Liver transplantation: An "in vivo" model for the pathophysiology of hemochromatosis?

Hepatology

Volumn 39, Issue 6, 2004, Pages 1495-1498

  Kowdley, Kris V ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE MODEL; EDITORIAL; GENE; GENE MUTATION; HEMOCHROMATOSIS; HFE GENE; HUMAN; LIVER FUNCTION; LIVER TRANSPLANTATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LIVER TRANSPLANTATION; MEMBRANE PROTEINS;

EID: 2542627532     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20269     Document Type: Editorial

References (36)

1. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
2. Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receivetheir cues? Blood Cells Mol Dis 2003;30: 288-297.
3. Pietrangelo A. Physiology of iron transport and the hemochromatosis gene. Am J Physiol Gastrointest Liver Physiol 2002;282:G403-414.
4. Miret S, Simpson RJ, McKie AT. Physiology and molecular biology of dietary iron absorption. Annu Rev Nutr 2003;23:283-301.
5. Brissot P, Troadec MB, Loreal O. Intestinal absorption of iron in HFE-1 hemochromatosis: local or systemic process? J Hepatol 2004;40:702-709
6. McLaren GD, Nathanson MH, Jacobs A, Trevett D, Thomson W. Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis. J Lab Clin Med 1991;117:390-401.
7. Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A 1998; 95:1472-1477.
8. Parkkila S, Niemela O, Britton RS, Fleming RE, Waheed A, Bacon BR, et al. Molecular aspects of iron absorption and HFE expression. Gastroenterology 2001;121:1489-1496.
9. Whittington CA, Kowdley KV. Review article: haemochromatosis. Aliment Pharmacol Ther 2002;16:1963-1975
10. Feder JN, Tsuchihashi Z, Irrinki A, Lee VK, Mapa FA, Morikang E, et al. The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J Biol Chem 1997;272: 14025-14028.
11. Lombard M, Bomford A, Hynes M, Naoumov NV, Roberts S, Crowe J, et al. Regulation of the hepatic transferrin receptor in hereditary hemochromatosis. Hepatology 1989;9:1-5.
12. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-788.
13. Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to nontransferrin-bound iron. Blood 2003;102:371-376.
14. Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003;361: 669-673.
15. Merryweather-Clarke AT, Cadet E, Bomford A, Capron D, Viprakasit V, Miller A, McHugh PJ, et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum Mol Genet 2003;12:2241-2247.
16. Asberg A, Hveem K, Thorstensen K, Ellekjter E, Kannelonning K, Fjosne U, et al. Screening for hemochromatosis: high prevalence and low morbidity in an unselected population of 65,238 persons. Scand J Gastroenterol 2001;36:1108-1115.
17. Beutler E, Felitti VJ, Koziol JA, Ho NJ, Gelbart T. Penetrance of 845GA (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 2002;359:211-218.
18. Pillay P, Tzoracoleftherakis E, Tzakis AG, Kakizoe S, Van Thiel DH, Starzl TE. Orthotopic liver transplantation for hemochromatosis. Transplant Proc 1991;23:1888-1889.
19. Kilpe VE, Krakauer H, Wren RE. An analysis of liver transplant experience from 37 transplant centers as reported to Medicare. Transplantation 1993; 56:554-561.
20. Kowdley KV, Hassanein T, Kaur S, Farrell FJ, Van Thiel DH, Keeffe EB, et al. Primary liver cancer and survival in patients undergoing liver transplantation for hemochromatosis. Liver Transpl Surg 1995;1:237-241.
21. Cotler SJ, Bronner MP, Press RD, Carlson TH, Perkins JD, Emond MJ, Kowdley KV. End-stage liver disease without hemochromatosis associated with elevated hepatic iron index. J Hepatol 1998;29:257-262.
22. Brandhagen DJ. Liver transplantation for hereditary hemochromatosis. Liver Transpl 2001;7:663-672.
23. Kowdley KV, Brandhagen D, Gish R, Bass N, Weinstein J, Schilsky M, et al. Survival after orthotopic liver transplant (OLT) among patients with hepatic iron overload: interim results from the National Hemochromatosis Transplant Registry (NHTR) [abstract]. HEPATOLOGY 2001;34(Suppl): 236A.
24. Brandhagen DJ, Alvarez W, Therneau TM, Kruckeberg KE, Thibodeau SN, Ludwig J, et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. HEPATOLOGY 2000;31:456-460.
25. Stuart KA, Fletcher LM, Clouston AD, Lynch SV, Purdie DM, Kerlin P, et al. Increased hepatic iron and cirrhosis: no evidence for an adverse effect on patient outcome following liver transplantation. HEPATOLOGY 2000; 32:1200-1207.
26. Crawford DHG,.
27. Adams PC. Lessons from liver transplantation: flip, flop, and why? Gut 2003;52:318.
28. Alanen KW, Chakrabarti S, Rawlins JJ, Howson W, Jeffrey G, Adams PC. Prevalence of the C282Y mutation of the hemochromatosis gene in liver transplant recipients and donors. HEPATOLOGY 1999;30:665-669.
29. Powell LW. Does transplantation of the liver cure genetic hemochromatosis? J Hepatol 1992;16:259-261.
30. Dabkowski PL, Angus PW, Smallwood RA, Ireton J, Jones RM. Site of principal metabolic defect in idiopathic haemochromatosis: insights from transplantation of an affected organ. BMJ 1993;306:1726.
31. Koskinas J, Portmann B, Lombard M, Smith T, Williams R. Persistent iron overload 4 years after inadvertent transplantation of a haemochromatotic liver in a patient with primary biliary cirrhosis. J Hepatol 1992;16: 351-354.
32. Parolin MB, Batts KP, Wiesner RH, Bernstein PS, Zinsmeister AR, Harmsen WS, et al. Liver allograft iron accumulation in patients with and without pretransplantation hepatic hemosiderosis. Liver Transpl 2002;8:331-339.
33. Drakesmith H, Sweetland E, Schimanski L, Edwards J, Cowley D, Ashraf M, e al. The hemochromatosis protein HFE inhibits iron export from macrophages. Proc Natl Acad Sci U S A 2002;99:15602-15607.
34. Montosi G, Paglia P, Garuti C, Guzman CA, Bastin JM, Colombo MP, et al. Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis. Blood 2000;96:1125-1129.
35. Nicolas G, Viatte L, Lou DQ, Bennoun M, Beaumont C, Kahn A, et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet 2003;34:97-101.
36. Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol Dis 2003;30: 288-297.