Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants

Biochemistry

Volumn 44, Issue 16, 2005, Pages 6153-6163

  Vedula, L Sangeetha ^a   Rynkiewicz, Michael J ^a,d   Pyun, Hyung Jung ^b,e   Coates, Robert M ^b   Cane, David E ^c   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c BROWN UNIVERSITY   (United States)

^d DAIICHI SANKYO CO   (Japan)

^e GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; HYDROGEN BONDS; THERMODYNAMICS; X RAY ANALYSIS;

CARBOCATION; CYCLIZATION; DISPHOSPHATE; SYNTHASES;

SUBSTRATES;

5 EPI ARISTOLOCHENE SYNTHASE; BORNYLDIPHOSPHATE SYNTHASE; MAGNESIUM; PYROPHOSPHATE; SYNTHETASE; TRICHODIENE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFORMATION; CONTROLLED STUDY; CYCLIZATION; ELECTRICITY; HYDROGEN BOND; LIGAND BINDING; MOLECULAR RECOGNITION; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; THERMODYNAMICS; WILD TYPE;

AMINO ACID SUBSTITUTION; CARBON-CARBON LYASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHATES; FUSARIUM; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; SUBSTRATE SPECIFICITY; TERPENES; THERMODYNAMICS;

EID: 17644362311     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050059o     Document Type: Article

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