Local application of L-threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta

Journal of Neural Transmission

Volumn 109, Issue 10, 2002, Pages 1275-1294

  Loopuijt, L D ^a  

^a Zoologisches Institut   (Germany)

Author keywords

Glutamate uptake inhibitor; Parkinson's disease; Substantia nigra

Indexed keywords

ASPARTIC ACID DERIVATIVE; ENZYME INHIBITOR; MALONIC ACID; SUCCINATE DEHYDROGENASE; THREO HYDROXYASPARTATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BEHAVIOR; CATALEPSY; CONTROLLED STUDY; CYTOARCHITECTURE; IN VIVO STUDY; LOCOMOTION; MALE; MORPHOLOGY; NERVE CELL; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; REARING; RIGIDITY; SUBSTANTIA NIGRA;

ANIMALS; ASPARTIC ACID; BEHAVIOR, ANIMAL; BRAIN MAPPING; CATALEPSY; CELL COUNT; COLORING AGENTS; LOCOMOTION; MALE; MALONATES; MUSCLE RIGIDITY; NERVE DEGENERATION; NEURONS; PARKINSON DISEASE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 0036387723     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-002-0720-9     Document Type: Article

References (42)

1. Albin RL, Makowiec RL, Hollingsworth ZR, Dure IV LS, Penney JB, Young AB (1992) Excitatory amino acid binding sites in the basal ganglia of the rat: a quantitative autoradiographic study. Neurosci 46: 35-48
2. Beal MF, Brouillet E, Jenkins B, Henshaw R, Rosen B, Hyman BT (1993) Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. J Neurochem 61: 1147-1150
3. Bubser M, Keseberg U, Notz PK, Schmidt WJ (1992) Differential behavioural and neurochemical effects of compertitive and non-competitive NMDA receptor antagonists in rats. Eur J Pharmacol 229: 75-82
4. Cai G, Zhen X, Uryu K, Friedman E (2000) Activation of extracellular signal-regulated protein kinases is associated with a sensitised locomotor response to D(2) dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. J Neurosci 20: 1849-1857
5. Carey RJ (1983) Differential effects of limbic versus striatal dopamine loss on motoric function. Behav Brain Res 7: 283-296
6. Carter CJ (1982) Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats. Neurosci 21: 379-383
7. Choi DW (1992) Excitotoxic cell death. Neurobiol 23: 1261-1276
8. Connor B, Kozlowski DA, Schallert T, Tillerson JL, Davidson BL, Bohn MC (1999) Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the agd Parkinsonian rat. Gene Ther 6: 1936-1951
9. Damier P, Hirsch EC, Agid Y, Graybiel AM (1999) The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 122: 1437-1448
10. Dixon WJ, Massey FJ (1973) Introduction of statistical analysis. McGrawHill, New York
11. Elliott PJ, Close SP, Walsh DM, Hayes AG, Mariott AS (1990) Neuroleptic-induced catalepsy as a model of Parkinson's disease. II. Effect of glutamate antagonists. J Neural Transm [PD Sect] 2: 91-100
12. Emborg-Knott ME, Domino EF (1998) MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose. Exp Neurol 152: 214-220
13. Fallon JH, Riley JN, Moore RY (1978) Substantia nigra dopamine neurons: separate populations project to neostriatum and allocortex. Neurosci Lett 7: 157-162
14. Fearnly JM, Lees AJ (1991) Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114: 2283-2301
15. Gerfen CR, Baimbridge KG, Thibault J (1987) The neostriatal mosaic. III. Biochemical and developmental dissociation of patch-matrix mesostriatal systems. J Neurosci 7: 3935-3944
16. Greene JG, Greenamyre JT (1995) Exacerbation of NMDA, AMPA, and L-glutamate excitoxicity by the succinate dehydrogenase inhibitor malonate. J Neurochem 64: 2332-2338
17. Greene JG, Porter RH, Eller RV, Greenamyre JT (1993) Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. J Neurochem 61: 1151-1154
18. Guan J, Krishnamurthi R, Waldvogel HJ, Faull RL, Clark R, Gluckman P (2000) N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats. Brain Res 859: 286-292
19. Hassler R (1938) Zur Pathologie der Paralysis agitans und des postenzephalitischen Parkinsonismus. J Psychol Neurol 48: 387-476
20. Hazell AS, Itzhak Y, Liu H, Norenberg MD (1997) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. J Neurochem 68: 2216-2219
21. Hesselink, MB, Smolders H, De Boer H, Breimer DD, Danysz W (1999) Modification of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (3)MK-801 after chronic administration. Behav Pharmacol 10: 85-98
22. 28K- containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity. Mol Brain Res 13: 251-261
23. Karcz-Kubicha M, Lorenz B, Danysz W (1999) GlycineB antagonists and partial agonists in rodent models of Parkinson's disease-comparison with uncompetitive N-methyl-D-aspartate receptor antagonists. Neuropharmacol 38: 109-119
24. Kretschmer BD (1999) Modulation of mesolimbic dopamine system by glutamate: role of NMDA receptors. J Neurochem 73: 839-848
25. Kuno S (1997) Differential therapeutic effects of dopamine D1 and D2 agonists in MPTP-induced parkinsonoism monkeys: clinical implications. Eur Neurol 38 [Suppl]: 118-122
26. 28K exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegen 5: 313-318
27. Liévens J-C, Dutertre M, Forni C, Salin P, Kerkerian-Le Goff L (1997) Continous administration of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate produces striatal lesion. Mol Brain Res 50: 181-189
28. Loopuijt LD (1998) An in vivo rat model for Parkinson's disease. Eur J Neurosci 10: 318-318 (Abstract)
29. Loopuijt LD (1999) Neuronal degeneration in rat substantia nigra after repeated local injections of malonate and L-threo-hydroxyaspartate. Soc Neurosci Abstr 25: 1340 (Abstract)
30. Messam CA, Greene JG, Greenamyre JT, Robinson MB (1995) Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. Brain Res 684: 221-224
31. Mikkelsen M, Moller A, Jensen LH, Pedersen A, Harajehi JB, Pakkenberg H (1999) MPTP-induced Parkinsonism in minipigs: a behavioural, biochemical, and histological study. Neurotoxicol Teratol 21: 169-175
32. Miller DB, Reinhard JF, Daniels AJ, O'Callaghan JP (1991) Diethyldothiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium. J Neurochem 57: 541-549
33. Ozer HEAC, Starr MS (1997) Dopamine D1- and D2-dependent catalepsy in the rat requires functional NMDA receptors in the corpus striatum, nucleus accumbens and substantia nigra, pars reticulata. Brain Res 777: 51-59
34. Ögren SO, Fuxe K (1988) D1- and D2-receptor antagonists induce catalepsy via different efferent striatal pathways. Neurosci Lett 85: 333-338
35. Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates. Academic Press, New York
36. Pollack AE, Strauss JB (1999) Time dependence and role of N-methyl-D-aspartate glutamate receptors in the priming of D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats. Brain Res 827: 160-168
37. Schmidt WJ, Bubser M (1989) Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats. Pharmacol Biochem Behav 32: 621-623
38. Shashidharan P, Huntley GW, Murray JM, Buku A, Moran T, Walsh MJ, Morrison JH, Plaitakis A (1997) Immunohistochemicl localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spianl cord revealed by a novel monoclonal antibody. Brain Res 773: 139-148
39. Turski L, Klockgether T, Schwarz M, Sontag KH (1987) Substantia nigra and motor control in the rat: effect of intranigral alpha-kainate and gamma-D-glutamylaminomethyl-sulphonate on motility. Brain Res 424: 37-48
40. Volterra A, Bezzi P, Rizzini BL, Trotti D, Ullensvang K, Danbolt NC, Racagni G (1996) The competitive transport imhibitor L-trans-pyrrolidine-2,4-dicarboxylate triggers excitotoxicity in rat cortical nuron-astrocyte co-cultures via glutamate release rather than uptake inhibition. Eur J Neurosci 8: 2019-2028
41. 28K. Brain Res 526: 303-307
42. Zeevalk GD, Derr-Yellin E, Nicklas WJ (1995) Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. J Pharmacol Exp Ther 275: 1124-1130