A strategy to study tyrosinase transgenes in mouse melanocytes

BMC Cell Biology

Volumn 6, Issue , 2005, Pages

  Lavado, Alfonso ^a,c   Matheu, Ander ^b   Serrano, Manuel ^b   Montoliu, Lluís ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN; MONOPHENOL MONOOXYGENASE; TYROSINE 3 MONOOXYGENASE;

ALLELE; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXON; GENE DELETION; GENE LOCUS; GENE MUTATION; GENOTYPE; MELANOCYTE; MOUSE; NONHUMAN; SOUTHERN BLOTTING; TRANSGENE; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 25444518266     PISSN: 14712121     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-6-18     Document Type: Article

References (47)

1. Bonifer C: Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required? Trends Genet 2000, 16:310-315.
2. Giraldo P, Montoliu L: Size matters: use of YACs, BACs and PACs in transgenic animals. Transgenic Res 2001, 10:83-103.
3. Montoliu L: Gene transfer strategies in animal transgenesis. Cloning Stem Cells 2002, 4:39-46.
4. Regales L, Giraldo P, Garcia-Diaz A, Lavado A, Montoliu L: Identification and functional validation of a 5' upstream regulatory sequence in the human tyrosinase gene homologous to the locus control region of the mouse tyrosinase gene. Pigment Cell Res 2003, 16:685-692.
5. Beermann F, Schmid E, Schutz G: Expression of the mouse tyrosinase gene during embryonic development: recapitulation of the temporal regulation in transgenic mice. Proc Natl Acad Sci U S A 1992, 89:2809-2813.
6. Gimenez E, Lavado A, Giraldo P, Montoliu L: Tyrosinase expression is not detected in mouse brain outside the retinal pigment epithelium cells. European J of Neurosc 2003, 18:2673-2676.
7. Beermann F, Ruppert S, Hummler E, Bosch FX, Muller G, Ruther U, Schutz G: Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 1990, 9:2819-2826.
8. Schedl A, Beermann F, Thies E, Montoliu L, Kelsey G, Schutz G: Transgenic mice generated by pronuclear injection of a yeast artificial chromosome. Nucleic Acids Res 1992, 20:3073-3077.
9. Schedl A, Montoliu L, Kelsey G, Schutz G: A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice. Nature 1993, 362:258-261.
10. Giraldo P, Montoliu L: Artificial chromosome transgenesis in pigmentary research. Pigment Cell Res 2002, 15:258-264.
11. Porter S, Larue L, Mintz B: Mosaicism of tyrosinase-locus transcription and chromatin structure in dark vs. light melanocyte clones of homozygous chinchilla-mottled mice. Dev Genet 1991, 12:393-402.
12. Montoliu L, Umland T, Schutz G: A locus control region at -12 kb of the tyrosinase gene. EMBO J 1996, 15:6026-6034.
13. Gimenez E, Giraldo P, Jeffery G, Montoliu L: Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene. Genesis 2001, 30:21-25.
14. Ganss R, Montoliu L, Monaghan AP, Schutz G: A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice. EMBO J 1994, 13:3083-3093.
15. Giraldo P, Martinez A, Regales L, Lavado A, Garcia-Diaz A, Alonso A, Busturia A, Montoliu L: Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity. Nucleic Acids Res 2003, 31:6290-6305.
16. Jackson IJ, Bennett DC: Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant. Proc Natl Acad Sci U S A 1990, 87:7010-7014.
17. Shibahara S, Okinaga S, Tomita Y, Takeda A, Yamamoto H, Sato M, Takeuchi T: A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine-serine substitution at position 85. Eur J Biochem 1990, 189:455-461.
18. Yokohama T, Silversides DW, Waymire KG, Kwon BS, Takeuchi T, Overbeek PA: Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res 1990, 18:7293-7298.
19. Bennett DC, Cooper PJ, Dexter TJ, Devlin LM, Heasman J, Nester B: Cloned mouse melanocyte lines carrying the germline mutations albino and brown: complementation in culture. Development 1985, 105:379-385.
20. Bennett DC, Cooper PJ, Hart IR: A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth. Int J Cancer 1987, 39:414-418.
21. Tamura A, Halaban R, Moellmann G, Cowan JM, Lerner MR, Lerner AB: Normal murine melanocytes in culture. In Vitro Cell Dev Biol 1987, 23:519-522.
22. Halaban R, Moellmann G, Tamura A, Kwon BS, Kuklinska E, Pomerantz SH, Lerner AB: Tyrosinases of murine melanocytes with mutations at the albino locus. Proc Natl Acad Sci U S A 1988, 85:7241-7245.
23. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA: Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996, 85:27-37.
24. Rinchik EM, Stoye JP, Frankel WN, Coffin J, Kwon BS, Russell LB: Molecular analysis of viable spontaneous and radiation-induced albino (c)-locus mutations in the mouse. Mutat Res 1993, 286:199-207.
25. Spanakis E, Lamina P, Bennett DC: Effects of the developmental colour mutations silver and recessive spotting on proliferation of diploid and immortal mouse melanocytes in culture. Development 1992, 114:675-680.
26. Sviderskaya EV, Bennett DC, Ho L, Bailin T, Lee ST, Spritz RA: Complementation of hypopigmentation in p-mutant (pink-eyed dilution) mouse melanocytes by normal human P cDNA, and defective complementation by OCA2 mutant sequences. J Invest Dermatol 1997, 108:30-34.
27. Sviderskaya EV, Novak EK, Swank RT, Bennett DC: The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat. Genetics 1998, 148:381-390.
28. Suzuki T, Li W, Zhang O, Novak EK, Sviderskaya EV, Wilson A, Bennett DC, Roe BA, Swank RT, Spritz RA: The gene mutated in cocoa mice, carrying a deffect of organelle biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3 gene. Genomics 2001, 78:30-37.
29. Suzuki T, Li W, Zhang O, Karim A, Novak EK, Sviderskaya EV, Hill SP, Bennett DC, Levin AV, Nieuwenhuis HK, Fong CT, Castellan C, Miterski B, Swank RT, Spritz RA: Hermasky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene. Nat Genet 2002, 30:321-324.
30. Sviderskaya EV, Hill SP, Evans-Whipp TJ, Chin L, Orlow SJ, Easty DJ, Cheong SC, Beach D, DePinho RA, Bennett DC: p16(Ink4a) in melanocyte senescence and differentiation. J Natl Cancer Inst 2002, 94:446-454.
31. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602.
32. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cellcycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366:704-707.
33. Sharpless NE, DePinho RA: The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev 1999, 9:22-30.
34. del Marmol V, Beermann F: Tyrosinase and related proteins in mammalian pigmentation. FEBS Lett 1996, 381:165-168.
35. Sviderskaya EV, Gray-Schopfer VC, Hill SP, Smit NP, Evans-Whipp TJ, Bond J, Hill L, Bataille V, Peters G, Kipling D, Wynford-Thomas D, Bennett DC: p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression. J Natl Cancer Inst 2003, 95:723-732.
36. Toyofuku K, Wada I, Valencia JC, Kushimoto T, Ferrans VJ, Hearing VJ: Oculocutaneous albinism types 1 and 3 are ER retention diseases: mutation of tyrosinase or Tyrp1 can affect the processing of both mutant and wild-type proteins. FASEB J 2001, 15:2149-2161.
37. Zdarsky E, Favor J, Jackson IJ: The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type. Genetics 1990, 126:443-449.
38. Ioffe E, Liu Y, Bhaumik M, Poirier F, Factor SM, Stanley P: WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras. Proc Natl Acad Sci U S A 1995, 92:7357-7361.
39. Obata M, Lee GH, Kanda H, Kitagawa T, Ogawa K: Loss of heterozygosity at loci on chromosome 4, a common genetic event during the spontaneous immortalization of mouse embryonic fibroblasts. Mol Carcinog 1997, 19:17-24.
40. Orlow I, Lacombe L, Hannon GJ, Serrano M, Pellicer I, Dalbagni G, Reuter VE, Zhang ZF, Beach D, Cordon-Cardo C: Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst 1995, 87:1524-1529.
41. Gimenez E, Lavado A, Giraldo P, Cozar P, Jeffery G, Montoliu L: A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism. Pigment Cell Res 2004, 17:363-370.
42. Yavuzer U, Keenan E, Lowings P, Vachtenheim J, Currie G, Goding CR: The Microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription. Oncogene 1995, 10:123-134.
43. Matheu A, Pantoja C, Efeyan A, Criado LM, Martín-Caballero J, Flores JM, Klatt P, Serrano M: Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev 2004, 18:2736-2746.
44. Rheinwald JG, Green H: Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinising colonies from single cells. Cell 1975, 6:331-334.
45. Donatien PD, Orlow SJ: Interaction of melanosomal proteins with melanin. Eur J Biochem 1995, 232:159-164.
46. Pomerantz SH: Tyrosine hydroxylation catalysed by mammalian tyrosinase: an improved method of assay. Biochem Biophys Res Comun 1964, 16:188-194.
47. Solano F, García-Borron JC: Advances in enzymatic analysis of melanogenesis. In The Pigmentary System: Physiology and Pathophysiology Edited by: Norlund JJ, Boissy RE, Hearing VJ, King RA, Ortonne JP. New York: Oxford University Press; 1998:461-471.