Dual substrate and reaction specificity in mouse serine racemase: Identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the β-eliminase activity

Biochemistry

Volumn 44, Issue 39, 2005, Pages 13091-13100

  Strisovsky, Kvido ^a,c   Jiráskova, Jana ^a,b   Mikulová, Adriana ^a   Rulíšek, Lubomír ^a   Konvalinka, Jan ^a,b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; BIOSYNTHESIS; BRAIN; CATALYSIS; ENZYME INHIBITION; LIVING SYSTEMS STUDIES;

BACTERIAL EXPRESSION SYSTEMS; MOUSE SERINE RACEMASE (MSR); RACEMIZATION ACTIVITY;

ENZYMES;

3 HYDROXYASPARTIC ACID; BETA ELIMINASE; DEXTRO SERINE; DICARBOXYLIC ACID; GLYCINE; MALONIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PYRIDOXAL 5 PHOSPHATE; SERINE; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ARTICLE; BIOSYNTHESIS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RACEMIZATION;

AMINO ACIDS; ANIMALS; CLONING, MOLECULAR; DICARBOXYLIC ACIDS; ENZYME INHIBITORS; KINETICS; LYASES; MICE; RACEMASES AND EPIMERASES; SERINE; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 25444532514     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051201o     Document Type: Article

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