Adenosine inhibits PDGF-induced growth of human glomerular mesangial cells via A2B receptors

Hypertension

Volumn 46, Issue 3, 2005, Pages 628-634

  Dubey, Raghvendra K ^a,b,c   Gillespie, Delbert G ^a   Mi, Zaichuan ^a   Jackson, Edwin K ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Adenosine; Glomerulosclerosis; Kidney; Mesangium; Receptors, adenine; Remodeling; Renal disease

Indexed keywords

1,3 DIPROPYL 8 4 SULFOPHENYLXANTHINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLOROADENOSINE; 5' N METHYLCARBOXAMIDEADENOSINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 9 (2 HYDROXY 3 NONYL)ADENINE; ADENOSINE; ADENOSINE 5' (N METHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR; CYCLOHEXYLADENOSINE; IODOTUBERCIDIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DNA SYNTHESIS; DRUG INHIBITION; ENZYME ACTIVATION; GLOMERULUS; HUMAN; HUMAN CELL; HYPERTENSION; MESANGIUM CELL; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; CELL DIVISION; CELLS, CULTURED; GLOMERULAR MESANGIUM; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PLATELET-DERIVED GROWTH FACTOR; RATS; RECEPTOR, ADENOSINE A2B;

EID: 25444452169     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000178464.63393.88     Document Type: Article

References (16)

1. Jackson EK, Dubey RK. Role of the extracellular cAMP-adenosine pathway in renal physiology. Am J Physiol Renal Physiol. 2001;28: F597-F612.
2. Olah SN, Stiles GL. The role of receptor structure in determining adenosine receptor activity. Pharmacol Ther. 2000;85:55-75.
3. 2B receptors. Pharmacol Rev. 1997;49:381-402.
4. Dubey RK, Gillespie DG, Jackson EK. Cyclic AMP-adenosine pathway induces nitric oxide synthesis in aortic smooth muscle cells. Hypertension. 1998;31:296-302.
5. Zhao Z, Kapoian T, Shepard M, Lianos EA. Adenosine-induced apoptosis in glomerular mesangial cells. Kidney Int. 2002;61:1276-1285.
6. 2B receptors mediate antimitogenesis in vascular smooth muscle cells. Hypertension. 2000;35(pt 2):267-272.
7. 2B receptors mediate antimitogenic effects of adenosine in cardiac fibroblasts. Hypertension. 2001;37(pt 2):716-721.
8. 2B receptors. Circulation. 1997;96:2656-2666.
9. Dubey RK, Mi Z, Gillespie DG, Jackson EK. Dysregulation of extracellular adenosine levels by vascular smooth muscle cells from spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol. 2001;21: 249-254.
10. Dubey RK, Jackson EK, Rupprecht HD, Sterzel RB. Factors controlling growth and matrix production in vascular smooth muscle and glomerular mesangial cells. Curr Opin Nephrol Hypertens. 1997;6:88-105.
11. Jackson EK, Zhu C, Tofovic SP. Expression of adenosine receptors in the preglomerular microcirculation. Am J Physiol Renal Physiol. 2002;283: F41-F51.
12. Kreisberg JI, Karnovsky MJ. Glomerular cells in culture. Kidney Int. 1983;23:439-447.
13. Dubey RK, Jackson EK, Gillespie DG, Zacharia LC, Imthurn B, Keller PJ. Clinically used estrogens differentially inhibit human aortic smooth muscle cell growth and mitogen-activated protein kinase activity. Arterioscler Thromb Vasc Biol. 2000;20:964-972.
14. Schrader, J. Formation and metabolism of adenosine and adenine nucleotides in cardiac tissue. In: Phillis JW, ed. Adenosine and Adenine Nucleotides as Regulators of Cellular Function. Boca Raton/Ann Arbor/Boston/London: CRC Press; 1991:55-69.
15. Jackson EK, Kohler M, Mi Z, Dubey RK, Tofovic SP, Carcillo JA, Jones GS. Possible role of adenosine deaminase in vaso-occlusive diseases J Hypertens. 1996;14:19-29.
16. 1 adenosine receptor. Circ Res. 2005;96:982-990.