Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling

BMC Bioinformatics

Volumn 6, Issue , 2005, Pages

  Freyhult, Eva ^a   Prusis, Peteris ^a   Lapinsh, Maris ^a   Wikberg, Jarl E S ^a   Moulton, Vincent ^a   Gustafsson, Mats G ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COMMERCIAL SOFTWARE; LIGAND-RECEPTOR INTERACTIONS; MICROARRAY GENE EXPRESSION DATA ANALYSIS; MULTIVARIATE REGRESSION MODELS; PARAMETER SELECTION; PREDICTION OF PROTEIN FUNCTION; STATISTICAL EVALUATION; VARIABLE SUBSET SELECTIONS;

BINDING ENERGY; DESIGN; GENE EXPRESSION; LIGANDS; PROTEINS;

ESTIMATION;

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ALPHA [1 [2 (1,4 BENZODIOXAN 5 YLOXY)ETHYL] 3 PYRROLIDINYL] 4 FLUOROACETOPHENONE; AMPEROZIDE; ASENAPINE; CLOZAPINE; FLUPAROXAN; FLUSPIRILENE; G PROTEIN COUPLED RECEPTOR; HALOPERIDOL; OCAPERIDONE; OLANZAPINE; PIPAMPERONE; QUETIAPINE; RACLOPRIDE; RISPERIDONE; SERTINDOLE; TIOSPIRONE; YOHIMBINE; ZIPRASIDONE; ZOTEPINE; ALPHA 1 ADRENERGIC RECEPTOR; LIGAND; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CHEMOMETRIC ANALYSIS; COMPUTER PROGRAM; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; LINEAR REGRESSION ANALYSIS; MULTIVARIATE ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEOMICS; RECEPTOR AFFINITY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VALIDATION PROCESS; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER LANGUAGE; COMPUTER SIMULATION; GENETIC SELECTION; HUMAN; PREDICTIVE VALUE; PROCEDURES; PROTEIN CONFORMATION; RAT; REGRESSION ANALYSIS; REPRODUCIBILITY; SOFTWARE; STATISTICAL MODEL; THEORETICAL MODEL;

ALGORITHMS; ANIMALS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MODELS, STATISTICAL; MODELS, THEORETICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROGRAMMING LANGUAGES; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, G-PROTEIN-COUPLED; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SELECTION, GENETIC; SOFTWARE;

EID: 25444521952     PISSN: 14712105     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-6-50     Document Type: Article

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