteins in males carrying complete or partial loss-of-function mutations as well as in XX individuals in which formation of the dosage compensation complex has been induced by ectopic induction of MSL-2. MSL-1 and MSL-2 bind first, followed - in apparent order - by MLE, MOF and MSL-3.
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Lyman LM, Copps K, Rastelli L, Kelley RL, Kuroda MI. Drosophila male-specific lethal-2 protein: structure/function analysis and dependence on MSL-1 for chromosome association. of special interest Genetics. 147:1997;1743-1753 Together with [16], indirect cytoimmunofluorescence is used to monitor the binding of MSL proteins in males carrying complete or partial loss-of-function mutations as well as in XX individuals in which formation of the dosage compensation complex has been induced by ectopic induction of MSL-2. MSL-1 and MSL-2 bind first, followed - in apparent order - by MLE, MOF and MSL-3.
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Genetics
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Lyman, L.M.1
Copps, K.2
Rastelli, L.3
Kelley, R.L.4
Kuroda, M.I.5
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9
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0031917787
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Targeting of MOF, a putative histone acetyl transferase, to the X chromosome of Drosophila melanogaster
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Gu W, Szauter P, Lucchesi JC. Targeting of MOF, a putative histone acetyl transferase, to the X chromosome of Drosophila melanogaster. of special interest Dev Genet. 22:1998;56-64 See annotation [15].
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Gu, W.1
Szauter, P.2
Lucchesi, J.C.3
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0026566417
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Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei
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Turner, B.M.1
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11
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0028009294
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Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila
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Turner, B.M.5
Kuroda, M.I.6
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12
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0342378132
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RoX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system
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of outstanding interest. Together with [20], a report of the cloning of two X-linked genes, roX1 and roX2, that encode RNAs with no ORF and are, therefore, of apparent structural function. The transcripts are not eliminated in males homozygous for loss-of-function mutations of the sex-differentiation genes but are eliminated by mutations in the msl genes. They are induced in XX individuals, if the function of the master regulatory gene Sxl is impaired or if ectopic expression of MSL-2 has been induced. In males, the roX1 transcript co-localizes with the dosage compensation protein MSL-1 in whole larval salivary gland nuclei.
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Meller VH, Wu KH, Roman G, Kuroda MI, Davis RL. roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system. of outstanding interest Cell. 88:1997;445-457 Together with [20], a report of the cloning of two X-linked genes, roX1 and roX2, that encode RNAs with no ORF and are, therefore, of apparent structural function. The transcripts are not eliminated in males homozygous for loss-of-function mutations of the sex-differentiation genes but are eliminated by mutations in the msl genes. They are induced in XX individuals, if the function of the master regulatory gene Sxl is impaired or if ectopic expression of MSL-2 has been induced. In males, the roX1 transcript co-localizes with the dosage compensation protein MSL-1 in whole larval salivary gland nuclei.
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Meller, V.H.1
Wu, K.H.2
Roman, G.3
Kuroda, M.I.4
Davis, R.L.5
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13
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0030975363
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Genes expressed in neurons of adult male Drosophila
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Amrein, H.1
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Hodgkin, J.1
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Meyer, B.J.1
Casson, L.P.2
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0029807745
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Sex-specific assembly of a dosage compensation complex on the nematode X chromosome
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of outstanding interest. Together with [25-27], indirect cytoimmunofluorescence is here used to demonstrate the binding of DPY-26, DPY-27, MIX-1 and SDC-3 to the X chromosomes of hermaphrodites and that this binding is influenced by loss-of-function mutations of the sdc-2 and dpy-30 genes. The papers also provide biochemical proof for the existence of a large multi-protein dosage compensation complex.
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Chuang PT, Lieb JD, Meyer BJ. Sex-specific assembly of a dosage compensation complex on the nematode X chromosome. of outstanding interest Science. 274:1996;1736-1739 Together with [25-27], indirect cytoimmunofluorescence is here used to demonstrate the binding of DPY-26, DPY-27, MIX-1 and SDC-3 to the X chromosomes of hermaphrodites and that this binding is influenced by loss-of-function mutations of the sdc-2 and dpy-30 genes. The papers also provide biochemical proof for the existence of a large multi-protein dosage compensation complex.
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Science
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Chuang, P.T.1
Lieb, J.D.2
Meyer, B.J.3
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18
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0030934488
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SDC-3 coordinates the assembly of a dosage compensation complex on the nematode X chromosome
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Davis, T.L.1
Meyer, B.J.2
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19
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0028104856
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Chuang PT, Albertson DG, Meyer BJ. DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome. of outstanding interest Cell. 79:1994;459-474 See annotation [24].
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Chuang, P.T.1
Albertson, D.G.2
Meyer, B.J.3
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20
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0032559293
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Lieb JD, Albrecht MR, Chuang P-T, Meyer BJ. MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation. of outstanding interest Cell. 92:1998;1-20 See annotation [24].
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Lieb, J.D.1
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0029807952
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DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode
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Lieb JD, Capowski EE, Meneely P, Meyer BJ. DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode. Science. 274:1996;1732-1736.
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Lieb, J.D.1
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Meyer, B.J.4
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25
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0030447612
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0030797349
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