Stimulation of endothelial nitric oxide production by homocyst(e)ine

Atherosclerosis

Volumn 132, Issue 2, 1997, Pages 177-185

  Upchurch Jr , Gilbert R ^a,b   Welch, George N ^a   Fabian, Attila J ^a   Pigazzi, Alessio ^a   Keaney Jr , John F ^a   Loscalzo, Joseph ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Bradykinin; Calcium ionophore; Homocysteine; Homocystine; Nitric oxide

Indexed keywords

BRADYKININ; CYSTEINE; GLUTATHIONE; HOMOCYSTEINE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITROSO DERIVATIVE; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CATTLE; CELL DAMAGE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HYPERHOMOCYSTEINEMIA; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

ANIMALS; BRADYKININ; CATTLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HOMOCYSTEINE; NITRIC OXIDE; RNA, MESSENGER;

EID: 0030820780     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(97)00090-7     Document Type: Article

References (47)

1. Butz LW, du Vigneaud V. The formation of a homologue of cystine by the decomposition of methionine with sulfuric acid. J Biol Chem 1932;99:135-42.
2. McKully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969;56:111-28.
3. Kang SS, Wong PW, Cook HY, Norusis M, Messer JV. Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease. J Clin Invest 1986;77:1482-6.
4. Israelsson B, Brattstrom LE, Hultberg BL. Homocysteine and myocardial infarction. Atherosclerosis 1988;71:227-33.
5. Brattstrom LE, Hardebo JE, Hultberg BL. Moderate hyperhomocysteinemia - a possible risk factor for arteriosclerotic cerebrovascular disease. Stroke 1984;15:1012-6.
6. Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotidartery stenosis. N Engl J Med 1995;332:286-91.
7. Boers GH, Smals AG, Trijbels FJ. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N Engl J Med 1985;313:709-15.
8. Malinow MR, Kang SS, Taylor LM, et al. Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease. Circulation 1989;79:1180-8.
9. Mudd SH, Levy HL. Disorders of transsulfuration. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS, editors. The Metabolic Basis of Inherited Disease. New York: McGraw-Hill, 1983:522-559.
10. Mudd SH, Uhlendorf BW, Freeman JW, Finkelstein JD, Shih VE. Homocystinuria associated with decreased methylenete-trahydrofolate reductase activity. Biochem Biophys Res Commun 1972;46:905-12.
11. Kang SS, Wong PWK, Norusis M. Homocysteinemia due to folate deficiency. Metab, Clin Exp 1987;36:458-62.
12. 12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthetase deficiency. Metab, Clin Exp 1988;37:175-8.
13. 6: relationship to atherosclerosis. J Nutr 1983;113:2022-33.
14. Malinow MR. Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis. Circulation 1990;81:2004-6.
15. Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. J Am Med Assoc 1992;268:877-81.
16. Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest 1986;77:1370-6.
17. Stamler JS, Osborne JA, Jaraki O, et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 1993;91:308-18.
18. Upchurch GR Jr, Welch GN, Ramdev N, Fabian A, Keaney JF Jr, Loscalzo J. The effect of homocysteine on endothelial cell nitric oxide production. FASEB J 1995;9:A876.
19. Upchurch GR Jr, Welch GN, Freedman JF, Loscalzo J. Homocysteine attenuates endothelial glutathione peroxidase and thereby potentiates peroxide-mediated cell injury. Circulation 1995;92:I-228.
20. Freedman JF, Frei B, Welch GN, Loscalzo J. Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J Clin Invest 1995;96:394-400.
21. Tsai JC, Perrella MA, Yoshizumi M, et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci USA 1994;91:6369-73.
22. Schwartz SM. Selection and characterization of bovine aortic endothelial cells. In Vitro 1978;14:966-80.
23. Haudenschild CC, Zahniser D, Folkman J, Klagsbrun M. Human vascular endothelial cells in culture. Lack of response to serum growth factors. Exp Cell Res 1976;98:175-83.
24. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973;52:2745-56.
25. Jaffe EA, Hoyer LW, Nachman RL. Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J Clin Invest 1973;52:2757-64.
26. Fleming I, Hecker M, Busse R. Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells. Circ Res 1994;74:1220-6.
27. Cocks TM, Angus JA, Campbell JH, Campbell GR. Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture. J Cell Physiol 1985;123:310-20.
28. Pai TG, Payne WJ, LeGall J. Use of a chemiluminescence detector for quantitation of nitric oxide produced in assays of denitrifying enzymes. Anal Biochem 1987;166:150-7.
29. Stamler JS, Jaraki O, Osborne J, et al. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 1992;89:7674-7.
30. Welch GN, Upchurch GR Jr, Loscalzo J. S-nitrosothiol detection. Methods Enzymol 1996;268:293-8.
31. Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 1990;87:682-5.
32. Lamas S, Marsden PA, Li GK, Tempst P, Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinctive constitutive enzyme isoform. Proc Natl Acad Sci USA 1992;89:6348-52.
33. Jocelyn PC. Spectrophotometric assay of thiols. Methods Enzymol 1987;143:44-67.
34. Mohamed F, Monge JC, Gordon A, Cernacek P, Blais D, Stewart DJ. Lack of role for nitric oxide (NO) in the selective destablization of endothelial NO synthase by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol 1995;15:52-7.
35. Yoshizumi M, Perella MA, Burnett JC Jr., Lee ME. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 1993;73:205-9.
36. 2 reaction. Chem Res Toxicol 1994;7:519-25.
37. Meister A, Anderson ME. Glutathione (Review). Ann Rev Biochem 1983;52:711-60.
38. Kharitonov VG, Sundquist AR, Sharma VS. Kinetics of nitrosation of thiols by nitric oxide in the presence of oxygen. J Biol Chem 1995;270:28158-64.
39. Oae S, Tukushine D, Kim YH. Novel method of activating thiols by their conversion into thionitrites with dinitrogen tetraoxide. J Chem Soc Chem Commun 1977;407.
40. Ignarro LJ, Gruetter CA. Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite; possible involvement of S-nitrosothiols. Biochim Biophys Acta 1980;631:221-31.
41. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
42. Ignarro LJ, Lippton H, Edwards JC, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981;218:739-49.
43. Stamler JS, Loscalzo J. Capillary zone electrophoresis detection of biological thiols and their S-nitrosated derivatives. Anal Chem 1992;64:779-85.
44. Stamler JS, Simon DI, Osborne JA, et al. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA 1992;89:444-8.
45. Alpert CA, Ramdev N, George D, Loscalzo J. Detection of S-nitrosothiols and other NO-derivatives by photolysis-chemiluminescence spectroscopy. Anal Biochem 1997;245:1-7.
46. Ignarro LJ. Nitric oxide. A novel signal transduction mechanism for transcellular communication. Hypertension 1990;16:477-83.
47. Scharfstein JS, Keaney JF Jr., Slivka A, et al. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low-molecular weight thiols. J Clin Invest 1994;94:1432-9.