Homocysteine inhibits extra-embryonic vascular development in the avian embryo

Developmental Dynamics

Volumn 234, Issue 2, 2005, Pages 323-331

  Latacha, Kimberly S ^a,b   Rosenquist, Thomas H ^a  

^a NEBRASKA MEDICAL CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Homocysteine; Nitric Oxide; VEGF

Indexed keywords

HOMOCYSTEINE; MESSENGER RNA; NITRIC OXIDE; SULFUR AMINO ACID; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FOWL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; SYNTHESIS;

ANIMALS; BIRDS; CELL SURVIVAL; CELLS, CULTURED; CHICK EMBRYO; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; ENDOTHELIUM, VASCULAR; HOMOCYSTEINE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PATHOLOGIC; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXAZINES; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; TIME FACTORS; UMBILICAL VEINS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

AVES;

EID: 25444486633     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20527     Document Type: Article

References (27)

1. Az-ma T, Fujii K, Yuge O. 1995. Inhibitory effect of sevoflurane on nitric oxide release from cultured endothelial cells. Eur J Pharmacol 289:33-39.
2. Bhattacharyya A, 1994 Axons arrest the migration of Schwann cell precursors. Development 120:1411-1420.
3. Bikfalvi A, Sauzeau C, Moukadiri H, Maclouf J, Busso N, Bryckaert M, Plouet J, Tobelem G. 1991. Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects. J Cell Physiol 149:50-59.
4. Bouloumie A, Schini-Kerth VB, Busse R. 1999. Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovas Res 41:773-780.
5. Breier G. 2000. Angiogenesis in embryonic development: a review. Placenta 21(Suppl. A):S11-15.
6. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. 1996. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439.
7. Chow K, Cheung F, Lao TT, O K. 1999. Effect of homocysteine on the production of nitric oxide in endothelial cells. Clin Exp Pharmacol Physiol 26:817-818.
8. Clarke R, Stansbie D. 2001. Assessment of homocysteine as a cardiovascular risk factor in clinical practice. Ann Clin Biochem 38:624-632.
9. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. 1991. Hyperhomocysteinemia: An independent risk factor for vascular disease. N Engl J Med 324:1149-155.
10. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MS. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439-142.
11. Forsythe JA, Jiang BH, Oyer NV, Agani F, Leung SW, Koos RD, Semenza GL. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-16613.
12. Hamburger V, Hamilton HL. 1951. A series of normal stages in the development of the chick embryo. J Morph 88:49-58.
13. Ikeda U, Ikeda M, Minota S, Shimada K. 1999. Homocysteine increases nitric oxide synthesis in cytokine-stimulated vascular smooth muscle cells. Circulation 99:1230-1235.
14. Kanno S, Oda N, Abe M, Terai Y, Ito M, Shitara K, Tabayashi K, Shibuya M, Sato Y. 2000. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 19:2138-2146.
15. Kroll J, Waltenberger J. 1998. VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem Biophys Res Commun 252:743-746.
16. Limpach A, Dalton M, Miles R, Gadson P. 2000 Homocysteine Inhibits retinoic acid synthesis: a mechanism for homocyteine-induced congenital defects. Exp Cell Res 260:166-174
17. Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. 1998. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J Biol Chem 273:15257-15262.
18. McCully KS. 1969. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 56:111-128.
19. Medina MA, Urdialies JL, Amores-Sanchez MI. 2001. Roles of homocysteine in cell metabolism: Old and new functions. Eur J Biochem 268:3871-3882.
20. Nagai Y, Tasaki H, Takatsu H, Nihei S, Yamashita K, Toyokawa T, Nakachima Y. 2001. Homocysteine inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 281:726-731.
21. Quere I, Mercier E, Bellet H, Janbon C, Mares P, Gris JC. 2001. Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia. Fertil Steril 75:823-825.
22. Rosenquist TH, Ratashak SA, Shelub J. 1996. Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid. Proc Natl Acad Sci USA 93:15227-15232.
23. Shalaby F, Rossant J, Yamaguchi TP, Gerstenstein M, Wu FX, Breitman ML. 1995. Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice. Nature 376:62-66.
24. Tallquist MD, Soriano P, Klinghoffer RA. 1999. Growth factor signaling pathways in vascular development. Oncogene 18:7917-7932.
25. Upchurch GR, Welch GN, Fabian AJ, Pigazzi A, Keaney JF Jr, Loscalzo J. 1997. Stimulation of endothelial nitric oxide production by homocysteine. Atherosclerosis 132:177-185.
26. Welch GN, Upchurch GR, Farivar RS, Pigazzi A, Vu K, Breecher P, Keaney JF, Loscalzo J. 1998. Homocysteine-induced nitric oxide production in vascular smooth-muscle cells by NF-kappa B-dependent transcriptional activation of Nos2. Proc Assoc Am Physicians 110:22-31.
27. Ziche M, Morbidelli L. 2000. Nitric oxide and angiogenesis. J Neurononcol 50:139-148.