Comparison of gastric endoscopic lesions and tolerability to ibuprofen and ibuprofen-arginate in healthy subjects [1]

Journal of Clinical Gastroenterology

Volumn 39, Issue 9, 2005, Pages 834-835

  Gisbert, Javier P ^a   Abad Santos, Francisco ^a   Novalbos, Jesús ^a   Khorrami, Sam ^a   Callego Sandín, Sonia ^a   Rosado, Aránzazu ^a   Gálvez Múgica, Maria Ángeles ^a   Pajares, José María ^a  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ESPIDIFEN; IBUPROFEN; IBUPROFEN ARGININE; NONSTEROID ANTIINFLAMMATORY AGENT;

DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; EPIGASTRIC PAIN; GASTROINTESTINAL TOXICITY; GASTROSCOPY; HELICOBACTER PYLORI; HUMAN; LETTER; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARGININE; DRUG COMBINATIONS; GASTRIC MUCOSA; GASTROSCOPY; HUMANS; IBUPROFEN; PEPTIC ULCER; PROSPECTIVE STUDIES; REFERENCE VALUES; SEVERITY OF ILLNESS INDEX;

EID: 25444454822     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mcg.0000177259.95562.0a     Document Type: Letter

References (9)

1. Fornasini G, Monti N, Brogin G, et al. Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers. Chirality. 1997;9:297-302.
2. Sandrini G, Franchini S, Lanfranchi S, et al. Effectiveness of ibuprofen-arginine in the treatment of acute migraine attacks. Int J Clin Pharmacol Res. 1998;18:145-150.
3. Martin Calero MJ, Jimenez MD, Alarcon de la Lastra C, et al. Protective effect of L-arginine against ibuprofen-induced gastric injury in rats. Pharm Sci. 1997;3:609-612.
4. Lanza FL, Rack MF, Simon TJ, et al. Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen. Aliment Pharmacol Ther. 1999;13:761-767.
5. Cirino G. Nitric oxide releasing drugs: from bench to bedside. Dig Liver Dis. 2003;35(suppl 2):2-8.
6. Brzozowski T, Konturek SJ, Sliwowski Z, et al. Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. J Gastroenterol. 1997;32:442-452.
7. Black P, Max MB, Desjardins P, et al. A randomized, double-blind, placebo-controlled comparison of the analgesic efficacy, onset of action, and tolerability of ibuprofen arginate and ibuprofen in postoperative dental pain. Clin Ther. 2002;24:1072-1089.
8. Lanza FL, Royer GL Jr, Nelson RS, et al. The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers: a gastroscopic and photographic study. Dig Dis Sci. 1979;24:823-828.
9. Lanza FL. Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents. Am J Med. 1984;77:19-24.