Genital herpes: Review of the epidemic and potential use of type-specific serology

Clinical Microbiology Reviews

Volumn 12, Issue 1, 1999, Pages 1-8

  Ashley, Rhoda L ^a,b   Wald, Anna ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; FAMCICLOVIR; VALACICLOVIR; VIRUS ANTIBODY; VIRUS GLYCOPROTEIN;

CLINICAL FEATURE; CLINICAL TRIAL; DIAGNOSTIC ERROR; DISEASE TRANSMISSION; ENZYME IMMUNOASSAY; EPIDEMIC; GENITAL HERPES; GENITAL SYSTEM DISEASE; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOCOMPETENCE; NEWBORN; ORAL DRUG ADMINISTRATION; PREGNANCY; RECURRENCE RISK; REVIEW; RISK FACTOR; SEROLOGY; SEROPREVALENCE; SYMPTOMATOLOGY; VIRUS SHEDDING; WESTERN BLOTTING;

EID: 0032901976     PISSN: 08938512     EISSN: None     Source Type: Journal    
DOI: 10.1128/cmr.12.1.1     Document Type: Review

References (84)

1. Ashley, R., K. Mack, C. Critchlow, M. Shurtleff, and L. Corey. 1988. Differential effect of systemic acyclovir treatment of genital HSV-2 infections on antibody responses to individual HSV-2 proteins. J. Med. Virol. 24:309-320.
2. Ashley, R., A. Cent, V. Maggs, A. Nahmias, and L. Corey. 1991. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 or 2. Ann. Intern. Med. 115:520-526.
3. Ashley, R. 1993. Laboratory techniques in the diagnosis of herpes simplex infection. Genitourin. Med. 69:174-183.
4. Ashley, R., A. Warford, C. Gleaves, J. Zenilman, D. Alexander, and L. Corey. 1997. Evaluation of CHIRON RIBA HSV type-1/type-2 strip immunoblot assay for typing of HSV antibodies, abstr. 29, p. 360. In Abstracts of the 35th Annual Meeting of the Infectious Disease Society of America 1997.
5. Ashley, R. 1998. Type-specific antibodies to HSV-1 and -2: review of methodology. Herpes 5:33-38.
6. Ashley, R. L., J. Militoni, F. Lee, A. Nahmias, and L. Corey. 1988. Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. J. Clin. Microbiol. 26:662-667.
7. Ashley, R. L. 1995. Current concepts of laboratory diagnosis of herpes simplex infection, p. 137-171. In S. L. Sacks, S. E. Straus, R. J. Whitley, and P. D. Griffiths (ed.), Clinical management of herpes viruses. IOS Press, Washington, D.C.
8. Ashley, R. L., L. Wu, J. Pickering, M. Tu, and L. Schnorenberg. 1998. Premarket evaluation of a commercial glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific antibodies. J. Clin. Microbiol. 36:294-295.
9. Barton, S. E., L. K. Wright, C. M. Link, and P. E. Munday. 1986. Screening to detect asymptomatic shedding of herpes simplex virus (HSV) in women with recurrent genital HSV infection. Genitourin. Med. 62:181-185.
10. Barton, S. E., J. M. Davis, V. W. Moss, A. S. Tyms, and P. E. Munday. 1987. Asymptomatic shedding and subsequent transmission of genital herpes simplex virus. Genitourin. Med. 63:102-105.
11. Barton, S. E., P. E. Munday, and R. J. Patel. 1996. Asymptomatic shedding of herpes simplex virus from the genital tract: uncertainly and its consequences for patient management. Intern. J. Sex. Transm. Dis. AIDS 7:229-232.
12. Benedetti, J., L. Corey, and R. Ashley. 1994. Recurrence rates of genital herpes after symptomatic first-episode infection. Ann. Intern. Med. 121:847-854.
13. Bernstein, D. I., M. A. Lovett, and Y. J. Bryson. 1984. Serologic analysis of first-episode nonprimary genital herpes simplex virus infection. Am. J. Med. 77:1055-1060.
14. Boucher, F. D., L. L. Yasukawa, K. Kerns, M. Kastelein, A. M. Arvin, and C. G. Prober. 1993. Detection of antibodies to herpes simplex virus type 2 with a mammalian cell line expressing glycoprotein gG-2. Clin. Diagn. Virol. 1:29-38.
15. Breinig, M. K., L. A. Kingsley, J. A. Armstrong, D. J. Freeman, and M. Ho. 1990. Epidemiology of genital herpes in Pittsburgh: serologic, sexual, and racial correlates of apparent and inapparent herpes simplex infections. J. Infect. Dis. 162:299-305.
16. Brock, B. V., S. Selke, R. L. Ashley, and L. Corey. 1990. Frequency of asymptomatic shedding of HSV in women with genital herpes. JAMA 263: 418-420.
17. Brown, Z. A., J. Benedetti, R. Ashley, S. Burchett, S. Selke, S. Berry, L. A. Vontver, and L. Corey. 1991. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N. Engl. J. Med. 324:1247-1252.
18. Brown, Z. A., J. K. Benedetti, D. H. Watts, S. Selke, S. Berry, R. Ashley, and L. Corey. 1995. A comparison between detailed and simple histories in the diagnosis of genital herpes complicating pregnancy. Am. J. Obstet. Gynecol. 172:1299-1303.
19. Brown, Z. A., S. Selke, J. Zeh, J. Kopelman, A. Maslow, R. L. Ashley, D. H. Watts, S. Berry, M. Herd, and L. Corey. 1997. The acquisition of herpes simplex virus during pregnancy. N. Engl. J. Med. 337:509-515.
20. Catotti, D. N., P. Clarke, and K. K. Catoe. 1993. Herpes revisited: still a cause for concern. Sex. Transm. Dis. 20:77-80.
21. Christenson, B., M. Bottiger, A. Svensson, and S. Jeansson. 1992. A 15-year surveillance study of antibodies to nerpes simplex virus types 1 and 2 in a cohort of young girls. J. Infect. 25:147-154.
22. Corey, L. 1990. Genital herpes, p. 391-413. In K. K. Holmes, P. A. Mardh, P. F. Sparling, and P. J. Wiesner (ed.), Sexually transmitted diseases, 2nd ed. McGraw Hill Book Co., New York, N.Y.
23. Corey, L. 1994. The current trend in genital herpes. Progress in prevention. Sex. Transm. Dis. 21(Suppl. 2):S38-S44.
24. Corey, L., and K. K. Holmes. 1983. Genital herpes simplex virus infection: current concepts in diagnosis, therapy and prevention. Ann. Intern. Med. 98:973-983.
25. Corey, L., and A. Wald. 1995. New developments in the biology of genital herpes, p. 43-53. In S. L. Sacks, S. E. Straus, R. J. Whitley, and P. D. Griffiths (ed.), Clinical management of herpes viruses - IOS Press, New York, N.Y.
26. Cowan, F. M., A. M. Johnson, R. Ashley, L. Corey, and A. Mindel. 1996. Relationship between antibodies to herpes simplex virus (HSV) and symptoms of HSV infection. J. Infect. Dis. 174:470-475.
27. Cunningham, A. L., F. K. Lee, D. W. Ho, P. R. Field, C. L. H. Law, D. R. Packham, I. D. McCrossin, E. Sjogren-Jansson, S. Jeansson, and A. J. Nahmias. 1993. Herpes simplex virus type 2 antibody in patients attending antenatal or STD clinics. Med. J. Aust. 158:525-528.
28. Douglas, J. M., C. Critchlow, J. Benedetti, G. J. Mertz, J. D. Connor, M. A. Hintz, A. Fahnlander, M. Remington, C. Winter, and L. Corey. 1984. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N. Engl. J. Med. 310:1551-1556.
29. Fairley, I., and E. F. Monteiro. 1997. Patient attitudes to type-specific serological tests in the diagnosis of genital herpes. Genitourin. Med. 73:259-262.
30. Fleming, D. T., G. M. McQuillan, R. E. Johnson, A. J. Nahmias, S. O. Aral, F. K. Lee, and M. E. St. Louis. 1997. Herpes simplex virus type 2 in the United States, 1976 to 1994. N. Engl. J. Med. 337:1105-1111.
31. Forsgren, M., E. Skoog, S. Jeansson, S. Olofsson, and J. Giesecke. 1994. Prevalence of antibodies to herpes simplex virus in pregnant women in Stockholm in 1969, 1983 and 1989: implications for STD epidemiology. Int. J. Sex. Transm. Dis. AIDS 5:113-116.
32. Frenkel, L. M., E. M. Garratry, J. P. Shen, N. Wheeler, O. Clark, and Y. J. Bryson. 1993. Clinical reactivation of herpes simplex virus type 2 infection in seropositive pregnant women with no history of genital herpes. Ann. Intern. Med. 118:414-418.
33. Gibson, J. J., C. A. Hornung, G. R. Alexander, F. K. Lee, W. A. Potts, and A. J. Nahmias. 1990. A cross-sectional study of herpes simplex virus types 1 and 2 in college students: occurrence and determinants of infection. J. Infect. Dis. 162:306-312.
34. Green, J., and A. Kocsis. 1997. Psychological factors in recurrent genital herpes. Genitourin. Med. 73:253-258.
35. Hashido, M., F. K. Lee, S. Inouye, and T. Kawana. 1997. Detection of herpes simplex virus type-specific antibodies by an enzyme-linked immunosorbent assay based on glycoprotein G. J. Med. Virol. 53:319-323.
36. Ho, D. W. T., P. R. Field, E. Sjogren-Jansson, S. Jeansson, and A. L. Cunningham. 1992. Indirect ELISA for the detection of HSV-2 specific IgG and IgM antibodies with glycoprotein G (gG-2). J. Virol. Methods 36:249-264.
37. Ho, D. W. T., P. R. Field, W. L. Irving, D. R. Packham, and A. L. Cunningham. 1993. Detection of immunoglobulin M antibodies to glycoprotein G-2 by Western blot (immunoblot) for diagnosis of initial herpes simplex virus type 2 genital infections. J. Clin. Microbiol. 31:3157-3164.
38. Holmberg, S. D., J. A. Stewart, G. Russel, R. H. Byers, F. K. Lee, P. M. O'Malley, and A. J. Nahmias. 1988. Prior herpes simplex virus type 2 infection as a risk factor for HIV infection. JAMA 259:1048-1050.
39. Hook, E. W., R. O. Cannon, A. J. Nahmias, F. F. Lee, C. H. Campbell, D. Glasser, and T. C. Quinn. 1992. Herpes simplex virus infection as a risk factor for human immunodeficiency virus infection in heterosexuals. J. Infect. Dis. 165:251-255.
40. Johnson, L. S., and B. Polsky. 1993. Herpes simplex virus infection in the cancer patient. Infect. Med. 10:18-52.
41. Johnson, J. R., S. Egaas, C. A. Gleaves, R. Hackman, and R. A. Bowden. 1992. Hepatitis due to herpes simplex virus in marrow-transplant recipients. Clin. Infect. Dis. 14:38-45.
42. Koelle, D. N., J. Benedetti, A. Langenberg, and L. Corey. 1992 Asymptomatic reactivation of herpes simplex virus in women after first episode of genital herpes. Ann. Intern. Med. 116:433-437.
43. Koutsky, L., R. Ashley, K. Homes, C. Stevens, C. Critchlow, N. Kiviat, C. Lipinski, P. Wolner-Hanssen, and L. Corey. 1990. The frequency of unrecognized type 2 herpes simplex virus infection among women: implications for the control of genital herpes. Sex. Transm. Dis. 17:90-94.
44. Koutsky, L. A., C. E. Stevens, K. K. Holmes, R. L. Ashley, N. B. Kiviat, C. W. Critchlow, and L. Corey. 1992. Underdiagnosis of genital herpes by current clinical and viral isolation procedures. N. Engl. J. Med. 326:1533-1539.
45. Kusne, S., M. Schwartz, M. Breinig, J. S. Dummer, R. E. Lee, R. Selby, T. E. Starzl, R. L. Simmons, and M. Ho. 1991. Herpes simplex virus hepatitis after solid organ transplantation in adults. J. Infect. Dis. 163:1001-1007.
46. Lafferty, W. E., S. Krofft, M. Remington, R. Giddings, C. Winter, A. Cent, and L. Corey. 1987. Diagnosis of herpes simplex virus by direct immunofluorescence and viral isolation from samples of external genital lesions in a high prevalence population. J. Clin. Microbiol. 25:323-326.
47. Langenberg, A., J. Benedetti, J. Jenkins, R. L. Ashley, C. Winter, and L. Corey. 1989. Development of clinically recognizable genital lesions among women previously identified as having "asymptomatic" herpes simplex virus type 2 infection. Ann. Intern. Med. 110:882-887.
48. Lee, F. K., R. M. Coleman, L. Pereira, P. D. Bailey, M. Tatsuno, and A. J. Nahmias. 1985. Detection of herpes simplex virus type 2-specific antibody with glycoprotein G. J. Clin. Microbiol. 22:641-644.
49. Lee, F. K., L. Pereira, C. Griffin, E. Reid, and A. Nahmias. 1986. A novel glycoprotein for detection of herpes simplex virus type 1-specific antibodies. J. Virol. Methods 14:111-118.
50. Lopez, C., A. Arvin, and R. Ashley. 1993. Immunity to herpesvirus infection in humans, p. 397-425 In B. Roizman, R. J. Whitley, and C. Lopez (ed.), The human herpesviruses. Raven Press, New York, N.Y.
51. McGeoch, D. J., H. W. Moss, D. McNab, and M. C. Frame. 1987. DNA sequence and genetic content of the HindIII region in the short unique component of herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons. J. Gen. Virol. 68: 19-38.
52. Mertz, G., O. Schmidt, J. L. Jourden, M. E. Guinan, M. L. Remington, A. Fahnlander, C. Winter, K. K. Holmes, and L. Corey. 1985. Frequency of acquisition of first-episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts. Sex. Transm. Dis. 12:33-39.
53. Mertz, G., J. Benedetti, R. Ashley, S. Selke, and L. Corey. 1992. Risk factors for sexual transmission of genital herpes. Ann. Intern. Med. 116:197-202.
54. Mertz, G., M. O. Loveless, M. J. Levin, S. J. Kraus, S. L. Fowler, D. Goade, and S. K. Trying. 1997. Oral famciclovir for suppression of recurrent genital herpes simplex virus in women: a multicenter double-blind placebo controlled trial. Arch. Intern. Med. 157:343-349.
55. Mindel, A., A. Faherty, O. Carney, G. Patou, M. Freris, and P. Williams. 1988. Dosage and safety of long-term suppressive acyclovir therapy for recurrent genital herpes. Lancet ii:926-928.
56. Moore, D. E., R. L. Ashley, P. W. Zarutskie, R. Coombs, M. R. Soules, and L. Corey. 1989. Transmission of genital herpes by artificial insemination with a donor experiencing asymptomatic primary HSV-2 infection. JAMA 261: 3441-3443.
57. Nahmias A. J., F. K. Lee, and H. L. Keyserling. 1996. The epidemiology of genital herpes, p. 93-108. In L. Stanberry (ed.). Genital and neonatal herpes. John Wiley & Sons, Inc., New York, N.Y.
58. Oliver, L., A. Wald, M. Kim, J. Zeh, S. Selke, R. Ashley, and L. Corey. 1995. Seroprevalence of herpes simplex virus infections in a family medicine clinic. Arch. Fam. Med. 4:228-232.
59. Olofsson, S., M. Lundstrom, H. Marsden, S. Jeansson, and A. Vahine. 1986. Characterization of a herpes simplex virus type 2-specified glycoprotein with affinity for N-acetylgalactosamine-specific lectins and its identification as g92K or gG. J. Gen. Virol. 67:737-744.
60. Parks, D. L., C. M. Smith, J. M. Rose, J. Brandis, and S. R. Coates. 1991. Seroreactive recombinant herpes simplex virus type 2-specific glycoprotein G. J. Clin. Microbiol. 29:778-781.
61. Patel, R., N. J. Bodsworth, P. Woolley, B. Peters, G. Vejlsgaard, S. Saari, A. Gibb, J. Robinson, and the International Valaciclovir HSV Study Group. 1997. Valaciclovir for the suppression of recurrent genital HSV infection: a placebo controlled study of once daily therapy. Genitourin. Med. 73:105-109.
62. Prober, C. G., L. Corey, Z. A. Brown, P. A. Hensleigh, L. M. Frenkel, Y. J. Bryson, R. J. Whitley, and A. M. Arvin. 1992. The management of pregnancies complicated by genital infections with herpes simplex virus. Clin. Infect. Dis. 15:1031-1038.
63. Rapoport, T. A. 1986. Protein translocation across and integration into membranes. Crit. Rev. Biochem. 20:73-137.
64. Rattray, M. C., L. Corey, W. C. Reeves, L. A. Vontver, and K. K. Holmes. 1978. Recurrent genital herpes among women: symptomatic vs asymptomatic viral shedding. Br. J. Vener. Dis. 54:262-265.
65. Ross, J. D. C., J. W. Smith, and R. A. Elton. 1993. The epidemiology of herpes simplex types 1 and 2 infection of the genital tract in Edinburgh 1978-1991. Genitourin. Med. 69:381-383.
66. Safrin, S. 1992. Treatment of acyclovir-resistant herpes simplex virus infections in patients with AIDS. J. Acquired Immune Defic. Syndr. 5(Suppl. 1):S29-S32.
67. Sanchez-Martinez, D., D. S. Schmid, W. Whittington, D. Brown, W. C. Reeves, S. Chatterjee, R. J. Whitley, and P. E. Pellet. 1991. Evaluation of a test based on baculovirus-expressed glycoprotein G for detection of herpes simplex virus type-specific antibodies. J. Infect. Dis. 164:1196-1199.
68. Schacker, T., A. Ryncarz, J. Goddard, K. Diem, M. Shaughnessy, and L. Corey. 1998. Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men. JAMA 280:61-66.
69. Schacker, T., J. Zeh, H.-L. Hu, E. L. Hill, and L. Corey. Frequency of symptomatic and asymptomatic HSV-2 reactivations among HIV-infected men. J. Infect. Dis., in press.
70. Scoular, A., B. G. S. Leask, and D. Carrington. 1990. Changing trends in genital herpes due to herpes simplex virus type 1 in Glasgow, 1985-88. Genitourin. Med. 66:226.
71. Slomka, M. J., R. L. Ashley, R. M. Cowan, A. Cross, and D. W. G. Brown. 1995. Monoclonal antibody blocking testes for the detection of HSV-1 and HSV-2 specific humoral responses: comparison with Western blot assay. J. Virol. Methods 55:27-35.
72. Stamm, W. E., H. H. Handsfield, A. M. Rompalo, R. Ashley, P. Roberts, and L. Corey. 1988. The association between genital ulcer disease and acquisition of HIV infection in homosexual men. JAMA 260:1429-1433.
73. Stewart, J. A., S. E. Reef, P. E. Pellett, L. Corey, and R. J. Whitley. 1995. Herpesvirus infections in persons infected with human immunodeficiency virus. Clin. Infect. Dis. 21:S114-S120.
74. Strand, A., A. Vahlne, B. Svennerholm, J. Wallin, and E. Lycke. 1986. Asymptomatic virus shedding in men with genital herpes infection. Scand. J. Infect. Dis. 18:195-197.
75. Straus, S. E., H. E. Takiff, M. Seidlin, S. Bachrach, L. Lininger, and J. J. DiGiovanna. 1984. Suppression of frequently recurring genital herpes. N. Engl. J. Med. 310:1545-1550.
76. Straus, S. E., M. Seidlin, H. E. Takiff, J. F. Rooney, J. M. Felser, H. A. Smith, P. Roane, F. Johnson, C. Hallahan, J. M. Ostrove, and S. Nusinoff-Lehrman. 1989. Effect of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes. Sex. Transm. Dis. 16:107-113.
77. Sullender, W. M., L. L. Yasukawa, M. Schwartz, L. Pereira, P. A. Hensleigh, C. G. Prober, and A. M. Arvin. 1988. Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with neonatal herpes. J. Infect. Dis. 157:164-171.
78. Svennerholm, B., S. Olofsson, S. Jeansson, A. Vahlne, and E. Lycke. 1984. Herpes simplex virus type-selective enzyme-linked immunosorbent assay with Helix pomatia lectin-purified antigens. J. Clin. Microbiol. 19:235-239.
79. Wald, A., J. Zeh, S. Selke, R. L. Ashley, and L. Corey. 1995. Virologic characteristics of subclinical and symptomatic genital herpes infections. N. Engl. J. Med. 333:770-775.
80. Wald, A., L. Taylor, T. Warren, M. Remington, S. Selke, J. Zeh, and L. Corey. 1995. Subclinical shedding of herpes simplex virus in men with genital herpes, abstr. H-111, p. 199. In Program and Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
81. Wald, A., J. Zeh, G. Barnum, L. G. Davis, and L. Corey. 1996. Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir. Ann. Intern. Med. 124:8-15.
82. Wald, A., L. Koutsky, R. L. Ashley, and L. Corey. 1997. Genital herpes in a primary care clinic: demographic and sexual correlates of herpes simplex type 2 infections. Sex. Transm. Dis. 24:149-155.
83. Wald, A., L. Corey, R. Cone, A. Hobson, G. Davis, and J. Zeh. 1997. Frequent genital herpes simplex virus 2 shedding in immunocompetent women: effect of acyclovir treatment. J. Clin. Invest. 99:1092-1097.
84. Whitley, R. J. 1991. Perinatal herpes simplex virus infections. Rev. Med. Virol. 1:101-110.